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List of works by Jonathan Chernoff

6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF- B-dependent resistance to apoptosis in 3D mammary acini

scientific article published on 02 October 2007

A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish

scientific article published on May 2014

A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma

scientific article

A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

scientific article

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

scientific article

A major phosphotyrosyl-protein phosphatase from bovine heart is associated with a low-molecular-weight acid phosphatase

scientific article published in July 1985

A phosphotyrosyl-protein phosphatase activity associated with acid phosphatase from human prostate gland

scientific article published on 01 January 1984

A tale of two Paks

scientific article published on February 2008

Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A

scientific article published on 24 September 2011

Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells

scientific article published on 12 May 2009

Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice

scientific article published on 31 March 2014

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases

scholarly article

An emerging role for p21-activated kinases (Paks) in viral infections

scientific article

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

scientific article

Analysis and manipulation of intracellular signaling cascades

Analysis of PTP1B sumoylation

scientific article published on 25 September 2013

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

scientific article (publication date: 16 May 2003)

ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling

scientific article published on 11 June 2013

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.

scientific article

Back to the future: proceedings from the 2010 NF Conference.

scientific article published on 22 December 2010

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

scientific article

Cell cycle-regulated phosphorylation of p21-activated kinase 1.

scientific article

Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast

scientific article published in July 1998

Characterization of phosphotyrosyl-protein phosphatase activity associated with calcineurin

scientific article published in May 1984

Cloning and characterization of a human protein kinase with homology to Ste20

scientific article

Cloning and characterization of a member of the MST subfamily of Ste20-like kinases

scientific article

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase

scientific article

Detection of peptides, proteins, and drugs that selectively interact with protein targets

scientific article published in November 2002

Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)

scientific article

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice

scientific article published on 24 June 2015

Down-regulation of Insulin Signaling by Protein-tyrosine Phosphatase 1B Is Mediated by an N-terminal Binding Region

scientific article published in Journal of Biological Chemistry

Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells

scientific article published on 10 August 2015

Emerging from the Pak: the p21-activated protein kinase family.

scientific article published on April 1997

Epitope-tag vectors for eukaryotic protein production

article

Erratum: Close encounters of the LIM-kinase

scholarly article published in Nature Cell Biology

Essential role of CIB1 in regulating PAK1 activation and cell migration

scientific article

FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas

scientific article

Faculty of 1000 evaluation for Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma

scientific article published on 18 February 2020

Getting smart about p21-activated kinases

scientific article published on 29 November 2010

Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets

scientific article

Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro

scientific article published on 05 December 2016

Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer

scientific article published in Nature Communications

Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways

scientific article

Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis

scientific article published on 09 September 2009

H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization

scientific article published on 26 May 2016

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

scientific article

High midsummer for small GTPases

scientific article published in November 2002

Hras helps hippo heterodimerize to evade tumor suppression

scientific article published on 25 August 2016

Identification of a mouse p21Cdc42/Rac activated kinase

scientific article

Identification of a mouse p21cdc42/Racactivated kinase

scientific article published in Journal of Biological Chemistry

Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity

scientific article

Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways

scientific article

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo

scientific article published on 3 October 2011

Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA

scientific article

Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains

scientific article

Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development

scientific article

LOV conquers (sm)All GTPases

scientific article published on 12 April 2010

Lentivirus Nef specifically activates Pak2.

scientific article

Long-term culture and passage of human fetal liver cells that synthesize albumin

article

Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type 1.

scientific article

Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers

scientific article

Molecular pathways: targeting the kinase effectors of RHO-family GTPases

scientific article published on 21 October 2014

Multiple forms of phosphotyrosyl- and phosphoseryl-protein phosphatase from cardiac muscle: partial purification and characterization of an EDTA-stimulated phosphotyrosyl-protein phosphatase

scientific article published in October 1983

NF2: the wizardry of merlin

scientific article published on December 2003

Nerve Growth Factor Stimulates Tyrosine Phosphorylation and Activation of Src Homology-containing Protein-tyrosine Phosphatase 1 in PC12 Cells

scientific article published in Journal of Biological Chemistry

Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties

scientific article

P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice

scientific article published on 26 November 2012

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

scientific article

PAK signalling during the development and progression of cancer

scientific article

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

scientific article

PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics

scientific article

PKM2 enters the morpheein academy.

scientific article

PTP1B: a double agent in metabolism and oncogenesis

scientific article published on 08 April 2010

Pak GITs to Aurora-A.

scientific article

Pak1 and PIX regulate contact inhibition during epithelial wound healing

scientific article

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells

scientific article published on 10 April 2013

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration

scientific article published on June 2011

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells

scientific article published on 02 September 2008

Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance

scientific article

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation

scientific article

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation

scientific article

Pak2 regulates myeloid-derived suppressor cell development in mice

scientific article published on 10 October 2017

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

scientific article

Polymerase chain reaction cloning of related genes.

scientific article published on January 1995

Potential compensation among group I PAK members in hindlimb ischemia and wound healing

scientific article

Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction.

scientific article

Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin

scientific article

Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts

scientific article published on 5 August 2003

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

scientific article

Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

scientific journal article

Recent advances in methods to assess the activity of the kinome

scientific article

Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition

scientific article (publication date: 21 November 2016)

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

scientific article published in Journal of Biological Chemistry

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes

scientific journal article

Regulation of mammalian Ste20 (Mst) kinases

scientific article

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

scientific article (publication date: 21 April 2000)

Regulation of protein tyrosine phosphatase 1B by sumoylation

scientific article

Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310.

scientific article

Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer ⬇️

scientific article published on 20 July 2016

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1 ⬇️

scientific article published on October 13, 1995

Rho-GTPases: new members, new pathways

scientific article

Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors

scientific article

Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase.

scientific article

Role of p21-activated kinases in cardiovascular development and function

scientific article published on 04 May 2013

Search for Chemical Compounds for Pharmacotherapy of Neurofibromatosis Type 2

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells

scientific article

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

scientific article

Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells

scientific article published on March 2005

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites

scientific article

Src transforms in a Cool way.

scientific article

Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin

scientific article published on 20 January 2012

Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors

scientific article

Targeting Cdc42 in cancer ⬇️

scientific article published on August 19, 2013

Targeting PAK1.

scientific article published on February 2017

Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix

scientific article

Targeting effector pathways in RAC1P29S-driven malignant melanoma

scientific article published on 17 February 2020

Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis.

scientific article published on 22 May 2017

Temporal and spatial distribution of activated Pak1 in fibroblasts

scientific journal article

The DeMSTification of mammalian Ste20 kinases

scientific article published on May 2009

The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin

scientific article

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

scientific article published on 19 June 2013

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

scientific article

The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain

scientific article

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

scientific article

The cross-Rho'ds of cell-cell adhesion

scientific article published on 7 May 2004

The genetics of Pak.

scientific article published in September 2004

The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity.

scientific article published on 25 September 2006

The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers

scientific article

The role of p21-activated kinase in the initiation of atherosclerosis.

scientific article

The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein

scientific article

Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase

scientific article published on October 1994

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

scientific article published on December 2002

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP

scientific article

Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

scientific article published in Journal of Biological Chemistry

Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells

scientific article (publication date: 31 March 2005)

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways

scientific article published on 10 January 2013

p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear

scientific article published on 02 May 2013

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway

scientific article

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils

scientific article

p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

scientific article

p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

scientific article

p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.

scientific article

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

scientific article

p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

scientific article (publication date: August 2002)

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix

scientific article published on March 2016

p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation

scientific article published on 28 October 2011

p21-activated kinase inhibitors

scientific article (publication date: 2013)

p21-activated kinase links Rac/Cdc42 signaling to merlin

scientific article (publication date: 11 January 2002)

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics

scientific article published on 05 January 2009

p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target?

scientific article published on September 2010

p21-activated kinases: three more join the Pak.

scientific article

p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest

scientific article

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