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List of works by Claudio Tiribelli

"Two drinks per day does not take your fatty liver away".

scientific article published on 21 December 2017

1H NMR spectroscopic studies of lipid extracts from human fatty liver

scientific article published on 01 May 1993

A Hypothesis for Using Pathway Genetic Load Analysis for Understanding Complex Outcomes in Bilirubin Encephalopathy

scientific article published on 18 August 2016

A Novel Perspective on the Biology of Bilirubin in Health and Disease.

scientific article

A comparative characterization of the circulating miRNome in whole blood and serum of HCC patients

scientific article published on 04 June 2019

A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease

scientific article published on 24 June 2009

A simple in silico strategy identifies candidate biomarkers for the diagnosis of liver fibrosis in morbidly obese subjects

scientific article published on 26 June 2017

A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells

scientific article

ATP-dependent transport of unconjugated bilirubin by rat liver canalicular plasma membrane vesicles

scientific article published on April 1, 1998

Abc protein transport of MRI contrast agents in canalicular rat liver plasma vesicles and yeast vacuoles.

scientific article published on March 2001

Abnormal hepatic uptake of low doses of sulfobromophthalein in Gilbert's syndrome: the role of reduced affinity of the plasma membrane carrier of organic anions

scientific article published on 01 August 1990

Activation of hepatic stem cells compartment during hepatocarcinogenesis in a HBsAg HBV-transgenic mouse model

scientific article published in Scientific Reports

Affinity of human serum albumin for bilirubin varies with albumin concentration and buffer composition: results of a novel ultrafiltration method.

scientific article published on 7 June 2001

Alterations in the cell cycle in the cerebellum of hyperbilirubinemic Gunn rat: a possible link with apoptosis?

scientific article

Alterations in the redox state and liver damage: hints from the EASL Basic School of Hepatology.

scientific article published on 27 September 2012

An Animal Model for the Juvenile Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

scientific article

An improved method for isolation of unconjugated bilirubin from rat and dog bile.

scientific article published in May 2001

Anti-transglutaminase antibodies and age

scientific article published on 01 October 2004

Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management

article

Bilirubin and the risk of common non-hepatic diseases.

scientific article

Bilirubin induced neurological damage: from the cell to the newborn

scientific article published on 01 January 2009

Bilirubin inhibits the TNFalpha-related induction of three endothelial adhesion molecules.

scientific article

Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway

scientific article published on 2 December 2013

Bilirubin, Intestinal Integrity, the Microbiome, and Inflammation

scientific article published on 01 August 2020

Bilirubin-induced ER stress contributes to the inflammatory response and apoptosis in neuronal cells

scientific article

Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway

scientific article published on 04 May 2007

Bilirubin-induced neurologic damage

scientific article published on 01 March 2014

Bilirubin-induced neurologic damage--mechanisms and management approaches.

scientific article

Bilirubin-induced neurological damage.

scientific article published on October 2011

Bilistick: a low-cost point-of-care system to measure total plasma bilirubin.

scientific article published on 22 December 2012

Bilitranslocase and sulfobromophthalein/bilirubin-binding protein are both involved in the hepatic uptake of organic anions.

scientific article published on September 1993

Bilitranslocase is the protein responsible for the electrogenic movement of sulfobromophthalein in plasma membrane vesicles from rat liver: immunochemical evidence using mono- and poly-clonal antibodies

scientific article published on 01 May 1989

Biochemical and molecular aspects of the hepatic uptake of organic anions.

scientific article published on October 1990

Blue or green for yellow? Which light is more beneficial for jaundiced newborns?

scientific article published on 21 February 2019

Body mass index is a good predictor of an elevated alanine transaminase level in the general population: hints from the Dionysos study.

scientific article published in September 2003

Cellular localization of sulfobromophthalein transport activity in rat liver

scientific article published on 01 March 1986

Changing molecular epidemiology of hepatitis C virus infection in Northeast Italy.

scientific article published in November 2002

Chronic administration of ursodeoxycholic and tauroursodeoxycholic acid changes microsomal membrane lipid content and fatty acid compositions in rats

scientific article published on 01 March 1996

Circulatory miRNA as a Biomarker for Therapy Response and Disease-Free Survival in Hepatocellular Carcinoma

scientific article published on 29 September 2020

Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study

scientific article

Clinical, biochemical and histological features of primary haemochromatosis: a report of 67 cases

scientific article published on 01 October 1986

Cohort effect of HCV infection in liver cirrhosis assessed by a 25 year study.

scientific article

Comparison between Bilistick System and transcutaneous bilirubin in assessing total bilirubin serum concentration in jaundiced newborns

scientific article published on 15 June 2017

Comparison of nicotinic acid- and caloric restriction-induced hyperbilirubinaemia in the diagnosis of Gilbert's syndrome

scientific article published in January 1985

Competition of bile acids on the sulfobromophthalein uptake in basolateral rat liver plasma membrane vesicles

scientific article published on 01 September 1994

Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study

scientific article published on 20 April 2020

Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts

scientific article published in July 2014

Cryopreservation by slow cooling of rat neuronal cells

scientific article published on 6 May 2016

Curcumin Prevents Cerebellar Hypoplasia and Restores the Behavior in Hyperbilirubinemic Gunn Rat by a Pleiotropic Effect on the Molecular Effectors of Brain Damage

scientific article published on 30 December 2020

Cytotoxicity is predicted by unbound and not total bilirubin concentration.

scientific article published on November 2007

Detection of hepatitis B virus transcripts in patients with chronic liver disease.

scientific article published in March 1990

Difference in hepatic uptake of tetra- and di-bromosulfophthalein in rat. Role of hydrophobicity, binding to plasma proteins and affinity for plasma membrane carrier protein

scientific article published on 01 September 1993

Different genotypes of hepatitis C virus are associated with different severity of chronic liver disease.

scientific article published in July 1994

Different morphologic aspects and clinical features in massive hepatic amyloidosis

scientific article published on 01 January 1984

Differential proteomic analysis of subfractioned human hepatocellular carcinoma tissues

scientific article published in May 2009

Dissimilar expression of multidrug resistance mdr1 and bcrp by the replication of hepatitis C virus: role of the nonstructural 5A protein.

scientific article published on 28 November 2012

Drug-induced acute cholestatic liver damage in a patient with mutation of UGT1A1.

scientific article published in July 2007

Earliest Mechanisms of Dopaminergic Neurons Sufferance in a Novel Slow Progressing Ex Vivo Model of Parkinson Disease in Rat Organotypic Cultures of Substantia Nigra

scientific article published on 06 May 2019

Editorial: treatments for non-alcoholic steatohepatitis - still a long way to go.

scientific article published in October 2017

Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liver

scientific article

Effect of ethinylestradiol and epomediol on bile flow and biliary lipid composition in rat

scientific article (publication date: 17 March 1992)

Effect of phototherapy on the physiologic cholestasis of the neonate

scientific article published on 01 March 1984

Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line.

scientific article published on August 1995

Effect of ursodeoxycholic acid administration on bile duct proliferation and cholestasis in bile duct ligated rat

scientific article published on 01 July 1993

Effective treatment of unconjugated hyperbilirubinemia with oral bile salts in Gunn rats.

scientific article published on 6 November 2008

Effects of Oral Administration of Silymarin in a Juvenile Murine Model of Non-alcoholic Steatohepatitis

scientific article published on 12 September 2017

Efficient cold transfection of pea ferredoxin-NADP(H) oxidoreductase into rat hepatocytes.

scientific article

Epidemiology of fatty liver: an update

scientific article

Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy.

scientific article

Estrogens keep alive the hepatocyte memory

scientific article published in May 1988

Ethanol-induced apoptosis in vitro

scientific article published on 01 October 1999

Evaluation of liver parenchymal blood flow with contrast-enhanced US: preliminary results in healthy and cirrhotic patients.

scientific article

Evaluation of region selective bilirubin-induced brain damage as a basis for a pharmacological treatment

scientific article published on 19 January 2017

Evidence for carrier-mediated transport of unconjugated bilirubin across plasma membrane vesicles from human placental trophoblast.

scientific article

Factors affecting the binding of bilirubin to serum albumins: validation and application of the peroxidase method.

scientific article published on 25 October 2006

Familial clustering of Helicobacter pylori infection: population based study.

scientific article

Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin

scientific article

Further studies on bilitranslocase, a plasma membrane protein involved in hepatic organic anion uptake

scientific article published on 01 February 1982

Galectin-1 and its involvement in hepatocellular carcinoma aggressiveness

scientific article

Gene expression analysis in HBV transgenic mouse liver: a model to study early events related to hepatocarcinogenesis

scientific article published on April 2006

Gene expression and activity of urea cycle enzymes of rat hepatocytes cold stored up to 120h in University of Wisconsin solution

article

Genetic biomarkers for hepatocellular cancer risk in a caucasian population.

scientific article published on September 2017

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

scientific journal article

HBV, HCV, and TTV detection by in situ polymerase chain reaction could reveal occult infection in hepatocellular carcinoma: comparison with blood markers

scientific article

HCC occurrence after DAA treatments: molecular tools to assess the post-treatment risk and surveillance

scientific article published on 22 June 2020

HCV, HBV and alcohol - the Dionysos study.

scientific article published on January 2010

Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma.

scientific article published on March 2010

Hepatic uptake of organic anions affects the plasma bilirubin level in subjects with Gilbert's syndrome mutations in UGT1A1

scientific article published on 01 March 2001

Hepatitis B virus genotypes, core promoter variants, and precore stop codon variants in patients infected chronically in North-Eastern Italy.

scientific article published in June 2006

Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection.

scientific article published in January 2004

Hepatitis C virus infection, HBsAg carrier state and hepatocellular carcinoma: relative risk and population attributable risk from a case-control study in Italy.

scientific article published in November 1992

Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients

scientific article

Heterologous ferredoxin reductase and flavodoxin protect Cos-7 cells from oxidative stress

scientific article

Histone acetylation as a new mechanism for bilirubin-induced encephalopathy in the Gunn rat

scientific article published in Scientific Reports

Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis

scientific article published on 11 March 2019

In vitro and in vivo hepatic transport of the magnetic resonance imaging contrast agent B22956/1: role of MRP proteins

scientific article published on 01 April 2002

In vitro assessment of the ethanol-induced hepatotoxicity on HepG2 cell line

scientific article published on December 1993

In vitro models for the study of non-alcoholic fatty liver disease.

scientific article published on January 2011

Incidence and natural course of fatty liver in the general population: the Dionysos study.

scientific article published in November 2007

Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?

scientific article published on 01 March 2019

Inhibition of Glutamate Uptake by Unconjugated Bilirubin in Cultured Cortical Rat Astrocytes: Role of Concentration and pH

scientific article published on 01 November 1999

Interferon therapy in chronic hepatitis C virus: evidence of different outcome with respect to different viral strains.

scientific article published in April 1995

Intestinal flora and bilirubin

scientific article published on 01 February 2005

Is it time to change NAFLD and NASH nomenclature?

scientific article published in August 2017

Isolation of a sulfobromophthalein-binding protein from hepatocyte plasma membrane

scientific article published on January 25, 1978

Isolation of bilitranslocase, the anion transporter from liver plasma membrane for bilirubin and other organic anions

scientific article published on 01 January 1989

Mechanisms of bilirubin neurotoxicity

scientific article published in May 2002

Modeling, identification and parameter estimation of bilirubin kinetics in normal, hemolytic and Gilbert's states

scientific article published in December 1975

Modern strategies to identify new molecular targets for the treatment of liver diseases: The promising role of Proteomics and Redox Proteomics investigations.

scientific article

Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat.

scientific article

Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.

scientific article published on 25 December 2016

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis.

scientific article published on 22 January 2008

Molecular basis of bilirubin-induced neurotoxicity

scientific article published on February 2004

Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver.

scientific article published on 8 August 2006

Molecular mechanisms for the hepatic uptake of magnetic resonance imaging contrast agents.

scientific article published in April 1999

Multidrug resistance in hepatic cancer stem cells: the emerging role of miRNAs.

scientific article published on 28 April 2015

Natural course of chronic HCV and HBV infection and role of alcohol in the general population: the Dionysos Study.

scientific article published on 12 July 2008

Natural history of nonalcoholic steatohepatitis-associated hepatocellular carcinoma

scientific article published on 27 October 2016

Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat

scientific article published on 14 May 2016

New concepts in bilirubin encephalopathy.

scientific article published on November 2003

New concepts in bilirubin neurotoxicity and the need for studies at clinically relevant bilirubin concentrations

scientific article published on 01 March 2001

New molecular targets for functionalized nanosized drug delivery systems in personalized therapy for hepatocellular carcinoma

scientific article published on 16 October 2017

Nonalcoholic Fatty Liver Is Not Associated with the Relationship between Insulin Secretion and Insulin Sensitivity in Obese Children: Matched Case-Control Study.

scientific article published on 19 August 2016

Noninvasive in vivo quantitative assessment of fat content in human liver

scientific article published on 01 July 1997

Novel kinetic insights into treatment of unconjugated hyperbilirubinemia: phototherapy and orlistat treatment in Gunn rats

scientific article published on 01 April 2006

Obeticholic acid and INT-767 modulate collagen deposition in a NASH in vitro model

scientific article published on 03 February 2020

Occult hepatitis B virus infection predicts non-alcoholic steatohepatitis in severely obese individuals from Italy

scientific article published on 24 April 2020

Occult hepatitis B virus infection.

scientific article

Optimization of Point-Shear Wave Elastography by Skin-to-Liver Distance to Assess Liver Fibrosis in Patients Undergoing Bariatric Surgery

scientific article published on 07 October 2020

Phenobarbitone of jaundice in haemolytic patients

scientific article published in December 1973

Pitfalls in preparation of (3)H-unconjugated bilirubin by biosynthetic labeling from precursor (3)H-5-aminolevulinic acid in the dog.

scientific article published in November 2001

Podocyte expression of membrane transporters involved in puromycin aminonucleoside-mediated injury

scientific article

Predictors of non-alcoholic fatty liver disease in obese children

scientific article published on 06 December 2006

Preparation of an antibody recognizing both human and rodent MRP1.

scientific article

Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study.

scientific article published in July 2005

Prevalence of chronic liver disease in the general population of northern Italy: the Dionysos Study

scientific article published on 01 December 1994

Prevalence of hepatocellular carcinoma and relation to cirrhosis: comparison of two different cities of the world--Trieste, Italy, and Chiba, Japan

scientific article published in December 1989

Prevalence of non-organ-specific autoantibodies and chronic liver disease in the general population: a nested case-control study of the Dionysos cohort

scientific article

Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation

scientific article published in June 2006

Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro

scientific article published on 01 December 2003

Recent insights into hepatic cancer stem cells

scientific article published on 20 December 2013

Reconstitution in vitro of sulfobromophthalein transport by bilitranslocase

scientific article published on 01 February 1982

Relationship between fatty liver and glucose metabolism: a cross-sectional study in 571 obese children

scientific article published on 28 September 2010

Relationship between glucose metabolism and non-alcoholic fatty liver disease severity in morbidly obese women

scientific article published on 7 June 2014

Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler-Najjar Syndrome Type I.

scientific article published on 14 August 2017

Rescue of bilirubin‐induced neonatal lethality in a mouse model of Crigler‐Najjar syndrome type I by AAV9‐mediated gene transfer

scientific article published on November 17, 2011

Reversal of ethinylestradiol-induced cholestasis by epomediol in rat. The role of liver plasma-membrane fluidity.

scientific article

Risk factors for alcoholic liver disease

scientific article

Role of brain cytochrome P450 mono-oxygenases in bilirubin oxidation-specific induction and activity

scientific article published on 5 November 2014

Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells

scientific article published in July 1998

Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin

scientific journal article

Serum marker of type III procollagen in patients with idiopathic hemochromatosis and its relationship to hepatic fibrosis

scientific article published on 01 October 1983

Serum miRNA Are Promising Biomarkers for the Detection of Early Hepatocellular Carcinoma after Treatment with Direct-Acting Antivirals

scientific article published on 11 November 2019

Serum type III procollagen peptide in alcoholic liver disease and idiopathic hemochromatosis: its relationship to hepatic fibrosis, activity of the disease and iron overload

scientific article published on 01 May 1985

Sex differences in the hepatic uptake of sulphobromophthalein in the rat

scientific article published in November 1985

Sex differences of nicotinate-induced hyperbilirubinemia in Gilbert's syndrome

scientific article published on 01 January 1985

Sex steroid modulation of the hepatic uptake of organic anions in rat

scientific article published on 01 June 1988

Significance of hepatitis virus infection in the oncogenic initiation of hepatocellular carcinoma

scientific article

Silencing efficacy prediction: a retrospective study on target mRNA features.

scientific article published on 31 March 2015

Silybin Modulates Collagen Turnover in an In Vitro Model of NASH

scientific article published on 02 April 2019

Sorafenib Resistance in Hepatocellular Carcinoma: The Relevance of Genetic Heterogeneity

scientific article published on 15 June 2020

Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines

scientific article

Strategies in the study of hepatocellular carcinoma worldwide

scientific article published on January 1, 1993

Systematic review and meta-analysis on the adverse events of rimonabant treatment: considerations for its potential use in hepatology

scientific article

Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione.

scientific article published in November 2001

Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis

scientific article

The Biological Effects of Bilirubin Photoisomers

scientific article published in February 2016

The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and their Clinical Implications

scientific article published on 29 March 2020

The Extent of Intracellular Accumulation of Bilirubin Determines Its Anti- or Pro-Oxidant Effect

scientific article published on 30 October 2020

The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population

scientific article

The Pros and the Cons for the Use of Silybin-Rich Oral Formulations in Treatment of Liver Damage (NAFLD in Particular).

scientific article published on 29 July 2015

The Role of Bilirubin and the Other "Yellow Players" in Neurodegenerative Diseases

scientific article published on 22 September 2020

The activation of autophagy protects neurons and astrocytes against bilirubin-induced cytotoxicity

scientific article

The biological implication of cancer stem cells in hepatocellular carcinoma: a possible target for future therapy

scientific article

The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1.

scientific article

The effect of a hydrogen sulfide releasing molecule (Na2S) on the cold storage of livers from cardiac dead donor rats. A study in an ex vivo model.

scientific article published on 16 June 2015

The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.

scientific article published on 20 July 2007

The expression of CD90/Thy-1 in hepatocellular carcinoma: an in vivo and in vitro study

scientific article

The impact of translational research on gastroenterology

scientific article published on 05 February 2014

The implication of bilitranslocase function in the impaired rifamycin SV metabolism in Gilbert's syndrome

scientific article published on 01 June 1985

The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation

scientific article published on 20 December 2014

The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations

scientific article published on 12 December 2020

The molecular basis of bilirubin encephalopathy and toxicity: report of an EASL Single Topic Conference, Trieste, Italy, 1-2 October, 2004.

scientific article

The molecular basis of jaundice: An old symptom revisited.

scientific article published on 22 December 2016

The multiple origin of cancer stem cells in hepatocellular carcinoma.

scientific article published on 14 July 2015

The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease

scientific article

The spectrum of liver disease in the general population: lesson from the Dionysos study.

scientific article

Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis

scientific article published in December 2015

Translational approaches: from fatty liver to non-alcoholic steatohepatitis.

scientific article

Transport and metabolism at blood-brain interfaces and in neural cells: relevance to bilirubin-induced encephalopathy.

scientific article

Transport of sulfobromophthalein and taurocholate in the HepG2 cell line in relation to the expression of membrane carrier proteins

scientific article published on March 31, 1992

Treatment options in Western hepatocellular carcinoma: a prospective study of 224 patients.

scientific article

UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population

scientific article published on 12 March 2017

Upregulation in the expression of multidrug resistance protein Mrp1 mRNA and protein by increased bilirubin production in rat.

scientific article published in November 2003

Uptake of [(3)H]bilirubin in freshly isolated rat hepatocytes: role of free bilirubin concentration

scientific article published on 01 December 1999

Ursodiol in the long-term treatment of chronic hepatitis: a double-blind multicenter clinical trial

scientific article published on 01 November 1993

Vagaries of impaired transporter function in PFIC 2 and 3

scientific article published on 01 October 2005

Variation in UGT1A1 activity in Gilbert's syndrome

scientific article published on 01 April 2001

Vitamin D, Homocysteine, and Folate in Subcortical Vascular Dementia and Alzheimer Dementia

scientific article

Why, What and Where: 3W in hepatology

scientific article published on 15 April 2019

X-ray fluorescence elemental mapping and microscopy to follow hepatic disposition of a Gd-based magnetic resonance imaging contrast agent.

scientific article published in December 2011