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List of works by Aymelt Itzen

A pull-down procedure for the identification of unknown GEFs for small GTPases

scientific article published on 26 February 2016

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

scientific article

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection

scientific article (publication date: September 2013)

Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis

scientific article published on 28 January 2016

Adenylylation: renaissance of a forgotten post-translational modification

scientific article

Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria

scientific article

Catalytic mechanism of a mammalian Rab⋅RabGAP complex in atomic detail

scientific article

Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli

scientific journal article

Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein

scientific article published on 7 August 2012

Conformational control of small GTPases by AMPylation

scientific article published on 02 March 2020

Covalent Coercion by Legionella pneumophila

scientific article published on 01 August 2011

Covalent Protein Labeling by Enzymatic Phosphocholination

scientific article published on 03 July 2015

Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndrome

scientific article (publication date: April 2012)

Direct targeting of Rab-GTPase-effector interactions

scientific article published on 31 January 2014

Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets

scientific article published on 24 March 2020

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

scientific article published on 11 February 2014

Efficient Synthesis and Applications of Peptides containing Adenylylated Tyrosine Residues

scientific article published on 25 August 2011

Exploring adenylylation and phosphocholination as post-translational modifications.

scientific article published on 31 October 2013

Exploring the Substrate Scope of the Bacterial Phosphocholine Transferase AnkX for Versatile Protein Functionalization

scientific article published on 21 August 2019

GTPases involved in vesicular trafficking: Structures and mechanisms ⬇️

scientific article published on October 15, 2010

High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA

scientific article

Identification and characterisation of novel Mss4-binding Rab GTPases

scientific article

Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture

scientific article published on 06 July 2020

Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB

scientific article

Key Determinants of Rab Specificity

scientific article published on 01 October 2008

Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination

scientific article published on 15 May 2020

Locking GTPases covalently in their functional states.

scientific article published on 16 July 2015

Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB

scientific article

Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy

scientific article published on 29 July 2013

Modulation of small GTPases by Legionella

scientific article published on January 2013

Molecular perspectives on protein adenylylation

scientific article published on 17 December 2014

Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation

scientific article published on 13 November 2020

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a.

scientific article

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

scientific article

One-Pot Dual-Labeling of a Protein by Two Chemoselective Reactions

scientific article published on 14 July 2011

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

scientific article published on 30 March 2020

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.

scientific article published on 15 October 2015

Phosphorylation of Ser111 in Rab8a Modulates Rabin8-Dependent Activation by Perturbation of Side Chain Interaction Networks

scientific article published on 08 August 2019

Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor

scientific article published on 12 March 2012

Protein LidA from Legionella is a Rab GTPase supereffector

scientific article

Protein-DNA arrays as tools for detection of protein-protein interactions by mass spectrometry

scientific article published on 3 December 2012

Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo.

scientific article published on 28 September 2017

Proximitäts-vermittelte kovalente Stabilisierung niedrig-affiner Proteinkomplexe in vitro und in vivo

Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex

scientific article published on 27 January 2006

Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.

scientific article

Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1

scientific article published on 19 January 2021

RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity

scientific article

RabGEFs are a major determinant for specific Rab membrane targeting

scientific article

Reaction mechanism of adenylyltransferase DrrA from Legionella pneumophila elucidated by time-resolved fourier transform infrared spectroscopy

scientific article published on 20 June 2014

Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins

scientific article published on 3 February 2012

Sec2 is a Highly Efficient Exchange Factor for the Rab Protein Sec4

scientific article published on 03 November 2006

Specific localization of Rabs at intracellular membranes: Figure 1

scientific article published on 01 December 2012

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

scientific article

The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b

scientific article

The Legionella longbeachae Icm/Dot substrate SidC selectively binds phosphatidylinositol 4-phosphate with nanomolar affinity and promotes pathogen vacuole-endoplasmic reticulum interactions

scientific article

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

scientific article published on 3 January 2018

The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting.

scientific article published on 03 February 2014

The structure of the N-terminal domain of the Legionella protein SidC

scientific article

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

scientific article published on 09 June 2020

The versatile Legionella effector protein DrrA.

scientific article published on January 2011

Validation of Slow Off-Kinetics of Sirtuin Rearranging Ligands (SirReals) by Means of the Label-Free Electrically Switchable Nanolever Technology

scientific article published on 20 August 2019

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

scientific article published on 06 November 2019

bMERB domains are bivalent Rab8 family effectors evolved by gene duplication

scientific article published on 23 August 2016

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

scientific article

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