List of works - Long-Jun Wu

A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval.

scientific article

A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons

scientific article published in July 2001

ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents

scientific article published in June 2007

Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling.

scientific article

Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury

scientific article published on 11 January 2016

Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.

scientific article

Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons.

scientific article published on 28 July 2003

Bidirectional microglia-neuron communication in the healthy brain

scientific article

Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice.

scientific article published in January 2006

Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex

scientific article published in July 2005

Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording

scientific article published on 15 October 2009

Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury

scientific article

Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus.

scientific article

Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons

scientific article

DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory.

scientific article

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.

scientific article published on 29 July 2016

Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome.

scientific article published on August 2005

Dual Functions of Microglia in Ischemic Stroke

scientific article published on 06 May 2019

Efficacy and safety of rituximab for relapsing-remitting multiple sclerosis: A systematic review and meta-analysis

scientific article published on 04 March 2019

Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain.

scientific article published in August 2006

Enhancement of learning and memory by elevating brain magnesium

scientific journal article

Evidence for a role of CaMKIV in the development of opioid analgesic tolerance.

scientific article published in April 2006

Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor

scientific article

FMRP acts as a key messenger for dopamine modulation in the forebrain

scientific article published in August 2008

Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex

scientific article

Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P.

scientific article

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

scientific article published on 7 November 2017

Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization

scientific article published on 15 October 2019

Gene Expression Does Not Support the Developmental Hourglass Model in Three Animals with Spiralian Development

scientific article published on 01 July 2019

Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice

scientific article

Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV.

scientific article published in April 2008

High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury

scientific article

Hook-up of GluA2, GRIP and liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the hippocampus.

scientific article published on 17 June 2009

How microglia sense and regulate neuronal activity

scientific article published on 28 December 2020

Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain.

scientific article published on January 2011

Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice

scientific journal article

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

scientific article published on 12 May 2016

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

scientific article

Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex

scientific journal article

Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex

scientific article published on 11 July 2012

Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex

scientific article published in May 2007

Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons

scientific article

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

scientific article published on 01 June 2019

Microglia Receptors in Animal Models of Traumatic Brain Injury

scientific article published on 16 December 2018

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

scientific article published on 28 June 2016

Microglia in neuronal circuits

scientific article published on 22 December 2013

Microglia-Neuron Communication in Epilepsy

scientific article published on 18 May 2016

Microglia: Lifelong patrolling immune cells of the brain

scientific article published on 07 May 2019

Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage

scientific article

Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections

scientific article published on 09 October 2019

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

scientific article published on 19 August 2019

Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

scientific article published on 11 November 2015

Microglial calcium signaling is attuned to neuronal activity in awake mice

scientific article published on 27 July 2020

Microglial interactions with the neurovascular system in physiology and pathology.

scientific article published on 10 January 2018

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

scientific article published on 05 April 2019

Microglial voltage-gated proton channel Hv1 in ischemic stroke

scientific article published on 03 October 2013

Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium

scientific article

Molecular targets of anxiety: from membrane to nucleus.

scientific article published on 02 April 2008

Neurabin contributes to hippocampal long-term potentiation and contextual fear memory

scientific article

Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice.

scientific article

Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration

scientific article published on 30 May 2020

Neuronal and microglial mechanisms of neuropathic pain

scientific article published on 30 July 2011

Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus.

scientific article

Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling

scientific article published on 21 October 2019

P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation.

scientific article published on 12 June 2013

P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape.

scientific article

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

scientific article published on 04 December 2019

Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex

scientific article published on 30 April 2007

Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex.

scientific article published on July 2008

Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa

scientific article published in September 2006

Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons

scientific article

Proton extrusion during oxidative burst in microglia exacerbates pathological acidosis following traumatic brain injury

scientific article published on 22 October 2020

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.

scientific article

Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus

scientific article

Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex

scientific article published in December 2007

Resting microglial motility is independent of synaptic plasticity in mammalian brain

scientific article published on 6 February 2008

Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory

scientific journal article

Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.

scientific article published in April 2008

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

scientific article published on 23 April 2019

Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse.

scientific article

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

scientific article published on 29 June 2016

Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression

scientific journal article

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury.

scientific article published on January 2017

The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions

scientific article published on 16 January 2018

The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.

scientific article published on 12 July 2018

The channel kinase, TRPM7, is required for early embryonic development

scientific article published on 27 December 2011

The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus

scientific article published on 14 December 2020

The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior

scientific article published on January 2008

The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury

scientific article published on 20 October 2020

Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation

scientific article

Unilateral cerebral cortical encephalitis with epilepsy: a possible special phenotype of MOG antibody-associated disorders

scientific article published on 09 February 2020

Upregulation of CREB-mediated transcription enhances both short- and long-term memory.

scientific article published on June 2011

Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity.

scientific article published in October 2007

Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging

scientific article

Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.

scientific article published in November 2005

Voltage-gated proton channel HV1 in microglia.

scientific article published on 23 January 2014

[Identification and functional implication of acid-sensing ion channels in rat spinal dorsal horn neurons]

scientific article published on 01 April 2006

[Properties of whole-cell potassium currents in mechanically dissociated Drosophila larval central neurons].

scientific article published in October 2002

List of works by Long-Jun Wu

A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval.

A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons

ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents

Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling.

Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury

Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.

Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons.

Bidirectional microglia-neuron communication in the healthy brain

Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice.

Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex

Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording

Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury

Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus.

Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons

DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory.

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.

Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome.

Dual Functions of Microglia in Ischemic Stroke

Efficacy and safety of rituximab for relapsing-remitting multiple sclerosis: A systematic review and meta-analysis

Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain.

Enhancement of learning and memory by elevating brain magnesium

Evidence for a role of CaMKIV in the development of opioid analgesic tolerance.

Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor

FMRP acts as a key messenger for dopamine modulation in the forebrain

Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex

Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P.

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization

Gene Expression Does Not Support the Developmental Hourglass Model in Three Animals with Spiralian Development

Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice

Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV.

High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury

Hook-up of GluA2, GRIP and liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the hippocampus.

How microglia sense and regulate neuronal activity

Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain.

Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex

Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex

Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex

Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Microglia Receptors in Animal Models of Traumatic Brain Injury

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

Microglia in neuronal circuits

Microglia-Neuron Communication in Epilepsy

Microglia: Lifelong patrolling immune cells of the brain

Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage

Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

Microglial calcium signaling is attuned to neuronal activity in awake mice

Microglial interactions with the neurovascular system in physiology and pathology.

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

Microglial voltage-gated proton channel Hv1 in ischemic stroke

Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium

Molecular targets of anxiety: from membrane to nucleus.

Neurabin contributes to hippocampal long-term potentiation and contextual fear memory

Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice.

Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration

Neuronal and microglial mechanisms of neuropathic pain

Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus.

Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling

P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation.

P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape.

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex

Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex.

Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa

Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons

Proton extrusion during oxidative burst in microglia exacerbates pathological acidosis following traumatic brain injury

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.

Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus

Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex

Resting microglial motility is independent of synaptic plasticity in mammalian brain

Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory

Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice