List of works - Christopher L Karp

A Common Single Nucleotide Polymorphism in the CD14 Promoter Decreases the Affinity of Sp Protein Binding and Enhances Transcriptional Activity ⬇️

scientific article published on November 15, 2001

ATF3 is a novel regulator of mouse neutrophil migration

scientific article

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

scientific article

An adenoviral vector for probing promoter activity in primary immune cells

scientific article

An oily, sustained counter-regulatory response to TB.

scientific article published on June 2005

Association of CTLA4 polymorphism with regulatory T cell frequency

scientific article published in July 2005

Biomedicine. Eosinophils in asthma: remodeling a tangled tale

scientific article published in September 2004

Blockade of chronic type I interferon signaling to control persistent LCMV infection

scientific article published on April 2013

C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism

scientific article (publication date: 2 January 2004)

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

scientific article published on 08 April 2014

Can immunological principles and cross-disciplinary science illuminate the path to vaccines for HIV and other global health challenges?

scientific article published in June 2015

Chitin Checking — Novel Insights into Asthma

scientific article published on 01 September 2004

Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.

scientific article published on 13 December 2012

Cnr2 deficiency confers resistance to inflammation-induced preterm birth in mice.

scientific article

Coinfection with HIV and tropical infectious diseases. I. Protozoal pathogens.

scientific article

Coinfection with HIV and tropical infectious diseases. II. Helminthic, fungal, bacterial, and viral pathogens.

scientific article

Complement and IL-12: yin and yang.

scientific article

Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways

scientific article

Cryptosporidiosis stimulates an inflammatory intestinal response in malnourished Haitian children

scientific article published on 7 June 2002

Cutting Edge: Regulation of TLR4-Driven B Cell Proliferation by RP105 Is Not B Cell Autonomous ⬇️

scientific article published on January 30, 2012

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

scientific article

Cystic fibrosis and lipoxins.

scientific article

Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.

scientific article published on October 2004

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

scientific article published on 21 March 2004

Differential colonization with segmented filamentous bacteria and Lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL/6 mice

scientific article published on 10 May 2013

Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation

scientific article published on 3 December 2014

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.

scientific article

Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection

scientific article

Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology.

scientific article published on 18 August 2008

Evaluating the value proposition for improving vaccine thermostability to increase vaccine impact in low and middle-income countries

scientific article

Flt3 Ligand Treatment Reverses Endotoxin Tolerance-Related Immunoparalysis

scientific article published on 01 June 2005

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity

scientific article published on February 2014

Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

scientific article

Getting to the core of the gut microbiome

scientific article

Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients

scientific article published on 4 June 2003

I-Tim-izing the pathways of counter-regulation

scientific article published on 01 November 2003

IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.

scientific article

IL-12 Suppression During Experimental Endotoxin Tolerance: Dendritic Cell Loss and Macrophage Hyporesponsiveness

scientific article published on 01 June 2001

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice.

scientific article published on 27 March 2014

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

scientific article

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

scientific article published on 01 September 2000

Immune activation and IL-12 production during acute/early HIV infection in the absence and presence of highly active, antiretroviral therapy.

scientific article published on 19 September 2008

Immunological barriers (opportunities?) to the use of bioengineered tissue: taking note of the innate immune system.

scientific article

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma

scientific article

Inhibition of IL-12 production by thalidomide ⬇️

scientific article published on November 15, 1997

Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.

scientific article published on January 2005

Inhibition of human interleukin-12 production by pentoxifylline

scientific article published on 01 June 1997

Interferon-? therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production

scientific article published on 01 February 2002

Interferon-beta 1a and SARS coronavirus replication

scientific article published on February 2004

Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation

scientific article

Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever

scientific article published on 18 December 2012

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

scientific article

Interleukin-12: Amiss in MS

scientific article published on 01 June 1999

Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat liver

scientific article published on 01 April 1997

Leptin regulates proinflammatory immune responses ⬇️

scientific article published on January 1, 1998

Lipophosphoglycan masks recognition of the Leishmania donovani promastigote surface by human kala-azar serum

scientific article published in July 1991

Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis.

scientific article

Mapping of specific and promiscuous HLA-DR-restricted T-cell epitopes on the Plasmodium falciparum 27-kilodalton sexual stage-specific antigen.

scientific article

Measles: immunosuppression, interleukin-12, and complement receptors.

scientific article

Mechanism of suppression of cell-mediated immunity by measles virus

scientific article published in July 1996

Modulation of cell death by Bcl-x L through caspase interaction ⬇️

scientific article published on January 20, 1998

Modulation of the IL-12/IFN-gamma axis by IFN-alpha therapy for hepatitis C.

scientific article published on 15 December 2006

Natural Measles Causes Prolonged Suppression of Interleukin‐12 Production

scientific article published on 30 May 2001

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105

scientific article

Non-canonical alternatives: what a macrophage is 4

scientific article published in March 2012

Nonredundant roles for B cell-derived IL-10 in immune counter-regulation

scientific article published on 20 July 2009

Obesity and the gut microbiome: Striving for causality.

scientific article published on 03 August 2012

Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection

scientific article published on 11 October 2011

Outer membrane vesicles of a human commensal mediate immune regulation and disease protection

scientific article published on 20 September 2012

Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis ⬇️

scientific article published on April 19, 2012

Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance

scientific article published on 01 October 1998

Preparation of the HIV-infected Traveler to the Tropics.

scientific article published on February 2001

Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity

scientific article

Receptor mediated subversion of macrophage cytokine production by intracellular pathogens.

scientific article

Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105.

scientific article published on 30 April 2007

Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology.

scientific article published on 25 September 2013

SAM-pointed domain ETS factor mediates epithelial cell–intrinsic innate immune signaling during airway mucous metaplasia ⬇️

scientific article published on September 24, 2012

Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.

scientific article

Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells

scientific article published on December 2009

T-cell responses to infected autologous monocytes in patients with cutaneous and mucocutaneous leishmaniasis

scientific article published on May 1994

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

scientific article published on May 2013

The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma.

scientific article published on June 2004

The aryl hydrocarbon receptor promotes IL-10 production by NK cells

scientific article published on 08 January 2014

The effect of acute infectious illnesses on plasma human immunodeficiency virus (HIV) type 1 load and the expression of serologic markers of immune activation among HIV-infected adults

scientific article published in December 1998

The germless theory of allergic disease: revisiting the hygiene hypothesis.

scientific article

The strangest song: One father’s quest to help his daughter find her voice.

scientific article published in May 2007

Therapeutic enhancement of protective immunity during experimental leishmaniasis

scientific article

Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.

scientific article

Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool

scientific article

Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity

scientific article published on 01 July 2001

Unstressing intemperate models: how cold stress undermines mouse modeling

scientific article

List of works by Christopher L Karp

A Common Single Nucleotide Polymorphism in the CD14 Promoter Decreases the Affinity of Sp Protein Binding and Enhances Transcriptional Activity ⬇️

ATF3 is a novel regulator of mouse neutrophil migration

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

An adenoviral vector for probing promoter activity in primary immune cells

An oily, sustained counter-regulatory response to TB.

Association of CTLA4 polymorphism with regulatory T cell frequency

Biomedicine. Eosinophils in asthma: remodeling a tangled tale

Blockade of chronic type I interferon signaling to control persistent LCMV infection

C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

Can immunological principles and cross-disciplinary science illuminate the path to vaccines for HIV and other global health challenges?

Chitin Checking — Novel Insights into Asthma

Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.

Cnr2 deficiency confers resistance to inflammation-induced preterm birth in mice.

Coinfection with HIV and tropical infectious diseases. I. Protozoal pathogens.

Coinfection with HIV and tropical infectious diseases. II. Helminthic, fungal, bacterial, and viral pathogens.

Complement and IL-12: yin and yang.

Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways

Cryptosporidiosis stimulates an inflammatory intestinal response in malnourished Haitian children

Cutting Edge: Regulation of TLR4-Driven B Cell Proliferation by RP105 Is Not B Cell Autonomous ⬇️

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

Cystic fibrosis and lipoxins.

Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

Differential colonization with segmented filamentous bacteria and Lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL/6 mice

Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.

Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection

Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology.

Evaluating the value proposition for improving vaccine thermostability to increase vaccine impact in low and middle-income countries

Flt3 Ligand Treatment Reverses Endotoxin Tolerance-Related Immunoparalysis

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity

Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

Getting to the core of the gut microbiome

Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients

I-Tim-izing the pathways of counter-regulation

IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.

IL-12 Suppression During Experimental Endotoxin Tolerance: Dendritic Cell Loss and Macrophage Hyporesponsiveness

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice.

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

Immune activation and IL-12 production during acute/early HIV infection in the absence and presence of highly active, antiretroviral therapy.

Immunological barriers (opportunities?) to the use of bioengineered tissue: taking note of the innate immune system.

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma

Inhibition of IL-12 production by thalidomide ⬇️

Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.

Inhibition of human interleukin-12 production by pentoxifylline

Interferon-? therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production

Interferon-beta 1a and SARS coronavirus replication

Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation

Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

Interleukin-12: Amiss in MS

Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat liver

Leptin regulates proinflammatory immune responses ⬇️

Lipophosphoglycan masks recognition of the Leishmania donovani promastigote surface by human kala-azar serum

Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis.

Mapping of specific and promiscuous HLA-DR-restricted T-cell epitopes on the Plasmodium falciparum 27-kilodalton sexual stage-specific antigen.

Measles: immunosuppression, interleukin-12, and complement receptors.

Mechanism of suppression of cell-mediated immunity by measles virus

Modulation of cell death by Bcl-x L through caspase interaction ⬇️

Modulation of the IL-12/IFN-gamma axis by IFN-alpha therapy for hepatitis C.

Natural Measles Causes Prolonged Suppression of Interleukin‐12 Production

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105

Non-canonical alternatives: what a macrophage is 4

Nonredundant roles for B cell-derived IL-10 in immune counter-regulation

Obesity and the gut microbiome: Striving for causality.

Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection

Outer membrane vesicles of a human commensal mediate immune regulation and disease protection

Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis ⬇️

Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance

Preparation of the HIV-infected Traveler to the Tropics.

Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity

Receptor mediated subversion of macrophage cytokine production by intracellular pathogens.

Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105.

Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology.

SAM-pointed domain ETS factor mediates epithelial cell–intrinsic innate immune signaling during airway mucous metaplasia ⬇️

Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.

Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells