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List of works by Eddie James

124 Heterogeneity of Allergen Epitope-specific CD4+ T Cells Responses: Steps Toward Optimal Composition for Peptide-based Immunotherapy

A Comparative Analysis of the Peptide Repertoires of HLA-DR Molecules Differentially Associated With Rheumatoid Arthritis.

scientific article

A Novel Approach of Identifying Immunodominant Self and Viral Antigen Cross-Reactive T Cells and Defining the Epitopes They Recognize

article

A Novel HLA-DRB1*10:01-Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis.

scientific article

A composite immune signature parallels disease progression across T1D subjects

scientific article published on 05 December 2019

An improved optical technique for monitoring plant cell concentration

scientific article published on 01 January 2000

Analysis of pancreatic beta cell specific CD4+ T cells reveals a predominance of proinsulin specific cells

scientific article published on 07 November 2018

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

scientific article published on 31 October 2016

Antigen-Specific CD4+ T Cells Recognize Epitopes of Protective Antigen following Vaccination with an Anthrax Vaccine.

scientific article published in September 2007

Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope

scientific article published on 3 October 2013

Ara h 1-reactive T cells in individuals with peanut allergy

scientific article

Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development

scientific article

Autoreactive CD4(+) T cells in patients with atopic dermatitis

scientific article published on 26 May 2011

Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

scientific article published on 30 March 2020

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope

scientific article

CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.

scientific article published on March 2013

CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination.

scientific article published on 22 March 2013

CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65.

scientific article

Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.

scientific article

Characterization of CD4+ T cell subsets in allergy ⬇️

scientific article published on August 10, 2012

Citrullinated Aggrecan Epitopes as Targets of Auto-reactive CD4+ T cells in Patients with Rheumatoid Arthritis

scientific article published on 08 March 2019

Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy

scientific article

Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop

scientific article published in December 2017

Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls

scientific article published on 01 November 2011

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

scientific article published in August 2017

Corrigendum: Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis

scientific article published on 4 October 2017

DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9

scientific article published on 23 December 2011

DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes

scientific article published on 19 November 2018

Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes ⬇️

scientific article published on January 22, 2011

Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk

scientific article

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy

scientific article published on 5 October 2011

Direct Analysis of Insulin-Specific T Cells Provides New Insights

scientific article published in December 2017

Direct ex vivo analysis of allergen-specific CD4+ T cells

scientific article published on June 2010

Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes

scientific article published on 21 August 2019

Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ)

scientific article

Expanding antigen-specific regulatory networks to treat autoimmunity

scientific article

FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity

scientific article published on 01 February 2018

Factor VIII gene variants and inhibitor risk in African American hemophilia A patients

scientific article

Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire ⬇️

scientific article published on February 10, 2012

Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis

scientific article

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects

scientific article published on February 2009

Grass-specific CD4(+) T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy

scientific article

H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.

scientific article published on 3 May 2009

HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets

scientific article published on October 2010

Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain

scientific article published on 12 August 2019

Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection

scientific article published on 7 September 2011

Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires

scientific article published on 21 August 2017

Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development

scientific article published on 7 February 2017

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance

scientific article published on 01 June 2018

Immune recognition of citrullinated epitopes

scientific article

Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative

scientific article published on 01 November 2011

Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative.

scientific article published on November 2011

Increased islet antigen-specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes-protective haplotype

scientific article published on 01 February 2020

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

article

Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.

scientific article

Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen-specific modulation of immune reactivity

scientific article published on 14 December 2015

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.

scientific article

Loss and recovery of protein productivity in genetically modified plant cell lines.

scientific article published on 25 February 2006

Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes.

scientific article published on July 2008

MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.

scientific article

Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset

scientific article

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint

scientific article published on 28 May 2018

Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.

scientific article published on 13 April 2018

Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy

scientific article published on 07 June 2019

Multiplex mapping of CD4 T cell epitopes using class II tetramers

scientific article

Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome

scientific article published on 21 January 2016

Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis

scientific article

Peanut-specific T cell responses in patients with different clinical reactivity

scientific article published in PLoS ONE

Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses

scientific article

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

scientific article published on 15 July 2019

Production and characterization of biologically active human GM-CSF secreted by genetically modified plant cells

scientific article published on 01 June 2000

Protecting functional β cells with a therapeutic peptide

scientific article published on 01 September 2018

Rapid identification and expression of human TCRs in retrogenic mice

scientific article published on 30 August 2016

Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.

scientific article

Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes.

scientific article

Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals.

scientific article published on 02 December 2008

Specific immunotherapy modifies allergen-specific CD4(+) T-cell responses in an epitope-dependent manner.

scientific article published on 25 December 2013

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

scientific article published on 01 July 2019

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

scientific article published on 10 September 2017

Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis.

scientific article

T cell epitopes and post-translationally modified epitopes in type 1 diabetes

scientific article

T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses.

scientific article published on 12 January 2018

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire.

scientific article published on 28 July 2016

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

scientific article published on 01 July 2020

T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site.

scientific article

T-cell responses over time in a mild hemophilia A inhibitor subject: epitope identification and transient immunogenicity of the corresponding self-peptide

scientific article published in December 2007

Tetramer-guided epitope mapping reveals broad, individualized repertoires of tetanus toxin-specific CD4+ T cells and suggests HLA-based differences in epitope recognition

scientific article

The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells

scientific article published on 4 August 2008

The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.

scientific article

The production of foreign proteins from genetically modified plant cells.

scientific article

Tumour and placenta establishment: The importance of antigen processing and presentation

scientific article published on 28 February 2017

Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells

scientific article

Visualizing antigen specific CD4+ T cells using MHC class II tetramers

scientific article published on 6 March 2009

Yellow fever vaccination elicits broad functional CD4+ T cell responses that recognize structural and nonstructural proteins

scientific article published on 18 September 2013

β cell ER stress and the implications for immunogenicity in type 1 diabetes

scientific article published on 27 October 2015

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