List of works - Pieter Van der Veken

1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors

scientific article published on 09 February 2007

3-methyl-1,2,3-butanetricarboxylic acid: An atmospheric tracer for terpene secondary organic aerosol

article

ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice

scientific article

Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity

scientific article published on 4 April 2012

Adhesion of PLGA or Eudragit/PLGA nanoparticles to Staphylococcus and Pseudomonas

scientific article published on 7 August 2007

An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei

scientific article

Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinamides across α-chloro-N-sulfinylimines ⬇️

scientific article published on 5 December 2012

Author Correction: Virtual screening for inhibitors of the human TSLP:TSLPR interaction.

scientific article

Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma

scientific article published on 06 February 2019

Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited.

scientific article

Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy

scientific article published on 01 May 2019

Circulating Stromal Cell-Derived Factor 1α Levels in Heart Failure: A Matter of Proper Sampling.

scientific article published on 6 November 2015

Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling

scientific article published on 10 August 2017

Design and evaluation of Trypanosoma brucei metacaspase inhibitors.

scientific article

Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases.

scientific article published in November 2003

Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1.

scientific article published on 20 November 2013

Development of a novel antibody-tetrazine conjugate for bioorthogonal pretargeting

scientific article published on 19 July 2016

Development of a novel chemical probe for the selective enrichment of phosphorylated serine- and threonine-containing peptides

scientific article published in December 2005

Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator

scientific article published in May 2004

Development of potent and selective dipeptidyl peptidase II inhibitors

article

Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission

scientific article

Differential characterization using readily accessible NMR experiments of novel N- and O-alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives with antimycobacterial activity

scientific article published on 11 October 2016

Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases

scientific article published on 23 October 2007

Dipeptidyl peptidase 8/9-like activity in human leukocytes

scientific article published on 07 February 2007

Dipeptidyl peptidase II and leukocyte cell death.

scientific article published on 25 April 2006

Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis.

scientific article published on 23 April 2013

Diphenyl phosphonate inhibitors for the urokinase-type plasminogen activator: optimization of the P4 position.

scientific article published in September 2006

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

article

Efforts towards an On-Target Version of the Groebke-Blackburn-Bienaymé (GBB) Reaction for Discovery of Druglike Urokinase (uPA) Inhibitors

scientific article published on 29 August 2019

Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues

scientific article published on 02 February 2009

Evaluation of [18 F]BR420 and [18 F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer

scientific article published on 21 December 2016

Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis

scientific article

Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries.

scientific article published on March 2011

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

article

Fluoro-Olefins as Peptidomimetic Inhibitors of Dipeptidyl Peptidases

scientific article published on 01 March 2005

Formation of secondary organic aerosol marker compounds from the photooxidation of isoprene and isoprene-derived alkene diols under low-NOx conditions

scientific article published on 01 January 2013

Four day inhibition of prolyl oligopeptidase causes significant changes in the peptidome of rat brain, liver and kidney.

scientific article published on 21 April 2012

From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.

scientific article

Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors

scientific article

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part

scientific article published in October 2002

Hydroxydicarboxylic Acids: Markers for Secondary Organic Aerosol from the Photooxidation of α-Pinene

article

Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors

scientific article published on 13 December 2018

In Vivo Amyloid-β Imaging in the APPPS1-21 Transgenic Mouse Model with a (89)Zr-Labeled Monoclonal Antibody

scientific article published on 31 March 2016

In situ prolyl oligopeptidase activity assay in neural cell cultures

article

In vivo evaluation of (18)F-labeled TCO for pre-targeted PET imaging in the brain

scientific article published on 2 April 2014

Increased tissue and circulating levels of dipeptidyl peptidase-IV enzymatic activity in patients with pancreatic ductal adenocarcinoma.

scientific article published on 6 June 2016

Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay

scientific article

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads

scientific article published on 24 May 2008

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors

scientific article published on 24 May 2008

Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates

scientific article published on 24 October 2007

Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7).

scientific article published on March 2005

Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds

scientific article published on 26 March 2020

Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach

scientific article

Mass spectrometric characterization of organosulfates related to secondary organic aerosol from isoprene

scientific article

Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors

scientific article published on 07 November 2011

Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits.

scientific article

N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase

scientific article published on 18 June 2008

Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome

scientific article published on 23 July 2018

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

scientific article published on 22 December 2015

Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs).

scientific article published on September 2011

Novel drug discovery strategies for atherosclerosis that target necrosis and necroptosis

scientific article

Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition.

scientific article published on 31 August 2016

Novel triazine dimers with potent antitrypanosomal activity.

scientific article published on 27 November 2017

Occupational exposure to noise and the prevalence of hearing loss in a Belgian military population: A cross-sectional study ⬇️

scientific article published on January 1, 2011

Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.

scientific article

P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy

scientific article

Plasma carboxypeptidase U (CPU, CPB2, TAFIa) generation during in vitro clot lysis and its interplay between coagulation and fibrinolysis.

scientific article published on 6 July 2017

Plasma levels of carboxypeptidase U (CPU, CPB2 or TAFIa) are elevated in patients with acute myocardial infarction

scientific article published on 12 November 2015

Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity

scientific article

Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation

article

Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme

scientific article published on 19 July 2016

Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery

scientific article published on January 2007

Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity

scientific article published in September 2003

Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes

scientific article published on 01 May 2008

Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases

scientific article published in May 2003

Repositioning the substrate activity screening (SAS) approach as a fragment-based method for identification of weak binders

scientific article

Resistance and cross-resistance profile of the diaryltriazine NNRTI and candidate microbicide UAMC01398.

scientific article published on 4 February 2016

Schistosomicidal and molluscicidal activities of aminoalkylamino substituted neo- and norneocryptolepine derivatives

scientific article

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides.

scientific article

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads

scientific article published in November 2017

Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold

scientific article

Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold

article

Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties

scientific article published in December 2007

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.

scientific article published on 29 June 2017

Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?

scientific article

Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor

scientific article

Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry

scientific article published on 4 February 2016

Synthesis and Evaluation of a Zr-89-Labeled Monoclonal Antibody for Immuno-PET Imaging of Amyloid-β Deposition in the Brain

scientific article published on 4 February 2016

Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives

scientific article

Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors

scientific article published on 10 April 2007

Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines

scientific article published on 17 July 2006

Synthesis and electrophysiological characterization of cyclic morphiceptin analogues

scientific article published in May 2004

Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)

scientific article published on 27 December 2011

Synthesis and in vivo preclinical evaluation of an (18)F labeled uPA inhibitor as a potential PET imaging agent

scientific article published on 29 March 2014

Synthesis and preclinical evaluation of an 18F labeled PDE7 inhibitor for PET neuroimaging

scientific article published on 29 July 2015

Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors.

scientific article published in February 2009

Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents.

scientific article

Terpenylic acid and related compounds from the oxidation of alpha-pinene: implications for new particle formation and growth above forests

scientific article published in September 2009

The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8/9 Inhibition Attenuates M1 Macrophage Activation in Mice

scientific article published on 10 October 2015

The Effect of Acute Pharmacological Inhibition of Urokinase Plasminogen Activator and Neuropsin Extracellular Proteases on Neuronal Networks in vitro

scholarly article published 20 February 2018

The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics

The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases.

scientific article

Tozasertib Analogues as Inhibitors of Necroptotic Cell Death

scientific article published on 13 February 2018

UPLC-TQD-MS/MS Method Validation for Quality Control of Alkaloid Content in <i>Lepidium meyenii</i> (Maca)-Containing Food and Dietary Supplements

scientific article published on 26 March 2024

Validation of a specific prolylcarboxypeptidase activity assay and its suitability for plasma and serum measurements

scientific article published on 10 September 2013

Virtual screening for inhibitors of the human TSLP:TSLPR interaction.

scientific article published on 8 December 2017

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.

scientific article published on 23 August 2014

α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

scientific article published on 11 January 2019

α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB.

scientific article published on October 2010

List of works by Pieter Van der Veken

1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors

3-methyl-1,2,3-butanetricarboxylic acid: An atmospheric tracer for terpene secondary organic aerosol

ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice

Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity

Adhesion of PLGA or Eudragit/PLGA nanoparticles to Staphylococcus and Pseudomonas

An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei

Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinamides across α-chloro-N-sulfinylimines ⬇️

Author Correction: Virtual screening for inhibitors of the human TSLP:TSLPR interaction.

Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma

Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited.

Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy

Circulating Stromal Cell-Derived Factor 1α Levels in Heart Failure: A Matter of Proper Sampling.

Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling

Design and evaluation of Trypanosoma brucei metacaspase inhibitors.

Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases.

Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1.

Development of a novel antibody-tetrazine conjugate for bioorthogonal pretargeting

Development of a novel chemical probe for the selective enrichment of phosphorylated serine- and threonine-containing peptides

Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator

Development of potent and selective dipeptidyl peptidase II inhibitors

Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission

Differential characterization using readily accessible NMR experiments of novel N- and O-alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives with antimycobacterial activity

Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases

Dipeptidyl peptidase 8/9-like activity in human leukocytes

Dipeptidyl peptidase II and leukocyte cell death.

Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis.

Diphenyl phosphonate inhibitors for the urokinase-type plasminogen activator: optimization of the P4 position.

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

Efforts towards an On-Target Version of the Groebke-Blackburn-Bienaymé (GBB) Reaction for Discovery of Druglike Urokinase (uPA) Inhibitors

Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues

Evaluation of [18 F]BR420 and [18 F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer

Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis

Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries.

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

Fluoro-Olefins as Peptidomimetic Inhibitors of Dipeptidyl Peptidases

Formation of secondary organic aerosol marker compounds from the photooxidation of isoprene and isoprene-derived alkene diols under low-NOx conditions

Four day inhibition of prolyl oligopeptidase causes significant changes in the peptidome of rat brain, liver and kidney.

From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.

Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part

Hydroxydicarboxylic Acids: Markers for Secondary Organic Aerosol from the Photooxidation of α-Pinene

Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors

In Vivo Amyloid-β Imaging in the APPPS1-21 Transgenic Mouse Model with a (89)Zr-Labeled Monoclonal Antibody

In situ prolyl oligopeptidase activity assay in neural cell cultures

In vivo evaluation of (18)F-labeled TCO for pre-targeted PET imaging in the brain

Increased tissue and circulating levels of dipeptidyl peptidase-IV enzymatic activity in patients with pancreatic ductal adenocarcinoma.

Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors

Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates

Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7).

Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds

Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach

Mass spectrometric characterization of organosulfates related to secondary organic aerosol from isoprene

Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors

Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits.

N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase

Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs).

Novel drug discovery strategies for atherosclerosis that target necrosis and necroptosis

Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition.

Novel triazine dimers with potent antitrypanosomal activity.

Occupational exposure to noise and the prevalence of hearing loss in a Belgian military population: A cross-sectional study ⬇️

Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.

P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy

Plasma carboxypeptidase U (CPU, CPB2, TAFIa) generation during in vitro clot lysis and its interplay between coagulation and fibrinolysis.

Plasma levels of carboxypeptidase U (CPU, CPB2 or TAFIa) are elevated in patients with acute myocardial infarction

Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity

Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation

Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme

Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery

Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity

Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes

Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases

Repositioning the substrate activity screening (SAS) approach as a fragment-based method for identification of weak binders

Resistance and cross-resistance profile of the diaryltriazine NNRTI and candidate microbicide UAMC01398.

Schistosomicidal and molluscicidal activities of aminoalkylamino substituted neo- and norneocryptolepine derivatives

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides.