Search filters

List of works by Hatem A Abdel-Aziz

"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII

scientific article published on 18 December 2019

(1Z,2E)-N'-{1-[2-(4-Bromo-phen-yl)hydrazin-1-yl-idene]-1-chloro-propan-2-yl-idene}thio-phene-2-carbohydrazide

scientific article

(1Z,2E)-N'-{2-Chloro-1-methyl-2-[2-(4-methyl-phen-yl)hydrazin-1-yl-idene]ethyl-idene}-4-meth-oxy-benzohydrazide

scientific article

(E)-2-(2,3-Dimethyl-anilino)-N'-(thio-phen-2-yl-methyl-idene)benzohydrazide.

scientific article

(E)-2-(2,3-Dimethyl-anilino)-N'-[2-methyl-5-(prop-1-en-2-yl)cyclo-hex-2-enyl-idene]benzohydrazide

scientific article

(E)-3-Anilino-2-benzoyl-3-(methyl-sulfan-yl)acrylonitrile.

scientific article

(E)-N'-(4-Isopropyl-benzyl-idene)isonicotinohydrazide monohydrate

scientific article

(Z)-1-(4-Methyl-phen-yl)-2-(phenyl-sulfon-yl)ethanone oxime.

scientific article

(Z)-2-(4-Chloro-benzyl-idene)benzo[d]thia-zolo[3,2-a]imidazol-3(2H)-one

scientific article

(Z)-2-(5-Acetyl-4-methyl-3-phenyl-2,3-dihydro-1,3-thia-zol-2-yl-idene)-3-(3-methyl-1-benzofuran-2-yl)-3-oxo-propane-nitrile.

scientific article

(Z)-2-Benzyl-idenebenzo[d]thia-zolo[3,2-a]imidazol-3(2H)-one

scientific article

(Z)-3-Hydrazinylidene-1-phenylindolin-2-one ⬇️

scientific article published on October 31, 2010

(Z)-3-p-Tolyl-2-(p-tolyl-imino)-1,3-thia-zolidin-4-one

scientific article

(Z)-7-[2-(4-Bromo-phen-yl)hydrazin-1-yl-idene]-6-methyl-3-(pyridin-4-yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thia-diazine.

scientific article

1-(1-Benzofuran-2-yl)-2-(phenylsulfonyl)ethanone ⬇️

scientific article published on September 17, 2011

1-(4-Fluoro-phen-yl)-2-(phenyl-sulfon-yl)ethanone.

scientific article

1-(4-Methyl-phen-yl)-2-(phenyl-sulfon-yl)ethanone.

scientific article

1-(5-Bromo-1-benzofuran-2-yl)ethanone.

scientific article

1-[(Z)-2-Phenylhydrazin-1-ylidene]-1-(piperidin-1-yl)propan-2-one ⬇️

scientific article published on July 30, 2011

1-[1-(3-Methyl-phen-yl)-5-phenyl-4-phenyl-sulfonyl-1H-pyrazol-3-yl]ethanone

scientific article published on 12 October 2011

2,3,5-Triphenyl-2H-tetra-zol-3-ium bromide ethanol monosolvate

scientific article

2,3,5-Triphenyl-2H-tetra-zol-3-ium iodide.

scientific article

2,3,5-Triphenyl-2H-tetra-zol-3-ium tetra-phenyl-borate.

scientific article

2-((Benzimidazol-2-yl)thio)-1-arylethan-1-ones: Synthesis, crystal study and cancer stem cells CD133 targeting potential.

scientific article published on 16 September 2015

2-(2,3-Dimethyl-anilino)benzohydrazide

scientific article

2-(6-Phenyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-1,3-benzothiazole ⬇️

scientific article published on September 14, 2011

2-Anilino-4-(1,3-benzothia-zol-2-yl)-5-(4-chloro-benzo-yl)thio-phene-3-carbonitrile

scientific article

2-Phenyl-N′-(2-phenylacetyl)acetohydrazide ⬇️

scientific article published on May 12, 2012

2-[(1H-Benzimidazol-2-yl)sulfan-yl]-1-phenyl-ethanone.

scientific article

3-(3-Meth-oxy-phen-yl)benzo[d]thia-zolo[3,2-a]imidazol-9-ium hydrogen sulfate.

scientific article

3-(5-Phenyl-4-phenyl-sulfonyl-1-p-tolyl-1H-pyrazol-3-yl)-1,2-dihydro-quinoxaline

scientific article published on 23 February 2011

3-Acetyl-1,5-diphenyl-1H-pyrazole-4-carbonitrile.

scientific article

3-Acetyl-5-methyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxamide ⬇️

scientific article published on October 31, 2010

3-Acetyl-5-phenyl-1-p-tolyl-1H-pyrazole-4-carbonitrile. ⬇️

scientific article

3-Chloro-4-methyl-quinolin-2(1H)-one

scientific article

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

scientific article

3-Methyl-1-benzofuran-2-carbohydrazide.

scientific article

3-[(E)-3-(4-Meth-oxy-phen-yl)prop-2-eno-yl]-1-(4-methyl-phen-yl)-5-phenyl-1H-pyrazole-4-carbonitrile

scientific article published on 23 February 2011

4-(3,4-Diacetyl-5-methyl-1H-pyrazol-1-yl)benzene-sulfonamide

scientific article published on 23 February 2011

5,6-Dimethyl-4-(thio-phen-2-yl)-1H-pyrazolo-[3,4-b]pyridin-3-amine

scientific article published on 4 February 2012

Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.

scientific article

Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono)indolin-2-ones as anticancer agents.

scientific article published on 19 March 2014

Bis-isatin hydrazones with novel linkers: Synthesis and biological evaluation as cytotoxic agents.

scientific article published on 2 December 2015

Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

scientific article published on December 2017

Carbonic anhydrase inhibitors. Benzenesulfonamides incorporating cyanoacrylamide moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase

scientific article published on 21 April 2013

Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.

scientific article

Charge Transfer Complex of Neostigmine with 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone: Synthesis, Spectroscopic Characterization, Antimicrobial Activity, and Theoretical Study

scientific article published on 06 October 2020

Clenbuterol Hydrochloride.

scientific article

Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives.

scientific article

Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylbenzofuran derivatives

scientific article published on 27 February 2009

Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents.

scientific article published on 8 December 2014

Design, synthesis and in vitro antiproliferative activity of novel isatin-quinazoline hybrids

scientific article

Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones.

scientific article

Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity.

scientific article

Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential naprosyn® analogs as COX-1 and/or COX-2 inhibitors.

scientific article

Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor

scientific article published on 08 March 2016

Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents.

scientific article published on 6 January 2016

Development of certain novel N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamides and 3-(2-oxoindolin-3-ylideneamino)-2-substituted quinazolin-4(3H)-ones as CFM-1 analogs: design, synthesis, QSAR analysis and anticancer activity

scientific article

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

scientific article published on 20 February 2020

Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.

scientific article published on 10 April 2018

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

scientific article published on 02 November 2018

Ethyl 1-(4-methylphenyl)-5-phenyl-4-phenylsulfonyl-1H-pyrazole-3-carboxylate ⬇️

scientific article published on September 14, 2011

Ethyl 5-bromo-1-benzofuran-2-carboxyl-ate

scientific article published on 23 February 2011

Exploring QSARs of some benzenesulfonamides incorporating cyanoacrylamide moieties as a carbonic anhydrase inhibitors (specifically against tumor-associated isoforms IX and XII).

scientific article published on 8 September 2014

Facile synthesis and in-vitro antitumor activity of some pyrazolo[3,4-b]pyridines and pyrazolo[1,5-a]pyrimidines linked to a thiazolo[3,2-a]benzimidazole moiety.

scientific article

Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

scientific article published on 31 May 2015

Induced in-source fragmentation pattern of certain novel (1Z,2E)-N-(aryl)propanehydrazonoyl chlorides by electrospray mass spectrometry (ESI-MS/MS).

scientific article published on 25 January 2013

Induction of ROS‑mediated cell death and activation of the JNK pathway by a sulfonamide derivative

scientific article published on 23 July 2019

Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives

scientific article published on 12 March 2014

Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cy

scientific article

Inhibition of human carbonic anhydrase isozymes I, II, IX and XII with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties

scientific article published on 25 March 2014

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

scientific article

Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.

scientific article

Losartan: Comprehensive Profile.

scientific article published on 09 April 2015

Microwave-assisted one-step synthesis of fenamic acid hydrazides from the corresponding acids

scientific article published on 28 April 2011

Microwave-assisted solution-phase synthesis and DART-mass spectrometric monitoring of a combinatorial library of indolin-2,3-dione schiff bases with potential antimycobacterial activity.

scientific article

Microwave-assisted synthesis and in-vitro anti-tumor activity of 1,3,4-triaryl-5-N-arylpyrazole-carboxamides

scientific article published on 16 February 2010

Mirtazapine

scientific article published on 30 March 2018

Modulation of carcinogen metabolizing enzymes by new fused heterocycles pendant to 5,6,7,8-tetrahydronaphthalene derivatives.

scientific article

Multistage fragmentation of ion trap mass spectrometry system and pseudo-MS3 of triple quadrupole mass spectrometry characterize certain (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones: a comparative study

scientific article published on 19 February 2014

N'-[(1E,2E)-3,7-Dimethyl-octa-2,6-dien-1-yl-idene]pyridine-4-carbohydrazide.

scientific article

Nanomolar detection of hypochlorite by a rhodamine-based chiral hydrazide in absolute aqueous media: application in tap water analysis with live-cell imaging.

scientific article published on 11 June 2014

New benzimidazothiazole derivatives as anti-inflammatory, antitumor active agents: Synthesis, in-vitro and in-vivo screening and molecular modeling studies

scientific article published on 24 October 2018

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

scientific article

Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.

scientific article published in August 2017

Novel Thiazolidinone/Thiazolo[3,2-a]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation

scientific article published on 12 June 2018

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

scientific article published on 01 December 2020

Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway.

scientific article

Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies

scientific article published on 03 April 2019

N′-[(1E,2E)-1-(2-Phenylhydrazin-1-ylidene)-1-(phenylsulfonyl)propan-2-ylidene]benzohydrazide ⬇️

scientific article published on August 11, 2011

Olmesartan

scientific article published on 31 March 2017

One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors

scientific article published on 10 December 2018

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells.

scientific article published in December 2018

Pioglitazone

article

Propranolol

scientific article published on 6 April 2017

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation.

scientific article published on 15 June 2018

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX

scientific article published on 14 November 2018

Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity ⬇️

scientific article published on May 30, 2012

Schiff bases of indoline-2,3-dione: potential novel inhibitors of Mycobacterium tuberculosis (Mtb) DNA gyrase

scientific article published on 13 September 2011

Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones

scientific article published on 6 September 2009

Stereoselective synthesis and antiviral activity of (1E,2Z,3E)-1-(piperidin-1-yl)-1-(arylhydrazono)-2-[(benzoyl/benzothiazol-2-oyl)hydrazono]-4-(aryl(1))but-3-enes.

scientific article published in March 2010

Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties.

scientific article published on 10 June 2016

Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors

scientific article published on 20 October 2018

Synthesis and anticancer activity of some pyrido[2,3-d]pyrimidine derivatives as apoptosis inducers and cyclin-dependent kinase inhibitors

scientific article published on 23 September 2019

Synthesis and anticancer potential of certain novel 2-oxo-N'-(2-oxoindolin-3-ylidene)-2H-chromene-3-carbohydrazides.

scientific article published on 16 October 2013

Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles.

scientific article

Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest.

scientific article

Synthesis and biological evaluation of certain 3-substituted benzylideneamino-2-(4-nitrophenyl)quinazolin-4(3H)-one derivatives

scientific article published on 18 June 2014

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents.

scientific article published in December 2018

Synthesis and biological evaluation of some N-arylpyrazoles and pyrazolo[3,4-d]pyridazines as anti-inflammatory agents.

scientific article published on 23 August 2013

Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase

scientific article published on 08 January 2019

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

scientific article published on December 2017

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

scientific article published on 01 December 2019

Synthesis and in vitro anticancer evaluation of some fused indazoles, quinazolines and quinolines as potential EGFR inhibitors

scientific article published on 15 May 2019

Synthesis and in-vitro anti-proliferative evaluation of some pyrazolo[1,5-a]pyrimidines as novel larotrectinib analogs

scientific article published on 21 November 2019

Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents.

scientific article

Synthesis of N-benzenesulfonamide-1H-pyrazoles bearing arylsulfonyl moiety: novel celecoxib analogs as potent anti-inflammatory agents

scientific article published on 24 April 2014

Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.

scientific article

Synthesis, Crystal Study, and Anti-Proliferative Activity of Some 2-Benzimidazolylthioacetophenones towards Triple-Negative Breast Cancer MDA-MB-468 Cells as Apoptosis-Inducing Agents.

scientific article published on 29 July 2016

Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors

scientific article published on 02 November 2019

Synthesis, in vitro biological evaluation and in silico studies of certain arylnicotinic acids conjugated with aryl (thio)semicarbazides as a novel class of anti-leishmanial agents

scientific article published on 24 June 2019

The reaction of ethyl 2-oxo-2H-chromene-3-carboxylate with hydrazine hydrate.

scientific article published on 6 February 2013

Thiazolo[3,2-a]benzimidazoles: synthetic strategies, chemical transformations and biological activities

scientific article published on 26 May 2010

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer

scientific article published on 07 September 2018

Tyrosine kinase inhibition effects of novel Pyrazolo[1,5-a]pyrimidines and Pyrido[2,3-d]pyrimidines ligand: Synthesis, biological screening and molecular modeling studies.

scientific article published on 26 March 2018

Paulina is supported by:

About Paulina

Help