List of works - Alexander K Buell

A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence

scientific article published on 16 April 2013

A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.

scientific article published on 9 January 2018

Acceleration of α-synuclein aggregation

scientific article published in March 2017

Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism ⬇️

scientific article published in July 2024

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

scientific article published on 21 August 2019

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

scientific article published on 21 August 2019

Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation

scientific article

Biosensor-based label-free assays of amyloid growth

scientific article published on 11 June 2009

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

scientific article published on 24 May 2018

Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation

scientific article published on 15 December 2021

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

scientific article

Compact fibril-like structure of amyloid β-peptide (1-42) monomers

scientific article published on 05 January 2021

Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study

scientific article published in 2021

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

article

Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis

scientific article published on 22 June 2017

Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy

scientific article published on 11 December 2013

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

scientific article published on 26 March 2018

Electrostatic effects in filamentous protein aggregation

scientific article

Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.

scientific article

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

scientific article published in Physical Review Letters

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

scientific article published on 25 March 2013

Influence of the protein context on the polyglutamine length-dependent elongation of amyloid fibrils

scientific article published on 06 December 2014

Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors

scientific article published on November 2010

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

scientific article published on 01 July 2018

Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils

scientific article published on 06 December 2019

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

scientific article

Measuring the kinetics of amyloid fibril elongation using quartz crystal microbalances

scientific article published on 01 January 2012

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

scientific article

Mécanismes fondamentaux de formation de fibres amyloïdes par la protéine α-synucléine dans la maladie de Parkinson

scientific article published on 01 June 2015

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

scientific article published on 01 April 2013

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

scientific article published on 3 July 2017

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons

scientific article published on 18 March 2016

Nanostructured films from hierarchical self-assembly of amyloidogenic proteins

scientific article published on 28 February 2010

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

scientific article published on 13 September 2017

Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

scientific article

Photodissociation dynamics of the reaction H2CO-->H+HCO via the singlet (S0) and triplet (T1) surfaces

scientific article

Population of nonnative states of lysozyme variants drives amyloid fibril formation

scientific article published on 29 April 2011

Position-dependent electrostatic protection against protein aggregation

scientific article published in May 2009

Probing small molecule binding to amyloid fibrils

scientific article

Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation

scientific article published on 29 July 2016

Protein Aggregation in Crowded Environments

scientific article published on 01 April 2010

Protein microgels from amyloid fibril networks

scientific article

Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways

scientific article published on 5 May 2017

Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems.

scientific article published on 4 February 2014

Quantitative thermophoretic study of disease-related protein aggregates

scientific article published on 17 March 2016

Relationship between prion propensity and the rates of individual molecular steps of fibril assembly

scientific article

Role of Hydrophobicity and Charge of Amyloid-Beta Oligomer Eliminating d-Peptides in the Interaction with Amyloid-Beta Monomers

scientific article published on 21 June 2018

Scaling behaviour and rate-determining steps in filamentous self-assembly

scientific article

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

scientific article

Spatial Propagation of Protein Polymerization

scientific article published in Physical Review Letters

Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation

scientific article published on 3 May 2018

Surface attachment of protein fibrils via covalent modification strategies

scientific article published on September 2010

Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform

scientific article published on 7 July 2016

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

scientific article

The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation

scientific article published on 14 March 2020

The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG

scientific article published on 11 December 2019

The Kinetics, Thermodynamics and Mechanisms of Short Aromatic Peptide Self-Assembly

scientific article published on 01 January 2019

The Nucleation of Protein Aggregates - From Crystals to Amyloid Fibrils

scientific article published on 22 October 2016

The Properties of α-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain

scientific article published on 28 February 2020

The growth of amyloid fibrils: rates and mechanisms

scientific article published on 01 October 2019

The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth

scientific article published on 04 May 2020

The length distribution of frangible biofilaments.

scientific article published on October 2015

The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

scientific article

The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.

scientific article published on 28 February 2014

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit

scientific article published on 10 October 2017

Thermodynamics of amyloid fibril formation from chemical depolymerization

scientific article published on 01 December 2019

Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase

scientific article

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation

scientific article published on 28 February 2019

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

scientific article published on 3 November 2016

List of works by Alexander K Buell

A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence

A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.

Acceleration of α-synuclein aggregation

Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism ⬇️

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation

Biosensor-based label-free assays of amyloid growth

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

Compact fibril-like structure of amyloid β-peptide (1-42) monomers

Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis

Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Electrostatic effects in filamentous protein aggregation

Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

Influence of the protein context on the polyglutamine length-dependent elongation of amyloid fibrils

Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

Measuring the kinetics of amyloid fibril elongation using quartz crystal microbalances

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

Mécanismes fondamentaux de formation de fibres amyloïdes par la protéine α-synucléine dans la maladie de Parkinson

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons

Nanostructured films from hierarchical self-assembly of amyloidogenic proteins

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

Photodissociation dynamics of the reaction H2CO-->H+HCO via the singlet (S0) and triplet (T1) surfaces

Population of nonnative states of lysozyme variants drives amyloid fibril formation

Position-dependent electrostatic protection against protein aggregation

Probing small molecule binding to amyloid fibrils

Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation

Protein Aggregation in Crowded Environments

Protein microgels from amyloid fibril networks

Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways

Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems.

Quantitative thermophoretic study of disease-related protein aggregates

Relationship between prion propensity and the rates of individual molecular steps of fibril assembly

Role of Hydrophobicity and Charge of Amyloid-Beta Oligomer Eliminating d-Peptides in the Interaction with Amyloid-Beta Monomers

Scaling behaviour and rate-determining steps in filamentous self-assembly

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

Spatial Propagation of Protein Polymerization

Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation

Surface attachment of protein fibrils via covalent modification strategies

Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation

The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG

The Kinetics, Thermodynamics and Mechanisms of Short Aromatic Peptide Self-Assembly

The Nucleation of Protein Aggregates - From Crystals to Amyloid Fibrils

The Properties of α-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain

The growth of amyloid fibrils: rates and mechanisms

The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth

The length distribution of frangible biofilaments.

The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit

Thermodynamics of amyloid fibril formation from chemical depolymerization

Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.