List of works by Rama Khokha

A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

scientific article published on 21 January 2020

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland

scientific article published on 19 February 2015

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland.

scientific article published on 10 March 2015

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

scientific article published on 11 May 2015

A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis.

scientific article published in September 2003

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site ⬇️

scientific article published on October 27, 2010

Abnormal B-cell development in TIMP-deficient bone marrow

scientific article published on 01 October 2021

Active allies: hormones, stem cells and the niche in adult mammopoiesis.

scientific article published on 19 May 2012

Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis.

scientific article published on November 2004

Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice

scientific article published on 21 April 2007

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

scientific article published on 15 July 2013

Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution.

scientific article

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.

scientific article published on 16 July 2008

Cbl-3-deficient mice exhibit normal epithelial development

scientific article

Clipping, shedding and RIPping keep immunity on cue.

scientific article published on 07 January 2008

Combination of Tumor Necrosis Factor-α Ablation and Matrix Metalloproteinase Inhibition Prevents Heart Failure After Pressure Overload in Tissue Inhibitor of Metalloproteinase-3 Knock-Out Mice

article

Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.

scientific article published on 29 March 2005

Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice.

scientific article published on 23 February 2015

Experimental manipulation of radiographic density in mouse mammary gland

scientific article

Fully interlocking: a story of teamwork among breast epithelial cells

scientific article published on January 2014

GATA6 expression distinguishes classical and basal-like subtypes in advanced pancreatic cancer

scientific article published on 10 March 2020

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

scientific article published on 22 January 2015

High CD49f expression is associated with osteosarcoma tumor progression: a study using patient-derived primary cell cultures

scientific article

Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells.

scientific article published in February 2012

Human somatic cell mutagenesis creates genetically tractable sarcomas

scientific article published on 17 August 2014

Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice

scientific article published on 01 March 2007

Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice.

scientific article published in January 2010

Insulin-like growth factor-II regulates PTEN expression in the mammary gland.

scientific article

Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.

scientific article published on 30 January 2013

Localized interleukin-12 delivery for immunotherapy of solid tumours.

scientific article

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis

scientific article

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

scientific article published on 24 August 2014

Mammary Gland Reprogramming: Metalloproteinases Couple Form with Function ⬇️

scientific article published on April 1, 2011

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities

scientific article published on 19 June 2018

Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention

scientific article published on 21 June 2019

Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.

scientific article published in August 2004

Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth

scientific article published on 01 August 2019

Metalloproteinases and their natural inhibitors in inflammation and immunity.

scientific article published on September 2013

Metalloproteinases in extracellular vesicles.

scientific article published on June 2017

MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1.

scientific article published on 6 June 2016

Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.

scientific article published on June 2010

Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors

scientific article published on 01 February 2005

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice.

scientific article published on 28 November 2007

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

scientific article published in January 2012

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

scientific article

PKA signaling drives mammary tumorigenesis through Src.

scientific article published on 24 March 2014

Planarians as models of cadmium-induced neoplasia provide measurable benchmarks for mechanistic studies

scientific article published on 5 May 2017

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice

scientific article

Progesterone Exposure and Breast Cancer Risk

scientific article published on 01 June 2015

Progesterone and Synthetic Progestin Controversies—Reply

scientific article published on 01 October 2015

Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.

scientific article published on 5 March 2013

Progesterone induces adult mammary stem cell expansion

scientific article published on June 2010

Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types

scientific article

Proteolytic factors in exosomes

scientific article published on May 2013

QUANTIFYING NANOPARTICLE TRANSPORT IN VIVO USING HYPERSPECTRAL IMAGING WITH A DORSAL SKINFOLD WINDOW CHAMBER.

scientific article published on October 2012

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.

scientific article

RANKL blockade prevents and treats aggressive osteosarcomas.

scientific article

RANKL/RANK control Brca1 mutation-driven mammary tumors

scientific article published on 31 May 2016

Regulation of cancer cell migration and bone metastasis by RANKL.

scientific article published on March 2006

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

scientific article

Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart

scientific article published on 22 July 2009

Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

Stromal TIMP3 regulates liver lymphocyte populations and provides protection against Th1 T cell-driven autoimmune hepatitis

scientific article

TIMP3 controls cell fate to confer hepatocellular carcinoma resistance

scientific article published on 27 October 2014

TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.

scientific article

TIMPs: versatile extracellular regulators in cancer

scientific article published on 09 December 2016

The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer.

scientific article published in February 2005

The mammary stem cell conundrum: is it unipotent or multipotent?

scientific article

The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis

scientific article published on 01 January 2008

Thinking outside the cell: proteases regulate hepatocyte division.

scientific article

Timp3 deficient mice show resistance to developing breast cancer

scientific article

Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer.

scientific article

Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma

scientific article published on 01 February 2003

Tumor suppression by stromal TIMPs

scientific article published on 30 March 2016

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

scientific article

Paulina is supported by:

About Paulina

Help