List of works - Hiroshi Hinou

A comprehensive glycome profiling of Huntington's disease transgenic mice.

scientific article published on 20 April 2015

A new approach for the synthesis of hyperbranched N-glycan core structures from locust bean gum

scientific article published on 21 November 2013

A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence.

scientific article

A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides

scientific article

A strategy for neuraminidase inhibitors using mechanism-based labeling information.

scientific article

Aglycone-focused randomization of 2-difluoromethylphenyl-type sialoside suicide substrates for neuraminidases.

scientific article

An efficient approach for the characterization of mucin-type glycopeptides: the effect of O-glycosylation on the conformation of synthetic mucin peptides

scientific article published on 24 January 2011

An efficient approach to the discovery of potent inhibitors against glycosyltransferases.

scientific article

An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation

scientific article published on 11 January 2012

An essential epitope of anti-MUC1 monoclonal antibody KL-6 revealed by focused glycopeptide library.

scientific article

Artificial Golgi apparatus: globular protein-like dendrimer facilitates fully automated enzymatic glycan synthesis

scientific article published on 29 October 2010

Attomolar detection of influenza A virus hemagglutinin human H1 and avian H5 using glycan-blotted field effect transistor biosensor.

scientific article published on 28 May 2013

Characterization of Vibrio cholerae neuraminidase by a novel mechanism-based fluorescent labeling reagent

scientific article published in September 2005

Chemical Synthesis Demonstrates That Dynamic O-Glycosylation Regulates the Folding and Functional Conformation of a Pivotal EGF12 Domain of the Human NOTCH1 Receptor.

scientific article published on 26 July 2017

Chemical synthesis, folding, and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor

scientific article

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery

scientific article published on 21 October 2020

Combinatorial synthesis of MUC1 glycopeptides: polymer blotting facilitates chemical and enzymatic synthesis of highly complicated mucin glycopeptides

scientific article published in August 2005

Construction and structural characterization of versatile lactosaminoglycan-related compound library for the synthesis of complex glycopeptides and glycosphingolipids.

scientific article published in December 2006

Construction of highly glycosylated mucin-type glycopeptides based on microwave-assisted solid-phase syntheses and enzymatic modifications.

scientific article

Convergent Solid-Phase Synthesis of Macromolecular MUC1 Models Truly Mimicking Serum Glycoprotein Biomarkers of Interstitial Lung Diseases.

scientific article published on 24 June 2016

Exploring serum and immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women

scientific article published on 17 June 2019

Fast epitope mapping for the anti-MUC1 monoclonal antibody by combining a one-bead-one-glycopeptide library and a microarray platform

scientific article

Functional neoglycopeptides: synthesis and characterization of a new class of MUC1 glycoprotein models having core 2-based O-glycan and complex-type N-glycan chains.

scientific article published in November 2009

Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase

scientific article published on 16 July 2018

Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer's disease brain, serum and cerebrospinal fluid towards potential biomarker discovery

scientific article

Glycoblotting of Egg White Reveals Diverse N-Glycan Expression in Quail Species

scientific article published on 19 December 2018

Glycoblotting-assisted O-glycomics: ammonium carbamate allows for highly efficient o-glycan release from glycoproteins

scientific article published on 15 November 2010

Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation

scientific article published on 26 May 2012

Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs.

scientific article published on 18 October 2017

Glycosidation promoted by a reusable solid superacid in supercritical carbon dioxide

scientific article published on 01 August 2006

Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers

scientific article published in PLoS ONE

High-throughput protein glycomics: combined use of chemoselective glycoblotting and MALDI-TOF/TOF mass spectrometry.

scientific article

Highly efficient and versatile synthesis of proteoglycan core structures from 1,6-anhydro-beta-lactose as a key starting material

scientific article published on 01 January 2007

Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes

scientific article published on 20 March 2020

Importance of sialic acid residues illuminated by live animal imaging using phosphorylcholine self-assembled monolayer-coated quantum dots

scientific article

Large-Scale Glycomics of Livestock: Discovery of Highly Sensitive Serum Biomarkers Indicating an Environmental Stress Affecting Immune Responses and Productivity of Holstein Dairy Cows

scientific article published on 23 November 2015

Macrocyclic mechanism-based inhibitor for neuraminidases

scientific article published on 11 December 2012

Mechanism-based inhibitors to probe transitional states of glycoside hydrolases

scientific article published in January 2006

Microwave effect for glycosylation promoted by solid super acid in supercritical carbon dioxide

scientific article published on 8 December 2009

Microwave-assisted solid-phase synthesis of antifreeze glycopeptides

scientific article published on 10 February 2013

Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articular chondrocytes.

scientific article

Molecular transporter between polymer platforms: highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports

scientific article published on 01 April 2005

One-pot solid-phase glycoblotting and probing by transoximization for high-throughput glycomics and glycoproteomics

scientific article published on 01 January 2007

One-pot synthesis of cyclic antifreeze glycopeptides

scientific article

Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase

scientific article

Potential usage for in vivo lectin screening in live animals utilizing cell surface mimetic glyco-nanoparticles, phosphorylcholine-coated quantum dots (PC-QDs).

scientific article published on January 2014

Rapid Endolysosomal Escape and Controlled Intracellular Trafficking of Cell Surface Mimetic Quantum-Dots-Anchored Peptides and Glycopeptides

scientific article

Rapid microwave-assisted solid-phase glycopeptide synthesis

scientific article published on 01 March 2005

Site-specific conformational alteration induced by sialylation of MUC1 tandem repeating glycopeptides at an epitope region for the anti-KL-6 monoclonal antibody

scientific article published on 02 January 2013

Strict stereocontrol by 2,4-O-di-tert-butylsilylene group on β-glucuronylations

scientific article published on 03 April 2012

Structural analysis of O-glycopeptides employing negative- and positive-ion multi-stage mass spectra obtained by collision-induced and electron-capture dissociations in linear ion trap time-of-flight mass spectrometry.

scientific article published on January 2007

Synthesis of neoglycosphingolipid from methoxyamino-functionalized ceramide

scientific article published on 29 December 2013

Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-Glycans in the Ligand-Binding Region

scientific article published on 14 January 2016

Synthetic Mucin-Like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on the Interaction with Adhesion/Growth-Regulatory Galectins in Arrays.

scientific article

Synthetic glycopeptides as a designated standard in focused glycoproteomics to discover serum cancer biomarkers

scientific article published on 29 June 2018

Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification

scientific article published on 06 May 2019

Systematic syntheses and inhibitory activities of bisubstrate-type inhibitors of sialyltransferases

scientific article published in July 2003

The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR.

scientific article published on 14 September 2015

The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.

scientific article published on 22 November 2017

Unexpected tolerance of glycosylation by UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase revealed by electron capture dissociation mass spectrometry: carbohydrate as potential protective groups.

scientific article published in July 2010

List of works by Hiroshi Hinou

A comprehensive glycome profiling of Huntington's disease transgenic mice.

A new approach for the synthesis of hyperbranched N-glycan core structures from locust bean gum

A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence.

A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides

A strategy for neuraminidase inhibitors using mechanism-based labeling information.

Aglycone-focused randomization of 2-difluoromethylphenyl-type sialoside suicide substrates for neuraminidases.

An efficient approach for the characterization of mucin-type glycopeptides: the effect of O-glycosylation on the conformation of synthetic mucin peptides

An efficient approach to the discovery of potent inhibitors against glycosyltransferases.

An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation

An essential epitope of anti-MUC1 monoclonal antibody KL-6 revealed by focused glycopeptide library.

Artificial Golgi apparatus: globular protein-like dendrimer facilitates fully automated enzymatic glycan synthesis

Attomolar detection of influenza A virus hemagglutinin human H1 and avian H5 using glycan-blotted field effect transistor biosensor.

Characterization of Vibrio cholerae neuraminidase by a novel mechanism-based fluorescent labeling reagent

Chemical Synthesis Demonstrates That Dynamic O-Glycosylation Regulates the Folding and Functional Conformation of a Pivotal EGF12 Domain of the Human NOTCH1 Receptor.

Chemical synthesis, folding, and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery

Combinatorial synthesis of MUC1 glycopeptides: polymer blotting facilitates chemical and enzymatic synthesis of highly complicated mucin glycopeptides

Construction and structural characterization of versatile lactosaminoglycan-related compound library for the synthesis of complex glycopeptides and glycosphingolipids.

Construction of highly glycosylated mucin-type glycopeptides based on microwave-assisted solid-phase syntheses and enzymatic modifications.

Convergent Solid-Phase Synthesis of Macromolecular MUC1 Models Truly Mimicking Serum Glycoprotein Biomarkers of Interstitial Lung Diseases.

Exploring serum and immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women

Fast epitope mapping for the anti-MUC1 monoclonal antibody by combining a one-bead-one-glycopeptide library and a microarray platform

Functional neoglycopeptides: synthesis and characterization of a new class of MUC1 glycoprotein models having core 2-based O-glycan and complex-type N-glycan chains.

Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase

Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer's disease brain, serum and cerebrospinal fluid towards potential biomarker discovery

Glycoblotting of Egg White Reveals Diverse N-Glycan Expression in Quail Species

Glycoblotting-assisted O-glycomics: ammonium carbamate allows for highly efficient o-glycan release from glycoproteins

Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation

Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs.

Glycosidation promoted by a reusable solid superacid in supercritical carbon dioxide

Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers

High-throughput protein glycomics: combined use of chemoselective glycoblotting and MALDI-TOF/TOF mass spectrometry.

Highly efficient and versatile synthesis of proteoglycan core structures from 1,6-anhydro-beta-lactose as a key starting material

Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes

Importance of sialic acid residues illuminated by live animal imaging using phosphorylcholine self-assembled monolayer-coated quantum dots

Large-Scale Glycomics of Livestock: Discovery of Highly Sensitive Serum Biomarkers Indicating an Environmental Stress Affecting Immune Responses and Productivity of Holstein Dairy Cows

Macrocyclic mechanism-based inhibitor for neuraminidases

Mechanism-based inhibitors to probe transitional states of glycoside hydrolases

Microwave effect for glycosylation promoted by solid super acid in supercritical carbon dioxide

Microwave-assisted solid-phase synthesis of antifreeze glycopeptides

Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articular chondrocytes.

Molecular transporter between polymer platforms: highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports

One-pot solid-phase glycoblotting and probing by transoximization for high-throughput glycomics and glycoproteomics

One-pot synthesis of cyclic antifreeze glycopeptides

Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase

Potential usage for in vivo lectin screening in live animals utilizing cell surface mimetic glyco-nanoparticles, phosphorylcholine-coated quantum dots (PC-QDs).

Rapid Endolysosomal Escape and Controlled Intracellular Trafficking of Cell Surface Mimetic Quantum-Dots-Anchored Peptides and Glycopeptides

Rapid microwave-assisted solid-phase glycopeptide synthesis

Site-specific conformational alteration induced by sialylation of MUC1 tandem repeating glycopeptides at an epitope region for the anti-KL-6 monoclonal antibody

Strict stereocontrol by 2,4-O-di-tert-butylsilylene group on β-glucuronylations

Structural analysis of O-glycopeptides employing negative- and positive-ion multi-stage mass spectra obtained by collision-induced and electron-capture dissociations in linear ion trap time-of-flight mass spectrometry.

Synthesis of neoglycosphingolipid from methoxyamino-functionalized ceramide

Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-Glycans in the Ligand-Binding Region

Synthetic Mucin-Like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on the Interaction with Adhesion/Growth-Regulatory Galectins in Arrays.

Synthetic glycopeptides as a designated standard in focused glycoproteomics to discover serum cancer biomarkers

Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification

Systematic syntheses and inhibitory activities of bisubstrate-type inhibitors of sialyltransferases

The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR.

The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.

Unexpected tolerance of glycosylation by UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase revealed by electron capture dissociation mass spectrometry: carbohydrate as potential protective groups.