List of works - Susanne Müller

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

scientific article published on August 2013

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

scientific article

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5

scientific article published on 20 March 2020

A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF.

scientific article published on 3 June 2013

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

scientific article published on 12 May 2014

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

scientific article

Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.

scientific article published on 04 February 2014

An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells

scientific article published on 22 November 2019

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

scientific article

Assessing histone demethylase inhibitors in cells: lessons learned.

scientific article

BET inhibition as a new strategy for the treatment of gastric cancer

scientific article

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

scientific article published in 2015

Chemical probes targeting epigenetic proteins: Applications beyond oncology

scientific article

Comprehensive characterization of the Published Kinase Inhibitor Set

scientific article

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

scientific article published in 2015

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

scientific article published on 9 January 2017

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

scientific article published on 23 March 2015

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

scientific article (publication date: 2 July 2014)

Discovery of BET bromodomain inhibitors and their role in target validation

scientific article published in 2014

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.

scientific article published on 14 May 2015

Donated chemical probes for open science

scientific article published on 20 April 2018

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

scientific article

Epigenomic regulation of oncogenesis by chromatin remodeling

scientific article

Erratum: Corrigendum: The promise and peril of chemical probes

scientific article published in November 2015

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

scientific article published on 19 October 2011

Frapid: achieving full automation of FRAP for chemical probe validation

scientific article published on 11 January 2016

Gastric cancer management: Kinases as a target therapy

scientific article published on 7 March 2017

Generation and analyses of human synthetic antibody libraries and their application for protein microarrays

scientific article

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

scientific article

HMGB1 is an endogenous immune adjuvant released by necrotic cells

scientific article

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

scientific article published on 21 January 2020

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

scientific article published on 06 April 2017

Histone recognition and large-scale structural analysis of the human bromodomain family

scientific article

Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules

scientific article published on 13 March 2015

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

scientific article

In Vivo Biotinylation of Antigens in E. coli

scientific article published in January 2017

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

scientific article

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

scientific article (publication date: 18 May 2015)

Large-scale structural analysis of the classical human protein tyrosine phosphatome

scientific article

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

scientific article

New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal

scientific article

Open access chemical probes for epigenetic targets

scientific article

Out of the box binding determines specificity of SH2 domain interaction

scientific article published on August 2009

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

scientific article

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

scientific article

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

scientific article

Progress towards a public chemogenomic set for protein kinases and a call for contributions

scientific article

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

scientific article published on 12 October 2016

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

scientific article

SH2 domains: modulators of nonreceptor tyrosine kinase activity

scientific article

Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation

scientific article published on 29 August 2017

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

scientific article published on 13 November 2015

Structural and Functional Characterization of the Human Protein Kinase ASK1

scientific article

Structural basis of fumarate hydratase deficiency

scientific article

Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

scientific article published on 26 February 2015

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies

scientific article

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

scientific article

Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

scientific article published on 5 January 2016

Targeting kinases for the treatment of inflammatory diseases

scientific article published on 15 July 2010

Targeting the Bromome: are we there yet?

scientific article

The (un)targeted cancer kinome

scientific article published in March 2010

The Long Acidic Tail of High Mobility Group Box 1 (HMGB1) Protein Forms an Extended and Flexible Structure That Interacts with Specific Residues within and between the HMG Boxes†

scientific article published in September 2004

The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells

scientific journal article

The promise and peril of chemical probes

scientific article

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins

scientific article published on September 2007

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma

scientific article published on 04 May 2020

Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice

scientific article

[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains

scientific article

List of works by Susanne Müller

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5

A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF.

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.

An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

Assessing histone demethylase inhibitors in cells: lessons learned.

BET inhibition as a new strategy for the treatment of gastric cancer

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

Chemical probes targeting epigenetic proteins: Applications beyond oncology

Comprehensive characterization of the Published Kinase Inhibitor Set

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

Discovery of BET bromodomain inhibitors and their role in target validation

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.

Donated chemical probes for open science

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

Epigenomic regulation of oncogenesis by chromatin remodeling

Erratum: Corrigendum: The promise and peril of chemical probes

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

Frapid: achieving full automation of FRAP for chemical probe validation

Gastric cancer management: Kinases as a target therapy

Generation and analyses of human synthetic antibody libraries and their application for protein microarrays

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

HMGB1 is an endogenous immune adjuvant released by necrotic cells

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Histone recognition and large-scale structural analysis of the human bromodomain family

Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

In Vivo Biotinylation of Antigens in E. coli

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Large-scale structural analysis of the classical human protein tyrosine phosphatome

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal

Open access chemical probes for epigenetic targets

Out of the box binding determines specificity of SH2 domain interaction

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Progress towards a public chemogenomic set for protein kinases and a call for contributions

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

SH2 domains: modulators of nonreceptor tyrosine kinase activity

Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Structural and Functional Characterization of the Human Protein Kinase ASK1

Structural basis of fumarate hydratase deficiency

Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

Targeting kinases for the treatment of inflammatory diseases

Targeting the Bromome: are we there yet?

The (un)targeted cancer kinome

The Long Acidic Tail of High Mobility Group Box 1 (HMGB1) Protein Forms an Extended and Flexible Structure That Interacts with Specific Residues within and between the HMG Boxes†

The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells

The promise and peril of chemical probes

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma

Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice

[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains