List of works - Heping Xu

A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis.

scientific article published on 7 August 2017

Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice.

scientific article

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

scientific article

Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration

scientific article

Analysis of retinal circulation using an image-based network model of retinal vasculature

scientific article published on 13 February 2010

Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.

scientific article published on 17 July 2018

Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

article

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7 ⬇️

scientific article published on 29 April 2019

CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation.

scientific article

Cataract surgery induces retinal pro-inflammatory gene expression and protein secretion.

scientific article

Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration

scientific article

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

scientific article published on 01 March 2018

Characterization of a spontaneous mouse retinal pigment epithelial cell line B6-RPE07.

scientific article

Cholesterol homeostasis, macrophage malfunction and age-related macular degeneration

scientific article published on 01 November 2018

Circulating Leukocyte Alterations and the Development/Progression of Diabetic Retinopathy in Type 1 Diabetic Patients - A Pilot Study

scientific article published on 30 January 2020

Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production.

scientific article published on 4 August 2017

Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

scientific article published in May 2013

Complement factor B in retinal pigment epithelial cell is up-regulated by inflammatory cytokine TNF-α and INF-γ

Comprehensive analysis of mouse retinal mononuclear phagocytes.

scientific article published on 4 May 2017

Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation

scientific article published on 7 April 2008

Culture and characterization of microglia from the adult murine retina.

scientific article published on 29 May 2014

Dendritic cell physiology and function in the eye.

scientific article

Development of an image-based model for capillary vasculature of retina

scientific article published on 28 January 2011

Development of an image-based network model of retinal vasculature.

scientific article published on 5 February 2010

Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2.

scientific article

Diabetic retinopathy and dysregulated innate immunity

scientific article published on 29 May 2017

Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators.

scientific article published on November 2005

Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice.

scientific article

Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72.

scientific article

Experimental autoimmune uveoretinitis (EAU)-related tissue damage and angiogenesis is reduced in CCL2⁻/⁻CX₃CR1gfp/gfp mice.

scientific article

Expression of Complement Components and Regulators by Different Subtypes of Bone Marrow-Derived Macrophages

scientific article published on 01 August 2012

Extremely complex populations of small RNAs in the mouse retina and RPE/choroid.

scientific article

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

article published in 2019

Good news-bad news: the Yin and Yang of immune privilege in the eye.

scientific article published on 27 November 2012

Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy

scientific article published on 16 December 2019

Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells.

scientific article published on 10 February 2017

Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD.

scientific article published on 16 February 2016

Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy

scientific article published on 29 October 2020

IL-33 attenuates the development of experimental autoimmune uveitis.

scientific article published on 18 October 2014

IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

scientific article published on 03 December 2019

Imaging ocular immune responses by intravital microscopy.

scientific article

Immune activation in retinal aging: a gene expression study

scientific article published on 10 June 2010

Immune regulation in the aging retina

scientific article published on 20 October 2018

Improved leukocyte tracking in mouse retinal and choroidal circulation.

scientific article

Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis

scientific article published on October 2010

Intravitreal Injection of Normal Saline Induces Retinal Degeneration in the C57BL/6J Mouse.

scientific article published on 27 March 2014

Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis

scientific article

Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier.

scientific article

LYVE-1-positive macrophages are present in normal murine eyes

scientific article published in May 2007

Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.

scientific article published on July 2005

Leukocyte trafficking in experimental autoimmune uveitis: breakdown of blood-retinal barrier and upregulation of cellular adhesion molecules

scientific article

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

article

Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse

scientific article

Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis

scientific article published on 05 April 2022

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration

scientific article published on 25 November 2020

Mechanistical retinal drug targets and challenges

scientific article published on 01 February 2018

Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing

scientific article published on 17 June 2019

Modelling of pulsatile blood flow in arterial trees of retinal vasculature.

scientific article published in November 2010

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

scientific article published on 01 October 2018

Molecular Mechanisms Underlying Age-Related Ocular Diseases.

scientific article published on 21 May 2018

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice

scientific article

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation

scientific article published on 9 October 2017

Para-inflammation in the aging retina.

scientific article published on 26 June 2009

Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent

scientific article published on 23 February 2012

Parainflammation, chronic inflammation, and age-related macular degeneration

scientific article

Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation

scientific article

Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8).

scientific article published on 23 February 2017

Persistent Inflammation Subverts Thrombospondin-1–Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation

article

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis

scientific article published on 14 November 2020

Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology

scientific article published on 30 August 2018

Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate.

scientific article

Quantitative In Situ Analysis of Claudin Expression at the Blood–Retinal Barrier

scientific article published on 01 January 2011

RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

scientific article

Requirements for passage of T lymphocytes across non-inflamed retinal microvessels ⬇️

scientific article published on September 1, 2003

Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye.

scientific article

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis.

scientific article

SOCS3 deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis.

scientific article published on 13 February 2018

STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration

scientific article

STAT3 activation in circulating myeloid-derived cells contributes to retinal microvascular dysfunction in diabetes

scientific article published on 08 July 2019

Single-cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors-Implications in subretinal immune regulation

scientific article published on 12 March 2020

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

scientific article published on 11 July 2018

Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2(Akita) diabetic mouse

scientific article

Sustained intraocular vascular endothelial growth factor neutralisation does not affect retinal and choroidal vasculature in Ins2Akita diabetic mice

scientific article published on 26 April 2019

Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis.

scientific article published on 4 December 2009

Targeting the complement system for the management of retinal inflammatory and degenerative diseases.

scientific article published on 03 March 2016

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.

scientific article

The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye.

scientific article published in June 2018

The keratan sulfate disaccharide Gal(6S03) beta1,4-GlcNAc(6S03) modulates interleukin 12 production by macrophages in murine Thy-1 type autoimmune disease

scientific article

The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic

scientific article published on 12 March 2019

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

scientific article published in May 2017

Turnover of resident retinal microglia in the normal adult mouse

scientific article published in August 2007

Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy

scientific article published on 05 December 2019

Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina

scientific article published on 26 September 2008

Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture

scientific article

List of works by Heping Xu

A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis.

Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice.

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration

Analysis of retinal circulation using an image-based network model of retinal vasculature

Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.

Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7 ⬇️

CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation.

Cataract surgery induces retinal pro-inflammatory gene expression and protein secretion.

Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

Characterization of a spontaneous mouse retinal pigment epithelial cell line B6-RPE07.

Cholesterol homeostasis, macrophage malfunction and age-related macular degeneration

Circulating Leukocyte Alterations and the Development/Progression of Diabetic Retinopathy in Type 1 Diabetic Patients - A Pilot Study

Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production.

Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

Complement factor B in retinal pigment epithelial cell is up-regulated by inflammatory cytokine TNF-α and INF-γ

Comprehensive analysis of mouse retinal mononuclear phagocytes.

Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation

Culture and characterization of microglia from the adult murine retina.

Dendritic cell physiology and function in the eye.

Development of an image-based model for capillary vasculature of retina

Development of an image-based network model of retinal vasculature.

Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2.

Diabetic retinopathy and dysregulated innate immunity

Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators.

Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice.

Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72.

Experimental autoimmune uveoretinitis (EAU)-related tissue damage and angiogenesis is reduced in CCL2⁻/⁻CX₃CR1gfp/gfp mice.

Expression of Complement Components and Regulators by Different Subtypes of Bone Marrow-Derived Macrophages

Extremely complex populations of small RNAs in the mouse retina and RPE/choroid.

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

Good news-bad news: the Yin and Yang of immune privilege in the eye.

Higher aqueous levels of matrix metalloproteinases indicated visual impairment in patients with retina vein occlusion after anti-VEGF therapy

Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells.

Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD.

Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy

IL-33 attenuates the development of experimental autoimmune uveitis.

IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

Imaging ocular immune responses by intravital microscopy.

Immune activation in retinal aging: a gene expression study

Immune regulation in the aging retina

Improved leukocyte tracking in mouse retinal and choroidal circulation.

Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis

Intravitreal Injection of Normal Saline Induces Retinal Degeneration in the C57BL/6J Mouse.

Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis

Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier.

LYVE-1-positive macrophages are present in normal murine eyes

Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.

Leukocyte trafficking in experimental autoimmune uveitis: breakdown of blood-retinal barrier and upregulation of cellular adhesion molecules

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse

Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration

Mechanistical retinal drug targets and challenges

Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing

Modelling of pulsatile blood flow in arterial trees of retinal vasculature.

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

Molecular Mechanisms Underlying Age-Related Ocular Diseases.

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation

Para-inflammation in the aging retina.

Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent

Parainflammation, chronic inflammation, and age-related macular degeneration

Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation

Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8).

Persistent Inflammation Subverts Thrombospondin-1–Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis

Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology

Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate.

Quantitative In Situ Analysis of Claudin Expression at the Blood–Retinal Barrier

RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

Requirements for passage of T lymphocytes across non-inflamed retinal microvessels ⬇️

Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye.

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis.

SOCS3 deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis.

STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration