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List of works by Michael Mullan

A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity

scientific article published on 01 December 2019

A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier

scientific article

A novel physico-chemical property based model for studying the effects of mutation on the aggregation of peptides

scientific article published in January 2009

Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis

scientific article

Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

scientific article published in February 1999

Alzheimer disease: the new agenda ⬇️

scientific article published on March 1, 1992

Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2.

scientific article published on 10 October 2009

Alzheimer's beta-amyloid vasoactivity: identification of a novel beta-amyloid conformational intermediate

scientific article published on 01 October 1998

Alzheimer's disease. In search of the soluble

scientific article published in September 1992

Alzheimer's β-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40 ⬇️

scientific article published on October 5, 1998

Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E.

scientific article published in October 1999

Amelioration of experimental autoimmune encephalomyelitis by anatabine

scientific article

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo.

scientific article published on 19 September 2011

Anti-Tumoral Activity of a Short Decapeptide Fragment of the Alzheimer's Abeta Peptide

scientific article

Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells

scientific article published in April 2005

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.

scientific article

Apolipoprotein E genotype and cognitive impairment in community-dwelling black older adults

scientific article published in January 2002

Apolipoprotein E genotype and oxidative stress response to traumatic brain injury

scientific article published on 25 January 2010

Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients--an open-label trial.

scientific article published on 10 May 2011

Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample

scientific article published in September 2004

Apolipoprotein E polymorphism and cognitive impairment in a bi-ethnic community-dwelling elderly sample

scientific article published in January 2002

Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury

scientific article published on 21 February 2009

Apolipoprotein-E epsilon 4 allele frequency and conferred risk for Cuban Americans with Alzheimer's disease

scientific article published in January 2000

Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency

scientific article published in October 1999

Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice

scientific article published in July 2004

Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.

scientific article published in May 2004

CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models

scientific article published on 24 February 2006

CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.

scientific article

CD40 signaling and Alzheimer's disease pathogenesis.

scientific article

CD40-CD40L interaction in Alzheimer's disease.

scientific article

CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling

scientific article

CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway

scientific article published on 01 November 2000

CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease

scientific article published in November 2002

Characteristics of the in vitro vasoactivity of beta-amyloid peptides

scientific article published on 01 March 1998

Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier ⬇️

scientific article published on October 19, 2010

Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42.

scientific article published in July 2001

Cholesterol modulates vascular reactivity to endothelin-1 by stimulating a pro-inflammatory pathway

scientific article published in August 2000

Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val→Ile mutation in the amyloid precursor protein gene

article

Clinical features of early onset, familial Alzheimer's disease linked to chromosome 14

scholarly article by Michael Mullan et al published 27 February 1995 in American Journal of Medical Genetics Part A

Cocaine induced inflammatory response in human neuronal progenitor cells

scientific article published on 15 March 2006

Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample.

scientific article

Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US.

scientific article

Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study.

scientific article published on 29 October 2010

Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer's disease.

scientific article published on 16 November 2010

Differences in executive functioning between Alzheimer's disease and subcortical ischemic vascular dementia

scientific article published in September 2002

Dopamine DRD2/Cys311 is not associated with chronic schizophrenia

scientific article published in September 1996

Epitope-dependent effects of Beta-amyloid antibodies on Beta-amyloid clearance in an in vitro model of the blood-brain barrier

scientific article published in July 2011

Factors associated with depressive symptoms in non-demented community-dwelling elderly

scientific article published in May 1999

Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology.

scientific article published in March 1992

Familial and population-based studies of apolipoprotein E and Alzheimer's disease

scientific article published in December 1996

Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid

scientific article

Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease

scientific article published in February 2000

Genomic analysis of response to traumatic brain injury in a mouse model of Alzheimer's disease (APPsw).

scientific article published on 25 September 2007

Genomic regulation after CD40 stimulation in microglia: Relevance to Alzheimer's disease

scientific article published on 22 September 2005

Identification of plasma biomarkers of TBI outcome using proteomic approaches in an APOE mouse model

scientific article published on 7 December 2011

Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis

article

Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's disease

scientific article

Improving image analysis in 2DGE-based redox proteomics by labeling protein carbonyl with fluorescent hydroxylamine

scientific article published on 19 December 2007

Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice

scientific article

Induction of CD40 on human endothelial cells by Alzheimer's beta-amyloid peptides.

scientific article published on September 1999

Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine

scientific article published on 28 March 2011

Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease

scientific article

Inhibition of Abeta production by NF-kappaB inhibitors

scientific article

Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism

scientific article

Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors

scientific article

Inhibition of angiogenesis by Abeta peptides

scientific article published on January 2004

Intravascular beta-amyloid infusion increases blood pressure: implications for a vasoactive role of beta-amyloid in the pathogenesis of Alzheimer's disease

scientific article published on 01 June 1999

Intravascular infusions of soluble beta-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage

scientific article published in February 1999

Isoform-specific vasoconstriction induced by apolipoprotein E and modulation of this effect by Alzheimer's beta-amyloid peptide

scientific article published on 01 November 1998

Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents

scientific article published on 14 July 2012

Long-term venous A beta 1-40 infusion in rats causes lung hemorrhage and brain perivascular gliosis

scientific article published in September 1997

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation

scientific article published in December 1999

Model of Alzheimer's disease amyloid-beta peptide based on a RNA binding protein

scientific article published on July 2005

Molecular genetic studies of manic-depression and schizophrenia.

scientific article published on January 1990

Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins.

scientific article

Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production

scientific article published in May 2004

Neuropsychological comparison of Alzheimer's disease and dementia with lewy bodies

scientific article published on 5 December 2006

Newly described form of X-linked arthrogryposis maps to the long arm of the human X chromosome

scientific article published on 01 August 1998

Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice

scientific article

No association between the NOS3 codon 298 polymorphism and Alzheimer's disease in a sample from the United States

scientific article published in May 2000

No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples

scientific article published on 01 April 1997

No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample

scientific article published in September 1997

No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples

scientific article published on 01 January 1997

No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples

scientific article published on 01 May 1999

No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease

scientific article published in April 1997

Novel role of CXCR2 in regulation of gamma-secretase activity

scientific article

Novel strategies for opposing murine microglial activation

scientific article published on 01 January 2000

Occurrence of the Cys311 DRD2 variant in a pedigree multiply affected with panic disorder

scientific article published on 01 August 1995

Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide

scientific article published in March 2008

Prion dementia without characteristic pathology

scientific article published in July 1990

Pro-inflammatory effect of freshly solubilized beta-amyloid peptides in the brain.

scientific article published on September 2002

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease

scientific article

Proteomic CNS profile of delayed cognitive impairment in mice exposed to Gulf War agents

scientific article published on 11 October 2011

Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42).

scientific article published in November 2002

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

scientific article published on 8 March 2010

Repetitive Mild Traumatic Brain Injury in a Mouse Model Produces Learning and Memory Deficits Accompanied by Histological Changes ⬇️

scientific article published on November 23, 2012

Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice

scientific article published in February 2013

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice

scientific article published in December 2002

Role of peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer's beta-amyloid1-40 peptide

scientific article published in July 1998

Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease

scientific article published in August 1991

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

scientific article (publication date: 21 February 1991)

Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier

scientific article published on 17 December 2010

Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier

scientific article published on 9 April 2011

Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo

scientific article published in November 1998

Soluble beta-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway

scientific article

Specialist versus general practitioner treatment of problem drinkers

scientific article published in October 1990

Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae

scientific article published in April 2002

Stimulation of the Retinoid X Receptor Facilitates Beta-Amyloid Clearance Across the Blood–Brain Barrier ⬇️

scientific article published on August 14, 2012

Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta

scientific article published on 3 October 2009

Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity.

scientific article published on July 1997

T-cells in Alzheimer's disease.

scientific article

The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism

scientific article published in August 1998

The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample

scientific article published in August 1999

The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations

scientific article

The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease

scientific article published on 23 November 2005

The genetic association between Cathepsin D and Alzheimer's disease

scientific article published in July 2000

The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) production.

scientific article published on 22 April 2008

The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levels

scientific article published on 02 October 2007

The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis

scientific article published in November 2001

The molecular genetics of Alzheimer's disease.

scientific article published on August 1994

The opioid receptor system and alcoholism: a genetic perspective.

scientific article

The role of genetic factors in the etiology of the affective disorders

scientific article

The vasoactivity of A beta peptides

scientific article published on 01 September 1997

Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation

scientific article published in September 2003

beta-Amyloid peptides and enhancement of vasoconstriction by endothelin-1

scientific article published on 01 September 1997

beta-Amyloid-mediated vasoactivity and vascular endothelial damage

scientific article published in March 1996

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

scientific article published on 01 August 2002

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