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List of works by Stanley Nattel

2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design ⬇️

scientific article published on March 1, 2012

2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design:

scientific article published on 01 March 2012

2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design

scientific article published on March 2012

2014 focused update of the Canadian Cardiovascular Society Guidelines for the management of atrial fibrillation

scientific article published on 13 August 2014

2016 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation.

scientific article published on September 2016

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

scientific article published on 9 May 2017

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

scientific article published on 15 September 2017

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

scientific article published on 15 September 2017

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary.

scientific article published on 15 September 2017

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary

scientific article

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

scientific article published on 15 September 2017

2018 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation

article

A Focus on Covid-19: Fast and Accurate Information to Guide Management for Pandemic-Related Issues in Cardiac Patients

scientific article published on 25 April 2020

A Focus on Hypertension: A Modest Condition of Enormous Significance ⬇️

scientific article published on 01 July 2011

A Practical Approach to Avoiding Cardiovascular Adverse Effects of Psychoactive Medications

scientific article

A Proud Tradition and a New Beginning With a Theme Issue on Atrial Fibrillation ⬇️

scientific article published on January 1, 2011

A Systematic Review on the Progression of Paroxysmal to Persistent Atrial Fibrillation: Shedding New Light on the Effects of Catheter Ablation

scientific article published on 13 May 2015

A clinical approach to early repolarization

scientific article published in April 2013

A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

scientific article

A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia

scientific article published on 4 February 2010

A look into the future of cardiology: perspectives from the Montreal Heart Institute.

scientific article published in December 2014

A mathematical model of human atrioventricular nodal function incorporating concealed conduction

scientific article published on 01 November 2002

A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene.

scientific article published on 14 April 2016

A proposal for new clinical concepts in the management of atrial fibrillation

scientific article published on 03 August 2012

A single residue in the S6 transmembrane domain governs the differential flecainide sensitivity of voltage-gated potassium channels

scientific article published on 9 May 2005

A spotlight on electrophysiological remodeling and the molecular biology of ion channels

scientific article published on 01 May 1999

AMP-activated protein kinase: potential role in cardiac electrophysiology and arrhythmias

scientific article published on August 2012

Absence of pharmacokinetic interaction between amiodarone and lidocaine

scientific article published in January 1994

Absence of protective effect of renin-angiotensin system inhibitors on atrial fibrillation development: insights from the Canadian Trial of Atrial Fibrillation (CTAF).

scientific article

Acquired delayed rectifier channelopathies: how heart disease and antiarrhythmic drugs mimic potentially-lethal congenital cardiac disorders

scientific article published on 01 November 2000

Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation.

scientific article published on 21 October 2013

Acute and chronic effects of cardiac resynchronization in patients developing heart failure with long-term pacemaker therapy for acquired complete atrioventricular block

scientific article published on 8 June 2007

Adenosine Testing in Atrial Flutter Ablation: Unmasking of Dormant Conduction Across the Cavotricuspid Isthmus and Risk of Recurrence

scientific article published on 23 May 2013

Adenosine and Atrial Arrhythmias: Exploring Electrophysiological Mechanisms In Vivo ⬇️

scientific article published on 05 April 2012

Adenosine following pulmonary vein isolation to target dormant conduction elimination (ADVICE): methods and rationale

scientific article published on 02 January 2012

Adenosine-guided pulmonary vein isolation for the treatment of paroxysmal atrial fibrillation: an international, multicentre, randomised superiority trial

scientific article published on 23 July 2015

Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes

scientific article published on 12 February 2007

Adrenergic control of the ultrarapid delayed rectifier current in canine atrial myocytes

scientific article published on 01 April 1999

Age as a Critical Determinant of Atrial Fibrillation: A Two-sided Relationship

scientific article published on 08 August 2018

Age, gender, and supraventricular arrhythmias: roles of ion channels, connexins, and tissue architecture?

scientific article published on 01 October 2004

Age-related regulation and region-specific distribution of ion channel subunits promoting atrial fibrillation in human left and right atria

scientific article published on 01 August 2019

Aging and Protein Kinase Activation: Is It the Missing Link Between Age and Atrial Fibrillation?

scientific article

Aldosterone antagonism and atrial fibrillation: time for clinical assessment?

scientific article

Allele-Specific Gene Silencing: Another Step in the Inexorable Advance of Gene Therapy for Cardiac Arrhythmia Management

scientific article published in August 2017

Altered calcium-handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts

scientific article published on 07 April 2020

Amiodarone reduces procedures and costs related to atrial fibrillation in a controlled clinical trial

scientific article published in July 2002

Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrillation Investigators

scientific article published on 01 March 2000

An Emerging Malignant Arrhythmia Epidemic Due to Loperamide Abuse: Underlying Mechanisms and Clinical Relevance

scientific article published on 19 December 2016

An N-/L-type calcium channel blocker, cilnidipine, suppresses autonomic, electrical, and structural remodelling associated with atrial fibrillation

scientific article published on 01 December 2019

Animal models for atrial fibrillation: clinical insights and scientific opportunities.

scientific article published on 29 October 2009

Anthrax lethal factor activates K(+) channels to induce IL-1β secretion in macrophages

scientific article published on 18 March 2011

Antiarrhythmic drugs for atrial fibrillation: Do we need better use, better drugs or a randomized trial of ablation as primary therapy?

scientific article published on September 2004

Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome

scientific article published on 26 March 2008

Anticoagulation for atrial fibrillation: state of the art and recommendations for a quickly moving target

scientific article published in July 2013

Aortic Vascular Calcification: Cholesterol Lowering Does Not Reduce Progression in Patients With Familial Hypercholesterolemia-or Does It?

scientific article

Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling

scientific article published on 11 June 2018

Are all sodium channel blockers created equal? Clinical-basic correlations based on observations in Brugada syndrome

scientific article published in March 2005

Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias

scientific article published on 29 January 2016

Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias

scientific article published on 4 January 2016

Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation.

scientific article published on April 2007

Arrhythmogenic ionic remodeling: adaptive responses with maladaptive consequences.

scientific article

Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model

article

Arrhythmogenic right ventricular dysplasia type 1 and mutations in transforming growth factor beta3 gene regulatory regions: a breakthrough?

scientific article published on 01 February 2005

Association of Atrial Fibrillation Episode Duration With Arrhythmia Recurrence Following Ablation: A Secondary Analysis of a Randomized Clinical Trial

scientific article published on 01 July 2020

Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model.

scientific article published in September 2009

Associations of Obstructive Sleep Apnea With Atrial Fibrillation and Continuous Positive Airway Pressure Treatment: A Review.

scientific article published on 14 March 2018

Atrial Cardiomyopathy: A Useful Notion in Cardiac Disease Management or a Passing Fad?

scientific article

Atrial Electrophysiology and Mechanisms of Atrial Fibrillation ⬇️

scientific article published on June 1, 2003

Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression

scientific article

Atrial Fibrillation and Body Composition: Is it Fat or Lean That Ultimately Determines the Risk?

scientific article

Atrial Infarction-Induced Spontaneous Focal Discharges and Atrial Fibrillation in Sheep: Role of Dantrolene-Sensitive Aberrant Ryanodine Receptor Calcium Release

scientific article published in March 2018

Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Post-Operative Atrial Fibrillation

scientific article published on 30 July 2020

Atrial Repolarization Alternans as a Path to Atrial Fibrillation ⬇️

scientific article published on July 12, 2012

Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling

scientific article published on 25 July 2007

Atrial cell action potential parameter fitting using genetic algorithms

scientific article published in September 2005

Atrial ectopic activity in long-standing persistent atrial fibrillation: an unanticipated potentially important role?

scientific article published on 18 October 2014

Atrial fibrillation

Atrial fibrillation ablation: translating basic mechanistic insights to the patient.

scientific article

Atrial fibrillation and congestive heart failure: specific considerations at the intersection of two common and important cardiac disease sets

scientific article

Atrial fibrillation compendium: historical context and detailed translational perspective on an important clinical problem.

scientific article published on April 2014

Atrial fibrillation pathophysiology: implications for management.

scientific article

Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model.

scientific article published on 10 April 2013

Atrial fibrillation promotion with long-term repetitive obstructive sleep apnea in a rat model

scientific article published on 3 November 2014

Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization

scientific article published on 12 April 2005

Atrial fibrillation-associated remodeling does not promote atrial thrombus formation in canine models

scientific article published on 24 October 2012

Atrial fibrillation: basic and clinical research at the Montreal Heart Institute.

scientific article

Atrial fibrillation: basic mechanisms, remodeling and triggers.

scientific article

Atrial fibrillation: evidence for genetically determined disease

scientific article published on May 2008

Atrial fibrillation: therapy with omega-3 fatty acids-is the case closed?

scientific article published on 01 March 2011

Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.

scientific article

Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure

scientific article published on 01 September 2004

Atrial ischemia promotes atrial fibrillation in dogs

scientific article published on 31 March 2003

Atrial remodeling and atrial fibrillation: mechanisms and implications.

scientific article published on April 2008

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

scientific article published on 19 March 2014

Atrial structural remodeling as an antiarrhythmic target

scientific article published on July 2008

Atrial tachycardia induces remodelling of muscarinic receptors and their coupled potassium currents in canine left atrial and pulmonary vein cardiomyocytes.

scientific article

Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis

scientific article published on 07 February 2005

Atrial-selective approaches for the treatment of atrial fibrillation

scientific article published on February 2008

Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope?

scientific article published on January 2009

Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents

scientific article

Basic electrophysiology of the pulmonary veins and their role in atrial fibrillation: precipitators, perpetuators, and perplexers.

scientific article published on December 2003

Bevantolol disposition in patients with hepatic cirrhosis

scientific article published on 01 December 1987

Binge Alcohol Exposure Triggers Atrial Fibrillation Through T-Type Ca2+ Channel Upregulation via Protein Kinase C (PKC) / Glycogen Synthesis Kinase 3β (GSK3β) / Nuclear Factor of Activated T-Cells (NFAT) Signaling　- An Experimental Account of Holida

scientific article published on 07 October 2020

Blinded Randomized Trial of Anticoagulation to Prevent Ischemic Stroke and Neurocognitive Impairment in Atrial Fibrillation (BRAIN-AF): Methods and Design

scientific article published on 07 May 2019

C-terminal domain of Kv4.2 and associated KChIP2 interactions regulate functional expression and gating of Kv4.2

scientific journal article

Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm

scientific article published on 09 May 2011

Caged ligands to study the role of intracellular GPCRs

scientific article published on 18 July 2015

Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics.

scientific article published on October 2008

Calcium handling and atrial fibrillation.

scientific article published on July 2012

Calcium-activated potassium current: a novel ion channel candidate in atrial fibrillation

scientific article published in April 2009

Calcium-dependent potassium channels control proliferation of cardiac progenitor cells and bone marrow-derived mesenchymal stem cells

scientific article

Calcium-dependent potassium channels in the heart: clarity and confusion

scientific article published on 02 January 2014

Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure

scientific article published on 30 April 2008

Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation

scientific article published on 11 September 2008

Can losartan prevent new-onset atrial fibrillation in hypertensive patients more effectively than atenolol?

scientific article published in July 2005

Canadian Cardiovascular Society 2014 algorithm for anticoagulation therapy in atrial fibrillation debated

scientific article published in January 2015

Canadian Cardiovascular Society Atrial Fibrillation Guidelines 2010: Rate and Rhythm Management ⬇️

scientific article published on January 1, 2011

Canadian Journal of Cardiology January 2013: Genetics and More ⬇️

scientific article published on 01 January 2013

Canadian Journal of Cardiology in 2014: from percutaneous intervention to regenerative medicine

scientific article published on 23 November 2013

Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers

scientific article published on 3 July 2003

Cardiac Potassium Channel Disorders: From Basics to Clinics

scientific article published in June 2016

Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training

scientific article

Cardiac pathways distinguish two epistatic modules enacting BP quantitative trait loci and candidate gene analysis

scientific article

Case studies with the experts: management decisions in atrial fibrillation

scientific article published in February 2008

Catheter ablation of atrial fibrillation and outcomes in heart failure patients: seeking the treasure in the CASTLE

scientific article published on 01 June 2018

Cell calcium, repolarization changes, and spontaneous postshock fibrillation in failing hearts: causes of refibrillation and electrical storm

scientific article published on 11 March 2009

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

scientific article published on April 2014

Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation.

scientific article

Cellular electrophysiology of atrial fibrillation

scientific article

Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties

scientific article published on 07 July 2003

Cellular properties of C-terminal KCNH2 long QT syndrome mutations: description and divergence from clinical phenotypes

scientific article published on 22 April 2008

Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current

scientific article published on 21 August 2008

Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes

scientific article published on 26 October 2007

Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure

scientific article published on 29 October 2009

Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation

scientific article

Changes in the atrial transcriptome and atrial fibrillation: susceptibility, persistence, causes, and consequences

scientific article published on 01 February 2015

Characterization of Sgo1 expression in developing and adult mouse

scientific article published on 29 April 2017

Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium

scientific article published on 12 March 2004

Characterization of the cardiac KCNE1 gene promoter

scientific article

Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog.

scientific article published in January 2006

Cholesterol Regulation of Cardiac Ion Channels

Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties

scientific article

Chronic obstructive pulmonary disease and atrial fibrillation: an interdisciplinary perspective

scientific article published on 18 November 2020

Clarity and controversy around rate control in AF, the orphan child in AF therapeutics

scientific article published on 15 November 2018

Clinical and mechanistic issues in early repolarization of normal variants and lethal arrhythmia syndromes.

scientific article

Close connections between contraction and rhythm: a new genetic cause of atrial fibrillation/cardiomyopathy and what it can teach us.

scientific article published on 23 October 2016

Combined parasympathetic-sympathetic nerve discharge and pulmonary vein afterdepolarizations: a new unifying concept with basic and clinical relevance

scientific article published in June 2005

Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy

scientific article

Comparison of Atrial Remodeling Caused by Sustained Atrial Flutter Versus Atrial Fibrillation

scientific article published on 01 July 2020

Comparison of Ca2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes

scientific article published on 23 June 2006

Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium

scientific article published in January 2005

Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle

scientific article published on 01 November 2002

Complex fractionated atrial electrograms: can they be made simple?

scientific article published on 16 April 2008

Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation.

scientific article

Computational models of atrial fibrillation: achievements, challenges, and perspectives for improving clinical care

scientific article

Computational models of the atrial fibrillation substrate: can they explain post-ablation recurrences and help to prevent them

scientific article published on 01 October 2019

Concealed automaticity from an island of atrial myocardium post cavotricuspid ablation

scientific article published on 01 December 2010

Concentration dependence of class III and beta-adrenergic blocking effects of sotalol in anesthetized dogs

scientific article published in April 1989

Congestive heart failure effects on atrial fibroblast phenotype: differences between freshly-isolated and cultured cells

scientific article

Connexins and atrial fibrillation: filling in the gaps

scientific article published on 08 December 2011

Consequences of Atrial or Ventricular Tachypacing on the Heat Shock Proteins (HSP) level of Expression and Phosphorylation ⬇️

scientific article published on November 16, 2009

Consequences of atrial tachycardia-induced remodeling depend on the preexisting atrial substrate

scientific article published on 01 January 2002

Contemporary Atrial Fibrillation Management: A Comparison of the Current AHA/ACC/HRS, CCS, and ESC Guidelines

scientific article

Contemporary management of atrial fibrillation: what can clinical registries tell us about stroke prevention and current therapeutic approaches?

scientific article

Contrasting gene expression profiles in two canine models of atrial fibrillation

scientific article published on 18 January 2007

Contribution of ATP-sensitive potassium channels to the electrophysiological effects of adenosine in guinea-pig atrial cells

scientific article published in May 1995

Controversies About Atrial Fibrillation Mechanisms: Aiming for Order in Chaos and Whether it Matters

scientific article

Controversies in atrial fibrillation

scientific article

Coronary artery endothelial protection after local delivery of 17beta-estradiol during balloon angioplasty in a porcine model: a potential new pharmacologic approach to improve endothelial function

scientific article published in November 2001

Corticosteroid use during pulmonary vein isolation is associated with a higher prevalence of dormant pulmonary vein conduction.

scientific article

Cost evaluation of rhythm control methods for atrial fibrillation: evidence from CTAF.

scientific article published on September 2003

CrossTalk proposal: Prolonged intense exercise training does lead to myocardial damage ⬇️

scientific article published on October 15, 2013

Cycle length alternation during supraventricular tachycardia: occurrence and mechanism in a canine model of AV reentrant tachycardia.

scientific article published on March 1990

Dataset of Sgo1 expression in cardiac, gastrointestinal, hepatic and neuronal tissue in mouse.

scientific article

Decade in review--arrhythmias: Cardiac fibrillation--challenges and evolving solutions

scientific article published on 09 September 2014

Deciphering the fundamental mechanisms of atrial fibrillation: a quest for over a century

scientific article published on 7 February 2016

Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure

scientific article

Defining "culprit mechanisms" in arrhythmogenic cardiac remodeling

scientific article published in June 2004

Delayed-rectifier potassium currents and the control of cardiac repolarization: Noble and Tsien 40 years after

scientific article published on 27 October 2008

Demystifying rotors and their place in clinical translation of atrial fibrillation mechanisms.

scientific article published on 6 April 2017

Detailed characterization of microRNA changes in a canine heart failure model: Relationship to arrhythmogenic structural remodeling

scientific article published on 12 October 2014

Determinants and significance of diltiazem plasma concentrations after acute myocardial infarction. The Multicenter Diltiazem Postinfarction Trial Research Group

scientific article

Determinants of atrial fibrillation in an animal model of obesity and acute obstructive sleep apnea

scientific article published on 20 March 2012

Development of a computer algorithm for the detection of phase singularities and initial application to analyze simulations of atrial fibrillation

scientific article

Differences in atrial fibrillation properties under vagal nerve stimulation versus atrial tachycardia remodeling

scientific article published on 21 July 2009

Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure

scientific article published on 01 August 2004

Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding K+ channels in canine atria with atrial fibrillation induced by experimental congestive heart failure

scientific article published in January 2004

Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences

scientific article

Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle

scientific article published on 01 September 2002

Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function

scientific article

Differential effectiveness of pharmacological strategies to reveal dormant pulmonary vein conduction: a clinical-experimental correlation

scientific article published on 12 April 2011

Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs.

scientific article

Differential interactions of Na+ channel toxins with T-type Ca2+ channels.

scientific article published on July 2008

Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling

scientific article published on 8 September 2011

Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia-induced atrial fibrillation

scientific article published on 01 May 1999

Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation

scientific article published on 26 August 2021

Direct Effects of Activation and Inhibition of the Coagulation System on the Atrial Fibrillation Substrate: Is Anticoagulation Antiarrhythmic?

scientific article published on 13 July 2016

Disease and region-related cardiac fibroblast potassium current variations and potential functional significance.

scientific article

Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure

scientific article published on 12 January 2004

Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation

scientific article

Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats

scientific article published on 01 October 2008

Do Atrial Fibrillation-Promoting Gene Variants Act by Enhancing Atrial Remodeling?

scientific article published on 01 November 2020

Dofetilide block involves interactions with open and inactivated states of HERG channels

scientific article published on 11 October 2001

Dormant pulmonary vein conduction unmasked by external electrical cardioversion

scientific article published on 02 December 2009

Driver regions in atrial fibrillation associated with congestive heart failure: where are they, and what are they telling us?

scientific article published on 01 December 2005

Dronedarone in Atrial Fibrillation — Jekyll and Hyde? ⬇️

scientific article published on November 14, 2011

Dronedarone: Basic Pharmacology and Clinical Use.

scientific article published on 19 March 2016

Drug Shortages: Patients and Health Care Providers Are All Drawing the Short Straw

scientific article published on 17 August 2016

Drugs to promote sinus rhythm reversion and maintenance in atrial fibrillation--why amiodarone is better

scientific article published in January 2003

Dynamic behavior of the atrioventricular node: a functional model of interaction between recovery, facilitation, and fatigue.

scientific article published on January 1994

Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs

scientific article published in June 2002

Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats.

scientific article published on 28 October 2017

EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication.

scientific article

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication

scientific article published on 10 June 2016

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication.

scientific article

Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'.

scientific article

Early and comprehensive management of atrial fibrillation: proceedings from the 2nd AFNET/EHRA consensus conference on atrial fibrillation entitled 'research perspectives in atrial fibrillation'.

scientific article published on 16 June 2009

Early management of atrial fibrillation to prevent cardiovascular complications

scientific article published on 16 February 2014

Editorial Commentary: Obesity, body composition and atrial fibrillation

scientific article published on 27 June 2019

Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial-tachycardia remodeling in dogs

scientific article published on 11 October 2004

Effects of Ionic Remodeling on Cardiac Antiarrhythmic Drug Actions ⬇️

scientific article published on December 1, 2001

Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia

scientific article published on 31 January 2008

Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes

scientific article

Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: insights into the mechanism of the superior efficacy of amiodarone

scientific article published in March 2003

Effects of encainide on the inducibility of ventricular arrhythmia in normal anesthetized dogs

scientific article published on 01 January 1986

Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines.

scientific article published on April 2003

Effects of flecainide on the rate dependence of atrial refractoriness, atrial repolarization and atrioventricular node conduction in anesthetized dogs

scientific article published in May 1992

Effects of heart disease on cardiac ion current density versus current amplitude: important conceptual subtleties in the language of arrhythmogenic ion channel remodeling

scientific article published on 01 June 2008

Effects of inhibiting Na(+)/H(+)-exchange or angiotensin converting enzyme on atrial tachycardia-induced remodeling

scientific article

Effects of resveratrol (trans-3,5,4'-trihydroxystilbene) treatment on cardiac remodeling following myocardial infarction

scientific article published on 17 September 2007

Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure

scientific article published on 11 January 2007

Effects of sustained beta-adrenergic stimulation on ionic currents of cultured adult guinea pig cardiomyocytes

scientific article published in March 2002

Effects of taurine depletion on rat cardiac electrophysiology: in vivo and in vitro studies

scientific article published on 01 March 1987

Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes

scientific article published in May 1998

Effects of the novel antiarrhythmic agent azimilide on experimental atrial fibrillation and atrial electrophysiologic properties

scientific article published on 01 March 1998

Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs

scientific article

Electrical coupling between cardiomyocytes and fibroblasts: experimental testing of a challenging and important concept

scientific article

Electrical storm: recent pathophysiological insights and therapeutic consequences.

scientific article published on 21 February 2013

Electrophysiological Effects of Atrial Epicardial Adipose Tissue: Keep Your Friends Close and Your Enemies Closer

scientific article published on 01 September 2020

Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation

scientific article published on 4 August 2016

Electrophysiological effects of alpha-adrenergic stimulation

scientific article published on 01 May 1990

Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure

scientific article

Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation

scientific article published on 24 October 2017

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation

scientific article

Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking

scientific article published on 12 August 2015

Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways

scientific article published in November 2003

Evolving developments in the therapeutics of atrial fibrillation: addressing an unmet need

scientific article published on 01 July 2008

Exchange protein activated by cyclic-adenosine monophosphate (Epac) regulates atrial fibroblast function and controls cardiac remodelling

scientific article published on 01 January 2019

Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts

scientific article

Exercise training as a treatment for heart failure: potential mechanisms and clinical implications

scientific article published in November 2009

Exercise training, inflammation and heart failure: working out to cool down

scientific article published on 01 July 2010

Experimental evidence for proarrhythmic mechanisms of antiarrhythmic drugs ⬇️

scientific article published on 01 March 1998

F 16915 prevents heart failure-induced atrial fibrillation: a promising new drug as upstream therapy

article

Factor XIa inhibition in atrial fibrillation: insights and knowledge gaps emerging from the PACIFIC-AF trial

scientific article published in 2023

Fast and furious: new ways to think about, study and treat cardiac arrhythmias

scientific article published in April 2009

Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve

scientific article published on 18 August 2008

Fibroblast electrical remodeling in heart failure and potential effects on atrial fibrillation

scientific article

Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling.

scientific article published on 21 January 2015

Fish Oil for the Reduction of Atrial Fibrillation Recurrence, Inflammation, and Oxidative Stress

scientific article published on 01 October 2014

Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control

scientific article published on March 2012

Frequency-domain versus time-domain analysis: optimizing complex fractionated atrial electrogram identification for atrial fibrillation ablation

scientific article published on 02 September 2009

From Guidelines to Bench: Implications of Unresolved Clinical Issues for Basic Investigations of Atrial Fibrillation Mechanisms ⬇️

scientific article published on January 1, 2011

Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2

scientific article

Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome.

scientific article published on 16 March 2009

G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function.

scientific article published on 19 December 2011

G-protein signaling and arrhythmogenic atrial remodeling: relevance to novel therapeutic targets in atrial fibrillation

scientific article

Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts.

scientific article published on 21 June 2010

Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man.

scientific article

Guideline Implications of Prothrombotic State Assessment in Low-Risk Atrial Fibrillation Patients: Consistency With CHA2DS2-VASc and Support for CHADS-65

scientific article published on 08 March 2019

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications ⬇️

journal article from 'Cardiovascular Research' published in 2022

HERG K+ channel, a regulator of tumor cell apoptosis and proliferation

scientific article published on 01 September 2002

Heat shock proteins as molecular targets for intervention in atrial fibrillation

scientific article published on 07 March 2008

How does fibrosis promote atrial fibrillation persistence: in silico findings, clinical observations, and experimental data

scientific article published on 30 April 2016

Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation

scientific article

Hypoxia in early life is associated with lasting changes in left ventricular structure and function at maturity in the rat.

scientific article published on 4 December 2010

Identification of atrial tissue in pulmonary veins using intravascular ultrasound

scientific article published on 01 September 2003

Idiopathic atrial fibrillation in dogs: electrophysiologic determinants and mechanisms of antiarrhythmic action of flecainide

scientific article published on 01 July 1995

Impact of tissue geometry on simulated cholinergic atrial fibrillation: a modeling study.

scientific article published in March 2011

Impairment of HERG K(+) channel function by tumor necrosis factor-alpha: role of reactive oxygen species as a mediator

scientific article published on 17 February 2004

Improved outcome following restoration of sinus rhythm prior to catheter ablation of persistent atrial fibrillation: a comparative multicenter study

scientific article published on 15 February 2012

In Memoriam - Martial G. Bourassa (1931-2020)

scientific article published on 17 August 2020

In silico optimization of atrial fibrillation-selective sodium channel blocker pharmacodynamics

scientific article published on 6 March 2012

In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions

scientific article published in March 2004

Inappropriate sinus tachycardia and beta-receptor autoantibodies: a mechanistic breakthrough?

scientific article

Increasing appreciation for the role of single-pill combinations for the prevention of atherosclerotic disease: a pro-polypill polemic.

scientific article published on 14 March 2014

Induced KCNQ1 autoimmunity accelerates cardiac repolarization in rabbits: potential significance in arrhythmogenesis and antiarrhythmic therapy.

scientific article published on 31 July 2014

Induction of heat shock response protects the heart against atrial fibrillation.

scientific article published on 16 November 2006

Inefficacy of a highly selective T-type calcium channel blocker in preventing atrial fibrillation related remodeling

scientific article published on 30 January 2014

Inflammation and biomarkers in vascular disease: emerging insights and opportunities

scientific article published on 01 November 2012

Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

scientific article published in 2022

Innovative Therapeutics for Atrial Fibrillation: Imminent Breakthroughs or Much Ado About Nothing?

scientific article published on 01 November 2015

Innovative approaches to anti-arrhythmic drug therapy.

scientific article published on December 2006

Inositol Trisphosphate Receptors and Nuclear Calcium in Atrial Fibrillation

scientific article published on 30 December 2020

Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy

scientific article published on 10 September 2008

Interactions between cardiac fibrosis spatial pattern and ionic remodeling on electrical wave propagation

scientific article published on 01 January 2011

Intra-Atrial Pressure Increases Rate and Organization of Waves Emanating From the Superior Pulmonary Veins During Atrial Fibrillation

scientific article published on 04 August 2003

Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

scientific article published on 5 April 2017

Intracellular calcium changes and tachycardia-induced contractile dysfunction in canine atrial myocytes

scientific article published on 01 March 2001

Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes

scientific article published on 10 June 2013

Involvement of lipid rafts and caveolae in cardiac ion channel function.

scientific article

Inward rectifier-funny current balance and spontaneous automaticity: cautionary notes for biologic pacemaker development

scientific article

Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure

scientific article published on 9 April 2009

Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates

scientific article published on 23 July 2009

Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles

scientific article published on 01 October 2004

Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation

scientific article

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs.

scientific article published on 22 July 2013

Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model

scientific article published on 01 May 1999

Is atrial remodeling a viable target for prevention of atrial fibrillation recurrence?

scientific article

Isolation and study of cardiac nuclei from canine myocardium and adult ventricular myocytes

scientific article published in January 2015

JAK-STAT signaling and the atrial fibrillation promoting fibrotic substrate

scientific article

Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity

scientific article published in October 2002

Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias

scientific article published on 03 April 2006

Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability

scientific article published on 19 August 2010

KvLQT1 modulates the distribution and biophysical properties of HERG. A novel alpha-subunit interaction between delayed rectifier currents

scientific article published on 29 October 2003

Late pulmonary vein reconnection: insights into mechanisms of atrial fibrillation recurrence after pulmonary vein isolation

scientific article published on 29 January 2013

Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation

scientific article published on 24 July 2010

Linking Cellular Energy State to Atrial Fibrillation Pathogenesis: Potential Role of Adenosine Monophosphate-Activated Protein Kinase

scientific article published on 05 April 2020

Local delivery of 17beta-estradiol improves reendothelialization and decreases inflammation after coronary stenting in a porcine model

scientific article published in November 2005

Lone atrial fibrillation: does it exist?

scientific article

Long-term risk stratification with dipyridamole imaging.

scientific article published on May 1995

Looking into the left atrial crystal ball: a ray of hope for patients with organic mitral regurgitation

scientific article published on August 2010

Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model

scientific article

Loss of cardiomyocyte integrin-linked kinase produces an arrhythmogenic cardiomyopathy in mice

scientific article published on 12 June 2015

Lost anchors cost lives

scientific article published in Nature

M/M/Infinity Birth-Death Processes – A Quantitative Representational Framework to Summarize and Explain Phase Singularity and Wavelet Dynamics in Atrial Fibrillation

scientific article published in 2021

Maintenance of sinus rhythm and survival in patients with heart failure and atrial fibrillation

scientific article published on 01 April 2010

Management of Atrial Fibrillation in 2021: An Updated Comparison of the Current CCS/CHRS, ESC, and AHA/ACC/HRS Guidelines ⬇️

journal article from 'Canadian Journal of Cardiology' published in 2021

Management of atrial fibrillation in the year 2033: new concepts, tools, and applications leading to personalized medicine

scientific article published on 26 August 2013

Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure

scientific article published on 30 August 2008

Mechanisms and Clinical Significance of Arrhythmia-Induced Cardiomyopathy

scientific article published on 01 August 2018

Mechanisms by which adenosine restores conduction in dormant canine pulmonary veins

scientific article published on 16 February 2010

Mechanisms of atrial fibrillation termination by pure sodium channel blockade in an ionically-realistic mathematical model

scientific article

Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates

scientific article

Mechanisms of atrial fibrillation: lessons from animal models.

scientific article

Mechanisms of atrial remodeling and clinical relevance.

scientific article

Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model

scientific article published on 03 January 2011

Mechanisms of lethal arrhythmias due to acute myocardial ischemia: regional factors and challenges in sudden death prevention

scientific article published on 06 January 2010

Mechanisms of termination of atrial fibrillation by Class I antiarrhythmic drugs: evidence from clinical, experimental, and mathematical modeling studies

scientific article published on October 2003

Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes.

scientific article published on 21 August 2008

Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes

scientific article

Metabolic Considerations in Atrial Fibrillation　- Mechanistic Insights and Therapeutic Opportunities

scientific article published on 24 October 2017

Mexiletine therapy in 15 patients with drug-resistant ventricular tachycardia

scientific article published in March 1980

MicroRNA regulation and cardiac calcium signaling: role in cardiac disease and therapeutic potential

scientific article

MicroRNA-135a regulates sodium-calcium exchanger gene expression and cardiac electrical activity

scientific article published on 7 February 2017

MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation

scientific journal article

MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation

scientific article published on 4 March 2013

MicroRNAs and atrial fibrillation: mechanisms and translational potential

scientific article

Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice.

scientific article published on March 2010

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

scientific article

Model systems for the discovery and development of antiarrhythmic drugs.

scientific article published on October 2008

Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs

scientific article published on 15 January 2007

Modeling the aging heart: from local respiratory defects to global rhythm disturbances.

scientific article

Modifiable Risk Factors and Atrial Fibrillation.

scientific article published on August 2017

Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy: A Translational Perspective

scientific article published on 18 June 2020

Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics

scientific article published on 24 October 2018

Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation

scientific article published on 15 May 2017

Molecular basis of funny current (If) in normal and failing human heart.

scientific article published on 11 May 2008

Molecular basis of species-specific expression of repolarizing K+ currents in the heart

scientific article

Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation.

scientific article

Molecular mechanisms of the reversal of imipramine-induced sodium channel blockade by alkalinization in human cardiac myocytes

scientific article published on 01 May 1998

Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs.

scientific article

Multivariate clinical models and quantitative dipyridamole-thallium imaging to predict cardiac morbidity and death after vascular reconstruction

scientific article published on 01 August 1991

N-type calcium channel blockade: a new approach to preventing sudden cardiac death?

scientific article published on 21 August 2014

Natriuretic peptide receptors and atrial-selective fibrosis: potential role in atrial fibrillation

scientific article published on 01 February 2019

Nestin is a marker of lung remodeling secondary to myocardial infarction and type I diabetes in the rat

scientific article published on 01 January 2015

New antiarrhythmic drugs for treatment of atrial fibrillation.

scientific article published on 22 March 2010

New approaches to atrial fibrillation management: a critical review of a rapidly evolving field.

scientific article

New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation ⬇️

journal article from 'Cardiovascular Research' published in 2021

New directions in cardiac arrhythmia management: present challenges and future solutions.

scientific article published on 30 September 2014

New ideas about atrial fibrillation 50 years on.

scientific article

New insights into the mechanisms and management of atrial fibrillation

scientific article

New insights into the molecular basis of atrial fibrillation: mechanistic and therapeutic implications

scientific article published on 04 February 2011

Newer developments in the management of atrial fibrillation.

scientific article published on November 1995

Nicotinamide adenine dinucleotide phosphate oxidase 4 mediates the differential responsiveness of atrial versus ventricular fibroblasts to transforming growth factor-β.

scientific article published on 24 July 2013

Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity.

scientific article published on January 2003

Notes From Cardiology Clinic: Medicine Is More Than Just Pills, Procedures, and Devices

scientific article published on 21 August 2019

Novel anti-arrhythmic drugs for atrial fibrillation management

scientific article

Novel approaches for pharmacological management of atrial fibrillation.

scientific article published on January 2009

Novel molecular targets for atrial fibrillation therapy

scientific article published on 30 March 2012

Novel targets for cardiac antiarrhythmic drug development.

scientific article

Nuclear factor of activated T cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes

scientific article

Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression.

scientific article published on 12 May 2010

Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling

scientific article published on 22 October 2007

Oxidative preconditioning and apoptosis in L-cells. Roles of protein kinase B and mitogen-activated protein kinases.

scientific article published on 30 April 2001

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

scientific article published on 04 November 2020

Paroxysmal Atrial Fibrillation and Pulmonary Veins: Relationships Between Clinical Forms and Automatic Versus Re-entrant Mechanisms ⬇️

scientific article published on August 29, 2013

Pharmacological elimination of motion artifacts during optical imaging of cardiac tissues: is blebbistatin the answer?

scientific article published on 17 January 2007

Pharmacological prevention of atrial tachycardia induced atrial remodeling as a potential therapeutic strategy.

scientific article

Pharmacotherapy for inherited arrhythmia syndromes: mechanistic basis, clinical trial evidence and practical application.

scientific article published on 20 May 2015

Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes

scientific article published on 26 June 2013

Photoreleasable ligands to study intracrine angiotensin II signalling

scientific article published on 07 January 2015

Physical activity and atrial fibrillation risk: it's complicated; and sex is critical

scientific article published on 17 January 2020

Physiological versus pathological cardiac electrical remodelling: potential basis and relevance to clinical management

scientific article published on December 2010

Pilot study and protocol of the Canadian Trial of Atrial Fibrillation (CTAF)

scientific article published on 01 August 1997

Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure

scientific article published on 23 December 2007

Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure.

scientific article published on July 2004

Postoperative Atrial Fibrillation After Noncardiac Surgery: Maybe Not So Benign After All

scientific article published on 20 August 2019

Postoperative atrial fibrillation: mechanisms, manifestations and management

scientific article published on 01 July 2019

Potassium Channel Blockade Enhances Atrial Fibrillation-Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade

scientific article published on 23 October 2015

Potassium Channel Remodeling in Heart Disease.

scientific article published on 18 March 2016

Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes

scientific article published in January 2006

Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites.

scientific article

Predicting the entrainment of reentrant cardiac waves using phase resetting curves

scientific article published on 24 January 2002

Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs

scientific article published on 5 January 2006

Preoperative atrial cardiomyocyte ionic currents and postoperative AF: important insights into what is not the mechanism

scientific article published on 21 September 2006

Prevalence and clinical impact of spontaneous and adenosine-induced pulmonary vein reconduction in the Contact-Force vs. Cryoballoon Atrial Fibrillation Ablation (CIRCA-DOSE) study

scientific article published on 21 January 2020

Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop

scientific article published on February 2009

Prevention of propranolol withdrawal mechanism by prolonged small dose propranolol schedule

scientific article

Proarrhythmic atrial calcium cycling in the diseased heart.

scientific article published on January 2012

Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Multivitamins and Probucol Study Group

scientific article published on 01 August 1997

Prof Niels Voigt talks to Prof Stanley Nattel about advances in atrial fibrillation research and career insights

scientific article published on 01 July 2018

Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation

article by Cristina E Molina et al published 2018 in Frontiers in Physiology

Prognostic significance of ventricular arrhythmias post-myocardial infarction

scientific article published on November 2003

Properties of a time-dependent potassium current in pig atrium: evidence for a role of kv1.5 in repolarization

scientific article

Properties of potassium currents in Purkinje cells of failing human hearts

scientific article published on 15 August 2002

Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP.

scientific article published on August 2003

Protein kinase C, connexin43, and ischemic preconditioning: complex interactions of potential importance for controlling arrhythmias

scientific article published on 17 July 2007

Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure

scientific article published on 23 July 2010

Pulmonary Vein Stenosis after Atrial Fibrillation Ablation: Insights from the Adenosine following pulmonary Vein Isolation to target dormant Conduction Elimination Trial

scientific article published on 03 November 2020

Pulmonary vein cellular electrophysiology and atrial fibrillation: does basic research help us understand clinical pulmonary-vein arrhythmogenesis?

scientific article published on 01 December 2005

Pulmonary vein exit block despite recovery of entry conduction during redo-ablation for atrial fibrillation

scientific article published on 16 March 2015

Pulmonary vein isolation using "contact force" ablation: the effect on dormant conduction and long-term freedom from recurrent atrial fibrillation--a prospective study

scientific article published on 25 July 2014

Pulmonary vein isolation using a pace-capture-guided versus an adenosine-guided approach: effect on dormant conduction and long-term freedom from recurrent atrial fibrillation--a prospective study

scientific article published on 04 October 2013

Pulmonary vein reentry--properties and size matter: insights from a computational analysis

scientific article published on 24 August 2007

Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia

scientific article

Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects

scientific article

Rate-Dependent Role of IKur in Human Atrial Repolarization and Atrial Fibrillation Maintenance

scientific article

Rate-dependence of atrial tachycardia effects on atrial refractoriness and atrial fibrillation maintenance

scientific article

Rebuttal from Eduard Guasch and Stanley Nattel ⬇️

scientific article published on October 15, 2013

Recent Insights Into Mechanisms and Clinical Approaches to Electrical Storm

scientific article published in 2022

Recent advances in the molecular pathophysiology of atrial fibrillation.

scientific article

Recent advances in understanding the pharmacology of amiodarone.

scientific article published on August 1988

Redefining the Blanking Period After Catheter Ablation for Paroxysmal Atrial Fibrillation: Insights From the ADVICE (Adenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination) Trial.

scientific article published on August 2016

Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation

scientific article published on 24 November 2012

Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart

scientific article published on 03 May 2007

Regional discrepancies in ionic currents and arrhythmia susceptibility: clinical relevance

scientific article published on 01 February 2005

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts

scientific article published on 10 January 2014

Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors.

scientific article published on 17 May 2013

Remodeling of Ca(2+)-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation

scientific article

Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation

scientific article published on 01 November 2001

Remodeling of cardiac inward-rectifier currents: an often-overlooked contributor to arrhythmogenic states

scientific article

Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis.

scientific article published on 30 September 2008

Renewal Theory as a Universal Quantitative Framework to Characterize Phase Singularity Regeneration in Mammalian Cardiac Fibrillation

scientific article published on 09 December 2019

Reply to the Editor–Mechanoelectrical factors in M-cell debate

Reply: Could Different Thresholds for Tachycardic-Induced Atrial Myopathy Reflect Different Rates Between Atrial Fibrillation and Flutter?

scientific article published on 01 November 2020

Reply: Of mice and men: atrial fibrillation in veteran endurance runners

scientific article published on 27 September 2013

Repolarization indices or calcium-current recovery/repolarization balance: what determines torsadogenesis?

scientific article published on 07 November 2007

Resolving the M-cell debate: why and how.

scientific article

Response by Lau et al to Letters Regarding Article, "Modifiable Risk Factors and Atrial Fibrillation"

scientific article published on 01 April 2018

Results-Based Accountability for Cardiovascular Epidemiology Research by the National Heart, Lung, and Blood Institute

scientific article published on 27 October 2015

Rhythm control versus rate control for atrial fibrillation and heart failure

scientific article

Rhythm versus rate control for atrial fibrillation management: what recent randomized clinical trials allow us to affirm

scientific article

Right Atrial Mechanisms of Atrial Fibrillation in a Rat Model of Right Heart Disease

scientific article published on 01 September 2019

Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure.

scientific article

Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts.

scientific article published on 6 October 2011

Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice

scientific article published on 27 May 2011

Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence

scientific article

Role of atrial arrhythmia and ventricular response in atrial fibrillation induced atrial remodeling

scientific article published on 24 January 2020

Role of autonomic nervous system in atrial fibrillation

scientific article published on 18 November 2018

Role of constitutively active acetylcholine-mediated potassium current in atrial contractile dysfunction caused by atrial tachycardia remodelling

scientific article published on 2 August 2010

Role of inflammation in atrial fibrillation pathophysiology and management.

scientific article published on 16 February 2015

Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog.

scientific article published on 4 November 2013

Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential.

scientific article published on 03 December 2012

Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy

scientific article

Role of the lysyl oxidase enzyme family in cardiac function and disease

scientific article published on 01 November 2019

Roles of the left atrial roof and pulmonary veins in the anatomic substrate for persistent atrial fibrillation and ablation in a canine model

scientific article published on 01 November 2010

Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model

scientific article

Safety of dipyridamole testing in 73,806 patients: the Multicenter Dipyridamole Safety Study

scientific article published on January 1995

Serum uric acid concentration and left atrial thrombus: biomarker, pathophysiological indicator, or innocent bystander?

scientific article published on 24 July 2014

Sex as a Key Variable in Predicting Cardiovascular Outcomes: Rapidly Evolving Knowledge but Much More Needed

scientific article published on 25 November 2019

Sex differences in cardiac electrophysiology and clinical arrhythmias: epidemiology, therapeutics, and mechanisms

scientific article published on 28 March 2014

Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles

scientific article published on 24 February 2006

Single-channel recordings of a rapid delayed rectifier current in adult mouse ventricular myocytes: basic properties and effects of divalent cations

scientific article published on 23 January 2004

Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model

scientific article published on 21 March 2005

Sinus node dysfunction and sudden cardiac death following treatment with encainide

scientific article published on 01 October 1989

Specific potassium channel blockade for arrhythmia prevention in the ionically remodeled failing heart: peril or panacea?

scientific article published in July 2005

Spotlight on atrial fibrillation-the 'complete arrhythmia'

scientific article published on 01 May 2002

Stem cells are not proarrhythmic: letting the genie out of the bottle.

scientific article published on April 2009

Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium

scientific article published on 22 April 2005

Sudden cardio arrest: when normal ECG variants turn lethal

scientific article published on 01 June 2010

T-tubular collagen: a new player in mechanosensing and disease?

scientific article published in July 2017

T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice

scientific article published on 24 July 2013

Taking Hockey to Heart: Potential Coronary Risks of Watching Exciting Games

scientific article

Taking the Pulse of Atrial Fibrillation: A Practical Approach to Rate Control

scientific article published on 23 July 2018

Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure

scientific article published on September 2006

Targeting MicroRNA-208a to Suppress Adverse Postmyocardial Infarction Remodelling Related to RNA Activation of Endoglin Gene Expression

scientific article published on 12 March 2015

Teasing out circadian variability in heart rate turbulence: A new approach to detecting biorhythms underlying cardiac function

scientific article published on 22 December 2006

The 2014 Atrial Fibrillation Guidelines Companion: A Practical Approach to the Use of the Canadian Cardiovascular Society Guidelines

scientific article published on October 2015

The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society Comprehensive Guidelines for the Management of Atrial Fibrillation

scientific article published on 22 October 2020

The Canadian Cardiovascular Society Atrial Fibrillation Guidelines Program: A look back over the last 10 years and a look forward

scientific article published on 07 October 2020

The Canadian Journal of Cardiology: Open and Growing

scientific article published on 03 January 2019

The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity

scientific article published on 17 August 2019

The Kv4.2 N-terminal restores fast inactivation and confers KChIP2 modulatory effects on N-terminal-deleted Kv1.4 channels

scientific article published on 28 September 2004

The Past, Present, and Potential Future of Sodium Channel Block as an Atrial Fibrillation Suppressing Strategy

scientific article published on 25 April 2015

The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome

scientific article published on 17 April 2009

The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF.

scientific article

The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms

scientific article

The clinical relevance of connexin gating: how to control communication in the heart

scientific article

The effect of vagally induced dispersion of action potential duration on atrial arrhythmogenesis

scientific article published on September 2004

The heart on a chip: the role of realistic mathematical models of cardiac electrical activity in understanding and treating cardiac arrhythmias

scientific article published on 6 April 2007

The inflammation-resolution promoting molecule resolvin-D1 prevents atrial proarrhythmic remodeling in experimental right heart disease

scientific article published on 31 August 2020

The interaction between delayed rectifier channel alpha-subunits does not involve hetero-tetramer formation

scientific article published on 20 March 2015

The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities

scientific article published on 16 April 2012

The pathology of atrial fibrillation in dogs

scientific article published on 17 October 2005

The pharmacological response of ischemia-related atrial fibrillation in dogs: evidence for substrate-specific efficacy

scientific article published on 27 January 2007

The pioneering work of George Mines on cardiac arrhythmias: groundbreaking ideas that remain influential in contemporary cardiac electrophysiology.

scientific article

The role of cellular senescence in cardiac disease: basic biology and clinical relevance ⬇️

journal article from 'Nature Reviews Cardiology' published in 2022

The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation

scientific article published on 20 October 2010

The treatment of atrial fibrillation. An evaluation of drug therapy, electrical modalities and therapeutic considerations.

scientific article published on September 1994

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

scientific article published on 23 December 2015

Therapeutic blood lidocaine concentrations after local anesthesia for cardiac electrophysiologic studies

scientific article published on August 23, 1979

Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?

scientific article

Time-dependent transients in an ionically based mathematical model of the canine atrial action potential

scientific article published in April 2002

Tissue-specific expression of two human Ca(v)1.2 isoforms under the control of distinct 5' flanking regulatory elements

scientific article published in July 2003

Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction.

scientific article

Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases

scientific article published on 23 November 2008

Transcriptomic Profiling of Canine Atrial Fibrillation Models After One Week of Sustained Arrhythmia

scientific article published on 16 July 2021

Transforming growth factor-β and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes.

scientific article published on 2 February 2011

Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation

scientific article published on 19 September 2012

Translational Challenges in Atrial Fibrillation

scientific article

Transmural action potential and ionic current remodeling in ventricles of failing canine hearts

scientific article published on 01 September 2002

Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts

scientific article

Triggering of cardiac arrhythmic events in long QT syndrome: lessons from funny bunnies.

scientific article published on March 2012

Ultrarapid delayed rectifier K(+) current in H9c2 rat ventricular cell line: biophysical property and molecular identity.

scientific article published on January 2002

Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation.

scientific article published on 26 March 2013

Unique quantitative trait loci in synergy permanently improve diastolic dysfunction

scientific article published on 14 June 2013

Ventricular proarrhythmic effects of atrial fibrillation are modulated by depolarization and repolarization anomalies in patients with left ventricular dysfunction

scientific article published in January 2009

Ventricular tachyarrhythmia induction by strong cardiac shocks: can understanding underlying mechanisms lead to improved prevention of defibrillator failure?

scientific article

Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart

scientific article published on January 2010

Wave block formation in homogeneous excitable media following premature excitations: dependence on restitution relations

scientific article published on 30 September 2005

Wavelet analysis of cardiac optical mapping data.

scientific article

What is an antiarrhythmic drug? From clinical trials to fundamental concepts

scientific article published on 01 July 1990

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it ⬇️

journal article from 'Cardiovascular Research' published in 2021

[Anchoring proteins and cardiac sudden death: how and why?]

scientific article published on 01 April 2004

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