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List of works by Giampietro Schiavo

39 Tetanus and botulism neurotoxins: Isolation and assay

scientific article published on January 1, 1995

A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins.

scientific article published on September 2010

A motor-driven mechanism for cell-length sensing

scientific article

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

scientific article

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

scientific article published on 27 October 2017

A possible docking and fusion particle for synaptic transmission

scientific article published in Nature

A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels

scientific article published on 24 June 2020

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

scientific article

ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles

scientific article published on November 1998

ALS mice carrying pathological mutant TDP-43, but not mutant FUS, display axonal transport defects in vivo

Absence of disturbed axonal transport in spinal and bulbar muscular atrophy

scientific article

Activated leukocyte cell adhesion molecule modulates neurotrophin signaling.

scientific article published on 10 February 2012

Activation of MDA5 requires higher-order RNA structures generated during virus infection

scientific article

Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers

scientific article

Alternative energy for neuronal motors

scientific article published in Nature

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

scientific article published on 26 June 2013

Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays

scientific article published on 6 April 2009

Analysis of mutants of tetanus toxin HC fragment: ganglioside binding, cell binding and retrograde axonal transport properties

scientific article published on 01 September 2000

Analysis of mutants of tetanus toxin HC fragment: ganglioside binding, cell binding and retrograde axonal transport properties

scientific article published in 2000

Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR.

scientific article published on 21 January 2002

Antibodies against rat brain vesicle-associated membrane protein (synaptobrevin) prevent inhibition of acetylcholine release by tetanus toxin or botulinum neurotoxin type B

scientific article published on 01 September 1993

Axonal transport and neurological disease

scientific article published on 26 September 2019

Bacterial toxins with intracellular protease activity.

scientific article

Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors.

scientific article

Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins

scientific article published in May 1995

Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons

scientific article

Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds

scientific journal article

Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission

scientific article

Botulinum neurotoxins: mechanism of action.

scientific article

C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor.

scientific article published in April 2000

CAR-associated vesicular transport of an adenovirus in motor neuron axons

scientific article

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process

scientific article

Calcium Influx and Mitochondrial Alterations at Synapses Exposed to Snake Neurotoxins or Their Phospholipid Hydrolysis Products

scientific article published on 20 February 2007

Calcium-dependent oligomerization of synaptotagmins I and II. Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium

scientific article published in January 1999

Central effects of tetanus and botulinum neurotoxins

scientific article published on 03 March 2009

Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin

scientific article

Common and distinct fusion proteins in axonal growth and transmitter release

scientific article published on 01 April 1996

Comparative biochemistry of the ubiquinol-cytochrome c oxidoreductase (EC 1.10.2.2) isolated from different heart mitochondria

scientific article published on 01 January 1986

Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6

scientific article published on November 2008

Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity.

scientific article published on September 2016

Cytochrome c oxidase from the slime mold Dictyostelium discoideum: purification and characterization

scientific article published in 1985

Cytoplasmic dynein heavy chain: the servant of many masters

scientific article published on 10 September 2013

DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy

scientific article

Dangerous liaisons on neurons

scientific article published in Nature

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

scientific article published on 08 May 2019

Deficits in axonal transport precede ALS symptoms in vivo

scientific article

Developmental demands contribute to early neuromuscular degeneration in CMT2D mice

scientific article published on 23 July 2020

Diphtheria toxin and its mutant crm 197 differ in their interaction with lipids

scientific article

Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting.

scientific article

Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells

scientific article published on 01 May 2006

Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures

scientific article

Evidence-based review and assessment of botulinum neurotoxin for the treatment of urologic conditions.

scientific article published on 13 February 2013

Functional recycling of C2 domains throughout evolution: a comparative study of synaptotagmin, protein kinase C and phospholipase C by sequence, structural and modelling approaches

scientific article

Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells

scientific article published on 25 November 2007

Genetic Insights into Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in the Mouse

Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulating N-type Ca2+ channel activity

scientific article

Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons

scientific article published on 02 June 2006

Histidine-21 is involved in diphtheria toxin NAD+ binding

scientific article published on 01 January 1990

Human spastin has multiple microtubule-related functions

scientific article published in December 2005

Hydrophobic photolabelling of pertussis toxin subunits interacting with lipids

scientific article published in January 1986

IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons

scientific article published on 07 February 2020

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2).

scientific article published on 29 July 2009

In Vivo Imaging of Anterograde and Retrograde Axonal Transport in Rodent Peripheral Nerves

scientific article published on 01 January 2020

Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS.

scientific article

Interaction of tau protein with the dynactin complex

scientific article

Ion channel and membrane translocation of diphtheria toxin

scientific article

Kidins220/ARMS as a functional mediator of multiple receptor signalling pathways

scientific article published on April 2012

Kidins220/ARMS is a novel modulator of short-term synaptic plasticity in hippocampal GABAergic neurons

scientific article

Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development.

scientific article published on 3 November 2011

Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation

scientific article

Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems.

scientific article published on 3 November 2011

Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio

scientific article

Knockin' on heaven's door: Molecular mechanisms of neuronal tau uptake

scientific article published on 08 August 2020

Large-scale pathways-based association study in amyotrophic lateral sclerosis

scientific article

Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration

scientific article published on 23 October 2008

Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor

scientific article published on 25 August 2009

Lipid interaction of tetanus neurotoxin. A calorimetric and fluorescence spectroscopy study

scientific article published on 01 September 1992

Lipid microdomains are involved in neurospecific binding and internalisation of clostridial neurotoxins

scientific article

Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegans

scientific article published in December 2003

Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

scientific article published on 17 March 2020

Mechanism of action of tetanus and botulinum neurotoxins

scientific journal article

Mechanism of local anesthetic effect on mitochondrial ATP synthase as deduced from photolabelling and inhibition studies with phenothiazine derivatives

scientific article published in July 1990

Membrane Protein Labelling with Photoreactive Phospholipid Analogues

Methodological advances in imaging intravital axonal transport

scientific article published on March 2017

Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS)

scientific article

Molecular landmarks along the axonal route: axonal transport in health and disease

scientific article published on 19 May 2008

Molecular mechanisms of action of bacterial protein toxins.

scientific article published on January 1994

Morphological variability is greater at developing than mature mouse neuromuscular junctions

scientific article published on 13 June 2020

Motors, adaptors, and receptors: Key elements of neuronal transport

scientific article published on 01 February 2004

Mutant torsinA, which causes early-onset primary torsion dystonia, is redistributed to membranous structures enriched in vesicular monoamine transporter in cultured human SH-SY5Y cells.

scientific article

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

scientific article published in Science

Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons

scientific article

Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular development and homeostasis

Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis

scientific article published on 23 August 2017

Neurotransmission and secretion

scientific article published in Nature

Neurotrophins Redirect p75NTR from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport

scientific journal article

On the Cellular Mechanism of Action of Diphtheria Toxin

PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors

scientific article published on 30 March 2020

Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis

scientific article published on 29 July 2005

Phosphorylation of VAMP/synaptobrevin in synaptic vesicles

Phosphorylation of VAMP/synaptobrevin in synaptic vesicles by endogenous protein kinases.

scientific article published on October 1995

Polyphosphoinositol lipids: under-PPInning synaptic function in health and disease

scientific article published on August 2007

Presynaptic receptor arrays for clostridial neurotoxins.

scientific article published in October 2004

Purification and characterization of the human elongator complex

scientific article

Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway

scientific article published on October 2006

Rabies virus envelope glycoprotein targets lentiviral vectors to the axonal retrograde pathway in motor neurons

scientific article

Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity

scientific article published on 24 March 2011

Receptor-dependent and -independent axonal retrograde transport of poliovirus in motor neurons

scientific article

Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome

article published in 2019

SNARE complexes and neuroexocytosis: how many, how close?

scientific article

SNARE motif and neurotoxins

scientific article published in Nature

Sensory neuron fate is developmentally perturbed by Gars mutations causing human neuropathy

Signalling endosomes in axonal transport: travel updates on the molecular highway

scientific article published on 27 October 2013

Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles

scientific article

Spastin and microtubules: Functions in health and disease.

scientific article published on September 2007

Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells

scientific article published on March 2005

Structural Studies on the Zinc-endopeptidase Light Chain of Tetanus Neurotoxin

scientific article published in 1995

Structure and function of tetanus and botulinum neurotoxins.

scientific article published on November 1995

Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin

scientific article

Synaptotagmins: more isoforms than functions?

scientific article

Synthetic self-assembling clostridial chimera for modulation of sensory functions

scientific article published on 20 September 2013

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

scientific article published on 23 February 2022

Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus

scientific article

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

scientific article (publication date: 29 October 1992)

Tetanus and botulism neurotoxins: a new group of zinc proteases.

scientific article published on September 1993

Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons.

scientific article

Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1.

scientific article

Tetanus toxin is labeled with photoactivatable phospholipids at low pH

scientific article published on 01 February 1986

Tetanus toxin is transported in a novel neuronal compartment characterized by a specialized pH regulation

scientific article published on 18 October 2005

Tetanus toxin receptor. Specific cross-linking of tetanus toxin to a protein of NGF-differentiated PC 12 cells.

scientific article

The Neurospecific Binding of Tetanus Toxin is Mediated by a 20 kDa Protein and by Acidic Lipids

The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12

scientific article published on 01 June 2005

The Structure and Mode of Action of Botulinum and Tetanus Toxins

The dystonia-associated protein torsinA modulates synaptic vesicle recycling

scientific article

The effects of pH on the interaction of anthrax toxin lethal and edema factors with phospholipid vesicles

scientific article published on 01 March 1994

The elusive compass of clostridial neurotoxins: deciding when and where to go?

scientific article published on January 2013

The evolution of the axonal transport toolkit

scientific article published on 28 November 2019

The journey of tetanus and botulinum neurotoxins in neurons

scientific journal article

The many disguises of the signalling endosome

scientific article published on 17 September 2018

The mechanism of action of tetanus and botulinum neurotoxins

scientific article published on January 1996

The metallo-proteinase activity of tetanus and botulism neurotoxins ⬇️

scientific article published on January 1, 1995

The more, the better: the BICD family gets bigger.

scientific article

The phagocytic capacity of neurones

scientific article published on 01 May 2007

The travel diaries of tetanus and botulinum neurotoxins

scientific article published on 12 October 2017

The two oxygen-regulated subunits of cytochrome c oxidase in Dictyostelium discoideum derive from a common ancestor

scientific article published on 01 February 1990

TiME for TMEM106B

scientific article published on 4 February 2014

TorsinA and DYT1 dystonia: a synaptopathy?

scientific article published on April 2010

TorsinA and dystonia: from nuclear envelope to synapse.

scientific article published on 08 April 2009

Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations.

scientific article

Uptake and transport of Clostridium neurotoxins

VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes

scientific article published on 01 May 2003

X-ray Absorption Spectroscopy Study of Zinc Coordination in Tetanus Neurotoxin, Astacin, Alkaline Protease and Thermolysin

scientific article published on 01 February 1996

Zinc content of the Bacillus anthracis lethal factor

scientific article published on 01 December 1994

pH-dependent lipid packing, membrane permeability and fusion in phosphatidylcholine vesicles

scientific article published on 01 August 1991

siRNA screen of ES cell-derived motor neurons identifies novel regulators of tetanus toxin and neurotrophin receptor trafficking

scientific article

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