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List of works by Craig E Hughes

A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.

scientific article published on October 2006

A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1)

scientific article published in February 2012

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

scientific article

CLEC-2 activates Syk through dimerization

scientific article published on 12 February 2010

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

scientific article

CLEC-2 is not required for platelet aggregation at arteriolar shear

scientific article published on October 2010

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).

scientific article

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.

scientific article published on 27 September 2008

Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets

scientific article

Fibrin activates GPVI in human and mouse platelets

scientific article

Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2)

scientific article published on 22 January 2013

G6f-like is an ITAM-containing collagen receptor in thrombocytes ⬇️

scientific article

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

scientific article

Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex

scientific article published on 16 April 2008

Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets

scientific article published on 21 November 2013

How to perform aggregometry and lumi-aggregometry in mouse platelets

scientific article published on 04 June 2018

Immobilized fibrinogen activates human platelets through glycoprotein VI. ⬇️

scientific article published on 22 February 2018

Involvement of Src kinases and PLCgamma2 in clot retraction

scientific article published on 19 October 2006

Minimal regulation of platelet activity by PECAM-1.

scientific article published on February 2007

Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide

scientific article published on 20 November 2008

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

scientific article published in November 2017

SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice

scientific article

Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

scientific article published on 26 July 2019

Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells

scientific article

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets

scientific article

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.

scientific article published on 24 April 2009

Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway

scientific article

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