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List of works by Alice Y. Pollitt

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

scientific journal article

Abi Mutants in Dictyostelium Reveal Specific Roles for the SCAR/WAVE Complex in Cytokinesis

scientific article published in February 2008

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

scientific article

CLEC-2 activates Syk through dimerization

scientific article published on 12 February 2010

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

scientific article

CLEC-2 expression is maintained on activated platelets and on platelet microparticles.

scientific article

CLEC-2 is not required for platelet aggregation at arteriolar shear

scientific article published on October 2010

CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP

scientific article

Cell motility and SCAR localisation in axenically growing Dictyostelium cells

scientific article published in September 2006

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation

scientific article published on 06 December 2019

Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein

scientific article

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

scientific article

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

scientific article published on 12 February 2010

Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

scientific article

Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling

scientific article

Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation

scientific article

Regulation of actin assembly by SCAR/WAVE proteins.

scientific article

Renal cells activate the platelet receptor CLEC-2 through podoplanin

scientific article

Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells

scientific article

Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling

scientific article published on 22 November 2010

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.

scientific article published on 24 April 2009

WASP and SCAR/WAVE proteins: the drivers of actin assembly

scientific article

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