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List of works by Ian R. Humphreys

A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection

scientific article

A critical role for OX40 in T cell-mediated immunopathology during lung viral infection

scientific article

A role for dendritic cells in the dissemination of mycobacterial infection

scientific article published on 24 March 2006

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity

scientific article

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells

scientific article

CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue

scientific article published on 5 February 2015

Characterization in mice of the immunological properties of five allergenic acid anhydrides

scientific article published on 01 May 2000

Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands

scientific article

Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

scientific article

Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease.

scientific article published on 21 September 2016

Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway

scientific article

Herpesvirus exploitation of host immune inhibitory pathways

scientific article

Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity.

scientific article published on 13 September 2017

IL-10 Restricts Activation-Induced Death of NK Cells during Acute Murine Cytomegalovirus Infection ⬇️

scientific article published on August 17, 2011

IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation

scientific article published on 05 July 2016

IL-10 restricts memory T cell inflation during cytomegalovirus infection

scientific article published on 16 August 2010

IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance

scientific article published on 03 June 2016

Innate imprinting by the modified heat-labile toxin of Escherichia coli (LTK63) provides generic protection against lung infectious disease

scientific article published in December 2004

Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection.

scientific article published on 16 May 2018

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

scientific article published on 30 August 2014

Interleukin-6 signaling drives fibrosis in unresolved inflammation

scientific article published on 09 January 2014

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

scientific article published in September 2002

L-selectin Is Essential for Delivery of Activated CD8(+) T Cells to Virus-Infected Organs for Protective Immunity

scientific article published on 20 January 2016

Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines.

scientific article

NBEAL2 is required for neutrophil and NK cell function and pathogen defense

scientific article published on 7 August 2017

Nasal vaccination induces protective immunity without immunopathology

scientific article published in December 2002

Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

scientific article published on April 2014

Novel viral vectors in infectious diseases

scientific article published on 4 September 2017

OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism.

scientific article published in August 2007

OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia

scientific article published on 01 June 2003

Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner

scientific article

Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+ T-cell immunity.

scientific article published on 06 August 2012

TGF-beta prevents eosinophilic lung disease but impairs pathogen clearance.

scientific article published on 24 February 2005

The Role of IL-22 in Viral Infections: Paradigms and Paradoxes

scientific article published on 30 May 2016

The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis

scientific article

The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.

scientific article published on 16 May 2012

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors

scientific article published on 26 June 2019

The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis

scientific journal article

Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes

scientific article

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