Search filters

List of works by Lutz Heide

4-Coumaroyl coenzyme A 3-hydroxylase activity from cell cultures of Lithospermum erythrorhizon and its relationship to polyphenol oxidase

scientific article published on 01 November 1997

4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon : purification of a plant membrane-bound prenyltransferase ⬇️

scientific article published on July 1, 1998

A domain of RubC1 of rubradirin biosynthesis can functionally replace MbtH-like proteins in tyrosine adenylation

scientific article

A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042.

scientific article published on December 2006

A membrane-bound prenyltransferase catalyzes the O-prenylation of 1,6-dihydroxyphenazine in the marine bacterium Streptomyces sp. CNQ-509

scientific article published on 15 September 2014

Active expression of the ubiA gene from E. coli in tobacco: influence of plant ER-specific signal peptides on the expression of a membrane-bound prenyltransferase in plant cells

scientific article published on 01 December 2000

Acyl transfer in clorobiocin biosynthesis: involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar

scientific article published in December 2005

Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains

scientific article published on 29 March 2011

An artificial pathway to 3,4-dihydroxybenzoic acid allows generation of new aminocoumarin antibiotic recognized by catechol transporters of E. coli.

scientific article

An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. ⬇️

scientific article published in November 2003

Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis.

scientific article published on April 2004

Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus

scientific article published on April 2009

Artemisinin in traditional tea preparations of Artemisia annua

scientific article published on 15 May 2006

Assembly and heterologous expression of the coumermycin A1 gene cluster and production of new derivatives by genetic engineering

scientific article

Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.

scientific article published in November 2004

Availability and affordability of antimalarial and antibiotic medicines in Malawi.

scientific article

Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo

scientific article published on 07 January 2020

Biosynthesis of clorobiocin: investigation of the transfer and methylation of the pyrrolyl-2-carboxyl moiety

scientific article published on 25 November 2006

Biosynthesis of p-Hydroxybenzoate from p-Coumarate and p-Coumaroyl-Coenzyme A in Cell-Free Extracts of Lithospermum erythrorhizon Cell Cultures

scientific article published on 01 September 1994

Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042

scientific article published on 03 May 2007

Clarification of the Escherichia coli genetic map in the 92-minute region containing the ubiCA operon and the plsB, dgk, lexA, and dinF genes.

scientific article published on September 1993

CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin

scientific article published in August 2003

CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin

scientific article published in August 2003

CloQ, a prenyltransferase involved in clorobiocin biosynthesis

scientific article

CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis

scientific article (publication date: 15 August 2003)

Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891. ⬇️

scientific article

Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs. ⬇️

scientific article published in March 2003

Colour coding of labels for essential drugs

Complete genome sequence of Streptomyces sp. CNQ-509, a prolific producer of meroterpenoid chemistry.

scientific article published on 25 August 2015

Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes

scientific article published on 20 October 2006

Diversity and evolution of the phenazine biosynthesis pathway

scientific article published on 11 December 2009

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds

scientific article published on 14 December 2015

Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the Aminocoumarin Antibiotic Novobiocin

scientific article published on 9 January 2014

Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin

scientific article published on 9 January 2014

Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor

scientific article published on May 2007

Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials.

scientific article published on November 2004

Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial

scientific article published on 01 June 2001

Enzymatic synthesis of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis

scientific article published on 01 June 1981

Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis.

scientific article

Enzymic synthesis of o-succinylbenzoyl-CoA in cell-free extracts of anthraquinone producing Galium mollugo L. cell suspension cultures

scientific article published on 01 June 1982

Evolutionary relationships of microbial aromatic prenyltransferases

scientific article

Expression of bacterial chorismate pyruvate-lyase in tobacco: evidence for the presence of chorismate in the plant cytosol

scientific article published on 01 November 1998

Five gene products are required for assembly of the central pyrrole moiety of coumermycin A1.

scientific article published on 8 May 2013

Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin

scientific article published on 11 October 2002

Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.

scientific article

Genetic engineering of plant secondary metabolism. Accumulation of 4-hydroxybenzoate glucosides as a result of the expression of the bacterial ubiC gene in tobacco.

scientific article

Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene.

scientific article published on March 1999

Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete

scientific article

Geranylhydroquinone 3"-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures.

scientific article

HPLC-MS/MS analysis of willow bark extracts contained in pharmaceutical preparations

scientific article published in November 2005

Herba Artemisiae annuae tea preparation compared to sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria in adults: a randomized double-blind clinical trial

scientific article

Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters

scientific article published on May 2005

Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains

scientific article published in September 2010

High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon

scientific article published in August 2002

Identification and structural elucidation of new caprazamycins from Streptomyces sp. MK730-62F2 by liquid chromatography/electrospray ionization tandem mass spectrometry

scientific article published on 01 February 2011

Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489.

scientific article published in March 2004

Immobilization of isochorismate hydroxymutase. Comparison of native versus immobilized enzyme

scientific article published on 01 August 1993

Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics

scientific article published on 01 August 2007

In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach

scientific article

Influence of willow bark extract on cyclooxygenase activity and on tumor necrosis factor alpha or interleukin 1 beta release in vitro and ex vivo

scientific article published in March 2003

Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.

scientific article

Mass spectrometric pathway monitoring of secondary metabolites: systematic analysis of culture extracts of Streptomyces species

scientific article published on December 2004

Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host

scientific article published in August 2005

Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

scientific article published on 4 August 2006

Molecular replacement in the 'twilight zone': structure determination of the non-haem iron oxygenase NovR from Streptomyces spheroides through repeated density modification of a poor molecular-replacement solution

scientific article published on 23 November 2006

New Aminocoumarins from the Rare Actinomycete Catenulispora acidiphila DSM 44928: Identification, Structure Elucidation, and Heterologous Production

scientific article published on 19 February 2014

New Aspects of Shikonin Biosynthesis: Geranyl Pyrophosphate Synthase and Origin of p-Hydroxybenzoic Acid

scientific article published on 01 December 1988

New aminocoumarin antibiotics as gyrase inhibitors.

scientific article published on 04 September 2013

New aminocoumarin antibiotics derived from 4-hydroxycinnamic acid are formed after heterologous expression of a modified clorobiocin biosynthetic gene cluster

scientific article published in August 2007

New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN.

scientific article

New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976.

scientific article

New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

scientific article

NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis.

scientific article published in June 2005

Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation.

scientific article published on 8 May 2003

Overexpression, purification and characterization of SimL, an amide synthetase involved in simocyclinone biosynthesis

scientific article published on 6 April 2005

Partial purification and properties of geranyl pyrophosphate synthase from Lithospermum erythrorhizon cell cultures

scientific article published on 01 September 1989

Partial purification, properties, and kinetic studies of UDP-glucose:p-hydroxybenzoate glucosyltransferase from cell cultures of Lithospermum erythrorhizon

scientific article published on 01 July 1991

Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster

scientific article (publication date: 2013)

Pharmacokinetics of salicin after oral administration of a standardised willow bark extract

scientific article

Prenyl transfer to aromatic substrates: genetics and enzymology.

scientific article published on 18 March 2009

Prices, availability and affordability of medicines in Rwanda

scientific article published on 03 August 2020

Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains. ⬇️

scientific article published in November 2004

Properties of isochorismate hydroxymutase from Flavobacterium K3-15.

scientific article

Purification and characterization of an alcohol dehydrogenase from Lithospermum erythrorhizon cell cultures

scientific article published in June 1996

Quality assurance in anti-tuberculosis drug procurement by the Stop TB Partnership-Global Drug Facility: Procedures, costs, time requirements, and comparison of assay and dissolution results by manufacturers and by external analysis

scientific article published on 03 December 2020

Quality of medicines in southern Togo: Investigation of antibiotics and of medicines for non-communicable diseases from pharmacies and informal vendors

scientific article published in PLoS ONE

Quality of oxytocin and misoprostol in health facilities of Rwanda

scientific article published on 08 January 2021

Quality, availability and storage conditions of oxytocin and misoprostol in Malawi

scientific article published on 29 March 2020

Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria

scientific article published in May 2004

Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates

scientific article published on 16 September 2009

Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase for shikonin biosynthesis in Lithospermum erythrorhizon cell suspension cultures

scientific article published on 01 February 1998

Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis.

scientific article published on 02 September 2011

S-Adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces

scientific article published on 23 February 2010

Salicin and treatment of rheumatic diseases.

scientific article published in May 2003

Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action

scientific article published on March 2005

Stability of misoprostol tablets collected in Malawi and Rwanda: Importance of intact primary packaging

scientific article published on 02 September 2020

Structure and Mechanism of the Magnesium-Independent Aromatic Prenyltransferase CloQ from the Clorobiocin Biosynthetic Pathway ⬇️

scientific article published on October 12, 2010

Structure-Based Engineering Increased the Catalytic Turnover Rate of a Novel Phenazine Prenyltransferase

scientific article

Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis

scientific article

Surveillance for falsified and substandard medicines in Africa and Asia by local organizations using the low-cost GPHF Minilab.

scientific article published on 6 September 2017

The ABBA family of aromatic prenyltransferases: broadening natural product diversity

scientific article

The aminocoumarins: biosynthesis and biology.

scientific article published on 10 August 2009

The biosynthetic gene clusters of aminocoumarin antibiotics.

scientific article published on 25 July 2006

The biosynthetic genes for prenylated phenazines are located at two different chromosomal loci of Streptomyces cinnamonensis DSM 1042 ⬇️

scientific article published on December 8, 2010

Transcriptional regulation of the novobiocin biosynthetic gene cluster.

scientific article published on 17 September 2009

Two pathways for pyrrole formation in coumermycin A(1) biosynthesis: the central pyrrole moiety is formed from L-threonine

scientific article published on 27 September 2011

Ubiquinone biosynthesis. Cloning of the genes coding for chorismate pyruvate-lyase and 4-hydroxybenzoate octaprenyl transferase from Escherichia coli

scientific article

Unusual N-prenylation in diazepinomicin biosynthesis: the farnesylation of a benzodiazepine substrate is catalyzed by a new member of the ABBA prenyltransferase superfamily

scientific article (publication date: 2013)

Use of a halogenase of hormaomycin biosynthesis for formation of new clorobiocin analogues with 5-chloropyrrole moieties

scientific article published in August 2008

Use of an inducible promoter for antibiotic production in a heterologous host.

scientific article published on 2 February 2010

Use of thin-layer chromatography to detect counterfeit sulfadoxine/pyrimethamine tablets with the wrong active ingredient in Malawi

scientific article published on 14 April 2016

Wirksamkeit und Verträglichkeit eines standardisierten Weidenrindenextraktes bei Arthrose-Patienten: Randomisierte, Placebo-kontrollierte Doppelblindstudie

scientific article published on 01 October 2000

[Pharmaceutical biology in the spotlight]

scientific article published on 01 April 1994

[Untersuchungen zur Biosynthese des Vitamin K2. Isolierung des aktivierten Derivates der o-Succinylbenzoesäure aus zellfreien Extrakten von Mycobacterium phlei.].

scientific article published on 01 June 1981

cDNA cloning and gene expression of phenylalanine ammonia-lyase in Lithospermum erythrorhizon ⬇️

scientific article published in December 1997

novE and novG act as positive regulators of novobiocin biosynthesis.

scientific article published on 21 June 2008

Paulina is supported by:

About Paulina

Help