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List of works by Deborah H. Spector

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

scientific article

A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication

scientific article

A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization

scientific article

Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses

scientific article published on February 1978

Cloning, characterization, and expression of the murine cytomegalovirus homologue of the human cytomegalovirus 28-kDa matrix phosphoprotein (UL99).

scientific article published on December 1994

Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production

scientific article published on October 2004

Cytomegalovirus Activates Interferon Immediate-Early Response Gene Expression and an Interferon Regulatory Factor 3-Containing Interferon-Stimulated Response Element-Binding Complex ⬇️

scientific article published on July 1, 1998

DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge.

scientific article published on 16 May 2007

Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replication

scientific article

Early CMV gene expression and function

article

Exon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation.

scientific article

Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases

scientific article published on October 1979

Human Cytomegalovirus Replication is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 Through Distinctively Different Mechanisms.

scientific article published on 13 December 2017

Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.

scientific article

Human cytomegalovirus early gene expression

scientific article published on January 1990

Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication

scientific article

Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.

scientific article published on 22 January 2014

Human cytomegalovirus riding the cell cycle.

scientific article published on 17 March 2015

IUGR and congenital cytomegalovirus infection

scientific article published on 12 February 2014

Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease

scientific article

In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins.

scientific article published on February 1993

Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge ⬇️

scientific article published on October 12, 2012

Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.

scientific article

Infection of vascular endothelial cells with human cytomegalovirus under fluid shear stress reveals preferential entry and spread of virus in flow conditions simulating atheroprone regions of the artery

scientific article

Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome

scientific article published on 17 October 2007

Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus

scientific article published on December 2003

Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith strain)

scientific article published on 01 August 1983

Multiple epitopes in the murine cytomegalovirus early gene product M84 are efficiently presented in infected primary macrophages and contribute to strong CD8+-T-lymphocyte responses and protection following DNA immunization

scientific article published on October 2004

Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.

scientific article

Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporter

scientific article published on 22 August 2007

POSITIVE AND NEGATIVE EFFECTS OF HUMAN CYTOMEGALOVIRUS ON HIV REPLICATION

article

Polyadenylic acid on poliovirus RNA IV. Poly(U) in replicative intermediate and double-stranded RNA.

scientific article

Post-transcriptional control of avian oncornavirus transforming gene sequences in mammalian cells ⬇️

scientific article published on September 8, 1977

Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription

scientific article published on 30 December 2009

Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites

scientific article published on December 1978

Replication of the murine cytomegalovirus genome: structure and role of the termini in the generation and cleavage of concatenates.

scientific article published in January 1988

Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription

scientific article

Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.

scientific article published on February 2004

Specific chromosome 1 breaks induced by human cytomegalovirus.

scientific article

Strong CD8 T-cell responses following coimmunization with plasmids expressing the dominant pp89 and subdominant M84 antigens of murine cytomegalovirus correlate with long-term protection against subsequent viral challenge

scientific article

Studies of HIV infection and the development of Epstein-Barr virus-related B cell lymphomas following transfer of human lymphocytes to mice with severe combined immunodeficiency

scientific article published in January 1989

Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits A

scientific article published on 22 April 2015

Studies on the function of polyadenylic acid on poliovirus RNA.

scientific article

Subversion of cell cycle regulatory pathways

scientific article published on January 2008

Systemic priming-boosting immunization with a trivalent plasmid DNA and inactivated murine cytomegalovirus (MCMV) vaccine provides long-term protection against viral replication following systemic or mucosal MCMV challenge

scientific article

The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.

scientific article published on 3 January 2007

The use of recombinant baculoviruses for sustained expression of human cytomegalovirus immediate early proteins in fibroblasts.

scientific article published in June 2001

Transcription analysis and sequence of the putative murine cytomegalovirus DNA polymerase gene

scientific article published on November 1991

Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169.

scientific article published in February 1983

Transcription in mouse embryo cells permissively infected by murine cytomegalovirus.

scientific article published in November 1983

Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types

scientific article

Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses

scientific article published on February 1978

Viral induction of site-specific chromosome damage.

scientific article

Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose

scientific article published on 16 December 2020

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