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List of works by Pirkko J Pussinen

A common periodontal pathogen has an adverse association with both acute and stable coronary artery disease

scientific article published on 29 May 2012

A. actinomycetemcomitans serotypes associate with periodontal and coronary artery disease status.

scientific article published on 31 January 2018

Acute Myocardial Infarction is Reflected in Salivary Matrix Metalloproteinase-8 Activation Level

scientific article published on 23 November 2010

Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis

scientific article published on 19 December 2011

Adaptation to acute coronary syndrome-induced stress with lowering of testosterone: a possible survival factor

scientific article

Aggregatibacter actinomycetemcomitans induces MMP-9 expression and proatherogenic lipoprotein profile in apoE-deficient mice

scientific article published on 24 August 2007

Alveolar bone loss associated with age-related macular degeneration in males

scientific article published on 13 March 2012

Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases

scientific article published on February 2016

Antibodies to periodontal pathogens are associated with coronary heart disease

scientific article published on 24 April 2003

Antibodies to periodontal pathogens are associated with coronary plaque remodeling but not with vulnerability or burden

scientific article published on 6 September 2014

Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease

scientific article published on 04 March 2022

Association between Dental Factors and Mortality

scientific article published on 04 December 2020

Association of periodontitis with persistent, pro-atherogenic antibody responses

article

Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation

scientific article

Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study

scientific article published on 17 September 2013

Carotid artery calcification in panoramic radiographs associates with oral infections and mortality

scientific article published on 31 August 2020

Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.

scientific article published in June 2016

Childhood Oral Infections Associate with Adulthood Metabolic Syndrome: A Longitudinal Cohort Study

scientific article published on 01 June 2020

Chlamydial LPS and high-sensitivity CRP levels in serum are associated with an elevated body mass index in patients with cardiovascular disease

scientific article published on December 2008

Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice

scientific article published on 18 May 2009

Chlamydial lipopolysaccharide (cLPS) is present in atherosclerotic and aneurysmal arterial wall--cLPS levels depend on disease manifestation

scientific article published on 15 January 2009

Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis

scientific article published on 4 January 2006

Cohort Profile: the Corogene study

scientific article

Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines

scientific article published on 16 October 2010

Combining salivary pathogen and serum antibody levels improves their diagnostic ability in detection of periodontitis

scientific article

Cumulative use of salivary markers with an adaptive design improves detection of periodontal disease over fixed biomarker thresholds

scientific article published on 20 February 2018

Detection and quantification of five major periodontal pathogens by single copy gene-based real-time PCR.

scientific article

Detection of hydrogen cyanide from oral anaerobes by cavity ring down spectroscopy

scientific article published on 04 March 2016

Detection of multiple pathogenic species in saliva is associated with periodontal infection in adults

scientific article

Elevated MMP-8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm1

scientific article published on 01 August 2010

Endotoxemia Is Associated With an Increased Risk of Incident Diabetes ⬇️

scientific article published on February 1, 2011

Endotoxemia is associated with an adverse metabolic profile

scientific article published on 27 November 2020

Endotoxemia, nutrition, and cardiometabolic disorders

scientific article published on 19 October 2014

Genetic variation on the BAT1-NFKBIL1-LTA region of major histocompatibility complex class III associates with periodontitis

scientific article published on 24 February 2014

Gingival tissue human beta-defensin levels in relation to infection and inflammation

scientific article published on 07 January 2020

HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes

scientific article published on 24 October 2017

High-fat meals induce systemic cytokine release without evidence of endotoxemia-mediated cytokine production from circulating monocytes or myeloid dendritic cells

scientific article published on 3 September 2014

Identifying volatile in vitro biomarkers for oral bacteria with proton-transfer-reaction mass spectrometry and gas chromatography-mass spectrometry

scientific article published on 19 August 2021

Immunization with malondialdehyde-modified low-density lipoprotein (LDL) reduces atherosclerosis in LDL receptor-deficient mice challenged with Porphyromonas gingivalis.

scientific article published on 17 August 2014

Immunologic burden links periodontitis to acute coronary syndrome

scientific article published on 6 December 2017

Immunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis

scientific article published on 05 August 2020

Infections as a stimulus for coronary occlusion, obstruction, or acute coronary syndromes

scientific article published on 22 September 2009

Infectious burden as a determinant of atopy-- a comparison between adults in Finnish and Russian Karelia

scientific article published on 22 March 2006

Is periodontal infection behind the failure of antibiotics to prevent coronary events?

scientific article published on 28 July 2006

Letters to the Editor: Authors’ response

scientific article published on 01 January 2014

Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease

scientific article

Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis

scientific article

Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease.

scientific article

MMP activation in diagnostics of periodontitis and systemic inflammation

scientific article published on 26 June 2011

Matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy

scientific article published on 28 November 2013

Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux capacity

scientific article published on 30 December 2014

Mediators between oral dysbiosis and cardiovascular diseases

scientific article published on 01 October 2018

Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death.

scientific article published on 19 May 2015

Molecular Forms and Fragments of Salivary MMP-8 in Relation to Periodontitis

scientific article published on 18 November 2018

Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease

scientific article

Oral health: A modifiable risk factor for cardiovascular diseases or a confounded association?

article

Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals

scientific article

Periodontal pathogen carriage, rather than periodontitis, determines the serum antibody levels

scientific article published on 01 March 2011

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

scientific article published on 5 April 2009

Periodontitis is associated with a low concentration of vitamin C in plasma

scientific article published in September 2003

Periodontitis is associated with angiographically verified coronary artery disease

scientific article published on 15 September 2011

Periodontopathogen- and host-derived immune response in acute coronary syndrome

scientific article published in October 2011

Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium

scientific article published in 2022

Population-based study of salivary carriage of periodontal pathogens in adults

scientific article

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction

article

Practical implications of novel serum ELISA-assay for matrix metalloproteinase-8 in acute cardiac diagnostics

scientific article published on 01 January 2015

Presence ofAggregatibacter actinomycetemcomitansin young individuals: a 16-year clinical and microbiological follow-up study

scientific article published on 12 August 2009

Pro-atherogenic lung and oral pathogens induce an inflammatory response in human and mouse mast cells

scientific article published on January 2009

Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans

scientific article published on January 2006

Quantitative PCR analysis of salivary pathogen burden in periodontitis

scientific article published on October 2015

Recognition of Porphyromonas gingivalis gingipain epitopes by natural IgM binding to malondialdehyde modified low-density lipoprotein.

scientific article

Response to Comment on: Lassenius et al. Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation. Diabetes Care 2011;34:1809–1815.

scientific article

Saliva and Serum Immune Responses in Apical Periodontitis

scientific article published on 21 June 2019

Saliva and serum biomarkers in periodontitis and coronary artery disease

scientific article published on 16 August 2018

Salivary Cytokine Biomarker Concentrations in Relation to Obesity and Periodontitis

scientific article published on 05 December 2019

Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis

scientific article

Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype

scientific article published on 03 September 2018

Salivary interleukin-1beta concentration and the presence of multiple pathogens in periodontitis

scientific article published on 2 October 2009

Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis

scientific article published on 19 October 2012

Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Triggers, Causes, and Outcome (SECRETO): Rationale and design

scientific article published on 04 April 2017

Serum antibody levels to Actinobacillus actinomycetemcomitans predict the risk for coronary heart disease.

scientific article

Serum antibody response to periodontal pathogens and herpes simplex virus in relation to classic risk factors of cardiovascular disease

scientific article published on 22 September 2006

Serum lipopolysaccharide activity is associated with the progression of kidney disease in finnish patients with type 1 diabetes

scientific article published on 05 June 2009

Serum lipopolysaccharide neutralizing capacity in ischemic stroke

scientific article published on 21 February 2020

Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men.

scientific article

Serum tissue-degrading proteinases and incident cardiovascular disease events

scientific article published on 18 October 2012

Single nucleotide polymorphism –799C/T in matrix metalloproteinase-8 promoter region in arterial disease

scientific article published on 12 October 2011

Smoking and matrix metalloproteinases, neutrophil elastase and myeloperoxidase in chronic periodontitis

scientific article published on 01 January 2011

Smoking confounds the periodontal diagnostics using saliva biomarkers

scientific article published on 14 December 2018

Subantimicrobial-dose doxycycline treatment increases serum cholesterol efflux capacity from macrophages

scientific article published on 07 May 2013

Subgingival Aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease

scientific article

Subgingival bacterial burden in relation to clinical and radiographic periodontal parameters

scientific article published on 14 March 2013

Systemic exposure to Pseudomonal bacteria: a potential link between type 1 diabetes and chronic inflammation

scientific article published on 5 August 2012

Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome

scientific article

The Association of Serum Neutrophil Markers and Acute Coronary Syndrome

article published in 2012

The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence

scientific article published on 16 January 2012

The effect of proatherogenic microbes on macrophage cholesterol homeostasis in apoE-deficient mice

scientific article published on 21 March 2011

The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

scientific article

The effect of prolonged systemic doxycycline therapy on serum tissue degrading proteinases in coronary bypass patients: a randomized, double-masked, placebo-controlled clinical trial

scientific article published on 31 December 2013

Use of host- and bacteria-derived salivary markers in detection of periodontitis: a cumulative approach.

scientific article published on January 2011

Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function.

scientific article

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