List of works by Fergal O'Brien

A Fatigue-Based Model of Disuse Osteoporosis

article

A Natural, Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis.

scientific article published on 24 June 2017

A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair.

scientific article

A biomimetic multi-layered collagen-based scaffold for osteochondral repair

scientific article published on 10 January 2014

A collagen cardiac patch incorporating alginate microparticles permits the controlled release of hepatocyte growth factor and insulin-like growth factor-1 to enhance cardiac stem cell migration and proliferation

scientific article published on 12 December 2016

A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes

scientific article

A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates

scientific article

A comparative study of shear stresses in collagen-glycosaminoglycan and calcium phosphate scaffolds in bone tissue-engineering bioreactors

scientific article published in May 2009

A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.

scientific article published in January 2007

A novel collagen scaffold supports human osteogenesis--applications for bone tissue engineering

scientific article published on 3 March 2010

A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells

scientific article published on 28 December 2014

A physiologically relevant 3D collagen-based scaffold - neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models

scientific article published on 12 February 2018

A prediction of cell differentiation and proliferation within a collagen–glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow

A short history of bioengineering research in Ireland

scientific article published on 19 December 2017

A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents

scientific article published on 20 October 2016

A study of needle stick injuries among non-consultant hospital doctors in Ireland

scientific article published on 29 December 2010

Activation of the SOX-5, SOX-6, and SOX-9 Trio of Transcription Factors Using a Gene-Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

scientific article published on 24 April 2020

Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering

scientific article published on 6 December 2011

Addition of hydroxyapatite improves stiffness, interconnectivity and osteogenic potential of a highly porous collagen-based scaffold for bone tissue regeneration.

scientific article published on 4 October 2010

Advanced Strategies for Articular Cartilage Defect Repair

scientific article published on 22 February 2013

Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation

scientific article published on 30 August 2017

An Endochondral Ossification-Based Approach to Bone Repair: Chondrogenically Primed Mesenchymal Stem Cell-Laden Scaffolds Support Greater Repair of Critical-Sized Cranial Defects Than Osteogenically Stimulated Constructs In Vivo

scientific article published on 19 February 2016

An efficient, non-viral dendritic vector for gene delivery in tissue engineering.

scientific article published on 14 September 2017

An endochondral ossification approach to early-stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair.

scientific article

An experimental investigation of the effect of mechanical and biochemical stimuli on cell migration within a decellularized vascular construct.

scientific article published on 2 July 2014

An improved labelling technique for monitoring microcrack growth in compact bone

scientific article published in April 2002

Anisotropic Shape-Memory Alginate Scaffolds Functionalized with Either Type I or Type II Collagen for Cartilage Tissue Engineering

scientific article published on 6 October 2016

Anti-Ageing Protein β-Klotho Rejuvenates Diabetic Stem Cells for Improved Gene-Activated Scaffold Based Wound Healing

scientific article published on 22 December 2020

Bioinspired Star-Shaped Poly(l-lysine) Polypeptides: Efficient Polymeric Nanocarriers for the Delivery of DNA to Mesenchymal Stem Cells

scientific article published on 06 April 2018

Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives.

scientific article published on 3 February 2016

Biomaterials & scaffolds for tissue engineering

scholarly article by Fergal O'Brien published March 2011 in Materials Today

Biomechanical comparison of the pullout properties of external skeletal fixation pins in the tibiae of intact and ovariectomised ewes

scientific article published in January 2008

Biomechanical properties across trabeculae from the proximal femur of normal and ovariectomised sheep

scientific article published on 25 January 2009

Biomechanics and mechanobiology in osteochondral tissues

scientific article published on September 2008

Bioreactors in tissue engineering

scientific article published on 01 January 2011

Book Review

scholarly article by Andrew R. Cameron & Fergal O'Brien published December 2013 in Journal of the Mechanical Behavior of Biomedical Materials

Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints.

scientific article

Cell-scaffold interactions in the bone tissue engineering triad

scientific article

Chitosan for gene delivery and orthopedic tissue engineering applications.

scientific article published on 15 May 2013

Chondrogenic Priming of Human Bone Marrow Stromal Cells: A Better Route to Bone Repair?

scholarly article by Eric Farrell et al published June 2009 in Tissue Engineering. Part C. Methods

Collagen GAG scaffold supports human osteogenesis in vitro

Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo

scientific article published on 23 January 2019

Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold

scientific article published on 13 August 2014

Comparative study on the effects of substrate stiffness on cell morphology and focal adhesion expression between hMSCs and AFSCs

scientific article

Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart

scientific article

Compression data on bovine bone confirms that a "stressed volume" principle explains the variability of fatigue strength results.

scientific article

Content-Dependent Osteogenic Response of Nanohydroxyapatite: An in Vitro and in Vivo Assessment within Collagen-Based Scaffolds

scientific article published on 18 August 2016

Controlled Non-Viral Gene Delivery in Cartilage and Bone Repair: Current Strategies and Future Directions

article

Controlled release of transforming growth factor-β3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.

scientific article published on 4 June 2014

Controlled release of vascular endothelial growth factor from spray-dried alginate microparticles in collagen-hydroxyapatite scaffolds for promoting vascularization and bone repair

scholarly article by Elaine Quinlan et al published April 2017 in Journal of Tissue Engineering and Regenerative Medicine

Controlling the dose-dependent, synergistic and temporal effects of NGF and GDNF by encapsulation in PLGA microparticles for use in nerve guidance conduits for the repair of large peripheral nerve defects

scientific article published on 02 May 2019

Coupling Freshly Isolated CD44(+) Infrapatellar Fat Pad-Derived Stromal Cells with a TGF-β3 Eluting Cartilage ECM-Derived Scaffold as a Single-Stage Strategy for Promoting Chondrogenesis

scientific article published on 6 February 2015

Creep Does Not Contribute to Fatigue in Bovine Trabecular Bone

article

Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds

scientific article published on 17 January 2011

DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior

scientific article published on 03 February 2016

Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model

article

Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives

scientific article

Delivery of the improved BMP-2-Advanced plasmid DNA within a gene-activated scaffold accelerates mesenchymal stem cell osteogenesis and critical size defect repair ⬇️

article

Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds

scientific article published on 8 December 2007

Detecting microdamage in bone

scientific article

Development and characterisation of a collagen nano-hydroxyapatite composite scaffold for bone tissue engineering

article

Development of a biomimetic collagen-hydroxyapatite scaffold for bone tissue engineering using a SBF immersion technique

scientific article published on August 2009

Development of a collagen calcium-phosphate scaffold as a novel bone graft substitute.

scientific article published in January 2008

Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffolds

scientific article published on 15 May 2015

Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia

article

Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering.

scientific article

Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque

scientific article published on 3 February 2016

Distribution of microcrack lengths in bone in vivo and in vitro

scientific article published on 5 April 2012

Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells

scientific article published on 11 October 2008

ENHANCED ENDOCHONDRAL OSSIFICATION IN VESSEL DERIVED STEM CELLS BY ATHEROSCLEROTIC ENVIRONMENT

ESTROGEN DEPLETION AND ZOLEDRONIC ACID THERAPY: EFFECTS ON OSTEOCYTE APOPTOSIS AND MICRODAMAGE

Effect of collagen-glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types

scientific article published on 19 September 2015

Effect of different hydroxyapatite incorporation methods on the structural and biological properties of porous collagen scaffolds for bone repair

scientific article published on 20 November 2014

Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution.

scientific article published on 14 September 2013

Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis

article

Effects of high bone turnover on the biomechanical properties of the L3 vertebra in an ovine model of early stage osteoporosis.

scientific article published on November 2008

Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo

scientific article published on 10 March 2008

Effects of ovariectomy on bone turnover, porosity, and biomechanical properties in ovine compact bone 12 months postsurgery

scientific article

Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity

Enamel Matrix Derivative has No Effect on the Chondrogenic Differentiation of Mesenchymal Stem Cells

scientific article published on 2 September 2014

Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly

scientific article published on 25 February 2015

Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro

scientific article

Estrogen withdrawal from osteoblasts and osteocytes causes increased mineralization and apoptosis

scientific article

Evaluation of early healing events around mesenchymal stem cell-seeded collagen-glycosaminoglycan scaffold. An experimental study in Wistar rats.

scientific article published on 20 July 2010

Evaluation of the ability of collagen–glycosaminoglycan scaffolds with or without mesenchymal stem cells to heal bone defects in Wistar rats

article

Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model.

scientific article

FABRICATION METHODOLOGIES REGULATE THE INITIAL MECHANICAL PROPERTIES OF CELL SEEDED HYDROGELS

Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration

scientific article published on 4 March 2016

Flexor tendon repair: a comparative study between a knotless barbed suture repair and a traditional four-strand monofilament suture repair

scientific article published on 21 May 2013

Form and function in regenerative medicine: introduction.

scientific article published in December 2015

Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles To Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model

scientific article published on 23 November 2016

Freeze-Drying as a Novel Biofabrication Method for Achieving a Controlled Microarchitecture within Large, Complex Natural Biomaterial Scaffolds

scientific article published on 31 July 2017

Functionalising Collagen-Based Scaffolds With Platelet-Rich Plasma for Enhanced Skin Wound Healing Potential

scientific article published on 03 December 2019

Functionalization of a Collagen-Hydroxyapatite Scaffold with Osteostatin to Facilitate Enhanced Bone Regeneration

scientific article published on 28 September 2015

Future Perspectives on the Role of Stem Cells and Extracellular Vesicles in Vascular Tissue Regeneration

scientific article published on 03 July 2018

Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering

scientific article

Gene expression by marrow stromal cells in a porous collagen-glycosaminoglycan scaffold is affected by pore size and mechanical stimulation

scientific article published on 27 June 2008

Growth plate extracellular matrix-derived scaffolds for large bone defect healing.

scientific article published on 14 February 2017

Harnessing a Novel Inhibitory Role of miR-16 in Osteogenesis by Human Mesenchymal Stem Cells for Advanced Scaffold-Based Bone Tissue Engineering.

scientific article published on 28 February 2018

Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties

scientific article

High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix

scientific article

Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: From development to application in tissue engineering

scientific article published on 13 June 2019

How Does Bone Detect Cracks?

Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy

scientific article published on 16 January 2014

Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair

scientific article published on 03 March 2015

IV.1. Scaffolds & surfaces

scientific article published in January 2010

IV.3. Bioreactors in tissue engineering

scientific article published in January 2010

Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis

scientific article published on 13 September 2017

Identification of the mechanisms by which age alters the mechanosensitivity of mesenchymal stromal cells on substrates of differing stiffness: Implications for osteogenesis and angiogenesis

scientific article published on 16 February 2017

In vitro efficacy of a gene-activated nerve guidance conduit incorporating non-viral PEI-pDNA nanoparticles carrying genes encoding for NGF, GDNF and c-Jun

article

In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells

scientific article

Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential

scientific article published on 19 March 2015

Incorporation of fibrin into a collagen-glycosaminoglycan matrix results in a scaffold with improved mechanical properties and enhanced capacity to resist cell-mediated contraction

scientific article published on 19 August 2015

Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute

scientific article

Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair

scientific article published on 17 May 2008

Influence of flow rate and scaffold pore size on cell behavior during mechanical stimulation in a flow perfusion bioreactor

scientific article published on 17 January 2012

Influence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds.

scientific article published in March 2004

Influence of shear stress in perfusion bioreactor cultures for the development of three-dimensional bone tissue constructs: a review

scientific article published on 12 October 2010

Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy

scientific article published on 6 September 2017

Innovations in Gene and Growth Factor delivery systems for Diabetic Wound Healing

scientific article published on 8 May 2017

Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation

scientific article

Insoluble elastin reduces collagen scaffold stiffness, improves viscoelastic properties, and induces a contractile phenotype in smooth muscle cells

scientific article published on 25 September 2015

Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells.

scientific article published on 31 March 2015

Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates.

scientific article

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

scientific article published on 16 December 2020

Life in 3D is never flat: 3D models to optimise drug delivery

scientific article published on 25 July 2015

Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis

article

Long-term controlled delivery of rhBMP-2 from collagen-hydroxyapatite scaffolds for superior bone tissue regeneration

scientific article published on 25 March 2015

Macrophage Polarization in Response to Collagen Scaffold Stiffness Is Dependent on Cross-Linking Agent Used To Modulate the Stiffness

scientific article published on 17 December 2018

Material stiffness influences the polarization state, function and migration mode of macrophages

scientific article published on 28 February 2019

Mechanical stimulation of osteoblasts using steady and dynamic fluid flow

scientific article

Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation

scientific article

Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector

scientific article published on 28 March 2017

Mesenchymal stem cell fate is regulated by the composition and mechanical properties of collagen-glycosaminoglycan scaffolds

scientific article published on 3 December 2011

Microcrack accumulation at different intervals during fatigue testing of compact bone

scientific article published in July 2003

Microcracks in compact bone: a three-dimensional view

scientific article

Microcracks in cortical bone: how do they affect bone biology?

scientific article

Microdamage and bone mechanobiology

scientific article published on January 2006

Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits

scientific article published on 24 December 2015

Multifunctional biomaterials from the sea: Assessing the effects of chitosan incorporation into collagen scaffolds on mechanical and biological functionality

scientific article published on 8 July 2016

New embedding medium for sectioning undecalcified bone

scientific article published on 01 March 2006

Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis

scientific article published on 14 June 2016

Non-viral gene-activated matrices: next generation constructs for bone repair

scientific article published on January 2013

Novel Freeze-Drying Methods to Produce a Range of Collagen–Glycosaminoglycan Scaffolds with Tailored Mean Pore Sizes

scientific article published on 01 October 2010

Novel microhydroxyapatite particles in a collagen scaffold: a bioactive bone void filler?

scientific article published on 03 January 2014

Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo.

scientific article

Orchestrating osteogenic differentiation of mesenchymal stem cells--identification of placental growth factor as a mechanosensitive gene with a pro-osteogenic role

scientific article

Osteoblast activity on collagen-GAG scaffolds is affected by collagen and GAG concentrations

scientific article published on October 2009

Osteoblast response to rest periods during bioreactor culture of collagen-glycosaminoglycan scaffolds

scientific article published in March 2010

Osteomimicry of mammary adenocarcinoma cells in vitro; increased expression of bone matrix proteins and proliferation within a 3D collagen environment

scientific article

Osteonal crack barriers in ovine compact bone

Part 1: scaffolds and surfaces

scientific article published in January 2008

Personalized Scaffolds for Diabetic Foot Ulcer Healing Using Extracellular Matrix from Induced Pluripotent Stem‐Reprogrammed Patient Cells

scientific article published in 2022

Platelet-rich plasma releasate differently stimulates cellular commitment toward the chondrogenic lineage according to concentration.

scientific article published on January 2015

Platelet‐derived growth factor stabilises vascularisation in collagen‐glycosaminoglycan scaffolds in vitro

scientific article published on 24 January 2019

Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues

scientific article published on 08 March 2019

Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing.

scientific article published on 31 May 2015

Primary cilia-mediated mechanotransduction in human mesenchymal stem cells

scientific article

Pro-angiogenic impact of SDF-1α gene-activated collagen-based scaffolds in stem cell driven angiogenesis.

scientific article

Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a rodent model of oestrogen deficiency.

scientific article published on 21 October 2017

Rapid healing of a critical-sized bone defect using a collagen-hydroxyapatite scaffold to facilitate low dose, combinatorial growth factor delivery

scientific article published on 08 August 2019

Recapitulating endochondral ossification: a promising route to in vivo bone regeneration

scientific article

Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete.

scientific article published on 20 May 2016

Respiratory Tissue Engineering: Current Status and Opportunities for the Future.

scientific article

Scaffold mean pore size influences mesenchymal stem cell chondrogenic differentiation and matrix deposition

scientific article

Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair

scientific article published on 23 May 2019

Scaffold-Based microRNA Therapies in Regenerative Medicine and Cancer

scientific article published on 25 October 2017

Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency

scientific article published on 15 May 2011

Spatiotemporal delivery of small molecule therapeutics using a thermosensitive liposome loaded hydrogel.

scientific article published on 19 August 2015

Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions.

scientific article

Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection

scientific article

Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis

scientific article

Staphylococcus aureus protein A causes osteoblasts to hyper-mineralise in a 3D extra-cellular matrix environment.

scientific article

Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis

scientific article

Staphylococcus epidermidis serine--aspartate repeat protein G (SdrG) binds to osteoblast integrin alpha V beta 3.

scientific article published on 5 March 2015

Stem cells display a donor dependent response to escalating levels of growth factor release from extracellular matrix-derived scaffolds

scientific article published on 12 July 2016

Stimulation of osteoblasts using rest periods during bioreactor culture on collagen-glycosaminoglycan scaffolds.

scientific article

Structural adaptation and intracortical bone turnover in an ovine model of osteoporosis

article

Subchondral osteopenia and accelerated bone remodelling post-ovariectomy - a possible mechanism for subchondral microfractures in the aetiology of spontaneous osteonecrosis of the knee?

scientific article published on 21 November 2012

Subchondral structural changes in the proximal tibia in an ovariectomised ovine model

Subchondral trabecular structural changes in the proximal tibia in an ovine model of increased bone turnover

article

Substrate composition and dimensionality direct osteocyte gene expression.

scientific article published on 27 October 2015

Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen-GAG scaffold

scientific article published on 8 June 2010

Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis

scientific article published on 18 October 2012

The Hounsfield value for cortical bone geometry in the proximal humerus--an in vitro study

scientific article published on 20 September 2011

The Incorporation of Marine Coral Microparticles into Collagen-Based Scaffolds Promotes Osteogenesis of Human Mesenchymal Stromal Cells via Calcium Ion Signalling

scientific article published on 23 January 2020

The Response of Bone Marrow-Derived Mesenchymal Stem Cells to Dynamic Compression Following TGF-β3 Induced Chondrogenic Differentiation

article

The behaviour of fatigue-induced microdamage in compact bone samples from control and ovariectomised sheep

article

The behaviour of microcracks in compact bone

scientific article published in February 2005

The benefits and limitations of animal models for translational research in cartilage repair

scientific article

The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo

scientific article

The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold

scientific article published on February 2016

The development of natural polymer scaffold-based therapeutics for osteochondral repair

scientific article published on 14 August 2020

The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds

scientific article published on 27 November 2011

The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation.

scientific article published on 27 November 2015

The effect of bone microstructure on the initiation and growth of microcracks

scientific article published in March 2005

The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels

scientific article published on 30 December 2008

The effect of dehydrothermal treatment on the mechanical and structural properties of collagen-GAG scaffolds

scientific article

The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering

scientific article published on 9 October 2009

The effect of pore size on cell adhesion in collagen-GAG scaffolds

scientific article published on February 2005

The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.

scientific article published on January 2007

The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering

scientific article published on 4 October 2008

The effects of cross-linking methods on osteogenesis within a collagen GAG scaffold

The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis

article

The effects of increased intracortical remodeling on microcrack behaviour in compact bone.

scientific article published on 25 July 2008

The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs

scientific article published on 22 September 2010

The marine-derived, multi-mineral formula, Aquamin, enhances mineralisation of osteoblast cells in vitro

scientific article published on 12 July 2011

The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D.

scientific article published on 19 July 2013

The pre-vascularisation of a collagen-chondroitin sulphate scaffold using human amniotic fluid-derived stem cells to enhance and stabilise endothelial cell-mediated vessel formation

scientific article published on 20 August 2015

The rationale and emergence of electroconductive biomaterial scaffolds in cardiac tissue engineering

scientific article published on 15 October 2019

The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation

scientific article

The synthesis and characterization of nanophase hydroxyapatite using a novel dispersant-aided precipitation method.

scientific article published on 28 September 2010

The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics

scientific article published on 14 July 2015

Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes

scientific article

Three hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold

article

Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness

scientific article published on 01 August 2010

Tissue engineered extracellular matrices (ECMs) in urology: Evolution and future directions

scientific article published on 12 August 2017

Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues

scientific article published on 04 October 2018

Towards 3D in vitro models for the study of cardiovascular tissues and disease

scientific article published on 23 April 2016

Towards in vitro vascularisation of collagen-GAG scaffolds.

scientific article

Tracking the changes in unloaded bone: Morphology and gene expression

scientific article published in October 2005

Transfection of autologous host cells in vivo using gene activated collagen scaffolds incorporating star-polypeptides

scientific article published on 08 May 2019

Translating the role of osteogenic-angiogenic coupling in bone formation: Highly efficient chitosan-pDNA activated scaffolds can accelerate bone regeneration in critical-sized bone defects

scientific article published on 4 October 2017

Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds

scientific article published on July 2010

Variation of trabecular microarchitectural parameters in cranial, caudal and mid-vertebral regions of the ovine L3 vertebra.

scientific article

Visualisation of three-dimensional microcracks in compact bone

scientific article

Visualizing feasible operating ranges within tissue engineering systems using a "windows of operation" approach: a perfusion-scaffold bioreactor case study

scientific article published on 11 June 2012

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