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List of works by Daniel S. Pilch

3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.

scientific article published on 17 October 2012

5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones and related compounds as TOP1-targeting agents: influence of structure on the ternary cleavable complex formation

scientific article

A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization ⬇️

scientific article published on October 26, 2012

A G-quadruplex stabilizer induces M-phase cell cycle arrest

scientific article published on 16 June 2009

A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin

scientific article

A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: A potential mechanism for topoisomerase I poisoning ⬇️

scientific article published on December 9, 1997

Aminoglycoside binding in the major groove of duplex RNA: the thermodynamic and electrostatic forces that govern recognition

scientific article published on 01 April 2000

Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes.

scientific article

Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity.

scientific article published on February 2006

An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivo

scientific article published on 16 September 2013

Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.

scientific article published on 26 June 2013

Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.

scientific article published on 02 October 2012

Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.

scientific article published on 20 September 2012

Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes.

scientific article published on 20 December 2012

Calorimetry of Nucleic Acids

scientific article published on 01 December 2015

Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus

scientific article published on 9 May 2016

Complete thermodynamic characterization of the multiple protonation equilibria of the aminoglycoside antibiotic paromomycin: a calorimetric and natural abundance 15N NMR study.

scientific article

DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles

scientific article published on 01 March 1998

Deciphering the origins of observed heat capacity changes for aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA a-sites: a calorimetric, computational, and osmotic stress study.

scientific article

Defining the basis for the specificity of aminoglycoside-rRNA recognition: a comparative study of drug binding to the A sites of Escherichia coli and human rRNA.

scientific article

Defining the molecular forces that determine the impact of neomycin on bacterial protein synthesis: importance of the 2'-amino functionality

scientific article published on 12 March 2007

Differential Poisoning of Topoisomerases by Menogaril and Nogalamycin Dictated by the Minor Groove-Binding Nogalose Sugar†

scientific article published on 01 October 1997

Drug self-association modulates the cellular bioavailability of DNA minor groove-directed terbenzimidazoles.

scientific article published on August 2006

Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication

scientific article

Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.

scientific article published on 25 June 2013

Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences.

scientific article published on March 2004

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

scientific article published on 01 April 2000

Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions

scientific article published in June 2000

Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex

scientific article

Inhibition of RND-type efflux pumps confers the FtsZ-directed prodrug TXY436 with activity against Gram-negative bacteria

scientific article published on 14 March 2014

Macrocyclic biphenyl tetraoxazoles: Synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity ⬇️

scientific article published on May 30, 2013

Macrocyclic pyridyl polyoxazoles: structure-activity studies of the aminoalkyl side-chain on G-quadruplex stabilization and cytotoxic activity.

scientific article published on 26 September 2013

Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs

scientific article published on 01 October 1997

Modulation of nucleic acid structure by ligand binding: induction of a DNA.RNA.DNA hybrid triplex by DAPI intercalation.

scientific article published on June 1997

Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723.

scientific article

Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: a potential role of ligand-induced DNA bending at a distal site

scientific article published on 01 August 2000

Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ.

scientific article published on 16 June 2017

Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens

scientific article published on 27 December 2019

Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents ⬇️

scientific article published on February 13, 2013

Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles

scientific article

TXA497 as a topical antibacterial agent: comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin

scientific article published on 26 September 2014

Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds.

scientific article

The thermodynamics of DNA structures that contain lesions of guanine tetrads ⬇️

scientific article published on June 1, 1995

The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA

scientific article published on 01 February 1999

Thermodynamics of aminoglycoside-rRNA recognition.

scientific article

Topoisomerase I-mediated DNA cleavage induced by the minor groove-directed binding of bibenzimidazoles to a distal site

scientific article published on 13 October 2006

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