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List of works by Mark C. Leake

A glucose-starvation response governs endocytic trafficking and eisosomal retention of surface cargoes in budding yeast

scientific article published in 2021

An automated image analysis framework for segmentation and division plane detection of single live Staphylococcus aureus cells which can operate at millisecond sampling time scales using bespoke Slimfield microscopy.

scientific article published on 17 October 2016

Analytical tools for single-molecule fluorescence imaging in cellulo

scientific article published in July 2014

Are Escherichia coli OXPHOS complexes concentrated in specialized zones within the plasma membrane?

scientific article

Association of the chaperone alphaB-crystallin with titin in heart muscle.

scientific article published on 4 December 2003

B cell zone reticular cell microenvironments shape CXCL13 gradient formation

scientific article published on 22 July 2020

Biophysical characterisation of DNA origami nanostructures reveals inaccessibility to intercalation binding sites

scientific article published on 26 February 2020

Clustering and dynamics of cytochrome bd-I complexes in the Escherichia coli plasma membrane in vivo

scientific article published on 23 October 2008

Correction: Transcription factor clusters regulate genes in eukaryotic cells

article

Correlating single-molecule characteristics of the yeast aquaglyceroporin Fps1 with environmental perturbations directly in living cells

scientific article published on 06 May 2020

Correlative single-molecule fluorescence barcoding of gene regulation in Saccharomyces cerevisiae

scientific article published on 18 October 2020

Damped elastic recoil of the titin spring in myofibrils of human myocardium

scientific article

Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart

scientific article published on 26 February 2004

Direct observation of steps in rotation of the bacterial flagellar motor.

scientific article

From Animaculum to single molecules: 300 years of the light microscope

scientific article

Functioning nanomachines seen in real-time in living bacteria using single-molecule and super-resolution fluorescence imaging.

scientific article published on 15 April 2011

Imaging the cell

scientific article published on 3 August 2017

In vivo architecture and action of bacterial structural maintenance of chromosome proteins

scientific article

Independent mobility of proteins and lipids in the plasma membrane of Escherichia coli

scientific article published on 30 April 2014

Inferring diffusion in single live cells at the single-molecule level

scientific article

Integration host factor bends and bridges DNA in a multiplicity of binding modes with varying specificity

scientific article published on 01 September 2021

Localisation and interactions of the Vipp1 protein in cyanobacteria

scientific article published on 13 October 2014

Mechanical properties of cardiac titin's N2B-region by single-molecule atomic force spectroscopy

scientific article published on 25 April 2006

Millisecond timescale slimfield imaging and automated quantification of single fluorescent protein molecules for use in probing complex biological processes

scientific article published on 4 August 2009

Molecular coordination of Staphylococcus aureus cell division.

scientific article published on 21 February 2018

Molecular crowding in single eukaryotic cells: using cell environment biosensing and single-molecule optical microscopy to probe dependence on extracellular ionic strength, local glucose conditions, and sensor copy number

scientific article published on 03 November 2020

Multiple sources of passive stress relaxation in muscle fibres

scientific article

Nonequivalence of membrane voltage and ion-gradient as driving forces for the bacterial flagellar motor at low load.

scientific article published on 6 April 2007

Positioning of chemosensory proteins and FtsZ through the Rhodobacter sphaeroides cell cycle

scientific article published on 9 September 2013

Shining the spotlight on functional molecular complexes: The new science of single-molecule cell biology

scientific article published on September 2010

Signal-dependent turnover of the bacterial flagellar switch protein FliM.

scientific article

Single-Organelle Quantification Reveals Stoichiometric and Structural Variability of Carboxysomes Dependent on the Environment

scientific article published on 02 May 2019

Single-molecule fluorescence microscopy review: shedding new light on old problems.

scientific article

Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation.

scientific article published on 7 February 2014

Single-molecule live cell imaging of Rep reveals the dynamic interplay between an accessory replicative helicase and the replisome

scientific article published on 01 July 2019

Single-molecule studies of the dynamics and interactions of bacterial OXPHOS complexes

scientific article published on 20 October 2015

Single-molecule techniques in biophysics: a review of the progress in methods and applications

scientific article published on 4 September 2017

Stoichiometry and turnover in single, functioning membrane protein complexes.

scientific article published on 13 September 2006

Superresolution imaging of single DNA molecules using stochastic photoblinking of minor groove and intercalating dyes.

scientific article published on 27 January 2015

The Effect of Lithium on the Budding Yeast upon Stress Adaptation

The case for biophysics super-groups in physics departments

scientific article published on 06 July 2018

The elasticity of single kettin molecules using a two-bead laser-tweezers assay.

scientific article

The elasticity of single titin molecules using a two-bead optical tweezers assay.

scientific article published on August 2004

The emergence of sequence-dependent structural motifs in stretched, torsionally constrained DNA

scientific article published on 01 February 2020

The maximum number of torque-generating units in the flagellar motor of Escherichia coli is at least 11

scholarly article

The molecular elasticity of the insect flight muscle proteins projectin and kettin

scholarly article

The yeast Mig1 transcriptional repressor is dephosphorylated by glucose-dependent and -independent mechanisms.

scientific article published in August 2017

Towards mapping the 3D genome through high speed single-molecule tracking of functional transcription factors in single living cells

scientific article published on 26 June 2019

Transcription factor clusters regulate genes in eukaryotic cells.

scientific article published on 25 August 2017

Transcription factors in eukaryotic cells can functionally regulate gene expression by acting in oligomeric assemblies formed from an intrinsically disordered protein phase transition enabled by molecular crowding

article

Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging

scientific article

Visualizing single molecular complexes in vivo using advanced fluorescence microscopy.

scientific article published on 8 September 2009

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