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List of works by Philippe L. Bedard

A Matched Cohort Study of Patients With End-Stage Heart Failure from Anthracycline-Induced Cardiomyopathy Requiring Advanced Cardiac Support

scientific article published on 23 August 2016

A New Model to Predict Benign Histology in Residual Retroperitoneal Masses After Chemotherapy in Nonseminoma

scientific article published on 7 February 2018

A Phase 1 open-label study to identify a dosing regimen of the pan-AKT inhibitor AZD5363 for evaluation in solid tumors and in PIK3CA-mutated breast and gynecologic cancers.

scientific article published on 24 October 2017

A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors

scientific article published on 21 October 2015

A classification system for clinical relevance of somatic variants identified in molecular profiling of cancer.

scientific article published on 16 April 2015

A common language in neoadjuvant breast cancer clinical trials: proposals for standard definitions and endpoints

scientific article published on June 2012

A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies

scientific article

A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer

scientific article published on 12 September 2017

A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors

scientific article published on 4 September 2015

A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503).

scientific article published on 18 July 2013

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).

scientific article published on 05 May 2013

A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI♯9041).

scientific article

A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin

scientific article published on 12 September 2014

A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors

scientific article published on 17 July 2013

A phase Ib dose-escalation study of the MEK inhibitor trametinib in combination with the PI3K/mTOR inhibitor GSK2126458 in patients with advanced solid tumors.

scientific article published on 23 July 2016

A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors

scientific article published on 10 December 2014

A phase Ib, open-label, dose-escalation study of the safety and pharmacology of taselisib (GDC-0032) in combination with either docetaxel or paclitaxel in patients with HER2-negative, locally advanced, or metastatic breast cancer

scientific article published on 31 July 2019

A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors.

scientific article published on 17 April 2015

AKT Inhibition in Solid Tumors With AKT1 Mutations

scientific article published on 10 May 2017

Aiming at the target: improved adjuvant medical therapy

scientific article published on October 2009

Androgen receptor expression and outcomes in early breast cancer: a systematic review and meta-analysis

scientific article

Anterior transpericardial approach for postchemotherapy residual midvisceral mediastinal mass in metastatic germ cell tumors

scientific article published on 9 January 2013

Are we HER-ting for innovation in neoadjuvant breast cancer trial design?

scientific article published on 16 January 2009

Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.

scientific article published on 27 April 2017

Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer

scientific article published on 15 June 2015

Author financial conflicts of interest, industry funding, and clinical practice guidelines for anticancer drugs

scientific article

Benefits and harms of detecting clinically occult breast cancer

scientific article

Beyond trastuzumab: overcoming resistance to targeted HER-2 therapy in breast cancer

scientific article published on March 2009

Brain metastases in HER2-positive breast cancer: the evolving role of lapatinib

scientific article published on 09 December 2009

Can some patients avoid adjuvant chemotherapy for early-stage breast cancer?

scientific article published on March 2011

Cancer genomics: technology, discovery, and translation

scientific article published on 23 January 2012

Cancer patients' experiences with immune checkpoint modulators: A qualitative study

scientific article published on 02 March 2020

Cardiac toxicity with anti-HER-2 therapies: what have we learned so far?

scientific article published on April 2009

Characteristics and Outcome of AKT1 E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry

scientific article published on 10 January 2020

Clinical Characteristics and Outcomes of Late Relapse in Stage I Testicular Seminoma

scientific article published on 20 June 2016

Clinical application of high-throughput genomic technologies for treatment selection in breast cancer

scientific article published on January 2013

Clinical genomics information management software linking cancer genome sequence and clinical decisions

scientific article published in September 2013

Clinical utility of multigene profiling assays in early-stage breast cancer

scientific article published on 25 October 2017

Comparison of reporting phase I trial results in ClinicalTrials.gov and matched publications.

scientific article published on 14 September 2017

Complete Response of Metastatic Androgen Receptor-Positive Breast Cancer to Bicalutamide: Case Report and Review of the Literature

scientific article published on 02 June 2014

Conditional Risk of Relapse in Surveillance for Clinical Stage I Testicular Cancer

scientific article published on 12 August 2016

Conditional Survival of Patients With Metastatic Testicular Germ Cell Tumors Treated With First-Line Curative Therapy

scientific article published on 19 January 2016

Cost-effectiveness of the 21-gene assay for guiding adjuvant chemotherapy decisions in early breast cancer

scientific article published in July 2013

Current paradigms for the use of HER2-targeted therapy in early-stage breast cancer

scientific article published on December 2008

Decoding the evolution of a breast cancer genome

scientific article

Development of the Functional Assessment of Cancer Therapy-Immune Checkpoint Modulator (FACT-ICM): A toxicity subscale to measure quality of life in patients with cancer who are treated with ICMs

scientific article published on 08 January 2020

Disease modification and biomarker development in Parkinson disease: Revision or reconstruction?

scientific article published on 26 February 2020

Doubling back on centromere 17 in early breast cancer

scientific article published in March 2010

Early mortality and overall survival in oncology phase I trial participants: can we improve patient selection?

scientific article

Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling.

scientific article

Elucidating the genomic landscape of breast cancer: how will this affect treatment?

scientific article

Enhancing reproducibility in cancer drug screening: how do we move forward?

scientific article

Evolution of clinical trial design in early drug development: systematic review of expansion cohort use in single-agent phase I cancer trials

scientific article published on 14 October 2013

Feasibility of real time next generation sequencing of cancer genes linked to drug response: results from a clinical trial

scientific article

Fertility preservation in post-pubescent female cancer patients: A practical guideline for clinicians

scientific article published on 3 November 2017

First-in-human trial of the PI3Kβ-selective inhibitor SAR260301 in patients with advanced solid tumors

scientific article published on 4 October 2017

Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the development of cisplatin-induced ototoxicity in testicular cancer patients

scientific article published on 22 January 2018

Gene expression signatures prognostic for relapse in stage I testicular germ cell tumours

article

Genomic testing in cancer: patient knowledge, attitudes, and expectations

scientific article published on 24 June 2014

Genotype-matched treatment for patients with advanced type I epithelial ovarian cancer (EOC).

scientific article

Hyperprogressive disease in early-phase immunotherapy trials: Clinical predictors and association with immune-related toxicities

scientific article published on 15 February 2019

Identification of a low-risk subgroup of HER-2-positive breast cancer by the 70-gene prognosis signature.

scientific article

Identification of genomic signatures in circulating tumor cells from breast cancer

scientific article published on 12 January 2015

Impact of Granulocyte-colony Stimulating Factor on Bleomycin-induced Pneumonitis in Chemotherapy-treated Germ Cell Tumors

scientific article published on 4 September 2017

Impact of multi-gene mutational profiling on clinical trial outcomes in metastatic breast cancer.

scientific article published on 24 November 2017

International guidelines for management of metastatic breast cancer: combination vs sequential single-agent chemotherapy

scientific article published on 05 August 2009

Large retroperitoneal lymphadenopathy and increased risk of venous thromboembolism in patients receiving first-line chemotherapy for metastatic germ cell tumors: A study by the global germ cell cancer group (G3)

scientific article published on 12 November 2019

Large retroperitoneal lymphadenopathy as a predictor of venous thromboembolism in patients with disseminated germ cell tumors treated with chemotherapy.

scientific article

Low CD10 mRNA expression identifies high-risk ductal carcinoma in situ (DCIS).

scientific article

Low residual proliferation after short-term letrozole therapy is an early predictive marker of response in high proliferative ER-positive breast cancer.

scientific article published on 14 November 2011

Lucitanib for the Treatment of HR+/HER2- Metastatic Breast Cancer: Results from the Multicohort Phase II FINESSE Study

scientific article published on 16 October 2019

Luminal-B breast cancer and novel therapeutic targets

scientific article published on 30 November 2011

Lung cancer in never smokers from the Princess Margaret Cancer Centre.

scientific article published on 27 April 2018

Lymph Node Yield in Primary Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumors

scientific article published on 28 March 2015

Management of small HER2 overexpressing tumours

scientific article published on 06 September 2012

Matters of the heart: cardiac toxicity of adjuvant systemic therapy for early-stage breast cancer

scientific article

Modifying phase I methodology to facilitate enrolment of molecularly selected patients

scientific article published on 16 January 2013

Molecular Biology of Breast Cancer

scholarly article by Natasa Snoj published in January 2010

Molecular Biology of Breast Cancer

scholarly article by Natasa Snoj published in January 2009

Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience

scientific article published on 23 October 2017

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.

scientific article published on 25 October 2016

Neratinib Efficacy and Circulating Tumor DNA Detection of HER2 Mutations in HER2 Nonamplified Metastatic Breast Cancer.

scientific article

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer.

scientific article published on 29 August 2016

Nonhormonal systemic therapy for advanced breast cancer: do the math!

scientific article published on 9 December 2008

Ocular toxicities of MEK inhibitors and other targeted therapies.

scientific article published on 6 March 2016

Ocular toxicity of targeted therapies

scientific article published on 29 May 2012

Overcoming endocrine resistance in breast cancer: are signal transduction inhibitors the answer?

scientific article published on 22 May 2007

PIK3CA genotype and treatment decisions in human epidermal growth factor receptor 2-positive breast cancer.

scientific article published on 5 January 2015

Patterns of relapse in patients with clinical stage I testicular cancer managed with active surveillance

scientific article

Personalized medicine for metastatic breast cancer

scientific article

Phase I Basket Study of Taselisib, an Isoform-Selective PI3K Inhibitor, in Patients with PIK3CA-Mutant Cancers

scientific article published on 04 November 2020

Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor-Positive Advanced Breast Cancer

scientific article published on 23 May 2018

Progress in tailoring adjuvant endocrine therapy for postmenopausal women with early breast cancer

scientific article

Promising SINEs for embargoing nuclear-cytoplasmic export as an anticancer strategy

scientific article published on 17 April 2014

Proposals for uniform collection of biospecimens from neoadjuvant breast cancer clinical trials: timing and specimen types

scientific article published in November 2011

Prospective Evaluation of the 21-Gene Recurrence Score Assay for Breast Cancer Decision-Making in Ontario

scientific article published on 23 November 2015

Quality of life and understanding of disease status among cancer patients of different ethnic origin

scientific article published on August 2003

Randomized controlled trials in testicular cancer: A demographic and quality assessment

scientific article

Recent advances in adjuvant systemic therapy for early-stage breast cancer.

scientific article published on July 2008

Recommendations for followup of stage I and II seminoma: The Princess Margaret Cancer Centre approach.

scientific article published in December 2017

Referrals to a Phase I Clinic and Trial Enrollment in the Molecular Screening Era

scientific article published on 04 March 2019

Regional myocardial edema detected by T2 mapping is a feature of cardiotoxicity in breast cancer patients receiving sequential therapy with anthracyclines and trastuzumab.

scientific article published on 16 January 2014

Right Ventricular Dysfunction in Patients Experiencing Cardiotoxicity during Breast Cancer Therapy

scientific article

Safety and Antitumor Activity of Pembrolizumab in Patients with Estrogen Receptor‒Positive/Human Epidermal Growth Factor Receptor 2‒Negative Advanced Breast Cancer.

scientific article published on 20 March 2018

Salvage chemotherapy for metastatic germ cell tumours: The known unknowns

scientific article published on April 2012

Serum miRNA Predicts Viable Disease after Chemotherapy in Patients with Testicular Nonseminoma Germ Cell Tumor.

scientific article published on 20 February 2018

Shrinking Hepatic Hemangiomas in a Patient Treated for Metastatic Germ Cell Tumor.

scientific article

Sowing the Soil for Cure? Results of the ABCSG-12 Trial Open a New Chapter in the Evolving Adjuvant Bisphosphonate Story in Early Breast Cancer

scientific article published on 03 August 2009

Spinal cord stimulators and radiotherapy: first case report and practice guidelines

scientific article published on 25 October 2011

Stage II seminomas and nonseminomas

scientific article published on June 2011

Standard and Genomic Tools for Decision Support in Breast Cancer Treatment

scientific article published on January 2017

Statistical power of negative randomized controlled trials presented at American Society for Clinical Oncology annual meetings

scientific article

Stemming resistance to HER-2 targeted therapy

scientific article published on 04 March 2009

Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer

scientific article published on 08 December 2009

Testicular cancer survivors' supportive care needs and use of online support: a cross-sectional survey.

scientific article published on 3 March 2012

Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer

scientific article published on September 2016

Testing personalized medicine: patient and physician expectations of next-generation genomic sequencing in late-stage cancer care

scientific article published on 17 July 2013

The association between institution at orchiectomy and outcomes on active surveillance for clinical stage I germ cell tumours.

scientific article published on May 2016

The genetic basis for cancer treatment decisions

scientific article

The positive effect of a dedicated adolescent and young adult fertility program on the rates of documentation of therapy-associated infertility risk and fertility preservation options

scientific article

Therapeutic management of breast cancer in the elderly

scientific article published on 16 February 2011

Tilting the Balance of Dose Modification for Oral Anticancer Drugs?

scientific article published on 07 April 2014

Transfer of follow-up care to family physicians for early-stage breast cancer

scientific article

Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials

scientific article

Tucatinib Combined With Ado-Trastuzumab Emtansine in Advanced ERBB2/HER2-Positive Metastatic Breast Cancer: A Phase 1b Clinical Trial

Tumour heterogeneity in the clinic

scientific article

Utility of molecular tools for extended adjuvant endocrine therapy decisions in early breast cancer.

scientific article published on 23 November 2017

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