Search filters

List of works by Jan Alsner

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients

scientific article published on 11 April 2017

A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers

scientific article

A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer

scientific article published on 01 January 2008

A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients

scientific article published on 01 January 2008

A drug-resistant variant of topoisomerase II alpha in human HL-60 cells exhibits alterations in catalytic pH optimum, DNA binding and sub-nuclear distribution.

scientific article published on December 1993

A prognostic profile of hypoxia-induced genes for localised high-grade soft tissue sarcoma

scientific article published on 4 October 2016

ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy

scientific article

Activation of peroxisome proliferator-activated receptor gamma bypasses the function of the retinoblastoma protein in adipocyte differentiation.

scientific article

An evaluation of multiplex bead-based analysis of cytokines and soluble proteins in archived lithium heparin plasma, EDTA plasma and serum samples.

scientific article published on 26 September 2016

An evolutionary-game model of tumour-cell interactions: possible relevance to gene therapy

scientific article

Antagonistic effect of aclarubicin on camptothecin induced cytotoxicity: role of topoisomerase I

scientific article published on 01 June 1994

Antiproton radiotherapy.

scientific article published on 26 December 2007

Application of microarray analyses to identify genes involved in radiation-induced fibrosis.

scientific article

Associations between skin rash, treatment outcome, and single nucleotide polymorphisms in head and neck cancer patients receiving the EGFR-inhibitor zalutumumab: results from the DAHANCA 19 trial

scientific article published on 17 May 2018

Biodistribution of 99mTc-HYNIC-lactadherin in mice--a potential tracer for visualizing apoptosis in vivo

scientific article published in April 2010

Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I

scientific article published on 01 December 1992

Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription

scientific article published on June 1990

Carbonic anhydrase IX and response to postmastectomy radiotherapy in high-risk breast cancer: a subgroup analysis of the DBCG82 b and c trials.

scientific article published on 20 March 2008

Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts

scientific article published on 11 September 2019

Characterization of an altered DNA catalysis of a camptothecin-resistant eukaryotic topoisomerase I.

scientific article

Clinical Impact of a Novel MicroRNA Chemo-Sensitivity Predictor in Gastrooesophageal Cancer

scientific article published on 17 February 2016

Comparison of Coding Transcriptomes in Fibroblasts Irradiated With Low and High LET Proton Beams and Cobalt-60 Photons

scientific article published on 06 December 2018

Conducting radiogenomic research--do not forget careful consideration of the clinical data

scientific article

DAHANCA 10 - Effect of darbepoetin alfa and radiotherapy in the treatment of squamous cell carcinoma of the head and neck. A multicenter, open-label, randomized, phase 3 trial by the Danish head and neck cancer group.

scientific article published on 6 March 2018

Danish retinoblastoma patients 1943-2013 - genetic testing and clinical implications.

scientific article published on 23 October 2015

Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort

scientific article published on 22 August 2014

Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer

scientific article

Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis

scientific article

Differential gene expression in primary fibroblasts induced by proton and cobalt-60 beam irradiation.

scientific article published on 8 September 2017

Differential protein expression of peroxiredoxin-1 in classical Hodgkin Lymphoma: a possible correlation to clinical behaviour

article

Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients

scientific article published on 17 May 2007

Does variability in normal tissue reactions after radiotherapy have a genetic basis--where and how to look for it?

scientific article

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart

scientific article published on 08 January 2007

Effect of ESA as a modifier of radiotherapy in curative intended treatment of squamous cell carcinoma of the head and neck (HNSCC)

scientific article published on 21 September 2018

Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck

scientific article published on 16 March 2009

Effect of radiation on cell proliferation and tumor hypoxia in HPV-positive head and neck cancer in vivo models

scientific article published on November 2014

Establishment of a Radiogenomics Consortium

scientific article

Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer

scientific article published on October 2015

FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial

scientific article published on 16 October 2012

Failure pattern and survival after breast conserving therapy. Long-term results of the Danish Breast Cancer Group (DBCG) 89 TM cohort

scientific article

Focal S100A4 protein expression is an independent predictor of development of metastatic disease in cystectomized bladder cancer patients

scientific article published on 09 March 2006

Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer

scientific article

Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck

scientific article published in January 2012

Gene-expression Classifier in Papillary Thyroid Carcinoma: Validation and Application of a Classifier for Prognostication

scientific article published on February 2016

Genetic markers for prediction of normal tissue toxicity after radiotherapy

scientific article published on April 2008

Genetic variants and normal tissue toxicity after radiotherapy: a systematic review

scientific article published on 14 August 2009

HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Rad

scientific article published on 29 November 2016

HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer

scientific article published on 10 November 2009

Heterogeneity in the clinical phenotype of TP53 mutations in breast cancer patients

scientific article published in October 2000

Heterogeneity in the clinical phenotype of TP53 mutations in breast cancer patients

scientific article published on 12 March 2000

Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation.

scientific article published on 23 May 2014

Hypoxia and local tumour control in squamous cell carcinoma of the anus – a hypothesis-generating study

scientific article published in 2022

Hypoxia gene expression signatures as prognostic and predictive markers in head and neck radiotherapy

scientific article published on April 2012

Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations

scientific article published on April 2001

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH.

scientific article published on 18 May 2007

Hypoxia-regulated MicroRNAs in Gastroesophageal Cancer

scientific article published on February 2016

Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer

scientific article

IMRT - Biomarkers for dose escalation, dose de-escalation and personalized medicine in radiotherapy for head and neck cancer

scientific article published on 18 September 2018

Identification of accurate reference genes for RT-qPCR analysis of formalin-fixed paraffin-embedded tissue from primary non-small cell lung cancers and brain and lymph node metastases

scientific article published on 03 May 2013

Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function

scientific article published in Journal of Biological Chemistry

Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c

scientific article

Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro

scientific article

Impact of BCL2 and p53 on postmastectomy radiotherapy response in high-risk breast cancer. A subgroup analysis of DBCG82 b&c

scientific article published on 01 January 2008

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients

scientific article published on 16 November 2016

Importance of overall treatment time for the response to radiotherapy in patients with squamous cell carcinoma of the head and neck

scientific article

In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome

scientific article

In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors

scientific article

Independent prospective validation of a predictive test for risk of radiation induced fibrosis based on the gene expression pattern in fibroblasts irradiated in vitro

scientific article

Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors

scientific article

Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

scientific article

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.

scientific article

Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins

scientific article published on 19 March 2013

Influence of intra-tumoral heterogeneity on the evaluation of BCL2, E-cadherin, EGFR, EMMPRIN, and Ki-67 expression in tissue microarrays from breast cancer.

scientific article published on 4 December 2017

Influence of oxygen concentration and pH on expression of hypoxia induced genes.

scientific article published on August 2005

Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer

scientific article

Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer

scientific article

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

scientific article published on 29 March 2017

Interaction between potential doubling time and TP53 mutation: predicting radiotherapy outcome in squamous cell carcinoma of the head and neck

scientific article

Intramolecular and intermolecular DNA ligation mediated by topoisomerase II

scientific article published on 01 August 1994

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

scientific article published on 01 October 2010

Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy - results from two independent randomized trials

scientific article published on 25 November 2017

LOH rather than genotypes ofTP53codon 72 is associated with disease-free survival in primary breast cancer

scientific article published on 01 January 2006

Long-term age-dependent failure pattern after breast-conserving therapy or mastectomy among Danish lymph-node-negative breast cancer patients

scientific article published on 8 June 2016

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.

scientific article published on 11 January 2016

Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer

scientific article

Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts

scientific article published on 17 November 2005

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

scientific article

Molecular profiles as predictive marker for the effect of overall treatment time of radiotherapy in supraglottic larynx squamous cell carcinomas

scientific article published in September 2004

Optimal reference genes for normalization of qPCR gene expression data from proton and photon irradiated dermal fibroblasts

scientific article published in Scientific Reports

Optimal reference genes for normalization of qRT-PCR data from archival formalin-fixed, paraffin-embedded breast tumors controlling for tumor cell content and decay of mRNA.

scientific article

Optimisation and validation of methods to assess single nucleotide polymorphisms (SNPs) in archival histological material

scientific article published on September 2004

Patient-reported outcomes in postmenopausal breast cancer survivors - comparisons with normative data

scientific article published on 04 November 2020

Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model

scientific article published on 01 October 2012

Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial.

scientific article published on 27 August 2005

Plasma proteins as prognostic biomarkers in radiotherapy treated head and neck cancer patients.

scientific article published on 7 February 2017

Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes

scientific article published on 01 November 2003

Prognostic value of hypoxia-regulated gene expression in loco-regional gastroesophageal cancer

scientific article published in December 2015

Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics.

scientific article

Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis

scientific article

Radiation-induced morbidity evaluated by high-frequency ultrasound.

scientific article published in September 2016

Radiogenomics: radiobiology enters the era of big data and team science

scientific article

Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells

scientific article published on 13 August 2013

Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum.

scientific article published in December 2005

Relationship between the prognostic and predictive value of the intrinsic subtypes and a validated gene profile predictive of loco-regional control and benefit from post-mastectomy radiotherapy in patients with high-risk breast cancer

scientific article

Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model

scientific article

Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection

scientific article

Reproductive death of cancer cells induced by femtosecond laser pulses

scientific article

Rethink radiotherapy - BIGART 2017.

scientific article published in November 2017

Retinoblastoma protein expression is an independent predictor of both radiation response and survival in muscle-invasive bladder cancer.

scientific article published on July 2003

Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples.

scientific article published on August 2006

SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling

scientific article published on 16 April 2013

Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro

scientific article published on 14 August 2015

Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2-nitroimidazole Ro 15-0216.

scientific article published on October 1990

Strain and tumour specific variations in the effect of hypoxia on osteopontin levels in experimental models

scientific article published on 21 August 2006

TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer

article

TP53 mutation is an independent prognostic marker for poor outcome in both node-negative and node-positive breast cancer

scientific article published on 01 January 2000

TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck

scientific article

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

scientific article

The effect of shark cartilage extracts on the growth and metastatic spread of the SCCVII carcinoma

scientific article published on 01 January 1998

The impact of hypoxia on the activity of lactate dehydrogenase in two different pre-clinical tumour models

scientific article published in January 2008

The importance of reference gene analysis of formalin-fixed, paraffin-embedded samples from sarcoma patients - an often underestimated problem

scientific article published on December 2014

The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.

scientific article published on December 1996

The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times

scientific article published on 01 August 2005

The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck

scientific article published in February 2004

The relative biological effectiveness of antiprotons

scientific article published on 14 December 2016

The usability of a 15-gene hypoxia classifier as a universal hypoxia profile in various cancer cell types.

scientific article published on 10 July 2015

Topoisomerase II-mediated DNA cleavage: evidence for distinct regions of enzyme-DNA contacts

scientific article published on 01 June 1996

Transformation of human mesenchymal stem cells in radiation carcinogenesis: long-term effect of ionizing radiation

scientific article published on November 2008

Validation of a 15-gene hypoxia classifier in head and neck cancer for prospective use in clinical trials.

scientific article published on 10 May 2016

Validation of a gene expression profile predictive of the risk of radiation-induced fibrosis in women treated with breast conserving therapy

scientific article published on 12 August 2015

Validation of genetic predictors of late radiation-induced morbidity in prostate cancer patients

scientific article published on 26 August 2017

Paulina is supported by:

About Paulina

Help