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List of works by Kenji Watanabe

A comprehensive and engaging overview of the type III family of polyketide synthases.

scientific article published on 7 May 2007

A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.

scientific article

A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae

scholarly article

Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples

scientific article published on 13 June 2019

Alkaloid Biosynthetic Enzyme Generates Diastereomeric Pair via Two Distinct Mechanisms

scientific article published on 18 March 2022

Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase

scientific article published on 30 November 2016

Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.

scientific article

Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis

scientific article

Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

scientific article published on 01 January 2019

Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.

scientific article published in November 2006

Biosynthesis of the Immunosuppressant (-)-FR901483

scientific article published on 29 December 2020

Biosynthetic machinery of ionophore polyether lasalocid: enzymatic construction of polyether skeleton.

scientific article published on 21 June 2013

Chapter 15. Plasmid-borne gene cluster assemblage and heterologous biosynthesis of nonribosomal peptides in Escherichia coli

scientific article published on 01 January 2009

Characterization of starch synthase I and II expressed in early developing seeds of kidney bean (Phaseolus vulgaris L.).

scientific article published in September 2004

Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha.

scientific article

Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases. ⬇️

scientific article

Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis.

scientific article published on 9 March 2016

Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.

scientific article published on 7 May 2013

Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus ⬇️

scientific article

Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis

scientific article

Core assembly mechanism of quinocarcin/SF-1739: bimodular complex nonribosomal peptide synthetases for sequential mannich-type reactions

scientific article published on 21 November 2013

Correction to A Novel o-Toluidine Metabolite in Rat Urine Associated with Urinary Bladder Carcinogenesis

scientific article published on 17 November 2020

Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis

scientific article published on 01 March 2014

Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk

scientific article published on 13 October 2013

Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

scientific article

Echinomycin biosynthesis

scientific article

Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation

scientific article published on 28 September 2015

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.

scientific article published on 29 July 2003

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis

scientific article

Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis

scientific article published on 04 March 2011

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis

scientific article published on 23 January 2017

Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis

scientific article

Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics

scientific article published on 23 March 2012

Exploring the biosynthesis of natural products and their inherent suitability for the rational design of desirable compounds through genetic engineering.

scientific article published on 07 October 2008

Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis

scientific article published on 11 September 2019

Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway

scientific article published on 11 March 2014

Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids.

scientific article

Genomic Mushroom Hunting Decrypts Coprinoferrin, A Siderophore Secondary Metabolite Vital to Fungal Cell Development

scientific article published on 09 September 2019

Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase.

scientific article published in November 2006

Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase ⬇️

scientific article

Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway

scientific article published on 01 October 2006

Integration of Chemical, Genetic, and Bioinformatic Approaches Delineates Fungal Polyketide-Peptide Hybrid Biosynthesis.

scientific article

Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition.

scientific article published on 11 September 2015

Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.

scientific article published on 24 November 2010

Isolation of New Colibactin Metabolites from Wild-Type <i>Escherichia coli</i> and <i>In Situ</i> Trapping of a Mature Colibactin Derivative

scientific article published in 2021

Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis

scientific article

Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway

scientific article published on June 2008

New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145. ⬇️

scientific article

Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids.

scientific article published on 22 September 2014

Novel o-Toluidine Metabolite in Rat Urine Associated with Urinary Bladder Carcinogenesis

scientific article published on 28 April 2020

Overexpressing transcriptional regulator in Chaetomium globosum activates a silent biosynthetic pathway: evaluation of shanorellin biosynthesis

scientific article published on 09 May 2012

Oxidative Cyclization in Natural Product Biosynthesis

scientific article published on 12 December 2016

Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.

scientific article published on 13 April 2016

Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis.

scientific article published on 10 March 2012

Plasmid construction using recombination activity in the fission yeast Schizosaccharomyces pombe

scientific article

Potent inhibition of macrophomate synthase by reaction intermediate analogs

scientific article published on 01 November 2000

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.

scientific article

Redirecting the cyclization steps of fungal polyketide synthase.

scientific article published on 12 December 2007

Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme

scientific article published on 25 August 2016

Relative and absolute configuration of antitumor agent SW-163D.

scientific article published on 7 December 2007

Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli.

scientific article published on 21 December 2006

Robustness analysis of cellular systems using the genetic tug-of-war method

scientific article published on October 2012

Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis

scientific article published on 20 April 2012

Site-directed mutagenesis establishes aspartic acids-227 and -342 as essential for enzyme activity in an isomalto-dextranase from Arthrobacter globiformis.

scientific article

Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis

scientific article published on 22 December 2020

Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis

scientific article published on 17 December 2020

Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.

scientific article

Structure of macrophomate synthase.

scientific article

Synergistic actions of a monooxygenase and cyclases in aromatic polyketide biosynthesis.

scientific article published in July 2008

Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids

scientific article published on 14 April 2015

Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol.

scientific article

The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: a novel function for a nonribosomal peptide synthetase.

scientific article published in January 2012

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

scientific article

Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete

scientific article published on 05 August 2020

Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

scientific article published on 15 August 2003

Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products

scientific article published on 02 July 2013

alpha-Glucosidase from a strain of deep-sea Geobacillus: a potential enzyme for the biosynthesis of complex carbohydrates.

scientific article published on 13 October 2005

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