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List of works by Pablo Machado

2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

scientific article published on 11 January 2016

2-Methyl-5-(4-tol-yl)-7-(trifluoro-meth-yl)pyrazolo[1,5-a]pyrimidine.

scientific article published on 6 December 2007

5-Halomethyl-5-Hydroxy-4,5-Dihydroisoxazoles: Synthesis and 13C, 17O,15N, 19F NMR Spectroscopy

A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.

scientific article

Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice

scientific article published on 17 April 2012

Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.

scientific article

Antinociceptive effect of novel trihalomethyl-substituted pyrazoline methyl esters in formalin and hot-plate tests in mice.

scientific article

Antioxidant potential of new pyrazoline derivatives to prevent oxidative damage

scientific article published on 18 December 2008

Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats.

scientific article published on 3 December 2010

Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures.

scientific article published on 5 February 2008

Design and microwave-assisted synthesis of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles: novel agents with analgesic and anti-inflammatory properties

scientific article published on 15 August 2007

Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer

scientific article published on 17 January 2019

Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity

scientific article published on 31 October 2013

Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats

scientific article

Efficient and highly regioselective synthesis of ethyl 1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylates under ultrasound irradiation

scientific article published on 30 June 2010

Evaluation of the synthesis of 1-(pentafluorophenyl)-4,5-dihydro-1H-pyrazoles using green metrics

Experimental and calculated structural parameters of 5-trihalomethyl-4,5-dihydro-1H-pyrazole derivatives, novel analgesic agents

Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis

scientific article published on 23 July 2014

Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles

Microwave-assisted synthesis of 5-trichloromethyl substituted 1-phenyl-1H-pyrazoles and 1,2-dimethylpyrazolium chlorides

Microwave-assisted synthesis of novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole methyl esters under solvent free conditions

N- and C-Acylation in β-Enamino Ketones: Structural Effects on Regiocontrol

New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis.

scientific article

Piperazine derivatives: synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies

scientific article published on 18 November 2014

Preclinical safety evaluation of IQG-607 in rats: Acute and repeated dose toxicity studies.

scientific article

Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase ⬇️

scientific article published on April 30, 2012

Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice

scientific article published on 23 July 2015

Simplified Approach to the Regiospecific Synthesis of Trichloromethylpyrazolines Using Microwave Irradiation

Single Turnover of Transient of Reactants Supports a Complex Interplay of Conformational States in the Mode of Action of Mycobacterium tuberculosis Enoyl Reductase ⬇️

scientific article published on 30 March 2023

Solvent-free heterocyclic synthesis

scientific article published on 01 September 2009

Straightforward and Regiospecific Synthesis of Pyrazole-5-carboxylates from Unsymmetrical Enaminodiketones

Structural improvement of compounds with analgesic activity: AC-MPF4, a compound with mixed anti-inflammatory and antinociceptive activity via opioid receptor

scientific article published on 13 December 2014

Structural investigations of 5-hydroxy-4,5-dihydroisoxazoles

Synthesis of Ethyl Pyrimidine-4-carboxylates from Unsymmetrical Enamino Diketones and Their Application in the First Synthesis of Pyrimido[4,5-d]pyridazin-8(7H)-ones

Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides

scientific article published on 04 January 2007

Targeting the histidine pathway in Mycobacterium tuberculosis.

scientific article published on January 2013

The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model

scientific article published on 15 February 2013

The potential antidepressant-like effect of imidazoline I2 ligand 2-BFI in mice

scientific article published on 21 November 2011

Toxicological profile of IQG-607 after single and repeated oral administration in minipigs: An essential step towards phase I clinical trial.

scientific article published on 21 August 2017

Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors

scientific article published on 6 March 2008

Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and β-enamino trihalomethyl ketones in water

scientific article published on 12 July 2005

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