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List of works by Frieke Kuper

A carcinogenicity study with mutagenic organic concentrates of drinking-water in the Netherlands

Acute and subacute inhalation toxicity of germanium dioxide in rats

scientific article published in November 1994

Acute, subacute, and subchronic inhalation toxicity studies of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats

scientific article published on 01 February 1994

Airway morphology and function of rats following dermal sensitization and respiratory challenge with low molecular weight chemicals

scientific article published in September 1998

Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB).

scientific article published on 21 January 2010

Alveolar macrophages have a dual role in a rat model for trimellitic anhydride-induced occupational asthma

scientific article published in July 2005

Alveolar macrophages suppress non-specific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albumin

scientific article published on 17 February 2006

Antitumour activity of endotoxin, concanavalin A and poly I: C and their ability to elicit tumour necrosis factor, cytostatic factors, and interferon in vivo.

scientific article

Carcinogenic response of the nasal cavity to inhaled chemical mixtures ⬇️

scientific article published on October 31, 1997

Chronic inhalation toxicity and carcinogenicity study of methyl bromide in Wistar rats

scientific article

Chronic inhalation toxicity and carcinogenicity study of propylene oxide in Wistar rats

scientific article published on 01 February 1988

Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats

scientific article

Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure.

scientific article published on 5 May 2009

Delay and impairment in brain development and function in rat offspring after maternal exposure to methylmercury

scientific article

Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies.

scientific article published on 6 June 2016

Disposition, accumulation and toxicity of iron fed as iron (II) sulfate or as sodium iron EDTA in rats

scientific article

Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age.

scientific article published in February 2007

Effects of endotoxin-treatment on inflammatory cell infiltrates in murine Meth A sarcoma.

scientific article

Effects of feeding stannous chloride on different parts of the gastrointestinal tract of the rat.

scientific article

Evaluation of C-reactive protein as an inflammatory biomarker in rabbits for vaccine nonclinical safety studies.

scientific article published on 23 April 2013

Evaluation of histological changes in the kidneys of the alloxan diabetic rat by means of factor analysis

scientific article published on July 1984

Evaluation of the oral toxicity of potassium nitrite in a 13-week drinking-water study in rats

scientific article published on 01 October 1988

Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice

scientific article published on 28 February 2015

Extended histopathology in immunotoxicity testing: interlaboratory validation studies

journal article published in 2004

Feasibility of a 3D human airway epithelial model to study respiratory absorption

scientific article published on 9 November 2013

Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months

scientific article published on 14 April 2007

Histopathology of mucosa-associated lymphoid tissue.

scientific article published on January 2006

Histopathology of the immune system as a tool to assess immunotoxicity.

scientific article

Humic acid enhances cigarette smoke-induced lung emphysema in mice and IL-8 release of human monocytes

scientific article published on 24 July 2011

Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15 ppm formaldehyde vapor

scientific article published on 26 September 2009

Influence of adrenoceptor blockade on endotoxin-induced histopathological changes in murine Meth A sarcoma

scientific article published on January 1982

Inhaled multiwalled carbon nanotubes modulate the immune response of trimellitic anhydride-induced chemical respiratory allergy in brown Norway rats

scientific article published on 03 April 2014

Integrated analysis of toxicity data of two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties to improve the understanding of side effects-A toxicopathologist׳s view.

scientific article

Local lymph node activation and IgE responses in brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals

scientific article published on 01 February 1997

Local lymph node activation in rats after dermal application of the sensitizers 2,4-dinitrochlorobenzene and trimellitic anhydride

scientific article published on 01 January 1996

Lymphoid and non-lymphoid cells in nasal-associated lymphoid tissue (NALT) in the rat. An immuno- and enzyme-histochemical study

scientific article published on 01 February 1990

Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats.

scientific article published on December 2008

Murine lung tumor response after exposure to cigarette mainstream smoke or its particulate and gas/vapor phase fractions

scientific article published on 04 June 2010

Nasal lymphoid tissue in the rat.

scientific article

Nasal passages of Göttingen minipigs from the neonatal period to young adult

scientific article published on 01 February 2012

Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats

scientific article published on 01 June 2003

Nitrite-induced adrenal effects in rats and the consequences for the no-observed-effect level

scientific article published on 01 March 1997

Non-clinical safety and biodistribution of AS03-adjuvanted inactivated pandemic influenza vaccines.

scientific article

Non-clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys

scientific article published on June 2015

On the mechanism of dialkyltin-induced thymus involution

scientific article published on 01 August 1985

Oxazolone (OXA) is a respiratory allergen in Brown Norway rats.

scientific article published on 26 August 2011

Potentially increased sensitivity of pregnant and lactating female rats to immunotoxic agents

scientific article published on 16 November 2011

Pre-exposure to sulfur dioxide attenuates most allergic reactions upon trimellitic anhydride challenge in sensitized Brown Norway rats

scientific article published in February 2010

Preexposure to amorphous silica particles attenuates but also enhances allergic reactions in trimellitic anhydride-sensitized brown Norway rats

scientific article published in August 2008

Progress and future of in vitro models to study translocation of nanoparticles.

scientific article

Recombinant insulin-like growth factor-II inhibits the growth-stimulating effect of growth hormone on the liver of Snell dwarf mice

scientific article published on 01 September 1994

Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats

scientific article published in February 2003

Respiratory allergy to trimellitic anhydride in rats: concentration-response relationships during elicitation

scientific article published in May 2004

Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation.

scientific article published on 05 May 2011

Role of histamine in the antitumour activity of endotoxin

scientific article published in January 1984

Role of vasoactive amines in the antitumor activity of endotoxin

scientific article published on 01 June 1984

Setting an indoor air exposure limit for formaldehyde: factors of concern

scientific article published on 26 August 2008

Subacute toxicity of a mixture of nine chemicals in rats: detecting interactive effects with a fractionated two-level factorial design

scientific article published on 01 March 1997

Subchronic (13-week) oral toxicity study in rats with fungal chitin-glucan from Aspergillus niger

scientific article

Subchronic oral toxicity studies with erythritol in mice and rats

scientific article published on 01 October 1996

The Göttingen minipig® as an alternative non-rodent species for immunogenicity testing: a demonstrator study using the IL-1 receptor antagonist anakinra

scientific article published on 07 November 2012

The accuracy of extended histopathology to detect immunotoxic chemicals

journal article published in 2004

The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat.

scientific article published on 2 February 2008

The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab

scientific article published on 5 June 2013

The respiratory allergen glutaraldehyde in the local lymph node assay: sensitization by skin exposure, but not by inhalation

scientific article published on 07 October 2010

The respiratory local lymph node assay as a tool to study respiratory sensitizers

scientific article published on 23 September 2008

The role of oxidative metabolism in hexachlorobenzene-induced porphyria and thyroid hormone homeostasis: a comparison with pentachlorobenzene in a 13-week feeding study

scientific article published in April 1993

The transferability from rat subacute 4-week oral toxicity study to translational research exemplified by two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties.

scientific article published on 28 March 2015

Thymic microenvironment at the light microscopic level

scientific article published on 01 August 1997

Transmaternal bisphenol A exposure accelerates diabetes type 1 development in NOD mice

scientific article published on 4 November 2013

Ultrastructure of free nerve endings in respiratory and squamous epithelium on the rat nasal septum

scientific article published on November 1993

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