List of works - David L. Wiest

A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly.

scientific article published in January 1998

A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice

scientific article published in March 2008

A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes

scientific article published on 25 January 2013

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

scientific journal article

Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint

scientific journal article

Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement

scientific article published on 01 October 1998

Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts

scientific article published on 7 October 2015

Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development

scientific article

Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage

scientific article published in May 2005

Branching out to gain control: how the pre-TCR is linked to multiple functions

scientific article

Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

scientific article published in November 2007

Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs

scientific article published on February 2013

Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery

scientific article published on 24 April 2007

Cutting Edge: Intrinsic Programming of Thymic γδT Cells for Specific Peripheral Tissue Localization ⬇️

scientific article published on November 10, 2010

Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

scientific article

Development of γδ T Cells, the Special-Force Soldiers of the Immune System.

scientific article published on January 2016

Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors

scientific article published on 20 June 2011

Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.

scientific article

Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.

scientific article published on 15 January 2009

Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B.

scientific article published on 10 November 2017

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

scientific article published on December 1999

Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength

scientific article published on 24 July 2014

Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity

scientific article published on 16 July 2018

Identification of the last cog in a ligand-independent signaling machine?

scientific article published in May 2009

In vitro functional correction of the mutation responsible for murine severe combined immune deficiency by small fragment homologous replacement.

scientific article

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

scientific article

Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent

scientific article published on October 2009

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

article

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish

scientific article published on 10 July 2015

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

scientific article published on 18 July 2016

Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates

scientific article published on 28 November 2014

Origins of gammadeltaT cells: a forum for opposing perspectives

scientific article published on 14 May 2010

Origins of γδ T cell effector subsets: a riddle wrapped in an enigma

scientific article

RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance

scientific article published on 03 October 2019

Recent advances in understanding the development and function of γδ T cells

scientific article published on 29 April 2020

Recent insights into the signals that control alphabeta/gammadelta-lineage fate.

scientific article

Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice

scientific article published on September 2009

Regulation of lineage commitment distinct from positive selection

scientific article published in November 1999

Reply to Chien: Clarification of the effect of ligand on γδ-TCR repertoire selection

scientific article

Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma

scientific article

Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint

scientific article published on January 2015

Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling.

scientific article published on 3 August 2016

Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

scientific article published on 29 June 2006

Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes ⬇️

scientific article published on March 15, 1993

Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required.

scientific article

Subversion of T lineage commitment by PU.1 in a clonal cell line system

scientific article

T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.

scientific article published on 14 December 2006

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

scientific article published on 01 May 1996

TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes.

scientific article

Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling.

scientific article

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

scientific article published on May 2016

The Ras/MAPK Pathway Is Required for Generation of iNKT Cells ⬇️

scientific article published on May 10, 2011

The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification

scientific article

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1

scientific article

Transcription factors NFAT2 and Egr1 cooperatively regulate the maturation of T-lymphoma in vitro

scientific article

Transmembrane polar residues of TCR beta chain are required for signal transduction

scientific article published in July 1998

Using the Zebrafish Model to Study T Cell Development.

scientific article published on January 2016

List of works by David L. Wiest

A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly.

A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice

A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint

Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement

Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts

Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development

Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage

Branching out to gain control: how the pre-TCR is linked to multiple functions

Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs

Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery

Cutting Edge: Intrinsic Programming of Thymic γδT Cells for Specific Peripheral Tissue Localization ⬇️

Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Development of γδ T Cells, the Special-Force Soldiers of the Immune System.

Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors

Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.

Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.

Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B.

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength

Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity

Identification of the last cog in a ligand-independent signaling machine?

In vitro functional correction of the mutation responsible for murine severe combined immune deficiency by small fragment homologous replacement.

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates

Origins of gammadeltaT cells: a forum for opposing perspectives

Origins of γδ T cell effector subsets: a riddle wrapped in an enigma

RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance

Recent advances in understanding the development and function of γδ T cells

Recent insights into the signals that control alphabeta/gammadelta-lineage fate.

Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice

Regulation of lineage commitment distinct from positive selection

Reply to Chien: Clarification of the effect of ligand on γδ-TCR repertoire selection

Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma

Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint

Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling.

Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes ⬇️

Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required.

Subversion of T lineage commitment by PU.1 in a clonal cell line system

T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes.

Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling.

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

The Ras/MAPK Pathway Is Required for Generation of iNKT Cells ⬇️

The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1

Transcription factors NFAT2 and Egr1 cooperatively regulate the maturation of T-lymphoma in vitro

Transmembrane polar residues of TCR beta chain are required for signal transduction

Using the Zebrafish Model to Study T Cell Development.