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List of works by Richard N Upton

A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption-Part I: Gastrointestinal pH.

scientific article

A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time

scientific article

A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia

scientific article published on December 2010

A physiologically-based recirculatory meta-model for nasal fentanyl in man.

scientific article published on 19 August 2012

A population model of early rheumatoid arthritis disease activity during treatment with methotrexate, sulfasalazine and hydroxychloroquine

scientific article published on May 2015

Altering blood flow does not reveal differences between nitrogen and helium kinetics in brain or in skeletal miracle in sheep

scientific article published on 18 December 2014

An introduction to physiologically-based pharmacokinetic models

scientific article

Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development

scientific article (publication date: September 2012)

Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods.

scientific article published on 17 April 2013

Basic concepts in population modeling, simulation, and model-based drug development: part 3-introduction to pharmacodynamic modeling methods

scientific article published on 2 January 2014

Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model

scientific article published in April 2007

Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep

scientific article published on 29 September 2009

Demonstrating Contribution of Components of Fixed-Dose Drug Combinations Through Longitudinal Exposure-Response Analysis

scientific article published on 27 January 2020

Development and validation of a recirculatory physiological model of the myocardial concentrations of lignocaine after intravenous administration in sheep

scientific article published in February 2000

Development of a physiologically based pharmacokinetic model for intravenous lenalidomide in mice

scientific article published on 06 September 2019

Diffusion-limited tissue equilibration and arteriovenous diffusion shunt describe skeletal muscle nitrous oxide kinetics at high and low blood flows in sheep

scientific article published in July 2001

Effects of Vasopressors on Cerebral Circulation and Oxygenation: A Narrative Review of Pharmacodynamics in Health and Traumatic Brain Injury

scientific article published on 01 January 2020

Estimation of Atenolol Transfer Into Milk and Infant Exposure During Its Use in Lactating Women

scientific article published on 05 June 2018

Food, gastrointestinal pH, and models of oral drug absorption.

scientific article published on 30 November 2016

Genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis

scientific article

Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration.

scientific article published on 14 October 2016

Mechanistic Assessment of the Effect of Omeprazole on the In Vivo Pharmacokinetics of Itraconazole in Healthy Volunteers

scientific article published on 01 April 2019

Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms

scientific article

Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis

scientific article published on 14 August 2019

Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study

scientific article published on 02 March 2020

Pharmacodynamic modelling of placebo and buprenorphine effects on event-related potentials in experimental pain.

scientific article published on 17 March 2014

Pharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model

scientific article published on 30 June 2016

Pharmacokinetic-Pharmacodynamic Modelling of the Analgesic and Antihyperalgesic Effects of Morphine after Intravenous Infusion in Human Volunteers

scientific article published on 17 March 2014

Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model.

scientific article published in May 2008

Pharmacokinetic-pharmacodynamic relationship of bosutinib in patients with chronic phase chronic myeloid leukemia

scientific article

Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.

scientific article published on 8 December 2010

Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery.

scientific article

Pharmacokinetics of fentanyl after subcutaneous administration in volunteers.

scientific article published on March 2010

Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study.

scientific article

Population Pharmacokinetic Model of Doxycycline Plasma Concentrations Using Pooled Study Data

scientific article

Population in vitro-in vivo pharmacokinetic model of first-pass metabolism: itraconazole and hydroxy-itraconazole

scientific article published on 17 November 2017

Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in fed and fasted states

scientific article

Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers

scientific article published on 28 October 2019

Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers

scientific article published on 16 September 2007

Population pharmacokinetics of lenalidomide in patients with B-cell malignancies

scientific article published on 27 February 2019

Reduced intrathoracic blood volume and left and right ventricular dimensions in patients with severe emphysema: an MRI study

scientific article published in April 2007

Response to Physiologically Based Pharmacokinetic Model for Prediction of Leflunomide and Teriflunomide-Should Consideration Be Given to Cannalicular Efflux Transporters?

scientific article

The contribution of the coronary concentrations of propofol to its cardiovascular effects in anesthetized sheep

scientific article published in June 2003

The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity.

scientific article published on 8 July 2014

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations

scientific article published on 29 October 2018

Translational pain research: evaluating analgesic effect in experimental visceral pain models.

scientific article published on January 2009

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