Search filters

List of works by Ramanarayanan Krishnamurthy

2,6-Diamino-5,8-diaza-7,9-dicarba-purine

scientific article published on 01 June 2003

2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations

scientific article published in April 2002

A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids

scientific article published on 12 October 2020

A plausible simultaneous synthesis of amino acids and simple peptides on the primordial Earth.

scientific article published on 25 June 2014

A unified mechanism for abiotic adenine and purine synthesis in formamide

scientific article published on 05 April 2012

An expedient synthesis of L-ribulose and derivatives

scientific article published on 31 January 2011

Anchimeric-Assisted Spontaneous Hydrolysis of Cyanohydrins Under Ambient Conditions: Implications for Cyanide-Initiated Selective Transformations

scientific article

Base-Mediated Cascade Aldol Addition and Fragmentation Reactions of Dihydroxyfumaric Acid and Aromatic Aldehydes: Controlling Chemodivergence via Choice of Base, Solvent, and Substituents

scientific article published on 12 October 2018

Base-pairing properties of a structural isomer of glycerol nucleic acid

scientific article published on 18 April 2013

Base-pairing systems related to TNA containing phosphoramidate linkages: synthesis of building blocks and pairing properties

scientific article published on 01 July 2004

Bis(dimethylamino)phosphorodiamidate: A Reagent for the Regioselective Cyclophosphorylation of cis-Diols Enabling One-Step Access to High-Value Target Cyclophosphates

scientific article published on 30 August 2019

C-Nucleosidations with 2,6-diamino-5,8-diaza-7,9-dicarba-purine

scientific article published on 01 June 2003

Carbohydrate isomer resolution via multi-site derivatization cyclic ion mobility-mass spectrometry

scientific article published on 01 December 2019

Chemical Etiology of Nucleic Acid Structure: Comparing Pentopyranosyl-(2'→4') Oligonucleotides with RNA

scientific article published in Science

Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'-->2') oligonucleotide system

scientific article (publication date: 17 November 2000)

Chemical etiology of nucleic acid structure: the pentulofuranosyl oligonucleotide systems: the (1'→3')-β-L-ribulo, (4'→3')-α-L-xylulo, and (1'→3')-α-L-xylulo nucleic acids

scientific article

Chemistry of Abiotic Nucleotide Synthesis

scientific article published on 09 January 2020

Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems

scientific article published on 10 August 2018

Correction to Role of pKa of Nucleobases in the Origins of Chemical Evolution.

scientific article published on 6 June 2013

Correctionto “Production of Tartrates by Cyanide-Mediated Dimerization of Glyoxylate: A Potential Abiotic Pathway to the Citric Acid Cycle”.

scientific article published on 7 August 2014

Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA

scientific article

Cyclophospholipids Increase Protocellular Stability to Metal Ions

scientific article published on 15 September 2019

Diastereoselective self-condensation of dihydroxyfumaric acid in water: potential route to sugars

scientific article published on 11 July 2011

Effect of temperature modulations on TEMPO-mediated regioselective oxidation of unprotected carbohydrates and nucleosides.

scientific article published on 2 February 2018

Ester-Mediated Amide Bond Formation Driven by Wet-Dry Cycles: A Possible Path to Polypeptides on the Prebiotic Earth.

scientific article

Experimentally investigating the origin of DNA/RNA on early Earth

scientific article published in Nature Communications

Exploratory Experiments on the Chemistry of the “Glyoxylate Scenario”: Formation of Ketosugars from Dihydroxyfumarate

scientific article published on February 10, 2012

Formation of glycolaldehyde phosphate from glycolaldehyde in aqueous solution

scientific article

Geochemical Sources and Availability of Amidophosphates on the Early Earth

scientific article published on 08 May 2019

Giving Rise to Life: Transition from Prebiotic Chemistry to Protobiology

scientific article published in March 2017

Glycosylation of a model proto-RNA nucleobase with non-ribose sugars: implications for the prebiotic synthesis of nucleosides

scientific article published on 8 January 2018

Heterogeneous Pyrophosphate-Linked DNA-Oligonucleotides: Aversion to DNA but Affinity for RNA

scientific article published on 23 April 2018

Hydrogen-Bonding Complexes of 5-Azauracil and Uracil Derivatives in Organic Medium

scientific article published on 7 July 2015

Introduction: Chemical Evolution and the Origins of Life

scientific article published on 01 June 2020

Kinetics of prebiotic depsipeptide formation from the ester-amide exchange reaction.

scientific article published on 3 October 2016

Life's Biological Chemistry: A Destiny or Destination Starting from Prebiotic Chemistry?

scientific article published on 13 August 2018

Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle

scientific article

Mannich-type C-nucleosidations in the 5,8-diaza-7,9-dicarba-purine family

scientific article published on 01 October 2004

Mapping the landscape of potentially primordial informational oligomers: (3'→2')-D-phosphoglyceric acid linked acyclic oligonucleotides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements

scientific article published on 08 March 2011

Mapping the landscape of potentially primordial informational oligomers: oligo-dipeptides tagged with orotic acid derivatives as recognition elements

scientific article published in January 2009

Mapping the landscape of potentially primordial informational oligomers: oligodipeptides and oligodipeptoids tagged with triazines as recognition elements

scientific article published on 01 January 2007

Mapping the landscape of potentially primordial informational oligomers: oligodipeptides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements

scientific article published on 01 January 2007

Microwave-assisted phosphitylation of DNA and RNA nucleosides and their analogs

scientific article

Microwave-assisted preparation of nucleoside-phosphoramidites

scientific article published on 01 July 2014

Mutually stabilizing interactions between proto-peptides and RNA

scientific article published on 19 June 2020

Nanopore Sequencing of an Expanded Genetic Alphabet Reveals High-Fidelity Replication of a Predominantly Hydrophobic Unnatural Base Pair

scientific article published on 27 January 2020

New codons for efficient production of unnatural proteins in a semisynthetic organism

scientific article published on 06 April 2020

Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water

scientific article published on 29 July 2017

Nucleobase modification by an RNA enzyme

scientific article published on February 2017

Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism

scientific article published on 26 June 2019

Organic acid shift reagents for the discrimination of carbohydrate isobars by ion mobility-mass spectrometry

scientific article published on 14 October 2020

Orotidine-Containing RNA: Implications for the Hierarchical Selection (Systems Chemistry Emergence) of RNA.

scientific article published on 14 July 2017

Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions.

scientific article published on 6 November 2017

Prebiotic Phosphorylation of Uridine using Diamidophosphate in Aerosols

scientific article published on 19 September 2019

Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction

scientific article published on 01 April 2019

Production of tartrates by cyanide-mediated dimerization of glyoxylate: a potential abiotic pathway to the citric acid cycle

scientific article published on 30 August 2013

RNA-DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World

scientific article published on 21 September 2016

Rapid resolution of carbohydrate isomers via multi-site derivatization ion mobility-mass spectrometry.

scientific article

Regioselective alpha-Phosphorylation of Aldoses in Aqueous Solution Chemistry of alpha-aminonitriles, Part 29. Part 28: Ref. 1, Part 27: Ref. 2. This work was supported by the Skaggs Foundation. S.G. thanks the NASA NSCORT Exobiology program (La Jol

scientific article published in July 2000

Role of pK(a) of nucleobases in the origins of chemical evolution

scientific article

Small molecule-mediated duplex formation of nucleic acids with 'incompatible' backbones.

scientific article

Spontaneous formation and base pairing of plausible prebiotic nucleotides in water

scientific article (publication date: 25 April 2016)

Spontaneous prebiotic formation of a β-ribofuranoside that self-assembles with a complementary heterocycle

scientific article

Surveying the sequence diversity of model prebiotic peptides by mass spectrometry.

scientific article published on 28 August 2017

Synthesis of 2-Thioorotidine and Comparison of Its Unusual Instability with Its Canonical Pyrimidine Counterparts

scientific article published on 28 October 2019

Synthesis of orotidine by intramolecular nucleosidation.

scientific article published in April 2015

Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid.

scientific article

The -L-Threofuranosyl-(3′→2′)-oligonucleotide System (‘TNA'): Synthesis and Pairing Properties

article

The Oligomerization of Glucose Under Plausible Prebiotic Conditions

scientific article published on 02 December 2019

The origin of RNA and "my grandfather's axe".

scientific article published on April 2013

The role of sugar-backbone heterogeneity and chimeras in the simultaneous emergence of RNA and DNA

scientific article published on 16 September 2019

The structure of a TNA-TNA complex in solution: NMR study of the octamer duplex derived from alpha-(L)-threofuranosyl-(3'-2')-CGAATTCG.

scientific article

Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II

scientific article published on 17 June 2021