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List of works by John R. Huguenard

A call for transparent reporting to optimize the predictive value of preclinical research

scientific article

A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures.

scientific article

A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release

scientific article

A model of spike initiation in neocortical pyramidal neurons

scientific article published in December 1995

A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy

scientific article

A thalamic sleep tonic

scientific article published on September 2006

Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms

scientific article published on January 2003

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction

scientific article published on 30 March 2015

Anatomical and physiological considerations in thalamic rhythm generation ⬇️

scientific article published on January 1, 1998

Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems

scientific article published on 23 August 2018

Assembly of functionally integrated human forebrain spheroids

scientific article published on 26 April 2017

Astrocytes as gatekeepers of GABAB receptor function

scientific article published on November 2010

Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling.

scientific article

Attentional flexibility in the thalamus: now we're getting SOMwhere

scientific article published in January 2015

Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons.

scientific article published in January 2006

Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode

scientific article published on 14 December 2016

Breathing control center neurons that promote arousal in mice

scientific article published on 30 March 2017

Catching a wave.

scientific article published on 11 October 2016

Cholinergic control of gamma power in the midbrain spatial attention network

scientific article

Cholinergic switching within neocortical inhibitory networks

scientific article published in August 1998

Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami.

scientific article published in June 2006

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

scientific article

Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons.

scientific article

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

scientific article published on 04 December 2020

Development of GABA responsiveness in embryonic turtle cortical neurons

scientific article published in July 1988

Differential effects of Na+-K+ ATPase blockade on cortical layer V neurons

scientific article published on 6 September 2010

Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade

scientific article published on August 1990

Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons

scientific journal article

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

scientific article published on 28 January 2019

Distinct electrical and chemical connectivity maps in the thalamic reticular nucleus: potential roles in synchronization and sensation.

scientific article published in August 2006

Early postnatal switch in GABAA receptor α-subunits in the reticular thalamic nucleus

scientific article published on 2 December 2015

Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish.

scientific article

Electrophysiological classification of somatostatin-positive interneurons in mouse sensorimotor cortex

scientific article published on 17 May 2006

Endogenous positive allosteric modulation of GABA(A) receptors by diazepam binding inhibitor

scientific article

Endozepines

scientific article

Enhanced NMDA Receptor-Dependent Thalamic Excitation and Network Oscillations in Stargazer Mice ⬇️

scientific article published on August 8, 2012

Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats.

scientific article published in May 2006

Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia

scientific article

Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target

scientific article

Enhancement of spike-timing precision by autaptic transmission in neocortical inhibitory interneurons

scientific article published in January 2006

Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit

scientific article published on 9 February 2006

Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.

scientific article

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

scientific article published on 25 May 2015

GABA affinity shapes IPSCs in thalamic nuclei.

scientific article

GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex

scientific article

Gamma oscillations are generated locally in an attention-related midbrain network

scientific article published on February 2012

Gamma-aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: a dynamic clamp study.

scientific article published on November 1996

Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus

scientific article

Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation ⬇️

scientific article published on September 11, 2012

Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice

scientific article published on January 2010

Heterogeneous axonal arborizations of rat thalamic reticular neurons in the ventrobasal nucleus

scientific article

Imaging of glutamate in brain slices using FRET sensors

scientific article published on 6 November 2007

Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex

scientific article

Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy

scientific article

Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex.

scientific article

Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons.

scientific article published in April 2006

Intrinsic excitability of cholinergic neurons in the rat parabigeminal nucleus

scientific article published on 26 September 2007

It takes T to tango.

scientific article

Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids

scientific article

Long-term maturation of human cortical organoids matches key early postnatal transitions

scientific article published on 22 February 2021

Low-threshold calcium currents in central nervous system neurons.

scientific article published on January 1996

Low-voltage-activated (T-type) calcium-channel genes identified

article

Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle.

scientific article published on 09 September 2009

Maladaptive myelination promotes generalized epilepsy progression

scientific article published on 02 May 2022

Martinotti cells: community organizers.

scientific article published on March 2011

Mechanism for Hypocretin-mediated sleep-to-wake transitions ⬇️

scientific article published on September 5, 2012

Microcircuits and their interactions in epilepsy: is the focus out of focus?

scientific article

Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy

scientific article published on 27 October 2006

Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors.

scientific article published on January 2014

NPY signaling through Y1 receptors modulates thalamic oscillations

scientific article published on 29 December 2006

Neocortical excitation/inhibition balance in information processing and social dysfunction ⬇️

scientific article (publication date: 27 July 2011)

Neurotransmitter Supply and Demand in Epilepsy.

scientific article published on March 2003

Neurotransmitter control of neocortical neuronal activity and excitability

scientific article published in September 1993

Nonlinear thermodynamic models of voltage-dependent currents

scientific article published in November 2000

Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

scientific article published on 09 September 2020

Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice.

scientific article published on 11 April 2008

Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus ⬇️

scientific article published on August 5, 1997

Optogenetics and epilepsy: past, present and future

scientific article

PKC and polyamine modulation of GluR2-deficient AMPA receptors in immature neocortical pyramidal neurons of the rat.

scientific article published on 22 March 2007

Parallel midbrain microcircuits perform independent temporal transformations.

scientific article

Patch-clamp studies of voltage-gated currents in identified neurons of the rat cerebral cortex.

scientific article

Perspective: Is Cortical Hyperexcitability the Only Path to Generalized Absence Epilepsy?

scientific article published on 14 October 2020

Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons

scientific article published in December 2004

Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures

scientific article published in January 2002

Purinergic inhibition of GABA and glutamate release in the thalamus: implications for thalamic network activity

scientific article published in October 1995

R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy

scientific article published on March 2012

Reciprocal inhibitory connections and network synchrony in the mammalian thalamus

scientific article

Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy.

scientific article

Reemerging role of cable properties in action potential initiation

scientific article published on 25 February 2013

Regulation of Thalamic and Cortical Network Synchrony by Scn8a

scientific article

Reorganization of inhibitory synaptic circuits in rodent chronically injured epileptogenic neocortex.

scientific article

Resilient RTN fast spiking in Kv3.1 null mice suggests redundancy in the action potential repolarization mechanism

scientific article published in March 2002

Resting our cortices by going DOWN to sleep

scientific article published in September 2009

Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation

scientific article published in June 2009

Role of ornithine decarboxylase in cardiac growth and hypertrophy

scientific article published in Science

Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex

scientific article

Seizing upon mechanisms for impaired consciousness.

scientific article

Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat.

scientific article published on 6 May 2006

Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit

scientific article published on December 2008

Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons

scientific article published on 09 November 2018

Sleep and epilepsy: a summary of the 2011 merritt-putnam symposium

scientific article published on January 2013

Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain

scientific article published on 21 January 2014

Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons

scientific article

T-Channel Defects in Patients with Childhood Absence Epilepsy.

scientific article

Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations

scientific article published on November 2016

Thalamic synchrony and dynamic regulation of global forebrain oscillations.

scientific article published on 4 June 2007

The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons

scientific article published on December 2008

Two classes of excitatory synaptic responses in rat thalamic reticular neurons.

scientific article published on 8 June 2016

Who let the spikes out?

scientific article published on August 2009

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