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List of works by Stylianos Michalakis

A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation

scientific article published on 19 August 2020

A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.

scientific article published on 10 December 2010

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

scientific journal article

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting

scientific article

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network

scientific article published on 03 February 2014

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments

scientific article published on 28 July 2016

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects

scientific article published on 24 May 2017

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

scientific article published on 31 August 2017

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy

scientific article published on 12 November 2018

Advancing Gene Therapy for PDE6A Retinitis Pigmentosa

scientific article published on 01 January 2019

Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues

scientific article

Author Response: Possibility of Cytoplasmic Transportation Between Donor-Host Cell Following Photoreceptor Transplantation

scientific article published in October 2016

CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration

scientific article published in March 2012

CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity

scientific article published on 01 August 2011

COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic

scientific article published on 06 May 2020

Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice

scientific article

Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction

scientific article published on 27 December 2012

Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium.

scholarly article

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

scientific article published on 9 September 2015

Cyclic nucleotide-gated channels

scientific article published on January 2009

Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa.

scientific article published in January 2018

Detection of cGMP in the degenerating retina

scientific article published in January 2013

Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial

scientific article published on 01 September 2018

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice

scientific article published in January 2017

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa

scientific article published in January 2017

Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.

scientific article published on 11 May 2017

Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency

scientific article

Function and dysfunction of CNG channels: insights from channelopathies and mouse models

scientific article published on June 2007

Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis

scientific article published on 17 August 2018

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa

scientific article

Gene replacement therapy for retinal CNG channelopathies

scientific article published on 17 July 2013

Gene therapy for achromatopsia.

scientific article published on 17 January 2017

Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia

scientific article published in January 2012

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

scientific article published on January 2014

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

scientific article

Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

scientific article published on 7 December 2017

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure

scientific article published on 25 January 2016

HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path

scientific article published on 10 July 2010

HCN3 contributes to the ventricular action potential waveform in the murine heart

scientific article

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

scientific article published on 17 April 2018

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

scientific article

Hyperpolarization-activated cation channels: from genes to function

scientific article

Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration

scientific article

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1

scientific journal article

Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.

scientific article published in April 2005

In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy

article

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

scientific article (publication date: 2016)

In vivo analysis of cone survival in mice

scientific article

In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.

scientific article published in January 2016

Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes

scientific article published on 19 October 2019

Investigation of the immunogenicity of different types of aggregates of a murine monoclonal antibody in mice

scientific article published on 15 August 2014

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency

scientific article published on 4 October 2012

Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping

scientific journal article

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia

scientific article published on 5 January 2016

Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study

scientific article published on 04 June 2013

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

scientific article published in 2021

Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry

scientific article published on 20 May 2019

Morphological characterization of the retina of the CNGA3(-/-)Rho(-/-) mutant mouse lacking functional cones and rods

scientific article

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

scientific article published on 26 October 2013

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

scientific article published in January 2017

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

scientific article published on 27 December 2019

Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1

scientific article published on 06 April 2020

Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders

scientific article published on 22 February 2021

Optimized Subretinal Injection Technique for Gene Therapy Approaches

article

Optimized technique for subretinal injections in mice

scientific article

Optogenetic Control of Neural Circuits in the Mongolian Gerbil

scientific article

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

scientific article

Patients and animal models of CNGβ1-deficient retinitis pigmentosa support gene augmentation approach

scientific article published on 20 November 2017

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.

scientific article

Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors

scientific article published on 24 June 2014

Photopharmacological control of bipolar cells restores visual function in blind mice

scientific article published on 5 June 2017

Physiological roles of cGMP-gated channels: lessons from mouse models and human channelopathies.

scientific article

Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis

article

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

scientific article published in July 2010

Quantitative LC-MS Provides No Evidence for m6 dA or m4 dC in the Genome of Mouse Embryonic Stem Cells and Tissues

scientific article

Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice.

scientific article published on 15 January 2015

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

scientific article published on 02 July 2021

Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization

scientific article published on 13 January 2016

Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function

scientific article

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy

scientific article published on 7 March 2018

Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications

scientific article

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

scientific article published on 17 July 2015

Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial

scientific article published on 30 April 2020

Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy.

scientific article published on June 2016

Structural and functional phenotyping in the cone-specific photoreceptor function loss 1 (cpfl1) mouse mutant - a model of cone dystrophies

scientific article

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

scientific article published in August 2017

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

scientific article published in November 2017

Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs

scientific article published in 2022

Synaptic plasticity in CNGA3(-/-) mice: cone bipolar cells react on the missing cone input and form ectopic synapses with rods.

scientific article

Synthesis of galactosyl-queuosine and distribution of hypermodified Q-nucleosides in mouse tissues

scientific article published on 11 March 2020

Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization

scientific article published in 2022

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

article

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.

scientific article published on 18 May 2014

The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the <i>Cnga3</i>-Deficient Mouse Model of Achromatopsia

scientific article published on 23 December 2020

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel

scientific article

The cyclic nucleotide-gated ion channel CNGA3 contributes to coolness-induced responses of Grueneberg ganglion neurons

scientific article published on 18 February 2010

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

scientific article published on January 2011

The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides

scientific journal article

The retinitis pigmentosa mutation c.3444+1G>A in CNGB1 results in skipping of exon 32

scientific article

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

scientific article published in 2010

Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).

scientific article published on 4 February 2013

Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia

scientific article published on 8 April 2015

cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function

scientific article published on September 2013

cGMP-dependent cone photoreceptor degeneration in the cpfl1 mouse retina.

scientific article published in September 2010

cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

scientific article

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