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List of works by Alex von Kriegsheim

-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--

scientific article published on 20 May 2021

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells

scientific article published on 04 October 2018

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

scientific article published on 01 July 2018

An Integrated Global Analysis of Compartmentalized HRAS Signaling

scientific article published on 01 March 2019

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein.

scientific article published on 11 April 2018

Asparagine hydroxylation is a reversible post-translational modification

scientific article published on 05 August 2020

BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome

scientific article

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

scientific article published on 27 January 2016

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

scientific article published on 27 December 2017

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.

scientific article published on 15 May 2017

Cell fate decisions are specified by the dynamic ERK interactome

scientific article

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

scientific article published on 13 July 2018

Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.

scientific article published on 9 May 2018

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

scientific article published on 25 April 2024

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

scientific article published on 7 June 2017

Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.

scientific article published on 27 October 2015

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

scientific article published on 26 July 2016

EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

scientific article published on 02 August 2019

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity

scientific article published on 16 September 2013

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

scientific journal article

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

scientific article

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.

scientific article

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus ⬇️

scientific article

HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

scientific article

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

scientific article published on 21 December 2016

Hypoxia Reduces the Pathogenicity of Pseudomonas aeruginosa by Decreasing the Expression of Multiple Virulence Factors.

scientific article published on 25 March 2017

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy

scientific article published on 11 March 2019

Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.

scientific article published in July 2018

In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells.

scientific article published on January 2014

Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species

scientific article published in January 2010

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability

scientific article published on 28 February 2017

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments

scientific article published on 01 November 2012

Mapping of signaling pathways by functional interaction proteomics

scientific article

Mass Spectrometry and Bioinformatic Analysis of Hydroxylation-Dependent Protein-Protein Interactions

scientific article published in January 2018

Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK.

scientific article published on 9 October 2014

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

scientific article published on 13 February 2017

NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.

scientific article published on 25 August 2016

Network-based identification of feedback modules that control RhoA activity and cell migration

scientific article published on 16 March 2015

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

scientific article

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity

scientific article

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.

scientific article

On-beads digestion in conjunction with data-dependent mass spectrometry: a shortcut to quantitative and dynamic interaction proteomics

scientific article

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

scientific article published on 01 July 2018

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins ⬇️

scientific article published on 10 April 2017

Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

scientific article published on 24 July 2020

Phosphatase and feedback regulation of Raf-1 signaling

scientific article published on 9 January 2007

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

scientific article published in October 2017

Potential mechanisms of calcium dependent regulation of the mammalian cell cycle revealed by comprehensive unbiased label-free nLC-MS/MS quantitative proteomics

scientific article

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.

scientific article published on 26 April 2016

Protein-Protein Interaction Detection Via Mass Spectrometry-Based Proteomics

scientific article published on January 2016

Proteomics and phosphoproteomics for the mapping of cellular signalling networks

scientific article

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

scientific article published on 20 April 2021

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

scientific article

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis

scientific article published on 17 September 2021

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

scientific article

Rac1 and RhoA: Networks, loops and bistability

scientific article published on 17 August 2016

Raf family kinases: old dogs have learned new tricks

scientific article

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.

scientific article

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

scientific article published on 21 October 2013

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

scientific journal article

Signalling by protein phosphatases and drug development: a systems-centred view.

scientific article

Signalling mechanisms regulating phenotypic changes in breast cancer cells

scientific article

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

scientific article

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

scientific journal article

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

scientific article published on 12 June 2017

The RNA-bound proteome of MRSA reveals post-transcriptional roles for helix-turn-helix DNA-binding and Rossmann-fold proteins

scientific article published on 24 May 2022

Towards complete analysis of the platelet proteome

scientific article (publication date: March 2002)

Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization.

scientific article published on 12 December 2017

Uncovering Bistability in the Rac1/RhoA Signaling Network Through Integrating Computational Modeling and Experimentation

scientific article published on 01 January 2018

WT1-Associated Protein-Protein Interaction Networks

scientific article published in January 2016

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

scientific article published on 13 June 2018

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