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List of works by Marta Giralt

9-cis Retinoic acid induces the expression of the uncoupling protein-2 gene in brown adipocytes

article

A 48-week study of fat molecular alterations in HIV naive patients starting tenofovir/emtricitabine with lopinavir/ritonavir or efavirenz

scientific article published on August 2014

A Novel Regulatory Pathway of Brown Fat Thermogenesis

scientific article published in Journal of Biological Chemistry

A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction

scientific article published on 21 August 2013

A study of fatty acid binding protein 4 in HIV-1 infection and in combination antiretroviral therapy-related metabolic disturbances and lipodystrophy

scientific article

Adipogenic/Lipid, Inflammatory, and Mitochondrial Parameters in Subcutaneous Adipose Tissue of Untreated HIV-1–Infected Long-Term Nonprogressors

article

Adipokines and the Endocrine Role of Adipose Tissues

scientific article published on 23 April 2015

Adipose tissue biology and HIV-infection.

scientific article published on June 2011

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue

scientific article published on 24 July 2018

Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in β-cells

article

Altered expression of master regulatory genes of adipogenesis in lipomas from patients bearing tRNALys point mutations in mitochondrial DNA

article

Autophagic control of cardiac steatosis through FGF21 in obesity-associated cardiomyopathy

scientific article published on 05 March 2018

Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation

scientific article published on 14 August 2019

Brown Adipokines

scientific article published on 01 January 2019

Brown adipose tissue as a secretory organ.

scientific article published on 12 September 2016

C/EBPβ is required in pregnancy-induced cardiac hypertrophy

scientific article published on 9 October 2015

CCAAT/Enhancer Binding-Proteins α and β Are Transcriptional Activators of the Brown Fat Uncoupling Protein Gene Promoter

article

CCAAT/enhancer-binding proteins alpha and beta in brown adipose tissue: evidence for a tissue-specific pattern of expression during development

scientific article published on September 1994

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

scientific article published on 16 August 2018

Circulating fibroblast growth factor 23 (FGF23) levels are associated with metabolic disturbances and fat distribution but not cardiovascular risk in HIV-infected patients

scientific article published on 19 February 2015

Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta

scientific article published on July 2005

Differential effects of efavirenz and lopinavir/ritonavir on human adipocyte differentiation, gene expression and release of adipokines and pro-inflammatory cytokines

scientific article published on October 2010

Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy

scientific article

Differential regulation of uncoupling protein-2 and uncoupling protein-3 gene expression in brown adipose tissue during development and cold exposure

scientific article published in February 1998

Differentially altered molecular signature of visceral adipose tissue in HIV-1-associated lipodystrophy

scientific article published on October 2013

Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart

scientific article published on 01 October 2012

Dominant negative regulation by c-Jun of transcription of the uncoupling protein-1 gene through a proximal cAMP-regulatory element: a mechanism for repressing basal and norepinephrine-induced expression of the gene before brown adipocyte differentia

scientific article published on July 1998

Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART: A randomized, double-blind, placebo-controlled study

scientific article

Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study

scientific article published on 19 February 2018

Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines.

scientific article published on 17 May 2011

Effects of switching from stavudine to raltegravir on subcutaneous adipose tissue in HIV-infected patients with HIV/HAART-associated lipodystrophy syndrome (HALS). A clinical and molecular study

scientific article

Epitope mapping of mitochondrial adenine nucleotide translocase-1 in idiopathic dilated cardiomyopathy

scientific article published in May 2002

Evidence for a differential physiological modulation of brown fat iodothyronine 5′-deiodinase activity in the perinatal period

scientific article published on 01 October 1988

FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptation

scientific article published on 07 November 2020

FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet- or surgically-induced weight loss

scientific article published on 04 May 2016

FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling

scientific article

Fgf21 is required for cardiac remodeling in pregnancy

scientific article published on 4 May 2017

Fibroblast growth factor 21 in breast milk controls neonatal intestine function.

scientific article

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice.

scientific article published in January 2013

Fibroblast growth factor 21 protects the heart from oxidative stress.

scientific article published on 23 December 2014

Fibroblast growth factor-21 and the beneficial effects of long-chain n-3 polyunsaturated fatty acids

scientific article

Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue

scientific article published on 23 November 2013

Fibroblast growth factor-21, energy balance and obesity

scientific article published on 25 September 2015

Functional Relationship between MyoD and Peroxisome Proliferator-Activated Receptor-Dependent Regulatory Pathways in the Control of the Human Uncoupling Protein-3 Gene Transcription

article

GPR120 controls neonatal brown adipose tissue thermogenic induction

scientific article published on 30 July 2019

Gene expression of leptin and uncoupling proteins: molecular end-points of fetal development

scientific article published in May 2001

Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia

scientific article published in December 2009

HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy

article

HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes

article

HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy.

scientific article

Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

scientific article

High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients

scientific article

Hormonal and nutritional signalling in the control of brown and beige adipose tissue activation and recruitment.

scientific article

Hypertrophied facial fat in an HIV-1-infected patient after autologous transplantation from ‘buffalo hump’ retains a partial brown fat-like molecular signature

article

Identification of tissue-specific protein binding domains in the 5'-proximal regulatory region of the rat mitochondrial brown fat uncoupling protein gene

scientific article

Impact of elvitegravir on human adipocytes: Alterations in differentiation, gene expression and release of adipokines and cytokines.

scientific article published on 20 May 2016

Impaired basal and noradrenaline-induced iodothyronine 5′-deiodinase activity in brown adipose tissue from pregnant and lactating rats

scientific article published on 01 August 1986

Impaired expression of mitochondrial and adipogenic genes in adipose tissue from a patient with acquired partial lipodystrophy (Barraquer-Simons syndrome): a case report

scientific article published on 27 August 2008

Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene

scientific article published in July 2000

Improved adipose tissue function with initiation of protease inhibitor-only ART.

scientific article published on 11 August 2016

In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells

scientific article

In vivo effects of highly active antiretroviral therapies containing the protease inhibitor nelfinavir on mitochondrially driven apoptosis.

scientific article published in January 2005

Inflammation of brown/beige adipose tissues in obesity and metabolic disease

scientific article published on 16 July 2018

Influence of thyroid hormones on the human ATP synthase beta-subunit gene promoter.

scientific article published on January 1996

Inhibition of iodothyronine 5'-deiodinase by iopanoic acid does not block nuclear T3 accumulation during rat fetal development

scientific article

Iodothyronine 5'-deiodinase activity and thyroid hormone content in brown adipose tissue during the breeding cycle of the rat.

scientific article published on October 1988

Iodothyronine 5'-deiodinase activity as an early event of prenatal brown-fat differentiation in bovine development

scientific article published on April 1989

Lactate induces expression and secretion of fibroblast growth factor-21 by muscle cells

scientific article published on 27 April 2018

Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity.

scientific article

Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans

scientific article published on 25 June 2016

Lipoprotein lipase mRNA expression in brown adipose tissue: translational and/or posttranslational events are involved in the modulation of enzyme activity

scientific article published on 01 April 1990

Lithium inhibits brown adipocyte differentiation.

scientific article

Maraviroc reduces cytokine expression and secretion in human adipose cells without altering adipogenic differentiation.

scientific article

Mitochondrial DNA: an up-and-coming actor in white adipose tissue pathophysiology.

scientific article published on 21 May 2009

Mitochondrial Uncoupling and the Regulation of Glucose Homeostasis

scientific article published on 17 February 2016

Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha

scientific journal article

Mitochondrial biogenesis in brown adipose tissue is associated with differential expression of transcription regulatory factors

scientific article published in November 2002

Ontogeny and perinatal modulation of gene expression in rat brown adipose tissue. Unaltered iodothyronine 5'-deiodinase activity is necessary for the response to environmental temperature at birth

article

Ontogeny of thyroid hormone receptors and c-erbA expression during brown adipose tissue development: evidence of fetal acquisition of the mature thyroid status

scientific article published in May 1993

Opposing actions of Fos and Jun on transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. Dominant negative regulation by Fos.

scientific article published on September 1992

Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients

scientific article published on 12 May 2014

Opposite regulation of PPAR-α and -γ gene expression by both their ligands and retinoic acid in brown adipocytes

article

PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle

article

Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis

scientific article published on 13 March 2019

Peroxisome Proliferator-Activated Receptors-α and -γ, and cAMP-Mediated Pathways, Control Retinol-Binding Protein-4 Gene Expression in Brown Adipose Tissue

article

Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.

scientific article published in January 2001

Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.

scientific article published on 27 October 2011

Pharmacological and gene modification-based models for studying the impact of perinatal metabolic disturbances in adult life.

scientific article published on January 2009

Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation

scientific article published in February 2002

Phytanic acid, but not pristanic acid, mediates the positive effects of phytol derivatives on brown adipocyte differentiation.

scientific article

Potential role of the melanocortin signaling system interference in the excess weight gain associated to some antiretroviral drugs in people living with HIV

scientific article published on 20 February 2020

Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBPδ.

scientific article

Quality assessment of human mitochondrial DNA quantification: MITONAUTS, an international multicentre survey

scientific article

Reciprocal effects of antiretroviral drugs used to treat HIV infection on the fibroblast growth factor-21/β-Klotho system

scientific article published on 16 April 2018

Reduced levels of serum FGF19 and impaired expression of receptors for endocrine FGFs in adipose tissue from HIV-infected patients.

scientific article

Regulation of mitochondrial biogenesis in brown adipose tissue: nuclear respiratory factor-2/GA-binding protein is responsible for the transcriptional regulation of the gene for the mitochondrial ATP synthase beta subunit

scientific article published on April 1998

Retinoids and adipose tissues: metabolism, cell differentiation and gene expression

article

Retinoids and retinoid receptors in the control of energy balance: novel pharmacological strategies in obesity and diabetes.

scientific article published on March 2004

Reverse transcriptase inhibitors alter uncoupling protein-1 and mitochondrial biogenesis in brown adipocytes.

scientific article published in January 2005

SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.

scientific article published on 24 June 2009

Secretory Proteome of Brown Adipocytes in Response to cAMP-Mediated Thermogenic Activation

scientific article published on 07 February 2019

Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients

scientific article published on November 2010

Sirt1 acts in association with PPAR to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

scientific article published on 29 November 2010

Sirt1 mediates the effects of a short-term high-fat diet on the heart

scientific article

TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway

scientific article

The Beneficial Effects of Brown Fat Transplantation: Further Evidence of an Endocrine Role of Brown Adipose Tissue

scientific article published in July 2015

The Lives and Times of Brown Adipokines.

scientific article

The Molecular Signature of HIV-1-Associated Lipomatosis Reveals Differential Involvement of Brown and Beige/Brite Adipocyte Cell Lineages

scientific article published on 25 August 2015

The chemokine CXCL14 is negatively associated with obesity and concomitant type-2 diabetes in humans

scientific article published on 07 January 2021

The chlorophyll-derived metabolite phytanic acid induces white adipocyte differentiation

scientific article published on 01 September 2002

The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism

scientific article published on 3 June 2004

The importance of brown adipose tissue

scientific article published on 01 July 2009

The kallikrein-kinin pathway as a mechanism for auto-control of brown adipose tissue activity

scientific article published on 01 May 2020

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes.

scientific article

Thermogenic activation induces FGF21 expression and release in brown adipose tissue.

scientific article

Thermogenic activation represses autophagy in brown adipose tissue.

scientific article published on 24 June 2016

Thermogenic brown and beige/brite adipogenesis in humans.

scientific article published on 18 September 2014

Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivati

article

Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice

scientific article

Toward an Understanding of How Immune Cells Control Brown and Beige Adipobiology

scientific article published on 01 May 2018

Transcriptional regulation of the uncoupling protein-1 gene.

scientific article

Uncoupling protein 1 gene expression implicates brown adipocytes in highly active antiretroviral therapy-associated lipomatosis.

scientific article published in April 2004

Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production.

scientific article published on April 2007

Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids

scientific article published in June 1999

Upregulatory mechanisms compensate for mitochondrial DNA depletion in asymptomatic individuals receiving stavudine plus didanosine

scientific article published in December 2004

Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome

scientific article

White, brown, beige/brite: different adipose cells for different functions?

scientific article published on 19 June 2013

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