List of works - Leonid Breydo

A putative role of the Sup35p C-terminal domain in the cytoskeleton organization during yeast mitosis

scientific article published on 19 February 2014

Activation of leinamycin by thiols: a theoretical study

scientific article published in December 2002

Agrochemicals, α-Synuclein, and Parkinson’s Disease ⬇️

scientific article published on August 30, 2012

Annealing prion protein amyloid fibrils at high temperature results in extension of a proteinase K-resistant core

scientific article published on 28 November 2005

Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide

scientific article published on 15 July 2009

Catalytically active alkaline molten globular enzyme: Effect of pH and temperature on the structural integrity of 5-aminolevulinate synthase

scientific article

Chemoenzymatic synthesis of HIV-1 V3 glycopeptides carrying two N-glycans and effects of glycosylation on the peptide domain

scientific article

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

scientific article published on 13 December 2010

Converting the prion protein: what makes the protein infectious.

scientific article published on 25 July 2006

Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils.

scientific article

DNA alkylation by leinamycin can be triggered by cyanide and phosphines

scientific article published in June 2001

Dichotomous versus palm-type mechanisms of lateral assembly of amyloid fibrils

scientific article published in June 2006

Effects of Polymer Hydrophobicity on Protein Structure and Aggregation Kinetics in Crowded Milieu.

scientific article

Effects of osmolytes on protein-solvent interactions in crowded environment: Analyzing the effect of TMAO on proteins in crowded solutions.

scientific article

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

scientific article

Hemicentin assembly in the extracellular matrix is mediated by distinct structural modules

scientific article published on 23 June 2006

High throughput characterization of structural differences between closely related proteins in solution

scientific article published on 19 November 2012

Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.

scientific article

In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc).

scientific article published on 19 December 2004

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

scientific article published on 27 May 2014

Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine

scientific article published on 16 April 2015

Mechanistic and structural analysis of Drosophila melanogaster arylalkylamine N-acetyltransferases

scientific article

Mechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax

scientific article published on 14 December 2015

Methionine oxidation interferes with conversion of the prion protein into the fibrillar proteinase K-resistant conformation

scientific article

Methods for conversion of prion protein into amyloid fibrils

scientific article published in January 2008

Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

scientific article

Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.

scientific article published on 18 October 2011

Nonpolar substitution at the C-terminus of the prion protein, a mimic of the glycosylphosphatidylinositol anchor, partially impairs amyloid fibril formation

scientific article

Polymorphism and ultrastructural organization of prion protein amyloid fibrils: an insight from high resolution atomic force microscopy

scientific article published on 20 February 2006

Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations

scientific article published on 2 April 2015

Role of monomer arrangement in the amyloid self-assembly

scientific article published on 24 December 2014

Role of solvent properties of aqueous media in macromolecular crowding effects

scientific article published on 26 February 2015

Semiautomated cell-free conversion of prion protein: applications for high-throughput screening of potential antiprion drugs

scientific article

Site-specific conformational studies of prion protein (PrP) amyloid fibrils revealed two cooperative folding domains within amyloid structure

scientific article published on 23 January 2007

Solvent interaction analysis of intrinsically disordered proteins in aqueous two-phase systems

scientific article published on 27 September 2013

Strain phenomenon in protein aggregation: Interplay between sequence and conformation

scientific article published on January 2013

Structural differences between amyloid beta oligomers

scientific article published on 27 June 2016

Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob Disease

scientific article published on 31 March 2005

Targeting the Chameleon: a Focused Look at α-Synuclein and Its Roles in Neurodegeneration ⬇️

scientific article published on September 1, 2012

The crowd you're in with: effects of different types of crowding agents on protein aggregation.

scientific article

The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product

scientific article

The presence of valine at residue 129 in human prion protein accelerates amyloid formation.

scientific article published on 8 April 2005

Thiol-dependent DNA cleavage by 3H-1,2-benzodithiol-3-one 1,1-dioxide

scientific article published on 01 May 2000

Thiol-independent DNA alkylation by leinamycin

scientific article published in March 2001

Two (E,E)- and (Z,E)-thiazol-5-ylpenta-2,4-dienones

scientific article published on 12 July 2002

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.

scientific article published on 6 August 2012

Α-synuclein misfolding and Parkinson's disease

scientific article published on 12 October 2011

List of works by Leonid Breydo

A putative role of the Sup35p C-terminal domain in the cytoskeleton organization during yeast mitosis

Activation of leinamycin by thiols: a theoretical study

Agrochemicals, α-Synuclein, and Parkinson’s Disease ⬇️

Annealing prion protein amyloid fibrils at high temperature results in extension of a proteinase K-resistant core

Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide

Catalytically active alkaline molten globular enzyme: Effect of pH and temperature on the structural integrity of 5-aminolevulinate synthase

Chemoenzymatic synthesis of HIV-1 V3 glycopeptides carrying two N-glycans and effects of glycosylation on the peptide domain

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

Converting the prion protein: what makes the protein infectious.

Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils.

DNA alkylation by leinamycin can be triggered by cyanide and phosphines

Dichotomous versus palm-type mechanisms of lateral assembly of amyloid fibrils

Effects of Polymer Hydrophobicity on Protein Structure and Aggregation Kinetics in Crowded Milieu.

Effects of osmolytes on protein-solvent interactions in crowded environment: Analyzing the effect of TMAO on proteins in crowded solutions.

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Hemicentin assembly in the extracellular matrix is mediated by distinct structural modules

High throughput characterization of structural differences between closely related proteins in solution

Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.

In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc).

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine

Mechanistic and structural analysis of Drosophila melanogaster arylalkylamine N-acetyltransferases

Mechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax

Methionine oxidation interferes with conversion of the prion protein into the fibrillar proteinase K-resistant conformation

Methods for conversion of prion protein into amyloid fibrils

Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.

Nonpolar substitution at the C-terminus of the prion protein, a mimic of the glycosylphosphatidylinositol anchor, partially impairs amyloid fibril formation

Polymorphism and ultrastructural organization of prion protein amyloid fibrils: an insight from high resolution atomic force microscopy

Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations

Role of monomer arrangement in the amyloid self-assembly

Role of solvent properties of aqueous media in macromolecular crowding effects

Semiautomated cell-free conversion of prion protein: applications for high-throughput screening of potential antiprion drugs

Site-specific conformational studies of prion protein (PrP) amyloid fibrils revealed two cooperative folding domains within amyloid structure

Solvent interaction analysis of intrinsically disordered proteins in aqueous two-phase systems

Strain phenomenon in protein aggregation: Interplay between sequence and conformation

Structural differences between amyloid beta oligomers

Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob Disease

Targeting the Chameleon: a Focused Look at α-Synuclein and Its Roles in Neurodegeneration ⬇️

The crowd you're in with: effects of different types of crowding agents on protein aggregation.

The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product

The presence of valine at residue 129 in human prion protein accelerates amyloid formation.

Thiol-dependent DNA cleavage by 3H-1,2-benzodithiol-3-one 1,1-dioxide

Thiol-independent DNA alkylation by leinamycin

Two (E,E)- and (Z,E)-thiazol-5-ylpenta-2,4-dienones

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.

Α-synuclein misfolding and Parkinson's disease