List of works by Jonathan M. Irish

Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells

scientific article published on 11 July 2006

Altered BCR and CD40 signalling are associated with clinical outcome in small lymphocytic lymphoma/chronic lymphocytic leukaemia and marginal zone lymphoma patients

scientific article published on 09 October 2012

Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications

scientific article published on March 2004

B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression

scientific article

BRAF and MEK inhibitor therapy eliminates nestin expressing melanoma cells in human tumors.

scientific article

Beyond the age of cellular discovery.

scientific article published in December 2014

Beyond the message: advantages of snapshot proteomics with single-cell mass cytometry in solid tumors

scientific article published on 07 January 2019

CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation

scientific article published on 20 August 2020

Characterization of patient specific signaling via augmentation of Bayesian networks with disease and patient state nodes

scientific article published on January 2009

Characterizing Phenotypes and Signaling Networks of Single Human Cells by Mass Cytometry.

scientific article published on January 2015

Characterizing cell subsets using marker enrichment modeling

scientific article

Computational immune monitoring reveals abnormal double negative T cells present across human tumor types

scientific article published on 09 November 2018

Correction: Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity

scientific article published on 01 March 2019

Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells

scientific article

Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo

scientific article published on 29 August 2016

Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo.

scientific article

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

scientific article published on 8 June 2016

Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics ⬇️

scientific article published on 2 January 2018

Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling

scientific article

Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53

scientific article published on 14 November 2006

Generating Quantitative Cell Identity Labels with Marker Enrichment Modeling (MEM).

scientific article published on 18 January 2018

Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies

scientific article published on 13 February 2018

Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma

scientific article published on 7 January 2013

High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells.

scientific article published on 7 January 2013

High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy

scientific article

High-Dimensional Data Analysis Algorithms Yield Comparable Results for Mass Cytometry and Spectral Flow Cytometry Data

scientific article published on 15 April 2020

High-dimensional single-cell cancer biology

scientific article

Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response

scientific article published on 05 March 2019

Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks

scientific article

In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment.

scientific article published on December 2015

Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data

scientific article

K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

scientific article published on 27 December 2006

Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry

scientific journal article

Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis

scientific article published on 25 March 2019

Machine learning reveals chronic graft--host disease phenotypes and stratifies survival after stem cell transplant for hematologic malignancies

scholarly article by Jocelyn S Gandelman et al published January 2019 in Haematologica

Mapping normal and cancer cell signalling networks: towards single-cell proteomics

scientific article

Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations

scientific article published on 9 December 2016

Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow.

scientific article published on 11 April 2017

Mass cytometry defines distinct immune profile in germinal center B-cell lymphomas

scientific article published on 09 January 2020

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.

scientific article

Methods for discovery and characterization of cell subsets in high dimensional mass cytometry data

scientific article

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma

scientific article

Multiparameter analysis of stimulated human peripheral blood mononuclear cells: A comparison of mass and fluorescence cytometry.

scientific article published on 24 November 2015

Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation

scientific article

Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy

scientific article published on 10 March 2016

NetworkPainter: dynamic intracellular pathway animation in Cytobank

scientific article

Nonclassical Monocytes Are Prone to Migrate Into Tumor in Diffuse Large B-Cell Lymphoma

scientific article published on 16 December 2021

Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity.

scientific article published on 08 December 2016

Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma

scientific article

Picturing Polarized Myeloid Phagocytes and Regulatory Cells by Mass Cytometry

scientific article published on 01 January 2019

Potentiated phospho-protein networks in cancer cells

Preparing Viable Single Cells from Human Tissue and Tumors for Cytomic Analysis

scientific article published on 3 April 2017

Regulatory myeloid cells: an underexplored continent in B-cell lymphomas

scientific article

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line.

scientific article published on March 2002

Single Cell Analysis of Human Tissues and Solid Tumors with Mass Cytometry

scientific article published on 18 July 2017

Single cell analysis of human tissues and solid tumors with mass cytometry.

scientific article published on 6 September 2016

Single cell profiling of potentiated phospho-protein networks in cancer cells.

scientific article

Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates

scientific article published on October 2008

Systems Immunology Analyses of <i>STAT1</i> Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1

scientific article published in 2022

Systems immune monitoring in cancer therapy.

scientific article published on 4 May 2016

T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling

scientific article published on 7 December 2017

Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation

scientific article published on 08 February 2021

The use of fluorescently-tagged apoptolidins in cellular uptake and response studies

scientific article

Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion

scientific article published on 29 July 2009

Training Novices in Generation and Analysis of High-Dimensional Human Cell Phospho-Flow Cytometry Data

scientific article published on 01 March 2020

Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy

scientific article published on 01 August 2020

Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells

scientific article published on 23 June 2020

Web-based analysis and publication of flow cytometry experiments

scientific article

WebFlow: a software package for high-throughput analysis of flow cytometry data

scientific article

Paulina is supported by:

About Paulina

Help