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List of works by Cleo Kontoravdi

A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus

scientific article published on 28 September 2011

A framework for the systematic design of fed-batch strategies in mammalian cell culture.

scientific article

A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

scientific article published on 20 April 2015

A systems biology approach to optimising hosts for industrial protein production.

scientific article published on 27 July 2013

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

scientific article published on 10 October 2014

An experimental approach probing the conformational transitions and energy landscape of antibodies: a glimmer of hope for reviving lost therapeutic candidates using ionic liquid

scientific article published on 22 June 2021

An optimized method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells

scientific article published on 11 September 2013

Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach

scientific article published on 29 November 2013

Analysis of the landscape of biologically-derived pharmaceuticals in Europe: dominant production systems, molecule types on the rise and approval trends.

scientific article published on 20 December 2012

Application of global sensitivity analysis to determine goals for design of experiments: an example study on antibody-producing cell cultures

scientific article published in July 2005

Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition

scientific article

Comparative analysis of amino acid metabolism and transport in CHO variants with different levels of productivity.

scientific article published on 20 September 2013

Development and design of bio-pharmaceutical processes

scientific article published in November 2013

Dynamic profiling of amino acid transport and metabolism in Chinese hamster ovary cell culture

scientific article published on 4 December 2013

Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation

scientific article

Genetically-encoded biosensors for monitoring cellular stress in bioprocessing.

scientific article

Genome-based kinetic modeling of cytosolic glucose metabolism in industrially relevant cell lines: Saccharomyces cerevisiae and Chinese hamster ovary cells.

scientific article published in August 2012

Global sensitivity analysis and meta-modeling of an ethanol production process

scientific article published in July 2014

Host cell protein removal from biopharmaceutical preparations: Towards the implementation of quality by design

scientific article published in July 2018

How does mild hypothermia affect monoclonal antibody glycosylation?

scientific article published on 17 April 2015

In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture

scientific article published on April 3, 2012

Metabolic characterization and modeling of fermentation process of an engineered Geobacillus thermoglucosidasius strain for bioethanol production with gas stripping

scientific article published in January 2015

Metabolic network reconstruction: advances in in silico interpretation of analytical information

scientific article published on November 24, 2011

Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia.

scientific article published on 21 November 2016

Model-based optimization of antibody galactosylation in CHO cell culture

scientific article published on 21 March 2019

Modeling amino acid metabolism in mammalian cells-toward the development of a model library

scientific article

Quantification of intracellular nucleotide sugars and formulation of a mathematical model for prediction of their metabolism

scientific article published on November 22, 2011

Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand

scientific article published on 23 December 2020

Systematic methodology for the development of mathematical models for biological processes

scientific article published in January 2013

The role of ER stress-induced apoptosis in neurodegeneration.

scientific article published on March 2012

Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation

scientific article

Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns

scientific article