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List of works by Henrik Franzyk

19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR

scientific article published on 18 March 2019

A 9-Hydroxyiridoid Isolated from Junellia seriphioides (Verbenaceae)

scientific article published on 01 March 2000

A High-Throughput Approach To Identify Compounds That Impair Envelope Integrity in Escherichia coli

scientific article

A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues

scientific article published in January 2003

Adaptive evolution of Escherichia coli to an α-peptide/β-peptoid peptidomimetic induces stable resistance

scientific article

Adjuvants Based on Synthetic Mycobacterial Cord Factor Analogues: Biophysical Properties of Neat Glycolipids and Nanoself-Assemblies with DDA.

scientific article published on 12 May 2017

Alpha-peptide/beta-peptoid chimeras

scientific article published on 13 March 2007

Alternating Cationic-Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity

scientific article published on 07 October 2020

Aminolysis of Resin-BoundN-Nosylaziridine-2-carboxylic Acids

scientific article published in July 2006

An Amphipathic Undecapeptide with All d-Amino Acids Shows Promising Activity against Colistin-Resistant Strains of Acinetobacter baumannii and a Dual Mode of Action.

scientific article published on 16 November 2015

Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization.

scientific article published on January 2017

Antibacterial Peptide Nucleic Acid-Antimicrobial Peptide (PNA-AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis.

scientific article

Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

scientific article published on 20 February 2020

Antifungal properties of peptidomimetics with an arginine-[β-(2,5,7-tri-tert-butylindol-3-yl)alanine]-arginine motif against Saccharomyces cerevisiae and Zygosaccharomyces bailii.

scientific article published on 10 March 2015

Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Isolated From Cystic Fibrosis Patients

scientific article published on 20 February 2019

Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones.

scientific article published on 9 August 2012

Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure

scientific article published on 17 October 2012

Antimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs

scientific article published on 01 July 2010

Antiplasmodial and Prehemolytic Activities of α-Peptide–β-Peptoid Chimeras

scientific article published on 01 October 2007

Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery

scientific article published on 09 January 2019

Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists

scientific article published on October 2010

Bacterial membrane activity of α-peptide/β-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains

scientific article

Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic

scientific article published on 29 March 2018

Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

scientific article

Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections

scientific article

Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides

scientific article

Characterization of a proteolytically stable multifunctional host defense peptidomimetic

scientific article published on 10 October 2013

Chemotaxonomy and evolution of Plantago L

article

Chemotaxonomy of Plantago. Iridoid glucosides and caffeoyl phenylethanoid glycosides.

scientific article

Chemotaxonomy of the Oleaceae: iridoids as taxonomic markers.

scientific article

Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists.

scientific article

Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration

article

Conjugation of cell-penetrating peptides to parathyroid hormone affects its structure, potency, and transepithelial permeation

scientific article published on 4 March 2015

Conserved Molecular Superlattices in a Series of Homologous Synthetic Mycobacterial Cell-Wall Lipids Forming Interdigitated Bilayers.

scientific article published on 22 November 2016

Constrained glycopeptide ligands for MPRs. Limitations of unprotected phosphorylated building blocks

scientific article published on 01 January 1997

Conversion of the iridoid glucoside antirrhinoside into 3-azabicyclo[3.3.0]octane building blocks

scientific article published on 01 May 2000

Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL.

scientific article published on 26 September 2014

Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts

scientific article published in March 2002

Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System

scientific article published on 10 December 2015

Dopaol 2-keto- and 2,3-diketoglycosides from Chelone obliqua

scientific article

End group modification: Efficient tool for improving activity of antimicrobial peptide analogues towards Gram-positive bacteria

scientific article published on 23 January 2015

Engineering of small interfering RNA-loaded lipidoid-poly(DL-Lactic-Co-Glycolic Acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach

scientific article

Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues

scientific article published in January 2004

Expedient protocol for solid-phase synthesis of secondary and tertiary amines

scientific article published on 01 June 2004

Expedite protocol for construction of chiral regioselectively N-protected monosubstituted piperazine, 1,4-diazepane, and 1,4-diazocane building blocks.

scientific article

Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimide-Thioether Linkage

scientific article published on 01 January 2020

Fluorescent Analogues of Human α-Calcitonin Gene-Related Peptide with Potent Vasodilator Activity

scientific article published on 17 February 2020

Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius

scientific article published on 02 July 2018

Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability

scientific article published on 14 September 2017

Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction.

scientific article

Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis

scientific article published on 01 January 2020

Glycopeptide mimics of mammalian Man9GlcNAc2. Ligand binding to mannan-binding proteins (MBPs).

scientific article published on November 1996

Halohydrins and polyols derived from antirrhinoside: structural revisions of muralioside and epimuralioside

scientific article

High in vitro antimicrobial activity of β-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis

scientific article

High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from

scientific article published on 17 July 2018

Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin

scientific article published on 27 March 2015

Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures

article

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

scientific article published on 02 August 2019

Iminolactones as tools for inversion of the absolute configuration of α-amino acids and as inhibitors of cancer cell proliferation

scientific article

Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein

article

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design.

scientific article

Improved in vitro evaluation of novel antimicrobials: potential synergy between human plasma and antibacterial peptidomimetics, AMPs and antibiotics against human pathogenic bacteria

scientific article published on 21 October 2015

Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo

scientific article

Influence of trehalose 6,6'-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes

scientific article published on 11 November 2014

Interaction of Peptidomimetics with Bilayer Membranes: Biophysical Characterization and Cellular Uptake

scientific article published on 07 March 2012

Iridoid glucosides from Myxopyrum smilacifolium.

scientific article published in May 2001

Iridoid glycoside biosynthesis in Penstemon secundiflorus. Another H-5, H-9 trans-iridoid glycoside

scientific article published on 01 November 1998

Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists

scientific article published in May 2018

Lipidated α-peptide/β-peptoid hybrids with potent anti-inflammatory activity.

scientific article published on 29 December 2014

Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

scientific article published on 11 June 2019

Lysine-Based α-Peptide/β-Peptoid Peptidomimetics: Influence of Hydrophobicity, Fluorination, and Distribution of Cationic Charge on Antimicrobial Activity and Cytotoxicity

scientific article published on 4 January 2017

Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling

scientific article published on 11 January 2019

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

scientific article published on 06 August 2019

Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: Effects of hydrogen bonding and α-chirality in the β-peptoid residues

scientific article published on 16 May 2012

Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines

scientific article published on 01 April 2008

Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae

scientific article published on 10 February 2019

Nano-Self-Assemblies Based on Synthetic Analogues of Mycobacterial Monomycoloyl Glycerol and DDA: Supramolecular Structure and Adjuvant Efficacy

scientific article published on 05 July 2016

Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells

scientific article

Naravelia zeylanica [corrected] occurrence of primary benzamides in flowering plants.

scientific article published in April 2005

Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position

scientific article published on 13 August 2020

On-resin N-formylation of peptides: a head-to-head comparison of reagents in solid-phase synthesis of ligands for formyl peptide receptors

scientific article

Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation

scientific article

Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity

scientific article published on 04 December 2019

Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency

scientific article published on 24 June 2019

Phorbol Rearrangements

scientific article published on 14 September 2018

Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

scientific article published on 15 June 2018

Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy

scientific article published in November 2006

Quantification of pharmaceutical peptides using selenium as an elemental detection label

scientific article published on 01 September 2014

Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics

scientific article published on 02 July 2019

Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators

scientific article published on 14 November 2018

Reversal of ABCG2/BCRP-Mediated Multidrug Resistance by 5,3',5'-Trihydroxy-3,6,7,4'-Tetramethoxyflavone Isolated from the Australian Desert Plant Chinnock

scientific article published in 2021

Selectively N-protected enantiopure 2,5-disubstituted piperazines: avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations

scientific article

Selectivity in the potentiation of antibacterial activity of α-peptide/β-peptoid peptidomimetics and antimicrobial peptides by human blood plasma.

scientific article published on 27 August 2013

Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

scientific article published on 01 April 2005

Soft hydrogels interpenetrating silicone--A polymer network for drug-releasing medical devices

scientific article published on 17 April 2015

Solid-phase peptide synthesis and circular dichroism study of chiral beta-peptoid homooligomers

scientific article published on 23 May 2007

Solid-phase polyamine synthesis using piperazine and piperidine building blocks

scientific article published on 01 October 2003

Solid-phase route to Fmoc-protected cationic amino acid building blocks

scientific article published on 23 February 2012

Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers.

scientific article published in September 2004

Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

scientific article published on 24 May 2018

Studies on acid stability and solid-phase block synthesis of peptide-peptoid hybrids: ligands for formyl peptide receptors

scientific article published on 28 September 2018

Studies towards improved cell-penetrating peptide-promoted macromolecular drug delivery

scholarly article by Jacob A.D. Clausen et al published December 2010 in Drug Discovery Today

Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro

scientific article published on 10 November 2015

Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices

scientific article published on 28 May 2015

Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A.

scientific article

Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli.

scientific article

The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2 Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase

scientific article published on 15 July 2016

The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics

scientific article published on 01 January 2018

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions

scientific article

The effects of conformational constraints in the polyamine moiety of philanthotoxins on AMPAR inhibition

scientific article published on 8 July 2014

The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse neutrophils

scientific article published on 7 September 2016

The proteolytically stable peptidomimetic Pam-(Lys-βNSpe)6-NH2 selectively inhibits human neutrophil activation via formyl peptide receptor 2.

scientific article

The supramolecular structure is decisive for the immunostimulatory properties of synthetic analogues of a mycobacterial lipid in vitro

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo

scientific article published on June 2016

Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers

scientific article published on 01 March 2006

UV-Guided isolation of verrucines A and B, novel quinazolines from penicillium verrucosum structurally related to anacine from penicilliumaurantiogriseum

scientific article published on 01 November 1999

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