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List of works by Aurora Martinez

A Kinetic and Conformational Study on the Interaction of Tetrahydropteridines with Tyrosine Hydroxylase†

scientific article published in November 2000

A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria

scientific article published on 04 December 2019

A dynamic model of long-range conformational adaptations triggered by nucleotide binding in GroEL-GroES.

scientific article published on 6 July 2012

A scavenger receptor B (CD36)-like protein is a potential mediator of intestinal heme absorption in the hematophagous ectoparasite Lepeophtheirus salmonis

scientific article published on 12 March 2019

Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237.

scientific article published in April 2003

Adsorption and bioactivity of tyrosine hydroxylase on gold surfaces and nanoparticles.

scientific article published on November 2010

Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR

scientific article

Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism.

scientific article

Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans

scientific article published on 6 May 2008

Arc is a flexible modular protein capable of reversible self-oligomerization

scientific article

Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif

scientific article published on 11 November 2020

Avidity of onconeural antibodies is of clinical relevance

scientific article published on 4 June 2013

Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability.

scientific article published on 26 January 2017

Biochemical characterization of mutant phenylalanine hydroxylase enzymes and correlation with clinical presentation in hyperphenylalaninaemic patients

scientific article

Blood phenylalanine reduction corrects CNS dopamine and serotonin deficiencies and partially improves behavioral performance in adult phenylketonuric mice

scientific article published on 19 October 2017

Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low s

scientific article

Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.

scientific article

Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR

scientific article published on 29 June 1993

Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity.

scientific article

Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations

scientific article

Conformational stability and activity analysis of two hydroxymethylbilane synthase mutants, K132N and V215E, with different phenotypic association with acute intermittent porphyria

scientific article published on 8 August 2013

Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia

scientific article published on 24 October 2017

Cooperative homotropic interaction of l-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase

scientific article published in October 1990

Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations

scholarly article

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

scientific article

Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase

scientific article published in April 1997

Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4).

scientific article published on 24 March 2015

DNAJC12 deficiency: A new strategy in the diagnosis of hyperphenylalaninemias

scientific article published on 20 November 2017

Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila

article

Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms

scientific article published on 8 May 2015

Dissection of binding between a phosphorylated tyrosine hydroxylase peptide and 14-3-3zeta: A complex story elucidated by NMR.

scientific article published on November 2014

Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine

scientific article

Domain structure and stability of human phenylalanine hydroxylase inferred from infrared spectroscopy

scientific article published on 30 January 1998

Dynamics, Flexibility and Ligand-Induced Conformational Changes in Biological Macromolecules: A Computational Approach ⬇️

scientific article published on December 1, 2011

Dynamics, flexibility, and allostery in molecular chaperonins

scientific article

EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors

scientific article published in June 1991

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

scientific article published on 07 January 2019

Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases

scientific article published on 01 January 2019

Effect of mutations at Cys237 on the activation state and activity of human phenylalanine hydroxylase

scientific article published on 2 June 1997

Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice

scientific article published on 30 August 2017

Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2.

scientific article published on 18 May 2010

Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets.

scientific article

Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

scientific article published on 25 May 2006

Evidence for a functionally important histidine residue in human tyrosine hydroxylase

scientific article published in 1995

Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris

scientific article

Formation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases.

scientific article

Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in Dopa-responsive dystonia

scientific article published on 3 June 2014

G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury

scientific article published on 17 February 2020

HAMLET Forms Annular Oligomers When Deposited with Phospholipid Monolayers ⬇️

scientific article published on February 16, 2012

HAMLET interacts with lipid membranes and perturbs their structure and integrity

scientific article

Identification of a novel lytic peptide for the treatment of solid tumours.

scientific article

Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

scientific article published on August 2008

Inactivation of purified phenylalanine hydroxylase by dithiothreitol

scientific article published in January 1992

Iron binding effects on the kinetic stability and unfolding energetics of a thermophilic phenylalanine hydroxylase from Chloroflexus aurantiacus

scientific article published on 20 January 2009

L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study.

scientific article

Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics

scholarly article

Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuria

scientific article

Long Noncoding RNA SChLAP1 Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling

scientific article published on 06 September 2019

Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations

scientific article published in November 2004

Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins

scientific article published on 20 November 2013

Overview of computational methods employed in early-stage drug discovery.

scientific article

Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria.

scientific article

Pathogenic variants of DNAJC12 and evaluation of the encoded co-chaperone as a genetic modifier of hyperphenylalaninemia

scientific article published on 25 April 2020

Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms

scientific article published on 7 March 2016

Pharmacological Chaperoning: A Potential Treatment for PMM2-CDG.

scientific article

Phenylalanine Hydroxylase from Legionella pneumophila Is a Thermostable Enzyme with a Major Functional Role in Pyomelanin Synthesis ⬇️

scientific article published on September 26, 2012

Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration

scientific article published on 25 June 2010

Phenylalanine hydroxylase misfolding and pharmacological chaperones.

scientific article

Phenylalanine hydroxylase variants interact with the co-chaperone DNAJC12

scientific article published on 06 February 2019

Phenylalanine hydroxylase: function, structure, and regulation.

scientific article published on 04 March 2013

Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects

scientific article published on 15 August 2002

Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules

scientific article published on 21 June 2017

Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ.

scientific article

Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure.

scientific article

Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases

scientific article published on 2 October 2007

Principal component and normal mode analysis of proteins; a quantitative comparison using the GroEL subunit

scientific article published in January 2011

Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations

scientific article published in June 2003

Purification and characterization of two trypsin-like enzymes from the digestive tract of anchovy Engraulis encrasicholus

scientific article published in January 1988

Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry.

scientific article

Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions

scientific article published in July 1991

Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles

scientific article published on 08 January 2021

Rescue of misfolded proteins and stabilization by small molecules.

scientific article published in January 2010

Rescuing proteins of low kinetic stability by chaperones and natural ligands phenylketonuria, a case study

scientific article published in January 2008

Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials

scientific article published on 4 September 2013

Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase

scientific article published on 27 March 2008

Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases

scientific article

Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo

article

Stabilization of human tyrosine hydroxylase in maltodextrin nanoparticles for delivery to neuronal cells and tissue

scientific article published on 4 January 2018

Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme.

scientific article published on 27 July 2016

Stimulation of hepatic phenylalanine hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice

scientific article

Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability

scientific article

Structural and stability effects of phosphorylation: Localized structural changes in phenylalanine hydroxylase

scientific article published on May 2004

Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophila

scientific article

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

scientific article published on 10 January 2022

Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin

scientific article published on 22 May 2019

Structure/function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme.

scientific article

Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications

scientific article published on 18 May 2010

Surface-Mediated Priming DuringIn VitroGeneration of Monocyte-Derived Dendritic Cells

scientific article published on 23 December 2014

Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity

scientific article published in November 2004

Tetrahydrobiopterin for patients with phenylketonuria

scientific article published in The Lancet

Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: implications for tetrahydrobiopterin-responsive hyperphenylalaninemia

scientific article published in November 2004

Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase

scientific article published on 14 April 2008

Tetrahydrobiopterin treatment reduces brain L-Phe but only partially improves serotonin in hyperphenylalaninemic ENU1/2 mice.

scientific article published on 8 March 2018

The 14-3-3 proteins in regulation of cellular metabolism.

scientific article published on 22 August 2011

The Benefit of Large Neutral Amino Acid Supplementation to a Liberalized Phenylalanine-Restricted Diet in Adult Phenylketonuria Patients: Evidence from Adult Pah-Enu2 Mice

scientific article published on 19 September 2019

The N-Terminal Sequence of Tyrosine Hydroxylase Is a Conformationally Versatile Motif That Binds 14-3-3 Proteins and Membranes

scientific article

The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase

scientific article published on 06 April 2021

The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase.

scientific article published in June 2005

The activity of wild-type and mutant phenylalanine hydroxylase and its regulation by phenylalanine and tetrahydrobiopterin at physiological and pathological concentrations: an isothermal titration calorimetry study

scientific article published on 3 June 2005

The binding of 14-3-3γ to membranes studied by intrinsic fluorescence spectroscopy

scientific article published on 21 March 2011

The binding of tyrosine hydroxylase to negatively charged lipid bilayers involves the N-terminal region of the enzyme

scientific article published in May 2002

The effect of substrate, dihydrobiopterin, and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase

scientific article published on 11 April 2001

The incorporation of divalent metal ions into recombinant human tyrosine hydroxylase apoenzymes studied by intrinsic fluorescence and 1H-NMR spectroscopy

scientific article published in November 1992

The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions

scientific article published on 26 March 2003

The mechanism of BH4-responsive hyperphenylalaninemia-As it occurs in the ENU1/2 genetic mouse model

scientific article published on 2 July 2012

The peripheral binding of 14-3-3γ to membranes involves isoform-specific histidine residues

scientific article

The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum

scientific article published on 16 September 2008

The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation

scientific article

Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase

scientific article published in October 2004

Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes

scientific article

Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity.

scientific article

Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease

scientific article published on 14 December 2016

Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity, as shown by kinetic analyses and surface plasmon resonance detection.

scientific article

alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids

scientific article published on 26 September 2005

pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40

scientific article published on 26 March 1990

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