List of works by Sébastien Wälchli

A Spheroid Killing Assay by CAR T Cells

scientific article published on 12 December 2018

A TCR-based Chimeric Antigen Receptor

scientific article published on 6 September 2017

A catalogue of Ovarian Cancer targets for CAR therapy

scientific article published on 17 June 2020

A practical approach to T-cell receptor cloning and expression

scientific article

A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation

scientific article published on 01 June 2011

Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.

scientific article published on 16 December 2013

Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity

scientific article published on 11 January 2019

Artesunate shows potent anti-tumor activity in B-cell lymphoma

scientific article published on 20 February 2018

Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells

scientific journal article

BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5

scientific article

BiP negatively affects ricin transport

scientific article

Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection

scientific article published on 02 July 2018

Characterization of clathrin and Syk interaction upon Shiga toxin binding

scientific article published on 13 March 2009

Colorectal cysts as a validating tool for CAR therapy

scientific article published on 01 June 2020

Combinatorial CAR design improves target restriction

scientific article published on 24 November 2020

Correction to: Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy

scientific article published on 01 January 2020

Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity.

scientific article published on 16 November 2015

Dendritic cells engineered to express defined allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumour cells.

scientific article published on April 2009

Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling

scientific article

EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol

scientific article

Enhancing Antitumor Immune Responses by Optimized Combinations of Cell-penetrating Peptide-based Vaccines and Adjuvants

scientific article published on 5 July 2016

Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel

scientific article

Gene Editing in B-Lymphoma Cell Lines Using CRISPR/Cas9 Technology

scientific article published on 01 January 2020

Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin.

scientific article

Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism

scientific article published in February 2005

Human c-SRC kinase (CSK) overexpression makes T cells dummy.

scientific article

Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

scientific article

Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants

scientific article published on 01 March 2000

Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation.

scientific article

Long-term surviving cancer patients as a source of therapeutic TCR

scientific article published on 08 January 2020

Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides

scientific article

MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes.

scientific article published on August 2000

NK cells specifically TCR-dressed to kill cancer cells

Next Generation of Adoptive T Cell Therapy Using CRISPR/Cas9 Technology: Universal or Boosted?

scientific article published on 01 January 2020

Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins

scientific article

Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus

scientific article published on 14 April 2008

Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy

scientific article published on 18 June 2019

Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma

article

Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library

scientific article published on 24 October 2003

Protein kinase Cdelta is activated by Shiga toxin and regulates its transport.

scientific article published on 2 April 2007

Protein tyrosine phosphatases as drug targets: PTP1B and beyond

scientific article

Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton

scientific article published on 24 September 2021

Reconstitution of active diphtheria toxin based on a hexahistidine tagged version of the B-fragment produced to high yields in bacteria

scientific article published on 2 November 2005

Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma

scientific article

SNX4 in complex with clathrin and dynein: implications for endosome movement

scientific article

Sap-1/PTPRH activity is regulated by reversible dimerization

scientific article published in June 2005

Shiga toxin regulates its entry in a Syk-dependent manner

scientific article

Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy

scientific article published on 10 April 2019

Soluble T-cell receptors produced in human cells for targeted delivery.

scientific article published on 13 April 2015

Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy

scientific article

Strategies for the design of random siRNA libraries and the selection of anti-GFP siRNAs

scientific article

Sympathetic improvement of cancer vaccine efficacy

scientific article published on 24 January 2020

T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth

scientific article

T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells

scientific article published on 12 August 2011

T-cell receptor therapy (TCR) against melanoma -immunotherapy for the future?

scientific article published on 08 July 2020

T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy

scientific article published on 24 October 2016

TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma

scientific article published on 18 January 2019

Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif

scientific article published on 16 September 2010

Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA

scientific article published on 18 February 2016

Targeting telomerase with an HLA class II-restricted TCR for cancer immunotherapy

scientific article published on 16 November 2020

The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

scientific article

The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking

scientific article

The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity.

scientific article

Transcriptional targeting of small interfering RNAs into cancer cells

scientific article

Transiently redirected T cells for adoptive transfer.

scientific article published on 21 December 2010

Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'.

scientific article

Treating osteosarcoma with CAR T cells

scientific article published on 15 January 2019

Unpredicted phenotypes of two mutants of the TcR DMF5.

scientific article published on 13 June 2015

Vector-based delivery of siRNAs: in vitro and in vivo challenges.

scientific article published on May 2008

beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells

scientific article

β-arrestins attenuate p38-mediated endosome to Golgi transport.

scientific article published on 21 January 2009

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