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List of works by Mitchell R McGill

A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen

scientific article

A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide

scientific article (publication date: 2015)

Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways

scientific article published on 30 January 2019

Acetaminophen-induced Liver Injury: from Animal Models to Humans

scientific article

Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.

scientific article

Animal models of drug-induced liver injury

scientific article published on 03 September 2018

Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.

scientific article published in November 2013

Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

scientific article

Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses

scientific article

Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes

scientific article

Biomarkers of drug-induced liver injury

scientific article published on 06 March 2019

Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation

scientific article published on 13 August 2018

Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro

scientific article published on 7 September 2016

Caveats of using acetaminophen hepatotoxicity models for natural product testing

scientific article published on 04 October 2012

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

scientific article published on 25 August 2013

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

scientific article

Connexin32: a mediator of acetaminophen-induced liver injury?

scientific article published on 07 January 2016

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

scientific article published on 02 June 2020

Critical review of resveratrol in xenobiotic-induced hepatotoxicity.

scientific article

Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products ⬇️

scientific article published on February 4, 2011

Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity

scientific article published on 6 April 2015

Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F₁ Mice

scientific article published on 03 April 2019

Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

scientific article published on 23 October 2016

Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats

scientific article published on 01 January 2019

Erratum to: Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

scientific article published on 27 February 2017

Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity

scientific article published on 15 May 2019

Falsely Elevated Plasma Creatinine Due to an Immunoglobulin M Paraprotein

scientific article published on 22 July 2016

Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients

scientific article

Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children

scientific article published on 01 January 2020

Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study

scientific article published on 16 March 2016

HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity Δσ ⬇️

scientific article published on February 11, 2011

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.

scientific article published on 30 April 2019

Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity

scientific article published on May 2010

Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations

scientific article published on 01 February 2020

Increased C-Reactive Protein in Healthy Controls.

scientific article published in January 2018

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

scientific article

Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

scientific article

Involvement of connexin43 in acetaminophen-induced liver injury.

scientific article

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity

scientific article

Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity

scientific article published on 30 September 2015

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration

scientific article published on 11 March 2018

Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury ⬇️

scientific article published on April 5, 2012

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

scientific article published on 31 December 2015

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.

scientific article

Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.

scientific article

Mechanisms and biomarkers of liver regeneration after drug-induced liver injury

scientific article published on 21 March 2019

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.

scientific article

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

scientific article published on 16 May 2014

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis ⬇️

scientific article published on 06 March 2013

MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.

scientific article published on 20 May 2015

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

scientific article

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.

scientific article published on 22 January 2013

Modulation of O-GlcNAc levels in the liver impacts acetaminophen-induced liver injury by affecting protein adduct formation and glutathione synthesis.

scientific article published on 9 January 2018

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

retracted scientific article

Monoacylglycerol acyltransferase 1 knockdown exacerbates hepatic ischemia-reperfusion injury in mice with hepatic steatosis

scientific article published on 11 September 2020

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.

scientific article published on 15 January 2014

Oxidant Stress, Antioxidant Defense, and Liver Injury

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity

scientific article published on 10 January 2012

Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration

scientific article published on 17 June 2019

Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells

scientific article published on 07 March 2011

Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity

scientific article published on 01 January 2013

Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity

scientific article (publication date: 2015)

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

scientific article published on 6 April 2013

Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis

scientific article published on 18 July 2016

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.

scientific article

Professionalism in Residency Training: A Compilation of Desirable Behaviors and a Case-Based Comparison Between Pathologists in Training and Practice.

scientific article published in January 2016

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange

scientific article published on 01 May 2019

Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning

scientific article published on 15 December 2013

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation

scientific article published on 17 September 2012

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

scientific article published on 11 October 2013

Redrawing the Map to Novel DILI Biomarkers in Circulation: Where Are We, Where Should We Go, and How Can We Get There?

scientific article published in December 2021

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

scientific article published on 2 May 2016

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

scientific article published on 9 April 2015

Serum Glutamate Dehydrogenase—Biomarker for Liver Cell Death or Mitochondrial Dysfunction?

scientific article published on 08 April 2013

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

scientific article

Strategies for folding of affinity tagged proteins using GroEL and osmolytes.

scientific article published on 12 December 2008

The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review

scientific article published on 27 October 2023

The Problem With Predictive Values: Are We Using the Right Metrics for Preclinical Prediction of Drug Hepatotoxicity?

scientific article published on 01 September 2018

The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation

scientific article published on 23 September 2013

The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling

scientific article published on 14 January 2019

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

scientific article published in March 2012

The past and present of serum aminotransferases and the future of liver injury biomarkers.

scientific article published on 15 December 2016

The role of cytochrome P450 3A4-mediated metabolism in sorafenib and lapatinib hepatotoxicity

scientific article published in June 2023

The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury

scientific article published on 25 November 2014

Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.

scientific article

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