Search filters

List of works by Xiang-Peng Kong

A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions

scientific article

A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design.

scientific article published on 13 September 2012

A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1

scientific article published on 09 November 2021

AMPA receptor tetramerization is mediated by Q/R editing

scientific article published in November 2003

An HIV vaccine targeting the V2 region of Envelope induces a highly durable polyfunctional Fc-mediated antibody response in rhesus macaques

scientific article published on 17 June 2020

An adenosine deaminase (ADA) allele contains two newly identified deleterious mutations (Y97C and L106V) that interact to abolish enzyme activity ⬇️

scientific article published on December 1, 1997

An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity

scientific journal article

Antigenic landscape of the HIV-1 envelope and new immunological concepts defined by HIV-1 broadly neutralizing antibodies.

scientific article

Antiretroviral Imprints and Genomic Plasticity of HIV-1 <i>pol</i> in Non-clade B: Implications for Treatment

scientific article published on 01 January 2021

Atomic force microscopy of Mammalian urothelial surface

scientific article

Author Correction: The wide utility of rabbits as models of human diseases

scientific article published on 04 July 2019

Biophysical dissection of the antigen-antibody interaction of the broadly reactive anti-V3 human mAb 447-52D.

scientific article published on 13 September 2012

Characteristics of the phagocytic cup induced by uropathogenic Escherichia coli.

scientific article published on 17 March 2008

Computational-guided determination of the functional role of 447-52D long CDRH3

scientific article published on 01 December 2018

Conserved structural elements in the V3 crown of HIV-1 gp120

scientific article

Contrasting antibody responses to intrasubtype superinfection with CRF02_AG.

scientific article

Cross-clade HIV-1 neutralizing antibodies induced with V3-scaffold protein immunogens following priming with gp120 DNA.

scientific article

Crystal structure analysis of anti-V2 mAb 2158 suggests a conformational epitope involving an N-linked glycan

scientific article published on 13 September 2012

Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation

scientific article published in July 2000

Crystallization of Proliferating Cell Nuclear Antigen (PCNA) from Saccharomyces cerevisiae

scientific article published on 01 August 1994

Determinants of HIV-1 CD4-independent brain adaptation.

scientific article published on 15 June 2017

Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines

scientific article published on 16 February 2022

Differential induction of anti-V3 crown antibodies with cradle- and ladle-binding modes in response to HIV-1 envelope vaccination.

scientific article

Distinct Glycan Structures of Uroplakins Ia and Ib

scientific article published in Journal of Biological Chemistry

Distinct Residues Contribute to Motility Repression and Autoregulation in the Proteus mirabilis Fimbria-Associated Transcriptional Regulator AtfJ.

scientific article published on 31 May 2016

Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli

scientific article

Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism

scientific article

Elicitation of broadly reactive antibodies against glycan-modulated neutralizing V3 epitopes of HIV-1 by immune complex vaccines.

scientific article published on 16 September 2013

Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection

scientific article (preprint)

Emergence of SARS-CoV-2 through recombination and strong purifying selection

scientific article published on 29 May 2020

Epitope mapping of conformational V2-specific anti-HIV human monoclonal antibodies reveals an immunodominant site in V2.

scientific article

Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials.

scientific article published on 11 January 2018

Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV

scientific article

Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL

scientific article published on 24 June 2015

Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals

scientific article

Gp120 V5 Is Targeted by the First Wave of Sequential Neutralizing Antibodies in SHIVSF162P3N-Infected Rhesus Macaques.

scientific article

High-resolution crystal structure of the Fv of quaternary neutralizing epitope mAb 2909 reveals atomic details of its antigen-binding site

Human Anti-V3 HIV-1 Monoclonal Antibodies Encoded by the VH5-51/VL Lambda Genes Define a Conserved Antigenic Structure

scientific article

Identification of conserved amino acids in murine B7-1IgV domain critical for CTLA4/CD28:B7 interaction by site-directed mutagenesis: a novel structural model of the binding site.

scientific article published on March 1998

Immune Correlates of Disease Progression in Linked HIV-1 Infection

article

Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120.

scientific article published on 17 January 2018

Integrity of all four transmembrane domains of the tetraspanin uroplakin Ib is required for its exit from the ER.

scientific article published on December 2006

Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice.

scientific article published on 22 November 2016

Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle.

scientific article

Modulation of Antibody Responses to the V1V2 and V3 Regions of HIV-1 Envelope by Immune Complex Vaccines

article

Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses

scientific article published on 01 July 2019

Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition

scientific article

Priming with DNA expressing trimeric HIV V1V2 alters the immune hierarchy favoring the development of V2-specific antibodies in rhesus macaques

scientific article published on 21 October 2020

Rabbit Anti-HIV-1 Monoclonal Antibodies Raised by Immunization Can Mimic the Antigen-Binding Modes of Antibodies Derived from HIV-1-Infected Humans

scientific article

Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in Rabbits

scientific article published on 05 October 2016

Rationally Designed Vaccines Targeting the V2 Region of HIV-1 gp120 Induce a Focused, Cross-Clade-Reactive, Biologically Functional Antibody Response.

scientific article

Rationally Targeted Mutations at the V1V2 Domain of the HIV-1 Envelope to Augment Virus Neutralization by Anti-V1V2 Monoclonal Antibodies.

scientific article published on 22 October 2015

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

article

Selective enrichment and fractionation of phosphopeptides from peptide mixtures by isoelectric focusing after methyl esterification

scientific article

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells

scientific article published on 23 March 2016

Sequential exposure to specific antibody escape mutations may program neutralization breadth during subtype A HIV-1 infection

scientific article published on 13 September 2012

Sequential trafficking of Env and Gag to HIV-1 T cell virological synapses revealed by live imaging

Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes

scientific article published on 28 December 2020

Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope.

scientific article

Skin tattooing as a novel approach for DNA vaccine delivery.

scientific article published on 18 October 2012

Skin tattooing as an effective tool for delivering DNA and protein vaccine immunogens

scientific article published on 13 September 2012

Specificity of staphylococcal phage and SaPI DNA packaging as revealed by integrase and terminase mutations.

scientific article published on April 2009

Structural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120

scientific article

Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens

scientific article

Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection

article

Structural analyses of antigen binding similarities and differences between rabbit and human anti-gp120 V3 mAbs

scientific article published on 13 September 2012

Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding.

scientific article published on 15 July 2015

Structural and Functional Studies of Aspergillus oryzae Cutinase: Enhanced Thermostability and Hydrolytic Activity of Synthetic Ester and Polyester Degradation

scientific article

Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution.

scientific article

Structural basis of urothelial permeability barrier function as revealed by Cryo-EM studies of the 16 nm uroplakin particle.

scientific article published on October 2003

Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein

scientific article published on 26 February 2019

Structure of a Sliding Clamp on DNA

scientific article

Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp

scientific article

Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

scientific article

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

scientific article

Structure-based functional characterization of repressor of toxin (Rot), a central regulator of Staphylococcus aureus virulence.

scientific article

Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold.

scientific article

Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity

scientific article

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein.

scientific article

Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy

scientific article published on 22 March 2019

The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel

scientific article

The efficiency of bridging sheet recruitment determines HIV-1 R5 envelope sensitivity to soluble CD4 and macrophage tropism

scientific article published on 13 September 2012

The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals

scientific article published on 27 December 2019

The wide utility of rabbits as models of human diseases.

scientific article published on 22 May 2018

Thermodynamic Signatures of the Antigen Binding Site of mAb 447–52D Targeting the Third Variable Region of HIV-1 gp120

scientific article

Uropathogenic E. coli adhesin-induced host cell receptor conformational changes: implications in transmembrane signaling transduction

scientific article published on 03 July 2009

Uroplakin Ia is the urothelial receptor for uropathogenic<i>Escherichia coli</i>: evidence from in vitro FimH binding

scientific article published in 2001

Uroplakins in urothelial biology, function, and disease

scientific article

VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA

scientific article published on 15 April 2020

Vaccine focusing to cross-subtype HIV-1 gp120 variable loop epitopes.

scientific article published on 18 July 2014

Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses

scientific article

Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV

scientific article published on 01 July 2019

Viral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization Breadth

scientific article

pH-dependent conformational switch activates the inhibitor of transcription elongation.

scientific article

Paulina is supported by:

About Paulina

Help