List of works - Pål Sætrom

A ChIP-Seq benchmark shows that sequence conservation mainly improves detection of strong transcription factor binding sites

scientific article

A Short-activating RNA Oligonucleotide Targeting the Islet β-cell Transcriptional Factor MafA in CD34(+) Cells

scientific article published on 4 June 2013

A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs.

scientific article published on 26 November 2010

A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine

scientific article

A two-step site and mRNA-level model for predicting microRNA targets

scientific article

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.

scientific article

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression

scientific article published on 29 November 2019

An integrated expression atlas of miRNAs and their promoters in human and mouse.

scientific article

Cell-type specificity of ChIP-predicted transcription factor binding sites

scientific article

Circular RNAs are depleted of polymorphisms at microRNA binding sites

scientific article published on 24 April 2014

Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements

scientific article

Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients

scientific article published on 28 October 2019

Designing Dual-Targeting siRNA Duplexes Having Two Active Strands that Combine siRNA and MicroRNA-Like Targeting ⬇️

scientific article published on January 1, 2013

Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer.

scientific article

Error-free versus mutagenic processing of genomic uracil--relevance to cancer

scientific article

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

scientific article published on 19 October 2016

Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells

scientific article

Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer.

scientific article published on 7 March 2018

Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks

scientific article

Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation

scientific article

Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring

scientific article published on 14 December 2015

Identification of metastasis-associated microRNAs in serum from rectal cancer patients.

scientific article published on 30 September 2017

Inferring causative variants in microRNA target sites

scientific article

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

scientific article published on 21 November 2019

MTL-CEBPA, a small activating RNA therapeutic up-regulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multi-centre, open-label, phase I trial

scientific article published on 01 May 2020

Mechanisms involved in the activation of C/EBPα by small activating RNA in hepatocellular carcinoma

scientific article published on 14 January 2019

Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation

scientific article

MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood

scientific article published on 7 August 2012

MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex

scientific article published on 4 March 2017

MicroRNAs--targeting and target prediction ⬇️

scientific article published on 26 February 2010

Motif kernel generated by genetic programming improves remote homology and fold detection

scientific article published on 25 January 2007

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase

scientific article published on 08 December 2012

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

scientific article published on January 2017

Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo.

scientific article

Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells

scientific article published on 22 May 2013

Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α

scientific article

RNA motif discovery: a computational overview

scientific article

Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA.

scientific article

Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation ⬇️

scientific article published on August 16, 2012

Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location

scientific article published on 20 February 2019

Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments

scientific article published on 10 February 2012

Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth In Vivo

scientific article

The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences

scientific article (publication date: 2014)

The importance of p53 pathway genetics in inherited and somatic cancer genomes.

scientific article published on March 2016

Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication

scientific article published on 15 January 2013

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

scientific article published on 08 July 2019

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

scientific article

sMETASeq: Combined Profiling of Microbiota and Host Small RNAs

scientific article published on 04 May 2020

List of works by Pål Sætrom

A ChIP-Seq benchmark shows that sequence conservation mainly improves detection of strong transcription factor binding sites

A Short-activating RNA Oligonucleotide Targeting the Islet β-cell Transcriptional Factor MafA in CD34(+) Cells

A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs.

A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine

A two-step site and mRNA-level model for predicting microRNA targets

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression

An integrated expression atlas of miRNAs and their promoters in human and mouse.

Cell-type specificity of ChIP-predicted transcription factor binding sites

Circular RNAs are depleted of polymorphisms at microRNA binding sites

Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements

Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients

Designing Dual-Targeting siRNA Duplexes Having Two Active Strands that Combine siRNA and MicroRNA-Like Targeting ⬇️

Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer.

Error-free versus mutagenic processing of genomic uracil--relevance to cancer

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells

Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer.

Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks

Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation

Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring

Identification of metastasis-associated microRNAs in serum from rectal cancer patients.

Inferring causative variants in microRNA target sites

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

MTL-CEBPA, a small activating RNA therapeutic up-regulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multi-centre, open-label, phase I trial

Mechanisms involved in the activation of C/EBPα by small activating RNA in hepatocellular carcinoma

Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation

MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood

MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex

MicroRNAs--targeting and target prediction ⬇️

Motif kernel generated by genetic programming improves remote homology and fold detection

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo.

Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells

Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α

RNA motif discovery: a computational overview

Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA.

Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation ⬇️

Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location

Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments

Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth In Vivo

The eGenVar data management system--cataloguing and sharing sensitive data and metadata for the life sciences

The importance of p53 pathway genetics in inherited and somatic cancer genomes.

Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

sMETASeq: Combined Profiling of Microbiota and Host Small RNAs