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List of works by Ilze Bot

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

scientific article

Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies

scientific article published on 06 August 2015

Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient mice

scientific article published on 28 June 2012

Agonistic anti-TIGIT treatment inhibits T cell responses in LDLr deficient mice without affecting atherosclerotic lesion development

scientific article

Akt2/LDLr double knockout mice display impaired glucose tolerance and develop more complex atherosclerotic plaques than LDLr knockout mice.

scientific article published on 12 November 2013

An unexpected intriguing effect of Toll-like receptor regulator RP105 (CD180) on atherosclerosis formation with alterations on B-cell activation.

scientific article

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

scientific article published in 2022

Anti-apoptotic serpins as therapeutics in cardiovascular diseases

scientific article published on August 2013

Antisense Oligonucleotide Inhibition of MicroRNA-494 Halts Atherosclerotic Plaque Progression and Promotes Plaque Stabilization

scientific article published on 30 September 2019

Atherosclerotic lesion progression changes lysophosphatidic acid homeostasis to favor its accumulation

scientific article

Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levels

scientific article published on 13 November 2010

B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells

scientific article published on 01 February 2020

CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mice

scientific article published on 27 May 2016

CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice

scientific article published on 18 January 2018

CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions

scientific article published on 11 April 2019

CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses

article

CXCR4 blockade induces atherosclerosis by affecting neutrophil function

scientific article published on 8 May 2014

Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis

scientific article

Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease

scientific article published on 14 October 2012

Complement factor C5a induces atherosclerotic plaque disruptions

scientific article published on 15 August 2014

Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis

article published in 2018

Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response

scientific article published on 7 April 2016

Differential effects of regulatory T cells on the initiation and regression of atherosclerosis

scientific article published on 5 May 2011

Disruption of a CD1d-mediated interaction between mast cells and NKT cells aggravates atherosclerosis

scientific article published on 14 November 2018

Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration

scientific article published on February 2014

Fibrin and Activated Platelets Cooperatively Guide Stem Cells to a Vascular Injury and Promote Differentiation Towards an Endothelial Cell Phenotype

scientific article published on 20 April 2006

Flow Cytometry-Based Characterization of Mast Cells in Human Atherosclerosis.

scientific article published on 9 April 2019

Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis ⬇️

scientific article published on 17 January 2011

Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

scientific article

Hematopoietic G‐protein‐coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor‐knockout mice ⬇️

scientific article published on October 9, 2012

Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice

scientific article

Hypercholesterolemia Induces a Mast Cell-CD4+ T Cell Interaction in Atherosclerosis

scientific article published on 25 January 2019

Identification of a novel CD40 ligand for targeted imaging of inflammatory plaques by phage display

scientific article

Identification of an internalising peptide in differentiated Calu-3 cells by phage display technology; application to gene delivery to the airways.

scientific article published in August 2003

Impaired effector memory T-cell regulation facilitates graft versus host disease in CCR7-deficient bone marrow transplant chimeras

scientific article published in September 2009

Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency.

scientific article published on 30 November 2016

Induction of HLA-A2 restricted CD8 T cell responses against ApoB100 peptides does not affect atherosclerosis in a humanized mouse model

scientific article published on 22 November 2019

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

scientific article published on 13 April 2017

Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice

scientific article published on 24 November 2016

Interference of the CD30-CD30L pathway reduces atherosclerosis development

scientific article

Interruption of the OX40-OX40 ligand pathway in LDL receptor-deficient mice causes regression of atherosclerosis

scientific article

Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo

scientific article published on 10 May 2005

Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice

scientific article published on 17 November 2008

Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation

scientific article published on 8 June 2017

Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis

scientific article

Leukocyte-Specific CCL3 Deficiency Inhibits Atherosclerotic Lesion Development by Affecting Neutrophil Accumulation ⬇️

scientific article published on January 3, 2013

Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner

scientific article published on 13 June 2018

Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice

scientific article

Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells

scientific article published on 10 October 2019

Low-dose FK506 blocks collar-induced atherosclerotic plaque development and stabilizes plaques in ApoE-/- mice.

scientific article published in June 2005

Mast Cells Induce Vascular Smooth Muscle Cell Apoptosis via a Toll-Like Receptor 4 Activation Pathway

scientific article published on 31 May 2012

Mast Cells in Cardiovascular Disease: From Bench to Bedside

scientific article published on 10 July 2019

Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE−/− mice ⬇️

scientific article published on August 6, 2010

Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile

scientific article published on 13 June 2016

Mast cells as effectors in atherosclerosis

scientific article

Mast cells in atherosclerosis

scientific article published on 25 August 2011

Mast cells in atherosclerotic cardiovascular disease - Activators and actions

scientific article published on 12 October 2017

Mast cells in human and experimental cardiometabolic diseases

scientific article published on 11 August 2015

Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events

scientific article published on 11 June 2013

Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression

scientific article

Mast cells: pivotal players in cardiovascular diseases

scientific article published on August 2008

Mesenchymal Stem Cells Reduce Murine Atherosclerosis Development

scientific article published on 22 October 2015

Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis

scientific article

Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF-1 in a rat model

scientific article published on October 2012

Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-β

scientific journal article

Myocardin regulates vascular smooth muscle cell inflammatory activation and disease

scientific article

NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report

scientific article

Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation

scientific article published on 26 April 2010

Oxidized low-density lipoprotein-induced apoptotic dendritic cells as a novel therapy for atherosclerosis

scientific article published on 4 February 2015

Perivascular Mast Cells Promote Atherogenesis and Induce Plaque Destabilization in Apolipoprotein E–Deficient Mice

scientific article published on 30 April 2007

Preface: Pathology and Pharmacology of Atherosclerosis

scientific article published in December 2017

Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis

scientific article published on 22 October 2010

Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis

scientific article published on 8 November 2007

Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression

scientific article

Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype

scientific article published on 20 August 2013

RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner

scientific article published on 22 November 2014

Relaxing the artery: A new strategy to limit atherogenesis

scientific article published on 10 June 2016

Reply to "Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner"

scientific article published on 27 August 2018

Reply to: "The "cholesterol paradox" in patients with mastocytosis"

scientific article published on 02 March 2019

Reply: The complexity of substance P-mediated mast cell activation

scientific article published on 5 January 2017

SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells

article by Alma Zernecke et al published 15 April 2005 in Circulation Research

Scavenger receptor-AI-targeted iron oxide nanoparticles for in vivo MRI detection of atherosclerotic lesions

scientific article published on 6 June 2013

Selective modulation of nuclear factor of activated T-cell function in restenosis by a potent bipartite peptide inhibitor

scientific article published on 23 November 2011

Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice.

scientific article published on 14 August 2003

Stress-induced mast cell activation contributes to atherosclerotic plaque destabilization

scientific article published in Scientific Reports

Stressed brain, stressed heart?

scientific article published on 11 January 2017

Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently

scientific article published on 07 February 2010

Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels

scientific article published on 8 December 2017

T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis

scientific article published on 29 August 2013

The IL-12 cytokine family in cardiovascular diseases.

scientific article published on 23 October 2017

The impact of mast cells on cardiovascular diseases

scientific article published on 08 May 2015

The origin of atherosclerotic plaque cells: Plasticity or not?

scientific article published on 2 July 2016

The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics

scientific article published on January 2009

The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation

scientific article published on August 2013

Uremia does not affect neointima formation in mice

scientific article published on 26 July 2017

Vaccination against Foxp3(+) regulatory T cells aggravates atherosclerosis.

scientific article

Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment.

scientific article

Vascular neuropeptide Y contributes to atherosclerotic plaque progression and perivascular mast cell activation

scientific article published on 10 May 2014

Viral cross-class serpin inhibits vascular inflammation and T lymphocyte fratricide; a study in rodent models in vivo and human cell lines in vitro

scientific article

Viral serine protease inhibitors as anti-atherosclerotic therapy

scientific article published on September 2007

Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice

scientific journal article

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