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List of works by Gerald Hoefler

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

scientific article published in August 2016

A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling

scientific article published on 25 September 2012

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis

scientific article

A stress-induced early innate response causes multidrug tolerance in melanoma

scientific article published on 24 November 2014

A synonymous EGFR polymorphism predicting responsiveness to anti-EGFR therapy in metastatic colorectal cancer patients.

scientific article published on 15 December 2015

ABL amplification in a patient with lymphoid blast crisis of chronic myelogenous leukaemia

scientific article published in March 1999

APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion

scientific article published on 30 May 2017

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

scientific article published on 21 August 2011

Activation of beta-catenin is a late event in the pathogenesis of nephroblastomas and rarely correlated with genetic changes of the APC gene

article

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

scientific article published in Science

Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice

scientific article

Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling ⬇️

scientific article published on December 6, 2012

Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids

scientific article

Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy

scientific article published in June 2009

Baseline plasma epinephrine levels predict Wisconsin Card Sorting Test scores in healthy volunteers

scientific article published on 28 November 2008

Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area

scientific article published on 19 July 2012

Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart

scientific article

Cardiac fibrosis in human transplanted hearts is mainly driven by cells of intracardiac origin.

scientific article published in March 2012

Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.

scientific article

Chlorination and oxidation of the extracellular matrix protein laminin and basement membrane extracts by hypochlorous acid and myeloperoxidase

scientific article published on 03 November 2018

Clinical and genetic criteria are important for identification and management of hereditary non-polyposis colorectal cancer

scientific article published on 01 October 2005

Clonality and loss of heterozygosity of WT genes are early events in the pathogenesis of nephroblastomas

article

Cloning and tissue expression of two cDNAs encoding the peroxisomal 2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in the guinea pig liver

scientific article published on January 1996

Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia

article

Comparison of the 2002 and 2010 TNM classification systems regarding outcome prediction in clear cell and papillary renal cell carcinoma

scientific article published on 28 September 2012

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients

scientific article published on 3 April 2015

Complete remission of generalized relapsed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type of the gastrointestinal tract after high-dose chemotherapy and autologous peripheral stem cell transplantation

scientific article published on 01 December 2000

Compound heterozygosity for twoMSH6 mutations in a patient with early onset colorectal cancer, vitiligo and systemic lupus erythematosus

scientific article published on 01 May 2008

Comprehensive Screening for Lynch Syndrome: Who Can Be the Driving Force in Daily Clinical Practice?

scientific article published on 23 March 2009

Corrigendum to "Tumor Macroenvironment and Metabolism" [Seminars in Oncology, Vol 41, No 2, April 2014, pp 281-295].

scientific article published on 28 August 2014

Critical issues in the identification and management of patients with hereditary non-polyposis colorectal cancer.

scientific article

Cyclooxygenase pathway in dermal fibroblasts from patients with metabolic disorders of peroxisomal origin

scientific article published on 01 August 1993

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

scientific article published on 16 August 2018

Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia.

scientific article published in June 2002

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

scientific article

Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas

Deletion of SPRY4 is a frequent event in secondary acute myeloid leukemia.

scientific article published on 25 July 2015

Detection of prognostically relevant mutations and translocations in myeloid sarcoma by next generation sequencing

scientific article published on 20 June 2017

Dietary glycine decreases both tumor volume and vascularization in a combined colorectal liver metastasis and chemotherapy model

scientific article published on 04 June 2019

Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer

scientific article

Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.

scientific article published on 18 September 2018

Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2receptors

scientific article published in March 2008

Effects of Lewis lung carcinoma and B16 melanoma on the innervation of the mouse trachea

scientific article published on 19 March 2014

Erratum: A stress-induced early innate response causes multidrug tolerance in melanoma

article

Erratum: Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable as well as inoperable pancreatic cancer

scholarly article published in British Journal of Cancer

Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors.

scientific article published on 12 February 2009

Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients

scientific article

Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1.

scientific article published on 14 July 2017

Expression of CD44 splice variant v10 in Hodgkin's disease is associated with aggressive behaviour and high risk of relapse

scientific article published on 01 December 1998

External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients

scientific article

Gastric cancer and concomitant renal cancer: a systematic immunohistochemical and molecular analysis

scientific article published on 15 June 2011

Genetic clonality is a feature unifying nephroblastomas regardless of the variety of morphological subtypes

scientific article published on 20 May 2006

Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.

scientific article published on 6 September 2016

Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.

scientific article

Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).

scientific article

Heavy-chain immunoglobulin gene rearrangement and cytoplasmic immunoglobulin expression in acute monocytic leukemia following primary germ cell tumor

article

Hedgehog pathway proteins SMO and GLI expression as prognostic markers in head and neck squamous cell carcinoma

scientific article published on 28 May 2019

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

scientific article published on 25 April 2019

Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation

scientific article published on 09 January 2019

High resolution SNP array genomic profiling of peripheral T cell lymphomas, not otherwise specified, identifies a subgroup with chromosomal aberrations affecting the REL locus

scientific article

Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases

scientific article

Identification of the transcription factor HOXB4 as a novel target of miR-23a.

scientific article published on 30 April 2013

Implementation of formalin-fixed, paraffin-embedded cell line pellets as high-quality process controls in quality assessment programs for KRAS mutation analysis.

scientific article

Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer.

scientific article published on 25 June 2013

Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis

scientific article

Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity

scientific article published on 17 December 2018

Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting

scientific article

Is predisposition for nephroblastoma linked to polymorphisms of the WTX gene?

scientific article

KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients

scientific article published on 8 November 2016

KRAS mutation analysis on low percentage of colon cancer cells: the importance of quality assurance

scientific article published on 15 December 2012

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program.

scientific article published on 18 September 2008

Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.

scientific article published on September 2011

Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas

scientific article

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase

scholarly article

Loss of PTEN/MMAC1 activity is a rare and late event in the pathogenesis of nephroblastomas

scientific article published on 8 April 2010

Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations.

scientific article published on 9 April 2009

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

scientific article published on 31 January 2020

Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration.

scientific article published on 2 January 2018

Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia

scientific article published on 17 May 2016

Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.

scientific article

Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice

scientific article published on 01 February 2020

Low spinophilin expression enhances aggressive biological behavior of breast cancer.

scientific article published on May 2015

Megakaryocytic morphology and clinical parameters in essential thrombocythemia, polycythemia vera, and primary myelofibrosis with and without JAK2 V617F.

scientific article published on September 2014

MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors

scientific article published on 01 February 2019

MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients

scientific article

MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients.

scientific article published on 25 September 2014

Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58.

scientific article published on 16 April 2015

Molecular cytogenetics and multiplex reverse-transcriptase polymerase chain reaction for risk stratification in acute myeloid leukemia

scientific article

Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice

scientific article

Multiple intratumoralKRASmutations can clonally segregate to different lymph node metastases in colon cancer

article

Muscle-specific overexpression of human lipoprotein lipase in mice causes increased intracellular free fatty acids and induction of peroxisomal enzymes

scientific article published on 01 February 1997

Mutant DNMT3A in acute myeloid leukemia: guilty of inducing genetic instability?

scientific article published on 18 February 2013

Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.

scientific article published in August 2001

Mutational analysis of the DNA mismatch repair gene hMLH1 in myeloid leukaemias

article

Mutational dichotomy in desmoplastic malignant melanoma corroborated by multigene panel analysis

scientific article published on 13 March 2015

Mutations inDNMT3A and loss of RKIP are independent events in acute monocytic leukemia.

scientific article

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

scientific article published on 01 November 2019

Neoplastic cell percentage estimation in tissue samples for molecular oncology: recommendations from a modified Delphi study

scientific article published on 18 July 2019

Nephroblastomas show low expression of microR-204 and high expression of its target, the oncogenic transcription factor MEIS1.

scientific article published on 11 March 2014

Next-Generation Sequencing in Diagnostics and Clinical Research

scientific article published on 30 November 2017

Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism

scientific article published on 23 June 2016

Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms

scientific article

Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

scientific article published on 05 April 2019

Peroxisomal bifunctional protein deficiency revisited: resolution of its true enzymatic and molecular basis

scientific article published on January 1999

Peroxisomal fatty acid beta-oxidation in HepG2 cells

scientific article published on September 1991

Plasmacytoid dendritic cells are absent in skin lesions of polymorphic light eruption

scientific article published on 01 February 2007

Preexisting TP53 mutation in therapy-related acute myeloid leukemia

scientific article published on 20 August 2014

Presence of mycobacterial dna in sarcoidosis

article

Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancer

scientific article

Quantitative short-tandem repeat analysis of recipient-derived cells as an additional tool for diagnosing cardiac allograft rejection

scientific article published in March 2010

Report from the OECI Oncology Days 2014

scientific article

Report of an international survey of molecular genetic testing laboratories

scientific article published in January 2007

Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia.

scientific article published on 29 September 2017

Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH)

scientific article

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

article

Serotonin signalling is crucial in the induction of PUVA-induced systemic suppression of delayed-type hypersensitivity but not local apoptosis or inflammation of the skin

scientific article published on 23 February 2016

Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity.

scientific article

Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation

scientific article

Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia.

scientific article

Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes.

scientific article published on 17 April 2012

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

scientific article published on 8 February 2013

Testing and clinical implications for non-V600 BRAF mutations in metastatic NRASmt melanoma.

scientific article

The TP53 Pro72Arg SNP in de novo acute myeloid leukaemia - results of two cohort studies involving 215 patients and 3759 controls

scientific article published on 20 January 2017

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

scientific article

The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer

scientific article published on 01 February 2015

The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

scientific article published on 09 August 2007

The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration

scientific article

The role of germline mutation profiling in the selection of related donors for haematopoietic stem cell transplantation

scientific article published on 25 September 2019

The role of morphology in combination with ploidy analysis in characterizing early gestational abortion

scientific article published on 21 December 2012

The role of triglyceride lipases in cancer associated cachexia.

scientific article published on 14 March 2013

The times have changed: molecular pathology is here to stay. A commentary on: analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma,

scientific article published on 23 February 2012

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin

scientific article published on 10 December 2019

Translational regulation mechanisms of AP-1 proteins

scientific article published on 09 January 2009

Trends of stage, grade, histology and tumour necrosis in renal cell carcinoma in a European centre surgical series from 1984 to 2010.

scientific article published on 25 May 2012

Tumor Macroenvironment: An Update

scientific article published on 04 September 2019

Tumor macroenvironment and metabolism

scientific article

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth.

scientific article published on 29 March 2016

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing.

scientific article published on 05 April 2013

Tumour heterogeneity: principles and practical consequences

scientific article published on 13 July 2016

Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia

scientific article

Validation of C-reactive protein levels as a prognostic indicator for survival in a large cohort of pancreatic cancer patients.

scientific article

Venous thrombosis in a replanted finger with underlying factor V Leiden mutation.

scientific article

Visualization of tumor heterogeneity by in situ padlock probe technology in colorectal cancer.

scientific article

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.

scientific article published on 22 June 2016

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.

scientific article published on 03 May 2013

cDNA cloning and analysis of tissue-specific expression of mouse peroxisomal straight-chain acyl-CoA oxidase

scientific article published in February 2000

cDNA cloning of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme and localization to chromosome 3q26.3-3q28: a free left Alu Arm is inserted in the 3' noncoding region

scientific article

miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor

scientific article

miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms ⬇️

scientific article published on March 19, 2012

miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.

scientific article published on 22 May 2017

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