List of works by Klaus Bønnelykke

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry

article

17q21 gene variation is not associated with asthma in adulthood.

scientific article published in January 2015

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use

scientific article published on 09 July 2018

4th Pediatric Allergy and Asthma Meeting (PAAM)

scientific article (publication date: November 2016)

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.

scientific article published on 4 January 2018

A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma

scientific article

A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.

scientific article

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

scientific article

A novel common variant in DCST2 is associated with length in early life and height in adulthood

scientific article published on 3 October 2014

A novel method for assessing unchallenged levels of mediators in nasal epithelial lining fluid

scientific article published on 20 March 2010

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma

scientific article

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

scientific article published on 01 October 2019

Aerosol particle size does not predict pharmacokinetic determined lung dose in children.

scientific article

Age dependent systemic exposure to inhaled salbutamol

scientific article

Airway immune mediator levels during asthma-like symptoms in young children and their possible role in response to azithromycin

scientific article published on 04 November 2020

Airway obstruction and bronchial reactivity from age 1 month until 13 years in children with asthma: A prospective birth cohort study

article by Henrik Wegener Hallas et al published January 2019 in PLOS MEDICINE

Allergen Specificity in Specific IgE Cutoff

scientific article published on 18 May 2020

Allergic rhinitis is associated with otitis media with effusion: a birth cohort study.

scientific article published in November 2012

Antibiotic exposure in infancy and development of BMI and body composition in childhood

scientific article published on 27 November 2019

Antibiotic use during pregnancy alters the commensal vaginal microbiota.

scientific article

Association between childhood asthma and attention deficit hyperactivity or autism spectrum disorders: a systematic review with meta-analysis

scientific article published on 30 September 2020

Association between respiratory infections in early life and later asthma is independent of virus type

scientific article published on 21 April 2015

Association between whole-blood polyunsaturated fatty acids in pregnant women and early fetal weight

scientific article published on 12 June 2013

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial

scientific article published on 05 August 2019

Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study

scientific article

Associations between Inhaled Corticosteroid Use in the First 6 Years of Life and Obesity-related Traits

scientific article published in 2021

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

article

Asthma-like Symptoms in Young Children Increase the Risk of COPD

scientific article published on 11 June 2020

Atopic endotype in childhood.

scientific article published on 17 November 2015

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

scientific article published on 01 September 2018

Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years: a randomised, double-blind, placebo-controlled trial

scientific article published on 15 December 2015

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

scientific article

Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis

scientific article published on 20 June 2020

Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments

Bronchiolitis needs a revisit: distinguishing between virus entities and their treatments

CDHR3 Genetics and Rhinovirus C Respiratory Illnesses

scientific article published on 9 November 2017

CDHR3 gene variation and childhood bronchiolitis.

scientific article published on 03 August 2017

Cat exposure in early life decreases asthma risk from the 17q21 high-risk variant

scientific article published on 14 October 2017

Cesarean Delivery and Body Mass Index at 6 Months and Into Childhood

scientific article published on 01 June 2017

Cesarean section and chronic immune disorders

scientific article published on December 2014

Cesarean section changes neonatal gut colonization

scientific article published on April 2016

Childhood asthma after bacterial colonization of the airway in neonates

scientific article published in October 2007

Childhood asthma: Danish guidelines for diagnosis and treatment

scientific article published in August 2013

Children Monosensitized to Can f 5 Show Different Reactions to Male and Female Dog Allergen Extract Provocation: A Randomized Controlled Trial

scientific article published on 19 December 2019

Children with Asthma Have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations

scientific article published on 09 November 2019

Children with allergic and nonallergic rhinitis have a similar risk of asthma ⬇️

scientific article published on September 1, 2010

Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.

scientific article published on 21 November 2008

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

scientific article published on 10 September 2015

Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children

scientific article published on 9 December 2011

Common variants at 12q15 and 12q24 are associated with infant head circumference

scientific article published on 15 April 2012

Consortium genome-wide meta-analysis for childhood dental caries traits

Consortium-based genome-wide meta-analysis for childhood dental caries traits

scholarly article by Simon Haworth published in September 2018

Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study

scientific article

Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age

scientific article published on 01 November 2012

Correspondence to "Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments"

scientific article published on 01 June 2020

Data representations and -analyses of binary diary data in pursuit of stratifying children based on common childhood illnesses

scientific article published in PLoS ONE

Deep phenotyping of the unselected COPSAC2010 birth cohort study.

scientific article

Delayed Motor Milestones Achievement in Infancy Associates with Perturbations of Amino Acids and Lipid Metabolic Pathways

scientific article published on 19 August 2020

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

scientific article published on 01 November 2020

Determinants of lung function and airway hyperresponsiveness in asthmatic children.

scientific article published on 2 March 2007

Determinants of neurodevelopment in early childhood – results from the copenhagen prospective studies on asthma in childhood ( COPSAC 2010 ) mother–child cohort

scientific article published on 21 March 2019

Disagreement between skin prick test and specific IgE in young children

scientific article published on 30 November 2014

Distinct immune phenotypes in infants developing asthma during childhood

scientific article published on 01 February 2020

Duration of wheezy episodes in early childhood is independent of the microbial trigger

scientific article published on 19 June 2015

Early bioavailability of inhaled salbutamol reflects lung dose in children

scientific article published on 10 April 2008

Early life bacterial airway colonization, local immune mediator response and risk of otitis media

scientific article published on 29 June 2020

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

scientific article published on 11 December 2018

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial

scientific article published on 24 February 2020

Effect of Vitamin D3 Supplementation During Pregnancy on Risk of Persistent Wheeze in the Offspring: A Randomized Clinical Trial

scientific article published on January 2016

Effect of delivery device on systemic exposure to inhaled fluticasone propionate in children with asthma.

scientific article

Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial

scientific article published in the British Medical Journal

Effect of prenatal bisphenol A exposure on early childhood body mass index through epigenetic influence on the insulin-like growth factor 2 receptor (IGF2R) gene

scientific article published on 06 July 2020

Elevated Exhaled Nitric Oxide in High-Risk Neonates Precedes Transient Early but Not Persistent Wheeze

scientific article published on 18 March 2010

Elevated eosinophil protein X in urine from healthy neonates precedes development of atopy in the first 6 years of life

scientific article published in September 2011

Endotyping early childhood asthma by quantitative symptom assessment

Environmental and Genetic Determinants of Serum 25(OH)-Vitamin D Levels during Pregnancy and Early Childhood

scientific article published on 21 October 2019

Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age

scientific article published on 18 July 2020

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

scholarly article by Zala Jevnikar et al published June 2018 in The Journal of Allergy and Clinical Immunology

Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

scholarly article published in Nature Genetics

Extrapolating evidence beyond age groups

scientific article published on 5 March 2008

FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

scientific article

FeNO and Exercise Testing in Children at Risk of Asthma

scientific article

Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth

scientific article published on 21 June 2010

Fish Oil Supplementation in Pregnancy Increases Gestational Age, Size for Gestational Age, and Birth Weight in Infants: A Randomized Controlled Trial

Fish Oil in Pregnancy and Asthma in Offspring

scientific article published on 01 March 2017

Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring

scientific article

Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

scientific article published on 06 August 2019

Fraction of exhaled nitric oxide and bronchial responsiveness are associated and continuous traits in young children independent of asthma.

scientific article published in December 2012

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

scientific article

From Skin Barrier Dysfunction to Asthma:Filaggrin Genotype Defined Atopic Phenotype in Early Childhood

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

scientific article published on 04 September 2019

Gene-environment interaction in atopic diseases: a population-based twin study of early-life exposures

article

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure

scientific article published in June 2008

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

Genetic association study of childhood aggression across raters, instruments, and age

scientific article

Genetic associations with viral respiratory illnesses and asthma control in children.

scientific article

Genetic variants linked to education predict longevity

scientific article (publication date: 22 November 2016)

Genetic, Clinical, and Environmental Factors Associated With Persistent Atopic Dermatitis in Childhood

Genetics of allergy and allergic sensitization: common variants, rare mutations

scientific article

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

scientific article

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

scientific article published on 24 November 2015

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

scholarly article by Johannes Waage et al published August 2018 in Nature Genetics

Genome-wide association study identifies 74 loci associated with educational attainment

scientific article published on 11 May 2016

Genome-wide associations for birth weight and correlations with adult disease

scientific article

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

High-Dose Vitamin D Supplementation in Pregnancy and Neurodevelopment in Childhood: A Prespecified Secondary Analysis of a Randomized Clinical Trial

scientific article published on 01 December 2020

Immune-mediated diseases and microbial exposure in early life.

scientific article

Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants

Infant airway microbiota and topical immune perturbations in the origins of childhood asthma

scientific article published on 01 November 2019

Interaction between Asthma and Lung Function Growth in Early Life

Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

scientific article published on 26 December 2019

Interaction between filaggrin null mutations and tobacco smoking in relation to asthma

Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium

scientific article

Levels of Systemic Low-grade Inflammation in Pregnant Mothers and Their Offspring are Correlated

scientific article published on 28 February 2019

Leveraging gene-environment interactions and endotypes for asthma gene discovery

scientific article published on March 2016

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

scientific article published in January 2018

Limited clinical value of exhaled volatile organic compound measurements in childhood asthma

article published in 2018

Living with cat and dog increases vaginal colonization with E. coli in pregnant women

scientific article

Long-term exposure to air pollution and asthma hospitalisations in older adults: a cohort study

scientific article (publication date: 2 September 2011)

Long-term studies of the natural history of asthma in childhood ⬇️

scientific article published on August 1, 2010

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

scientific article published in Nature Communications

Low-frequency variation inTP53has large effects on head circumference and intracranial volume

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

scientific article published on 01 May 2019

Maternal antibiotic use and risk of asthma in offspring--Authors' reply

scientific article

Maternal propensity for infections and risk of childhood asthma: a registry-based cohort study

scientific article published on 24 July 2014

Maturation of the gut microbiome and risk of asthma in childhood

scientific article published on 10 January 2018

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

scientific article published on 07 May 2020

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

scientific article

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

scientific article

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

scientific article published on 19 October 2015

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

scientific article published on 22 December 2017

Multiple Breath Washout for Diagnosing Asthma and Persistent Wheeze in Young Children

scientific article published on 01 May 2019

NKG2D gene variation and susceptibility to viral bronchiolitis in childhood

article

Neonatal Urine Metabolic Profiling and Development of Childhood Asthma

scientific article published on 16 September 2019

Neonatal cytokine profile in the airway mucosal lining fluid is skewed by maternal atopy

scientific article published on 10 November 2011

Neonates colonized with pathogenic bacteria in the airways have a low-grade systemic inflammation.

scientific article

Neonates with reduced neonatal lung function have systemic low-grade inflammation

scientific article

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

No evidence of intrauterine sensitization against inhalant allergens

article

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

scientific article

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

scientific article published on 12 October 2020

Null association between serum 25-hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non-allergic rhinitis: A Mendelian randomization study

scientific article published on 18 September 2020

Parent-specific effects on risk of developing allergic sensitization and asthma in childhood

scientific article published on 07 July 2020

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

scientific article

Picornavirus-Induced Airway Mucosa Immune Profile in Asymptomatic Neonates

scientific article published on 09 December 2015

Postmenopausal hormone therapy and asthma-related hospital admission

scientific article published on 8 January 2015

Precision allergy: Separate allergies to male and female dogs

scientific article

Predictors of indoor fine particulate matter in infants' bedrooms in Denmark

scientific article published on 6 November 2010

Prelabor cesarean section bypasses natural immune cell maturation

scholarly article by Anna Hammerich Thysen et al published October 2015 in The Journal of Allergy and Clinical Immunology

Prenatal Vitamin D Supplementation to Improve Health in Offspring

article

Prenatal and postnatal genetic influence on lung function development.

scientific article published on 21 May 2014

Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

scientific article published on 22 January 2020

Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials

scientific article published on 27 October 2017

Prevalence and predictors of antibiotic administration during pregnancy and birth

scientific article

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression

scientific article published on 09 November 2019

Publisher Correction: Maturation of the gut microbiome and risk of asthma in childhood

scientific article published on 13 February 2018

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

scientific article published on 16 November 2021

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

scientific article published on 22 June 2017

Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 years of life.

scientific article published on 2 May 2019

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age.

scientific article published on 22 July 2011

Reply

scientific article published on 12 April 2016

Reply: Allergy is not always the cause of asthma

scientific article

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

scientific article published on 27 March 2013

Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source

scientific article

Role of viruses in asthma

scientific article published on 27 January 2020

Season of birth shapes neonatal immune function.

scientific article published on 27 October 2015

Sensitivity of multiple breath washout to detect mild-to-moderate asthma in adolescence

scientific article published on 29 January 2019

Sensitization does not develop in utero

Sensitization trajectories in childhood revealed by using a cluster analysis

scientific article published on 24 March 2017

Shared genetic variants suggest common pathways in allergy and autoimmune diseases

scientific article published on 7 February 2017

Single and multiple time-point allergic sensitization during childhood and risk of asthma by age 13

scientific article published on 12 August 2019

Skin barrier abnormality caused by filaggrin (FLG) mutations is associated with increased serum 25-hydroxyvitamin D concentrations

Susceptibility to Lower Respiratory Infections in Childhood is Associated with Perturbation of the Cytokine Response to Pathogenic Airway Bacteria.

scientific article

Symptom burden of atopic dermatitis in early childhood assessed from daily monitoring of symptoms and topical steroid usage

scientific article published on 17 September 2020

The PCDH1 gene and asthma in early childhood

scientific article

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts

scientific article

The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review

scientific article published on 4 September 2017

The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D

scientific article published on 24 October 2019

Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood ⬇️

scientific article published on September 1, 2010

Urbanized microbiota in infants, immune constitution and later risk of atopic diseases

scientific article published on 15 December 2020

Use of antibiotics during pregnancy increases the risk of asthma in early childhood

scientific article published on 6 November 2012

VEGFA variants are associated with pre-school lung function, but not neonatal lung function.

scientific article published in November 2013

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

article

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

scientific article published on 02 September 2019

Variants of DENND1B associated with asthma in children

scientific article

Vitamin D Supplement During Pregnancy and Enamel Defects in Offspring-Reply

scientific article published on 27 January 2020

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

scientific article published on 23 September 2019

“To wheeze or not to wheeze”: That is not the question

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