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List of works by Christophe Le Tourneau

A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours

scientific article published on 25 August 2020

Antibody drug conjugates: the future of chemotherapy?

scientific article published on 29 June 2016

Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines

scientific article

Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial

scientific article

CD44 Isoform Status Predicts Response to Treatment with Anti-CD44 Antibody in Cancer Patients

scientific article

Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials

scientific article

Choice of starting dose for molecularly targeted agents evaluated in first-in-human phase I cancer clinical trials

scientific article published on February 2010

Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types

scientific article

Concomitant drugs with low risks of drug-drug interactions for use in oncology clinical trials

scientific article

Current challenges for the early clinical development of anticancer drugs in the era of molecularly targeted agents

scientific article published on March 2010

Current events in immunotherapy for upper aerodigestive tract cancer

scientific article published on 19 January 2017

Cytological features of NUT midline carcinoma arising in sino-nasal tract and parotid gland: Report of two new cases and review of the literature

scientific article published on 24 June 2016

Development of anti-cancer drugs

scientific article published on October 1, 2010

Dose escalation methods in phase I cancer clinical trials

scientific article published on 12 May 2009

Efficiency of New Dose Escalation Designs in Dose-Finding Phase I Trials of Molecularly Targeted Agents ⬇️

scientific article published on December 12, 2012

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

scientific article

Ethical considerations for precision psychiatry: A roadmap for research and clinical practice

scientific article published in 2022

Heterogeneity in the definition of dose-limiting toxicity in phase I cancer clinical trials of molecularly targeted agents: A review of the literature ⬇️

scientific article published on 07 April 2011

Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site

scientific article published on 16 November 2020

Identification of new candidate therapeutic target genes in head and neck squamous cell carcinomas

scientific article published on 18 June 2016

Ligand-receptor dissociated expression explains high TSLP without prognostic impact in human primary head and neck squamous cell carcinoma

scientific article published on 07 June 2016

Markers involved in resistance to cytotoxics and targeted therapeutics in pancreatic cancer

scientific article

Molecular profiling in precision medicine oncology

scientific article published on 01 May 2019

Molecular targeted therapies in all histologies of head and neck cancers: an update

scientific article published on May 2010

Molecular targeted therapy of head and neck cancer: review and clinical development challenges

scientific article published on 27 September 2007

Molecular-targeted therapies in the treatment of squamous cell carcinomas of the head and neck

scientific article published on May 2008

Molecularly targeted agents in the treatment of recurrent or metastatic squamous cell carcinomas of the head and neck

scientific article published on December 2008

Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial

scientific article published on 02 September 2015

Multi-factor data normalization enables the detection of copy number aberrations in amplicon sequencing data

scientific article

Ocular adverse events of molecularly targeted agents approved in solid tumours: a systematic review

scientific article

Optimizing drug development in oncology by clinical trial simulation: Why and how?

scientific article published on 29 May 2017

PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity

scientific article published on 13 April 2022

Pembrolizumab in cervical cancer: latest evidence and clinical usefulness

scientific article

Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort

scientific article

Phase I trial of Debio 1143, an antagonist of inhibitor of apoptosis proteins, combined with cisplatin-chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head & neck

scientific article published on 29 September 2020

Prognostic factors of successful on-purpose tumor biopsies in metastatic cancer patients included in the SHIVA prospective clinical trial

scientific article published on 15 September 2016

Progress and challenges in the identification of biomarkers for EGFR and VEGFR targeting anticancer agents

scientific article published on 02 June 2008

Pure and mixed fibrolamellar hepatocellular carcinomas differ in natural history and prognosis after complete surgical resection

scientific article published on 13 March 2012

Ramucirumab in Combination with Pembrolizumab in Treatment-Naïve Advanced Gastric or GEJ Adenocarcinoma: Safety and Antitumor Activity from the Phase 1a/b JVDF Trial

scientific article published on 15 October 2020

Reporting of time-to-event end points and tracking of failures in randomized trials of radiotherapy with or without any concomitant anticancer agent for locally advanced head and neck cancer

scientific article published on 05 October 2009

Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland

scientific article published on 22 December 2010

Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1-Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Study

scientific article published on 24 August 2017

Sunitinib: a novel tyrosine kinase inhibitor. A brief review of its therapeutic potential in the treatment of renal carcinoma and gastrointestinal stromal tumors (GIST).

scientific article published on June 2007

Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy

scientific article

Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials

scientific article

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